5'-methoxy-6'-(1-methyl-2,5,6,7-tetrahydro-1H-azepin-4-yl)spiro[cyclobutane-1,3'-indol]-2'-amine

ID: ALA5266889

Chembl Id: CHEMBL5266889

Max Phase: Preclinical

Molecular Formula: C19H25N3O

Molecular Weight: 311.43

Associated Items:

Names and Identifiers

Canonical SMILES:  COc1cc2c(cc1C1=CCN(C)CCC1)N=C(N)C21CCC1

Standard InChI:  InChI=1S/C19H25N3O/c1-22-9-3-5-13(6-10-22)14-11-16-15(12-17(14)23-2)19(7-4-8-19)18(20)21-16/h6,11-12H,3-5,7-10H2,1-2H3,(H2,20,21)

Standard InChI Key:  VMVRYCYPSDCNEH-UHFFFAOYSA-N

Alternative Forms

  1. Parent:

    ALA5266889

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Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT1 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Topical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 311.43Molecular Weight (Monoisotopic): 311.1998AlogP: 3.23#Rotatable Bonds: 2
Polar Surface Area: 50.85Molecular Species: BASEHBA: 4HBD: 1
#RO5 Violations: HBA (Lipinski): 4HBD (Lipinski): 2#RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: 9.28CX LogP: 2.69CX LogD: 0.04
Aromatic Rings: 1Heavy Atoms: 23QED Weighted: 0.91Np Likeness Score: 0.53

References

1. Nishigaya Y, Takase S, Sumiya T, Kikuzato K, Sato T, Niwa H, Sato S, Nakata A, Sonoda T, Hashimoto N, Namie R, Honma T, Umehara T, Shirouzu M, Koyama H, Yoshida M, Ito A, Shirai F..  (2023)  Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.,  66  (6): [PMID:36882960] [10.1021/acs.jmedchem.2c02059]

Source