| 1. Dickens JP, Ellames GJ, Hare NJ, Lawson KR, McKay WR, Metters AP, Myers PL, Pope AM, Upton RM.. (1991) 2-Chloro-1-(2,4-dichlorophenyl)-3-(1H-imidazol-1-yl)-2-phenylpropan-1-one hydrochloride, a novel, nonmutagenic antibacterial with specific activity against anaerobic bacteria., 34 (8): [PMID:1875335] [10.1021/jm00112a006] |
| 2. Tsubery H, Ofek I, Cohen S, Fridkin M.. (2000) Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria., 43 (16): [PMID:10956216] [10.1021/jm0000057] |
| 3. Awale S, Tezuka Y, Banskota AH, Kadota S.. (2003) Siphonols A-E: novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia., 13 (1): [PMID:12467611] [10.1016/s0960-894x(02)00854-5] |
| 4. Mora P, Masip I, Cortés N, Marquina R, Merino R, Merino J, Carbonell T, Mingarro I, Messeguer A, Pérez-Payá E.. (2005) Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins., 48 (4): [PMID:15715495] [10.1021/jm040834i] |
| 5. Cromer JR, Wood SJ, Miller KA, Nguyen T, David SA.. (2005) Functionalized dendrimers as endotoxin sponges., 15 (5): [PMID:15713373] [10.1016/j.bmcl.2005.01.026] |
| 6. Miller KA, Suresh Kumar EV, Wood SJ, Cromer JR, Datta A, David SA.. (2005) Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines., 48 (7): [PMID:15801849] [10.1021/jm049449j] |
| 7. Khownium K, Wood SJ, Miller KA, Balakrishna R, Nguyen TB, Kimbrell MR, Georg GI, David SA.. (2006) Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds., 16 (5): [PMID:16377188] [10.1016/j.bmcl.2005.11.059] |
| 8. Wei ZQ, Du XX, Yu YS, Shen P, Chen YG, Li LJ.. (2007) Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China., 51 (2): [PMID:17145797] [10.1128/aac.01053-06] |
| 9. Nguyen TB, Adisechan AK, Suresh Kumar EV, Balakrishna R, Kimbrell MR, Miller KA, Datta A, David SA.. (2007) Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide., 15 (17): [PMID:17583517] [10.1016/j.bmc.2007.06.015] |
| 10. Scheetz MH, Qi C, Warren JR, Postelnick MJ, Zembower T, Obias A, Noskin GA.. (2007) In vitro activities of various antimicrobials alone and in combination with tigecycline against carbapenem-intermediate or -resistant Acinetobacter baumannii., 51 (5): [PMID:17307973] [10.1128/aac.01099-06] |
| 11. Taylor K, McCullough B, Clarke DJ, Langley RJ, Pechenick T, Hill A, Campopiano DJ, Barran PE, Dorin JR, Govan JR.. (2007) Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens., 51 (5): [PMID:17353239] [10.1128/aac.01531-06] |
| 12. Kwon DH, Lu CD.. (2007) Polyamine effects on antibiotic susceptibility in bacteria., 51 (6): [PMID:17438056] [10.1128/aac.01472-06] |
| 13. Sil D, Shrestha A, Kimbrell MR, Nguyen TB, Adisechan AK, Balakrishna R, Abbo BG, Malladi S, Miller KA, Short S, Cromer JR, Arora S, Datta A, David SA.. (2007) Bound to shock: protection from lethal endotoxemic shock by a novel, nontoxic, alkylpolyamine lipopolysaccharide sequestrant., 51 (8): [PMID:17548488] [10.1128/aac.00200-07] |
| 14. Meehl M, Herbert S, Götz F, Cheung A.. (2007) Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus., 51 (8): [PMID:17502406] [10.1128/aac.00209-07] |
| 15. Randazzo RA, Bucki R, Janmey PA, Diamond SL.. (2009) A series of cationic sterol lipids with gene transfer and bactericidal activity., 17 (9): [PMID:19364656] [10.1016/j.bmc.2009.03.049] |
| 16. Andrä J, Monreal D, Martinez de Tejada G, Olak C, Brezesinski G, Gomez SS, Goldmann T, Bartels R, Brandenburg K, Moriyon I.. (2007) Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens., 282 (20): [PMID:17389605] [10.1074/jbc.m608920200] |
| 17. Krupovic M, Daugelavicius R, Bamford DH.. (2007) Polymyxin B induces lysis of marine pseudoalteromonads., 51 (11): [PMID:17709471] [10.1128/aac.00449-07] |
| 18. Beckloff N, Laube D, Castro T, Furgang D, Park S, Perlin D, Clements D, Tang H, Scott RW, Tew GN, Diamond G.. (2007) Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens., 51 (11): [PMID:17785509] [10.1128/aac.00208-07] |
| 19. Hawley JS, Murray CK, Jorgensen JH.. (2007) Development of colistin-dependent Acinetobacter baumannii-Acinetobacter calcoaceticus complex., 51 (12): [PMID:17876007] [10.1128/aac.01115-07] |
| 20. Castanheira M, Sader HS, Deshpande LM, Fritsche TR, Jones RN.. (2008) Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program., 52 (2): [PMID:18070960] [10.1128/aac.01114-07] |
| 21. Velkov T, Thompson PE, Nation RL, Li J.. (2010) Structure--activity relationships of polymyxin antibiotics., 53 (5): [PMID:19874036] [10.1021/jm900999h] |
| 22. Velkov T, Thompson PE, Nation RL, Li J.. (2010) Structure--activity relationships of polymyxin antibiotics., 53 (5): [PMID:19874036] [10.1021/jm900999h] |
| 23. Yang Q, Wang H, Sun H, Chen H, Xu Y, Chen M.. (2010) Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China., 54 (1): [PMID:19805565] [10.1128/aac.01099-09] |
| 24. Padilla E, Llobet E, Doménech-Sánchez A, Martínez-Martínez L, Bengoechea JA, Albertí S.. (2010) Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence., 54 (1): [PMID:19858254] [10.1128/aac.00715-09] |
| 25. Tam VH, Chang KT, Abdelraouf K, Brioso CG, Ameka M, McCaskey LA, Weston JS, Caeiro JP, Garey KW.. (2010) Prevalence, resistance mechanisms, and susceptibility of multidrug-resistant bloodstream isolates of Pseudomonas aeruginosa., 54 (3): [PMID:20086165] [10.1128/aac.01446-09] |
| 26. Robledo IE, Aquino EE, Santé MI, Santana JL, Otero DM, León CF, Vázquez GJ.. (2010) Detection of KPC in Acinetobacter spp. in Puerto Rico., 54 (3): [PMID:20038618] [10.1128/aac.00899-09] |
| 27. Jiang SS, Lin TY, Wang WB, Liu MC, Hsueh PR, Liaw SJ.. (2010) Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence., 54 (5): [PMID:20160049] [10.1128/aac.01384-09] |
| 28. Rhee JY, Park YK, Shin JY, Choi JY, Lee MY, Peck KR, Song JH, Ko KS.. (2010) KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea., 54 (5): [PMID:20211897] [10.1128/aac.00011-10] |
| 29. Page MG, Dantier C, Desarbre E.. (2010) In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli., 54 (6): [PMID:20308379] [10.1128/aac.01525-09] |
| 30. Jiang SS, Liu MC, Teng LJ, Wang WB, Hsueh PR, Liaw SJ.. (2010) Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion., 54 (4): [PMID:20123999] [10.1128/aac.01219-09] |
| 31. Fraud S, Campigotto AJ, Chen Z, Poole K.. (2008) MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor., 52 (12): [PMID:18838593] [10.1128/aac.01072-08] |
| 32. Monteiro J, Santos AF, Asensi MD, Peirano G, Gales AC.. (2009) First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil., 53 (1): [PMID:19015350] [10.1128/aac.00736-08] |
| 33. Zapor MJ, Barber M, Summers A, Miller GH, Feeney LA, Eberly LE, Wortmann G.. (2010) In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center., 54 (7): [PMID:20404121] [10.1128/aac.01173-09] |
| 34. Khalil H, Chen T, Riffon R, Wang R, Wang Z.. (2008) Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa., 52 (5): [PMID:18285485] [10.1128/aac.01071-07] |
| 35. Bodewits K, Raetz CR, Govan JR, Campopiano DJ.. (2010) Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex., 54 (8): [PMID:20516283] [10.1128/aac.01600-09] |
| 36. Hatfaludi T, Al-Hasani K, Dunstone M, Boyce J, Adler B.. (2008) Characterization of TolC efflux pump proteins from Pasteurella multocida., 52 (11): [PMID:18725450] [10.1128/aac.00245-08] |
| 37. Marti S, Sánchez-Céspedes J, Blasco MD, Ruiz M, Espinal P, Alba V, Fernández-Cuenca F, Pascual A, Vila J.. (2008) Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate., 52 (8): [PMID:18505859] [10.1128/aac.00072-08] |
| 38. Moland ES, Craft DW, Hong SG, Kim SY, Hachmeister L, Sayed SD, Thomson KS.. (2008) In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy., 52 (8): [PMID:18519722] [10.1128/aac.01581-07] |
| 39. Llobet E, March C, Giménez P, Bengoechea JA.. (2009) Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides., 53 (1): [PMID:19015361] [10.1128/aac.00657-08] |
| 40. Castanheira M, Bell JM, Turnidge JD, Mathai D, Jones RN.. (2009) Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18)., 53 (3): [PMID:19114677] [10.1128/aac.01011-08] |
| 41. Mendes RE, Bell JM, Turnidge JD, Castanheira M, Deshpande LM, Jones RN.. (2009) Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program., 53 (2): [PMID:19015330] [10.1128/aac.00999-08] |
| 42. Warshakoon HJ, Burns MR, David SA.. (2009) Structure-activity relationships of antimicrobial and lipoteichoic acid-sequestering properties in polyamine sulfonamides., 53 (1): [PMID:18955537] [10.1128/aac.00812-08] |
| 43. Vaara M, Siikanen O, Apajalahti J, Fox J, Frimodt-Møller N, He H, Poudyal A, Li J, Nation RL, Vaara T.. (2010) A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane., 54 (8): [PMID:20479195] [10.1128/aac.01439-09] |
| 44. Ruden S, Hilpert K, Berditsch M, Wadhwani P, Ulrich AS.. (2009) Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides., 53 (8): [PMID:19528287] [10.1128/aac.01106-08] |
| 45. Schurek KN, Sampaio JL, Kiffer CR, Sinto S, Mendes CM, Hancock RE.. (2009) Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa., 53 (10): [PMID:19635950] [10.1128/aac.01267-08] |
| 46. Barrow K, Kwon DH.. (2009) Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa., 53 (12): [PMID:19752280] [10.1128/aac.00893-09] |
| 47. Gootz TD, Lescoe MK, Dib-Hajj F, Dougherty BA, He W, Della-Latta P, Huard RC.. (2009) Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital., 53 (5): [PMID:19258268] [10.1128/aac.01355-08] |
| 48. Kitao T, Miyoshi-Akiyama T, Kirikae T.. (2009) AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates., 53 (6): [PMID:19349516] [10.1128/aac.01360-08] |
| 49. Vaara M, Fox J, Loidl G, Siikanen O, Apajalahti J, Hansen F, Frimodt-Møller N, Nagai J, Takano M, Vaara T.. (2008) Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents., 52 (9): [PMID:18591267] [10.1128/aac.00405-08] |
| 50. Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE.. (2010) Short cationic antimicrobial peptides interact with ATP., 54 (10): [PMID:20660668] [10.1128/aac.01664-09] |
| 51. Gutsmann T, Razquin-Olazarán I, Kowalski I, Kaconis Y, Howe J, Bartels R, Hornef M, Schürholz T, Rössle M, Sanchez-Gómez S, Moriyon I, Martinez de Tejada G, Brandenburg K.. (2010) New antiseptic peptides to protect against endotoxin-mediated shock., 54 (9): [PMID:20606063] [10.1128/aac.00534-10] |
| 52. Moffatt JH, Harper M, Harrison P, Hale JD, Vinogradov E, Seemann T, Henry R, Crane B, St Michael F, Cox AD, Adler B, Nation RL, Li J, Boyce JD.. (2010) Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production., 54 (12): [PMID:20855724] [10.1128/aac.00834-10] |
| 53. Urban C, Tiruvury H, Mariano N, Colon-Urban R, Rahal JJ.. (2011) Polymyxin-resistant clinical isolates of Escherichia coli., 55 (1): [PMID:21041507] [10.1128/aac.01088-10] |
| 54. Mishra NN, Liu GY, Yeaman MR, Nast CC, Proctor RA, McKinnell J, Bayer AS.. (2011) Carotenoid-related alteration of cell membrane fluidity impacts Staphylococcus aureus susceptibility to host defense peptides., 55 (2): [PMID:21115796] [10.1128/aac.00680-10] |
| 55. Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.. (2010) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species., 23 (1): [PMID:20014752] [10.1021/tx900326k] |
| 56. Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mullins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello DP, Warmus JS, Wishka DG.. (2012) Potent inhibitors of LpxC for the treatment of Gram-negative infections., 55 (2): [PMID:22175825] [10.1021/jm2014748] |
| 57. Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E.. (2015) Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile., 25 (22): [PMID:26459212] [10.1016/j.bmcl.2015.09.066] |
| 58. WHO Anatomical Therapeutic Chemical Classification, |
| 59. Allam A, Maigre L, Alves de Sousa R, Dumont E, Vergalli J, Pagès JM, Artaud I.. (2017) New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria., 127 [PMID:27823890] [10.1016/j.ejmech.2016.10.054] |
| 60. Becker B, Butler MS, Hansford KA, Gallardo-Godoy A, Elliott AG, Huang JX, Edwards DJ, Blaskovich MAT, Cooper MA.. (2017) Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria., 27 (11): [PMID:28454673] [10.1016/j.bmcl.2017.04.027] |
| 61. Carosso S, Liu R, Miller PA, Hecker SJ, Glinka T, Miller MJ.. (2017) Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted β-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii., 60 (21): [PMID:28994597] [10.1021/acs.jmedchem.7b01164] |
| 62. Moon SH, Zhang X, Zheng G, Meeker DG, Smeltzer MS, Huang E.. (2017) Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin., 60 (23): [PMID:29136469] [10.1021/acs.jmedchem.7b01064] |
| 63. Unpublished dataset, |
| 64. Gao F, Wang T, Xiao J, Huang G.. (2019) Antibacterial activity study of 1,2,4-triazole derivatives., 173 [PMID:31009913] [10.1016/j.ejmech.2019.04.043] |
| 65. Yang Z, He S, Wang J, Yang Y, Zhang L, Li Y, Shan A.. (2019) Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens., 62 (9): [PMID:30958004] [10.1021/acs.jmedchem.9b00149] |
| 66. Slingerland CJ, Wesseling CMJ, Innocenti P, Westphal KGC, Masereeuw R, Martin NI.. (2022) Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids., 65 (23.0): [PMID:36399613] [10.1021/acs.jmedchem.2c01528] |
| 67. Dhanda G, Sarkar P, Samaddar S, Haldar J.. (2019) Battle against Vancomycin-Resistant Bacteria: Recent Developments in Chemical Strategies., 62 (7.0): [PMID:30404451] [10.1021/acs.jmedchem.8b01093] |
| 68. Singla P, Salunke DB.. (2020) Recent advances in steroid amino acid conjugates: Old scaffolds with new dimensions., 187 [PMID:31830636] [10.1016/j.ejmech.2019.111909] |
| 69. Craig AJ, Ermolovich Y, Cameron A, Rodler A, Wang H, Hawkes JA, Hubert M, Björkling F, Molchanova N, Brimble MA, Moodie LWK, Svenson J.. (2023) Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents., 14 (6): [PMID:37312845] [10.1021/acsmedchemlett.3c00093] |
