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(S)-2-amino-3-(1H-imidazol-4-yl)-N-(2-(naphthalen-2-yl)ethyl)propanamide ID: ALA5094081
PubChem CID: 141882868
Max Phase: Preclinical
Molecular Formula: C18H20N4O
Molecular Weight: 308.38
Molecule Type: Unknown
Associated Items:
Names and Identifiers Canonical SMILES: N[C@@H](Cc1c[nH]cn1)C(=O)NCCc1ccc2ccccc2c1
Standard InChI: InChI=1S/C18H20N4O/c19-17(10-16-11-20-12-22-16)18(23)21-8-7-13-5-6-14-3-1-2-4-15(14)9-13/h1-6,9,11-12,17H,7-8,10,19H2,(H,20,22)(H,21,23)/t17-/m0/s1
Standard InChI Key: YHEJFEJJFPIYNO-KRWDZBQOSA-N
Molfile:
RDKit 2D
23 25 0 0 0 0 0 0 0 0999 V2000
2.4363 -0.3283 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.7218 0.0840 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.7218 0.9056 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.4317 1.3144 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.1448 0.9036 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.1448 0.0861 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.8567 -0.3226 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.5608 0.0914 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.5608 0.9047 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.8485 1.3119 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.0104 -0.3266 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2990 0.0840 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.4124 -0.3266 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.1247 0.0845 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.1247 0.9071 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
-1.8367 -0.3265 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.5486 0.0844 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.2605 -0.3265 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.0110 0.0076 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.5608 -0.6029 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-4.1500 -1.3144 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.3463 -1.1436 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.8367 -1.1484 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
2 1 1 0
3 2 2 0
4 3 1 0
5 4 2 0
6 5 1 0
1 6 2 0
6 7 1 0
7 8 2 0
8 9 1 0
9 10 2 0
5 10 1 0
11 2 1 0
12 11 1 0
13 12 1 0
14 13 1 0
14 15 2 0
16 14 1 0
16 17 1 0
17 18 1 0
19 18 2 0
20 19 1 0
21 20 1 0
22 21 2 0
22 18 1 0
16 23 1 1
M END Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 308.38Molecular Weight (Monoisotopic): 308.1637AlogP: 1.79#Rotatable Bonds: 6Polar Surface Area: 83.80Molecular Species: NEUTRALHBA: 3HBD: 3#RO5 Violations: ┄HBA (Lipinski): 5HBD (Lipinski): 4#RO5 Violations (Lipinski): ┄CX Acidic pKa: 13.09CX Basic pKa: 7.84CX LogP: 1.41CX LogD: 0.83Aromatic Rings: 3Heavy Atoms: 23QED Weighted: 0.65Np Likeness Score: -0.27
References 1. (2020) Enhancers of neurolysin activity, 2. Rahman MS, Kumari S, Esfahani SH, Nozohouri S, Jayaraman S, Kinarivala N, Kocot J, Baez A, Farris D, Abbruscato TJ, Karamyan VT, Trippier PC.. (2021) Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability., 64 (17.0): [PMID:34436882 ] [10.1021/acs.jmedchem.1c00759 ]