N-(2-((1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro-4-(2-methylpyridin-3-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide

ID: ALA5277299

Chembl Id: CHEMBL5277299

Max Phase: Preclinical

Molecular Formula: C29H26F2N6O2

Molecular Weight: 528.56

Names and Identifiers

Canonical SMILES:  COc1cccc(F)c1-c1nccc(C(=O)Nc2cc(F)c(-c3cccnc3C)cc2N2C[C@@H]3C[C@H]2CN3)n1

Standard InChI:  InChI=1S/C29H26F2N6O2/c1-16-19(5-4-9-32-16)20-12-25(37-15-17-11-18(37)14-34-17)24(13-22(20)31)36-29(38)23-8-10-33-28(35-23)27-21(30)6-3-7-26(27)39-2/h3-10,12-13,17-18,34H,11,14-15H2,1-2H3,(H,36,38)/t17-,18-/m0/s1

Standard InChI Key:  JBFWLYUTIKICBY-ROUUACIJSA-N

Alternative Forms

1. Parent:

   

   ALA5277299

   ---

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type:

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 528.56

Molecular Weight (Monoisotopic): 528.2085

AlogP: 4.60

#Rotatable Bonds: 6

Polar Surface Area: 92.27

Molecular Species: BASE

HBA: 7

HBD: 2

#RO5 Violations: 1

HBA (Lipinski): 8

HBD (Lipinski): 2

#RO5 Violations (Lipinski): 1

CX Acidic pKa: 13.62

CX Basic pKa: 9.69

CX LogP: 4.21

CX LogD: 1.95

Aromatic Rings: 4

Heavy Atoms: 39

QED Weighted: 0.38

Np Likeness Score: -0.91

References

1. Sokolsky A, Vechorkin O, Hummel JR, Styduhar ED, Wang A, Nguyen MH, Ye HF, Liu K, Zhang K, Pan J, Ye Q, Atasoylu O, Behshad E, He X, Conlen P, Stump K, Ye M, Diamond S, Covington M, Yeleswaram S, Yao W..  (2023)  Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).,  14  (1.0): [PMID:36655134] [10.1021/acsmedchemlett.2c00241]

Source

Source(1):

• Scientific Literature