| 1. Ahn JM, Medeiros M, Trivedi D, Hruby VJ.. (2001) Development of potent truncated glucagon antagonists., 44 (9): [PMID:11311060] [10.1021/jm000453e] |
| 2. Gysin B, Johnson DG, Trivedi D, Hruby VJ.. (1987) Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels., 30 (8): [PMID:3039134] [10.1021/jm00391a024] |
| 3. Trivedi D, Lin Y, Ahn JM, Siegel M, Mollova NN, Schram KH, Hruby VJ.. (2000) Design and synthesis of conformationally constrained glucagon analogues., 43 (9): [PMID:10794689] [10.1021/jm990559d] |
| 4. Azizeh BY, Van Tine BA, Sturm NS, Hutzler AM, David C, Trivedi D, Hruby VJ. (1995) [des His1, des Phe6, Glu9]glucagon amide: A newly designed pure glucagon antagonist, 5 (16): [10.1016/0960-894X(95)00307-F] |
| 5. Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ.. (1997) The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon., 40 (16): [PMID:9258362] [10.1021/jm960800d] |
| 6. Ahn JM, Gitu PM, Medeiros M, Swift JR, Trivedi D, Hruby VJ.. (2001) A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning., 44 (19): [PMID:11543679] [10.1021/jm010091q] |
| 7. Sueiras-Diaz J, Lance VA, Murphy WA, Coy DH.. (1984) Structure-activity studies on the N-terminal region of glucagon., 27 (3): [PMID:6699876] [10.1021/jm00369a014] |
| 8. Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.. (2009) A new glucagon and GLP-1 co-agonist eliminates obesity in rodents., 5 (10): [PMID:19597507] [10.1038/nchembio.209] |
| 9. Unpublished dataset, |
| 10. PubChem BioAssay data set, |
| 11. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
| 12. Liu Q, Li N, Yuan Y, Lu H, Wu X, Zhou C, He M, Su H, Zhang M, Wang J, Wang B, Wang Y, Ma D, Ye Y, Weiss HC, Gesing ER, Liao J, Wang MW.. (2012) Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., 55 (1): [PMID:22103243] [10.1021/jm201150j] |
| 13. Cui L, Li J, Xie X.. (2012) Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., 75 (6): [PMID:22650618] [10.1021/np3000359] |
| 14. WHO Anatomical Therapeutic Chemical Classification, |
| 15. British National Formulary (72nd edition), |
| 16. Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, Stengelin S, Lorenz M, Herling A, Konkar A, Lukasczyk U, Pfenninger A, Lorenz K, Haack T, Kadereit D, Wagner M.. (2018) Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations., 61 (13): [PMID:29879354] [10.1021/acs.jmedchem.8b00292] |
| 17. Zhou J, Cai X, Huang X, Dai Y, Sun L, Zhang B, Yang B, Lin H, Huang W, Qian H.. (2017) A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects., 138 [PMID:28772236] [10.1016/j.ejmech.2017.07.046] |
| 18. Knerr PJ, Finan B, Gelfanov V, Perez-Tilve D, Tschöp MH, DiMarchi RD.. (2018) Optimization of peptide-based polyagonists for treatment of diabetes and obesity., 26 (10): [PMID:29153547] [10.1016/j.bmc.2017.10.047] |
| 19. Unpublished dataset, |
| 20. Mroz PA, Perez-Tilve D, Liu F, Gelfanov V, DiMarchi RD, Mayer JP.. (2016) Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization., 59 (17): [PMID:27509198] [10.1021/acs.jmedchem.6b00840] |
| 21. European Medicines Agency, |
