(8S,10S)-10-(4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxy-acetyl)-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

ID: ALA53463

Chembl Id: CHEMBL53463

Cas Number: 23214-92-8

PubChem CID: 31703

Product Number: Y31755

Max Phase: Approved

Molecular Formula: C27H29NO11

Molecular Weight: 543.53

Molecule Type: Small molecule

Names and Identifiers

Synonyms: Adriablastin | Adriamycin | Doxil | Doxorubicin | Hydroxydaunorubicin | Rubex | NSC-123127 | NSC-759155 | doxorubicin|Adriamycin|23214-92-8|Adriablastin|Doxil|Doxorubicine|Adriblastina|Doxorubicinum|14-Hydroxydaunomycin|Hydroxydaunorubicin|Doxorubicina|14-Hydroxydaunorubicine|Adriamycin semiquinone|Doxorubicine [INN-French]|Doxorubicinum [INN-Latin]|Doxorubicina [INN-Spanish]|CCRIS 739|HSDB 3070|NCI-C01514|NDC 38242-874|EINECS 245-495-6|FI 106|CHEBI:28748|UNII-80168379AG|NSC-759155|CHEMBL53463|CShow More⌵

Synonyms from Alternative Forms(21): Doxorubicin Trifluoroacetate | Doxorubicin hydrochloride | Doxorubicin liposomal complex of the hydrochloride | Adriablastina cs | Adriamycin, hydrochloride | Doxorubicin citrate | Doxorubicin citric acid salt | Doxorubicin hcl | Doxorubicini hydrochloridum | Hydroxydaunomycin hydrochloride | Liposomal doxorubicin hydrochloride | Adriamycin | Adriamycin pfs | Adriamycin Rdf | Caelyx | Caelyx pegylated liposomal | Doxil | Doxil (liposomal) | Doxorubicin hydrochloride (liposomal) | Myocet | Rubex

Canonical SMILES:  COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1

Standard InChI:  InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

Standard InChI Key:  AOJJSUZBOXZQNB-TZSSRYMLSA-N

Alternative Forms

1. Parent:

   

   ALA53463

   DOXORUBICIN

2. Alternative Forms:

   

   ALA53463

   DOXORUBICIN TRIFLUOROACETATE
3. 

   ALA53463

   (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-(114C)methoxy-8,10-dihydro-7H-tetracene-5,12-dione
4. 

   ALA53463

   Doxorubicin hydrochloride

Molecule Features

Natural Product: Yes

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: Yes

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 543.53

Molecular Weight (Monoisotopic): 543.1741

AlogP: 0.00

#Rotatable Bonds: 5

Polar Surface Area: 206.07

Molecular Species: BASE

HBA: 12

HBD: 6

#RO5 Violations: 3

HBA (Lipinski): 12

HBD (Lipinski): 7

#RO5 Violations (Lipinski): 3

CX Acidic pKa: 8.00

CX Basic pKa: 9.03

CX LogP: 0.53

CX LogD: 0.10

Aromatic Rings: 2

Heavy Atoms: 39

QED Weighted: 0.24

Np Likeness Score: 1.81

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235. Li N, Wu JL, Hasegawa T, Sakai J, Bai LM, Wang LY, Kakuta S, Furuya Y, Ogura H, Kataoka T, Tomida A, Tsuruo T, Ando M..  (2007)  Bioactive lignans from Peperomia duclouxii.,  70  (4): [PMID:17358082] [10.1021/np0604533]

236. Duarte N, Varga A, Cherepnev G, Radics R, Molnár J, Ferreira MJ..  (2007)  Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.,  15  (1): [PMID:17035027] [10.1016/j.bmc.2006.09.028]

237. Ali HI, Tomita K, Akaho E, Kambara H, Miura S, Hayakawa H, Ashida N, Kawashima Y, Yamagishi T, Ikeya H, Yoneda F, Nagamatsu T..  (2007)  Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.,  15  (1): [PMID:17049252] [10.1016/j.bmc.2006.09.063]

238. Bharate SB, Khan SI, Yunus NA, Chauthe SK, Jacob MR, Tekwani BL, Khan IA, Singh IP..  (2007)  Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.,  15  (1): [PMID:17070063] [10.1016/j.bmc.2006.10.006]

239. Wang SS, Lee YJ, Hsu SC, Chang HO, Yin WK, Chang LS, Chou SY..  (2007)  Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo.,  15  (2): [PMID:17107806] [10.1016/j.bmc.2006.10.054]

240. Hsieh PW, Huang ZY, Chen JH, Chang FR, Wu CC, Yang YL, Chiang MY, Yen MH, Chen SL, Yen HF, Lübken T, Hung WC, Wu YC..  (2007)  Cytotoxic withanolides from Tubocapsicum anomalum.,  70  (5): [PMID:17417907] [10.1021/np0605541]

241. Rózalski M, Krajewska U, Panczyk M, Mirowski M, Rózalska B, Wasek T, Janecki T..  (2007)  Synthesis and biological evaluation of 4-methylideneisoxazolidin-5-ones--a new class of highly cytotoxic alpha-methylidene-gamma-lactones.,  42  (2): [PMID:17069934] [10.1016/j.ejmech.2006.09.005]

242. Lee HJ, Kim JS, Suh ME, Park HJ, Lee SK, Rhee HK, Kim HJ, Seo EK, Kim C, Lee CO, Park Choo HY..  (2007)  Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones.,  42  (2): [PMID:17070967] [10.1016/j.ejmech.2006.09.007]

243. Shchekotikhin AE, Dezhenkova LG, Susova OY, Glazunova VA, Luzikov YN, Sinkevich YB, Buyanov VN, Shtil AA, Preobrazhenskaya MN..  (2007)  Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties.,  15  (7): [PMID:17276690] [10.1016/j.bmc.2007.01.034]

244. Barrachina I, Royo I, Baldoni HA, Chahboune N, Suvire F, DePedro N, Zafra-Polo MC, Bermejo A, El Aouad N, Cabedo N, Saez J, Tormo JR, Enriz RD, Cortes D..  (2007)  New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone.,  15  (13): [PMID:17482824] [10.1016/j.bmc.2007.04.039]

245. Hernández-Guerrero CJ, Zubía E, Ortega MJ, Carballo JL..  (2007)  Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni.,  15  (15): [PMID:17512741] [10.1016/j.bmc.2007.05.014]

246. Li N, Wu JL, Hasegawa T, Sakai J, Bai LM, Wang LY, Kakuta S, Furuya Y, Ogura H, Kataoka T, Tomida A, Tsuruo T, Ando M..  (2007)  Bioactive polyketides from Peperomia duclouxii.,  70  (6): [PMID:17547458] [10.1021/np070089n]

247. Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Parker P, Workman P, Waterfield MD..  (2007)  Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.,  15  (17): [PMID:17601739] [10.1016/j.bmc.2007.05.070]

248. Castanheiro RA, Pinto MM, Silva AM, Cravo SM, Gales L, Damas AM, Nazareth N, Nascimento MS, Eaton G..  (2007)  Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7.,  15  (18): [PMID:17614292] [10.1016/j.bmc.2007.06.037]

249. Metwally K, Pratsinis H, Kletsas D..  (2007)  Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity.,  42  (3): [PMID:17141923] [10.1016/j.ejmech.2006.10.008]

250. Moreira DR, Lima Leite AC, Pinheiro Ferreira PM, da Costa PM, Costa Lotufo LV, de Moraes MO, Brondani DJ, Pessoa Cdo O..  (2007)  Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1,3-benzodioxole system.,  42  (3): [PMID:17175071] [10.1016/j.ejmech.2006.10.007]

251. Kanokmedhakul S, Kanokmedhakul K, Buayairaksa M..  (2007)  Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia.,  70  (7): [PMID:17567069] [10.1021/np070083y]

252. Pan Y, Wang X, Hu X..  (2007)  Cytotoxic withanolides from the flowers of Datura metel.,  70  (7): [PMID:17583953] [10.1021/np070096b]

253. Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH..  (2007)  Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.,  50  (15): [PMID:17585747] [10.1021/jm061366a]

254. Zhao M, Bai L, Wang L, Toki A, Hasegawa T, Kikuchi M, Abe M, Sakai J, Hasegawa R, Bai Y, Mitsui T, Ogura H, Kataoka T, Oka S, Tsushima H, Kiuchi M, Hirose K, Tomida A, Tsuruo T, Ando M..  (2007)  Bioactive cardenolides from the stems and twigs of Nerium oleander.,  70  (7): [PMID:17595134] [10.1021/np068066g]

255. Rhee HK, Park HJ, Lee SK, Lee CO, Choo HY..  (2007)  Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones.,  15  (4): [PMID:17194596] [10.1016/j.bmc.2006.12.012]

256. Das Sarma M, Ghosh R, Patra A, Hazra B..  (2007)  Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid.,  15  (11): [PMID:17400463] [10.1016/j.bmc.2007.03.050]

257. Di Giorgio C, Shimi K, Boyer G, Delmas F, Galy JP..  (2007)  Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.,  42  (10): [PMID:17418916] [10.1016/j.ejmech.2007.02.010]

258. Vik A, Hedner E, Charnock C, Tangen LW, Samuelsen Ø, Larsson R, Bohlin L, Gundersen LL..  (2007)  Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs.,  15  (12): [PMID:17442577] [10.1016/j.bmc.2007.03.086]

259. Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH..  (2007)  First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.,  50  (16): [PMID:17622129] [10.1021/jm070363a]

260. Van Quaquebeke E, Mahieu T, Dumont P, Dewelle J, Ribaucour F, Simon G, Sauvage S, Gaussin JF, Tuti J, El Yazidi M, Van Vynckt F, Mijatovic T, Lefranc F, Darro F, Kiss R..  (2007)  2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.,  50  (17): [PMID:17658777] [10.1021/jm070315q]

261. Kalet BT, McBryde MB, Espinosa JM, Koch TH..  (2007)  Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.,  50  (18): [PMID:17696516] [10.1021/jm070569b]

262. Woo S, Jung J, Lee C, Kwon Y, Na Y..  (2007)  Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study.,  17  (5): [PMID:17194586] [10.1016/j.bmcl.2006.12.030]

263. Tatsuzaki J, Taniguchi M, Bastow KF, Nakagawa-Goto K, Morris-Natschke SL, Itokawa H, Baba K, Lee KH..  (2007)  Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.,  15  (18): [PMID:17591444] [10.1016/j.bmc.2007.06.027]

264. Tschamber T, Adam S, Matsuya Y, Masuda S, Ohsawa N, Maruyama S, Kamoshita K, Nemoto H, Eustache J..  (2007)  OSW-1 analogues: modification of the carbohydrate moiety.,  17  (18): [PMID:17656091] [10.1016/j.bmcl.2007.07.017]

265. Kamal A, Khan MN, Reddy KS, Ahmed SK, Kumar MS, Juvekar A, Sen S, Zingde S..  (2007)  1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.,  17  (19): [PMID:17723301] [10.1016/j.bmcl.2007.08.018]

266. Militão GC, Pinheiro SM, Dantas IN, Pessoa C, de Moraes MO, Costa-Lotufo LC, Lima MA, Silveira ER..  (2007)  Bioassay-guided fractionation of pterocarpans from roots of Harpalyce brasiliana Benth.,  15  (21): [PMID:17764956] [10.1016/j.bmc.2007.08.011]

267. Kamal A, Ramu R, Tekumalla V, Khanna GB, Barkume MS, Juvekar AS, Zingde SM..  (2007)  Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates.,  15  (22): [PMID:17822905] [10.1016/j.bmc.2007.08.026]

268. da Silva Júnior EN, de Souza MC, Pinto AV, Pinto Mdo C, Goulart MO, Barros FW, Pessoa C, Costa-Lotufo LV, Montenegro RC, de Moraes MO, Ferreira VF..  (2007)  Synthesis and potent antitumor activity of new arylamino derivatives of nor-beta-lapachone and nor-alpha-lapachone.,  15  (22): [PMID:17827021] [10.1016/j.bmc.2007.07.043]

269. Shanab K, Pongprom N, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E..  (2007)  Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.,  17  (22): [PMID:17904839] [10.1016/j.bmcl.2007.09.054]

270. Hranjec M, Kralj M, Piantanida I, Sedić M, Suman L, Pavelić K, Karminski-Zamola G..  (2007)  Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1,2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3.,  50  (23): [PMID:17935309] [10.1021/jm070876h]

271. Shah BA, Kumar A, Gupta P, Sharma M, Sethi VK, Saxena AK, Singh J, Qazi GN, Taneja SC..  (2007)  Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.,  17  (23): [PMID:17950603] [10.1016/j.bmcl.2007.10.011]

272. Hasegawa T, Bai J, Zhang S, Wang J, Matsubara J, Kawakami J, Tomida A, Tsuruo T, Hirose K, Sakai J, Kikuchi M, Abe M, Ando M..  (2007)  Structure-activity relationships of some taxoids as multidrug resistance modulator.,  17  (4): [PMID:17239597] [10.1016/j.bmcl.2006.09.068]

273. Kohfeld S, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C..  (2007)  1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.,  42  (11): [PMID:17448574] [10.1016/j.ejmech.2007.02.007]

274. Hasegawa T, Bai J, Dai J, Bai L, Sakai J, Nishizawa S, Bai Y, Kikuchi M, Abe M, Yamori T, Tomida A, Tsuruo T, Hirose K, Ando M..  (2007)  Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.,  17  (13): [PMID:17490878] [10.1016/j.bmcl.2007.04.030]

275. Van HT, Le QM, Lee KY, Lee ES, Kwon Y, Kim TS, Le TN, Lee SH, Cho WJ..  (2007)  Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.,  17  (21): [PMID:17827007] [10.1016/j.bmcl.2007.08.062]

276. Liu J, Cui G, Zhao M, Cui C, Ju J, Peng S..  (2007)  Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetates.,  15  (24): [PMID:17888666] [10.1016/j.bmc.2007.08.061]

277. Müller H, Klinkhammer W, Globisch C, Kassack MU, Pajeva IK, Wiese M..  (2007)  New functional assay of P-glycoprotein activity using Hoechst 33342.,  15  (23): [PMID:17890094] [10.1016/j.bmc.2007.07.024]

278. Di YT, He HP, Liu HY, Yi P, Zhang Z, Ren YL, Wang JS, Sun QY, Yang FM, Fang X, Li SL, Zhu HJ, Hao XJ..  (2007)  Trijugin-type limonoids from the leaves of Cipadessa cinerascens.,  70  (8): [PMID:17655260] [10.1021/np0700624]

279. Youn UJ, Chen QC, Jin WY, Lee IS, Kim HJ, Lee JP, Chang MJ, Min BS, Bae KH..  (2007)  Cytotoxic lignans from the stem bark of Magnolia officinalis.,  70  (10): [PMID:17918910] [10.1021/np070388c]

280. Yang YL, Chang SM, Wu CC, Hsieh PW, Chen SL, Chang FR, Hung WC, Issa HH, Wu YC..  (2007)  Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus.,  70  (11): [PMID:17970595] [10.1021/np070331q]

281. Suzuki K, Okasaka M, Kashiwada Y, Takaishi Y, Honda G, Ito M, Takeda Y, Kodzhimatov OK, Ashurmetov O, Sekiya M, Ikeshiro Y..  (2007)  Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity.,  70  (12): [PMID:18052129] [10.1021/np0703996]

282. Xu YM, McLaughlin SP, Gunatilaka AA..  (2007)  Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1).,  70  (12): [PMID:18052324] [10.1021/np0704553]

283. Paranagama PA, Wijeratne EM, Gunatilaka AA..  (2007)  Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.,  70  (12): [PMID:18052326] [10.1021/np070504b]

284. Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH..  (2008)  Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.,  51  (2): [PMID:18173233] [10.1021/jm7011479]

285. Arya K, Dandia A..  (2008)  The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs.,  18  (1): [PMID:18023182] [10.1016/j.bmcl.2007.11.002]

286. Min HY, Park EJ, Hong JY, Kang YJ, Kim SJ, Chung HJ, Woo ER, Hung TM, Youn UJ, Kim YS, Kang SS, Bae K, Lee SK..  (2008)  Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.,  18  (2): [PMID:18063366] [10.1016/j.bmcl.2007.11.082]

287. Kang DH, Kim JS, Jung MJ, Lee ES, Jahng Y, Kwon Y, Na Y..  (2008)  New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.,  18  (4): [PMID:18178085] [10.1016/j.bmcl.2007.12.053]

288. Girard D, Weagle G, Gupta A, Bérubé G, Chapados C..  (2008)  Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents.,  18  (1): [PMID:17993275] [10.1016/j.bmcl.2007.10.069]

289. Yoneda Y, Steiniger SC, Capková K, Mee JM, Liu Y, Kaufmann GF, Janda KD..  (2008)  A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.,  18  (5): [PMID:18243696] [10.1016/j.bmcl.2008.01.060]

290. Passarella D, Belinghieri F, Scarpellini M, Pratesi G, Zunino F, Gia OM, Via LD, Santoro G, Danieli B..  (2008)  Synthesis and biological evaluation of pyrroloiminoquinone derivatives.,  16  (5): [PMID:18077173] [10.1016/j.bmc.2007.11.063]

291. Václavíková R, Kondrová E, Ehrlichová M, Boumendjel A, Kovár J, Stopka P, Soucek P, Gut I..  (2008)  The effect of flavonoid derivatives on doxorubicin transport and metabolism.,  16  (4): [PMID:18024139] [10.1016/j.bmc.2007.10.093]

292. Marzano C, Gandin V, Pellei M, Colavito D, Papini G, Lobbia GG, Del Giudice E, Porchia M, Tisato F, Santini C..  (2008)  In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.,  51  (4): [PMID:18251492] [10.1021/jm701146c]

293. Abou El Ella DA, Ghorab MM, Noaman E, Heiba HI, Khalil AI..  (2008)  Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities.,  16  (5): [PMID:18086527] [10.1016/j.bmc.2007.11.072]

294. Wells JA, McClendon CL..  (2007)  Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.,  450  (7172): [PMID:18075579] [10.1038/nature06526]

295. Fong WF, Shen XL, Globisch C, Wiese M, Chen GY, Zhu GY, Yu ZL, Tse AK, Hu YJ..  (2008)  Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.,  16  (7): [PMID:18313307] [10.1016/j.bmc.2008.02.029]

296. Farag AM, Mayhoub AS, Barakat SE, Bayomi AH..  (2008)  Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives.,  16  (2): [PMID:17962022] [10.1016/j.bmc.2007.10.015]

297. Kamal A, Shankaraiah N, Devaiah V, Laxma Reddy K, Juvekar A, Sen S, Kurian N, Zingde S..  (2008)  Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.,  18  (4): [PMID:18207392] [10.1016/j.bmcl.2007.12.063]

298. Verhaeghe P, Azas N, Gasquet M, Hutter S, Ducros C, Laget M, Rault S, Rathelot P, Vanelle P..  (2008)  Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines.,  18  (1): [PMID:17981462] [10.1016/j.bmcl.2007.10.027]

299. Colabufo NA, Berardi F, Cantore M, Perrone MG, Contino M, Inglese C, Niso M, Perrone R, Azzariti A, Simone GM, Porcelli L, Paradiso A..  (2008)  Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.,  16  (1): [PMID:17936633] [10.1016/j.bmc.2007.09.039]

300. Liu XL, Tee HW, Go ML..  (2008)  Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein.,  16  (1): [PMID:17964170] [10.1016/j.bmc.2007.10.006]

301. Benites J, Valderrama JA, Rivera F, Rojo L, Campos N, Pedro M, José Nascimento MS..  (2008)  Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines.,  16  (2): [PMID:17964791] [10.1016/j.bmc.2007.10.028]

302. Kaskiw MJ, Tassotto ML, Th'ng J, Jiang ZH..  (2008)  Synthesis and cytotoxic activity of diosgenyl saponin analogues.,  16  (6): [PMID:18164206] [10.1016/j.bmc.2007.12.022]

303. Bharate SB, Khan SI, Tekwani BL, Jacob M, Khan IA, Singh IP..  (2008)  S-Euglobals: biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities.,  16  (3): [PMID:17976995] [10.1016/j.bmc.2007.10.055]

304. Kouznetsov VV, Vargas Méndez LY, Sortino M, Vásquez Y, Gupta MP, Freile M, Enriz RD, Zacchino SA..  (2008)  Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.,  16  (2): [PMID:17981473] [10.1016/j.bmc.2007.10.034]

305. Vieira NC, Espíndola LS, Santana JM, Veras ML, Pessoa OD, Pinheiro SM, de Araújo RM, Lima MA, Silveira ER..  (2008)  Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora.,  16  (4): [PMID:18053728] [10.1016/j.bmc.2007.11.027]

306. Kim JS, Rhee HK, Park HJ, Lee SK, Lee CO, Park Choo HY..  (2008)  Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.,  16  (8): [PMID:18321715] [10.1016/j.bmc.2008.02.049]

307. Ge X, Ye G, Li P, Tang WJ, Gao JL, Zhao WM..  (2008)  Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida.,  71  (2): [PMID:18181575] [10.1021/np0706421]

308. Ahmed AF, Wen ZH, Su JH, Hsieh YT, Wu YC, Hu WP, Sheu JH..  (2008)  Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa.,  71  (2): [PMID:18198839] [10.1021/np070356p]

309. Wijeratne EM, Paranagama PA, Marron MT, Gunatilaka MK, Arnold AE, Gunatilaka AA..  (2008)  Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert.,  71  (2): [PMID:18247573] [10.1021/np070600c]

310. Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC..  (2007)  Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.,  104  (49): [PMID:18040043] [10.1073/pnas.0709443104]

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580. Kaskiw MJ, Tassotto ML, Mok M, Tokar SL, Pycko R, Th'ng J, Jiang ZH..  (2009)  Structural analogues of diosgenyl saponins: synthesis and anticancer activity.,  17  (22): [PMID:19819703] [10.1016/j.bmc.2009.09.046]

581. Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R..  (2009)  Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.,  17  (17): [PMID:19647439] [10.1016/j.bmc.2009.07.012]

582. Du-Cuny L, Song Z, Moses S, Powis G, Mash EA, Meuillet EJ, Zhang S..  (2009)  Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.,  17  (19): [PMID:19734051] [10.1016/j.bmc.2009.08.022]

583. Slade D, Galal AM, Gul W, Radwan MM, Ahmed SA, Khan SI, Tekwani BL, Jacob MR, Ross SA, Elsohly MA..  (2009)  Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.,  17  (23): [PMID:19879765] [10.1016/j.bmc.2009.10.019]

584. Manohar S, Khan SI, Rawat DS..  (2010)  Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates.,  20  (1): [PMID:19910192] [10.1016/j.bmcl.2009.10.106]

585. Goswami A, Saikia PP, Barua NC, Bordoloi M, Yadav A, Bora TC, Gogoi BK, Saxena AK, Suri N, Sharma M..  (2010)  Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.,  20  (1): [PMID:19913412] [10.1016/j.bmcl.2009.10.097]

586. Krauth F, Dahse HM, Rüttinger HH, Frohberg P..  (2010)  Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity.,  18  (5): [PMID:20153202] [10.1016/j.bmc.2010.01.053]

587. Lu CM, Chen YL, Chen HL, Chen CA, Lu PJ, Yang CN, Tzeng CC..  (2010)  Synthesis and antiproliferative evaluation of certain indolo[3,2-c]quinoline derivatives.,  18  (5): [PMID:20171108] [10.1016/j.bmc.2010.01.033]

588. Larroque-Lombard AL, Todorova M, Golabi N, Williams C, Jean-Claude BJ..  (2010)  Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5.,  53  (5): [PMID:20151639] [10.1021/jm9016043]

589. Liu J, Zhao M, Qian K, Zhang X, Lee KH, Wu J, Liu YN, Peng S..  (2010)  Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis.,  18  (5): [PMID:20171109] [10.1016/j.bmc.2010.01.038]

590. Chen Z, Liang X, Zhang H, Xie H, Liu J, Xu Y, Zhu W, Wang Y, Wang X, Tan S, Kuang D, Qian X..  (2010)  A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.,  53  (6): [PMID:20170164] [10.1021/jm100025u]

591. Yang XW, Feng L, Li SM, Liu XH, Li YL, Wu L, Shen YH, Tian JM, Zhang X, Liu XR, Wang N, Liu Y, Zhang WD..  (2010)  Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr.,  18  (2): [PMID:20022253] [10.1016/j.bmc.2009.11.055]

592. Yen CT, Nakagawa-Goto K, Hwang TL, Wu PC, Morris-Natschke SL, Lai WC, Bastow KF, Chang FR, Wu YC, Lee KH..  (2010)  Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.,  20  (3): [PMID:20036537] [10.1016/j.bmcl.2009.12.041]

593. Hu Z, Jiang X, Albright CF, Graciani N, Yue E, Zhang M, Zhang SY, Bruckner R, Diamond M, Dowling R, Rafalski M, Yeleswaram S, Trainor GL, Seitz SP, Han W..  (2010)  Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents.,  20  (3): [PMID:20060717] [10.1016/j.bmcl.2009.12.084]

594. Mazzini S, Scaglioni L, Animati F, Mondelli R..  (2010)  Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755.,  18  (4): [PMID:20116264] [10.1016/j.bmc.2010.01.012]

595. Miyake K, Tezuka Y, Awale S, Li F, Kadota S..  (2009)  Quassinoids from Eurycoma longifolia.,  72  (12): [PMID:19919052] [10.1021/np900486f]

596. Pierson JT, Dumètre A, Hutter S, Delmas F, Laget M, Finet JP, Azas N, Combes S..  (2010)  Synthesis and antiprotozoal activity of 4-arylcoumarins.,  45  (3): [PMID:19914747] [10.1016/j.ejmech.2009.10.022]

597. Lee TH, Wang MJ, Chen PY, Wu TY, Wen WC, Tsai FY, Lee CK..  (2009)  Constituents of Polyalthia longifolia var. pendula.,  72  (11): [PMID:19860383] [10.1021/np900207z]

598. Ingavat N, Dobereiner J, Wiyakrutta S, Mahidol C, Ruchirawat S, Kittakoop P..  (2009)  Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.,  72  (11): [PMID:19824618] [10.1021/np9003883]

599. Devegowda VN, Kim JH, Han KC, Yang EG, Choo H, Pae AN, Nam G, Choi KI..  (2010)  Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents.,  20  (5): [PMID:20138760] [10.1016/j.bmcl.2010.01.029]

600. Mativandlela SP, Muthivhi T, Kikuchi H, Oshima Y, Hamilton C, Hussein AA, van der Walt ML, Houghton PJ, Lall N..  (2009)  Antimycobacterial flavonoids from the leaf extract of Galenia africana.,  72  (12): [PMID:20035557] [10.1021/np800778b]

601. Ibrahim DA, El-Metwally AM..  (2010)  Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors.,  45  (3): [PMID:20045222] [10.1016/j.ejmech.2009.12.026]

602. Jeon JE, Na Z, Jung M, Lee HS, Sim CJ, Nahm K, Oh KB, Shin J..  (2010)  Discorhabdins from the Korean marine sponge Sceptrella sp.,  73  (2): [PMID:20055495] [10.1021/np9005629]

603. Reyes F, Rodríguez-Acebes R, Fernández R, Bueno S, Francesch A, Cuevas C..  (2010)  Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis.,  73  (1): [PMID:20014800] [10.1021/np900700h]

604. Herath HM, Herath WH, Carvalho P, Khan SI, Tekwani BL, Duke SO, Tomaso-Peterson M, Nanayakkara NP..  (2009)  Biologically active tetranorditerpenoids from the fungus Sclerotinia homoeocarpa causal agent of dollar spot in turfgrass.,  72  (12): [PMID:19928902] [10.1021/np900334k]

605. Bunyapaiboonsri T, Yoiprommarat S, Srikitikulchai P, Srichomthong K, Lumyong S..  (2010)  Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789.,  73  (1): [PMID:20038128] [10.1021/np900650c]

606. Sousa E, Paiva A, Nazareth N, Gales L, Damas AM, Nascimento MS, Pinto M..  (2009)  Bromoalkoxyxanthones as promising antitumor agents: synthesis, crystal structure and effect on human tumor cell lines.,  44  (9): [PMID:19428155] [10.1016/j.ejmech.2009.04.011]

607. Kim KH, Choi SU, Lee KR..  (2010)  Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.,  20  (6): [PMID:20176479] [10.1016/j.bmcl.2010.01.156]

608. Santos HS, Barros FW, Albuquerque MR, Bandeira PN, Pessoa C, Braz-Filho R, Monte FJ, Leal-Cardoso JH, Lemos TL..  (2009)  Cytotoxic diterpenoids from Croton argyrophylloides.,  72  (10): [PMID:19780590] [10.1021/np900250k]

609. Isaka M, Palasarn S, Lapanun S, Chanthaket R, Boonyuen N, Lumyong S..  (2009)  Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199.,  72  (9): [PMID:19739600] [10.1021/np900316x]

610. Bao B, Dang HT, Zhang P, Hong J, Lee CO, Cho HY, Jung JH..  (2009)  Bicyclic alpha,omega-dicarboxylic acid derivatives from a colonial tunicate of the family Polyclinidae.,  19  (21): [PMID:19783438] [10.1016/j.bmcl.2009.08.094]

611. Vieira GM, Gonçalves Tde O, Regasini LO, Ferreira PM, Pessoa Cdo O, Costa Lotufo LV, Torres RB, Boralle N, Bolzani Vda S, Cavalheiro AJ..  (2009)  Cytotoxic clerodane diterpenoids from Casearia obliqua.,  72  (10): [PMID:19788290] [10.1021/np9004079]

612. Seephonkai P, Sangdee A, Bunchalee P, Pyne SG..  (2009)  Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.,  72  (10): [PMID:19778068] [10.1021/np900352n]

613. Darque A, Dumètre A, Hutter S, Casano G, Robin M, Pannecouque C, Azas N..  (2009)  Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates.,  19  (20): [PMID:19748781] [10.1016/j.bmcl.2009.08.013]

614. Ramalhete C, Mansoor TA, Mulhovo S, Molnár J, Ferreira MJ..  (2009)  Cucurbitane-type triterpenoids from the African plant Momordica balsamina.,  72  (11): [PMID:19795842] [10.1021/np900457u]

615. Kamel HN, Kim YB, Rimoldi JM, Fronczek FR, Ferreira D, Slattery M..  (2009)  Scalarane sesterterpenoids: semisynthesis and biological activity.,  72  (8): [PMID:19658408] [10.1021/np900326a]

616. Lee CL, Chiang LC, Cheng LH, Liaw CC, Abd El-Razek MH, Chang FR, Wu YC..  (2009)  Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.,  72  (9): [PMID:19691312] [10.1021/np900158f]

617. Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH..  (2009)  Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.,  52  (23): [PMID:19634903] [10.1021/jm900694z]

618. Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S..  (2009)  Cytotoxic constituents of Soymida febrifuga from Myanmar.,  72  (9): [PMID:19689125] [10.1021/np9003323]

619. Ché C, Yang G, Thiot C, Lacoste MC, Currie JC, Demeule M, Régina A, Béliveau R, Castaigne JP..  (2010)  New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration.,  53  (7): [PMID:20210346] [10.1021/jm9016637]

620. Mrozek-Wilczkiewicz A, Kalinowski DS, Musiol R, Finster J, Szurko A, Serafin K, Knas M, Kamalapuram SK, Kovacevic Z, Jampilek J, Ratuszna A, Rzeszowska-Wolny J, Richardson DR, Polanski J..  (2010)  Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones.,  18  (7): [PMID:20303768] [10.1016/j.bmc.2010.02.025]

621. Malancona S, Donghi M, Ferrara M, Martin Hernando JI, Pompei M, Pesci S, Ontoria JM, Koch U, Rowley M, Summa V..  (2010)  Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.,  18  (8): [PMID:20363140] [10.1016/j.bmc.2010.03.024]

622. Saeed S, Rashid N, Jones PG, Ali M, Hussain R..  (2010)  Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents.,  45  (4): [PMID:20056520] [10.1016/j.ejmech.2009.12.016]

623. Toropov AA, Toropova AP, Raska I, Benfenati E..  (2010)  QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.,  45  (4): [PMID:20106561] [10.1016/j.ejmech.2009.12.043]

624. Guerra A, Campillo NE, Páez JA..  (2010)  Neural computational prediction of oral drug absorption based on CODES 2D descriptors.,  45  (3): [PMID:20022146] [10.1016/j.ejmech.2009.11.034]

625. Barron GA, Bermano G, Gordon A, Kong Thoo Lin P..  (2010)  Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells.,  45  (4): [PMID:20064676] [10.1016/j.ejmech.2009.12.047]

626. Kornsakulkarn J, Thongpanchang C, Chainoy R, Choowong W, Nithithanasilp S, Thongpanchang T..  (2010)  Bioactive metabolites from cultures of basidiomycete Favolaschia tonkinensis.,  73  (4): [PMID:20329738] [10.1021/np900777r]

627. Choudhary MI, Ismail M, Shaari K, Abbaskhan A, Sattar SA, Lajis NH, Atta-ur-Rahman..  (2010)  cis-Clerodane-type furanoditerpenoids from Tinospora crispa.,  73  (4): [PMID:20356064] [10.1021/np900551u]

628. Izumikawa M, Hashimoto J, Hirokawa T, Sugimoto S, Kato T, Takagi M, Shin-Ya K..  (2010)  JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.,  73  (4): [PMID:20180542] [10.1021/np900788e]

629. Sevimli-Gur C, Akgun IH, Deliloglu-Gurhan I, Korkmaz KS, Bedir E..  (2010)  Cytotoxic naphthoquinones from Alkanna cappadocica ( perpendicular).,  73  (5): [PMID:20405844] [10.1021/np900778j]

630. Lee WY, Cheung CC, Liu KW, Fung KP, Wong J, Lai PB, Yeung JH..  (2010)  Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.,  73  (5): [PMID:20455578] [10.1021/np900792p]

631. Nolan KA, Humphries MP, Bryce RA, Stratford IJ..  (2010)  Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.,  20  (9): [PMID:20356739] [10.1016/j.bmcl.2010.03.051]

632. Bello C, Cea M, Dal Bello G, Garuti A, Rocco I, Cirmena G, Moran E, Nahimana A, Duchosal MA, Fruscione F, Pronzato P, Grossi F, Patrone F, Ballestrero A, Dupuis M, Sordat B, Nencioni A, Vogel P..  (2010)  Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.,  18  (9): [PMID:20346684] [10.1016/j.bmc.2010.03.009]

633. Alqasoumi SI, Al-Taweel AM, Alafeefy AM, Ghorab MM, Noaman E..  (2010)  Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents.,  45  (5): [PMID:20149941] [10.1016/j.ejmech.2010.01.022]

634. Zhang R, Wu X, Guziec LJ, Guziec FS, Chee GL, Yalowich JC, Hasinoff BB..  (2010)  Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents.,  18  (11): [PMID:20471276] [10.1016/j.bmc.2010.04.028]

635. Abdel-Mohsen HT, Ragab FA, Ramla MM, El Diwani HI..  (2010)  Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.,  45  (6): [PMID:20356655] [10.1016/j.ejmech.2010.02.011]

636. Hranjec M, Pavlović G, Marjanović M, Kralj M, Karminski-Zamola G..  (2010)  Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: synthesis, antitumor evaluation in vitro and crystal structure determination.,  45  (6): [PMID:20207049] [10.1016/j.ejmech.2010.02.022]

637. Liu X, Ou Y, Chen S, Lu X, Cheng H, Jia X, Wang D, Zhou GC..  (2010)  Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells.,  45  (6): [PMID:20149494] [10.1016/j.ejmech.2010.01.051]

638. Abdel-Aziz HA, El-Zahabi HS, Dawood KM..  (2010)  Microwave-assisted synthesis and in-vitro anti-tumor activity of 1,3,4-triaryl-5-N-arylpyrazole-carboxamides.,  45  (6): [PMID:20207452] [10.1016/j.ejmech.2010.02.026]

639. Yen CT, Wu CC, Lee JC, Chen SL, Morris-Natschke SL, Hsieh PW, Wu YC..  (2010)  Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: structure-activity relationships and synergistic studies.,  45  (6): [PMID:20334960] [10.1016/j.ejmech.2010.02.035]

640. Popsavin V, Srećo B, Benedeković G, Francuz J, Popsavin M, Kojić V, Bogdanović G..  (2010)  Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.,  45  (7): [PMID:20359789] [10.1016/j.ejmech.2010.03.010]

641. Yapi AD, Desbois N, Chezal JM, Chavignon O, Teulade JC, Valentin A, Blache Y..  (2010)  Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities.,  45  (7): [PMID:20362359] [10.1016/j.ejmech.2010.03.006]

642. Yoon J, Ryu JS..  (2010)  A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly.,  20  (13): [PMID:20570145] [10.1016/j.bmcl.2010.05.014]

643. Al-Said MS, Ghorab MM, Al-Qasoumi SI, El-Hossary EM, Noaman E..  (2010)  Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]benzenesulfonamides.,  45  (7): [PMID:20413187] [10.1016/j.ejmech.2010.03.030]

644. da Silva AP, Martini MV, de Oliveira CM, Cunha S, de Carvalho JE, Ruiz AL, da Silva CC..  (2010)  Antitumor activity of (-)-alpha-bisabolol-based thiosemicarbazones against human tumor cell lines.,  45  (7): [PMID:20413188] [10.1016/j.ejmech.2010.03.026]

645. Refaat HM..  (2010)  Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives.,  45  (7): [PMID:20399544] [10.1016/j.ejmech.2010.03.022]

646. Galisteo J, Navarro P, Campayo L, Yunta MJ, Gómez-Contreras F, Villa-Pulgarin JA, Sierra BG, Mollinedo F, Gonzalez J, Garcia-España E..  (2010)  Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine.,  18  (14): [PMID:20538470] [10.1016/j.bmc.2010.05.053]

647. Horwedel C, Tsogoeva SB, Wei S, Efferth T..  (2010)  Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells.,  53  (13): [PMID:20527917] [10.1021/jm100404t]

648. Schneemann I, Kajahn I, Ohlendorf B, Zinecker H, Erhard A, Nagel K, Wiese J, Imhoff JF..  (2010)  Mayamycin, a cytotoxic polyketide from a Streptomyces strain isolated from the marine sponge Halichondria panicea.,  73  (7): [PMID:20545334] [10.1021/np100135b]

649. Kumarihamy M, Fronczek FR, Ferreira D, Jacob M, Khan SI, Nanayakkara NP..  (2010)  Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.,  73  (7): [PMID:20550123] [10.1021/np1000939]

650. Lin BD, Han ML, Ji YC, Chen HD, Yang SP, Zhang S, Geng MY, Yue JM..  (2010)  Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.,  73  (7): [PMID:20593838] [10.1021/np100320h]

651. Kim KH, Lee IK, Piao CJ, Choi SU, Lee JH, Kim YS, Lee KR..  (2010)  Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity.,  20  (15): [PMID:20594848] [10.1016/j.bmcl.2010.06.035]

652. Kwak JH, Kim Y, Park H, Jang JY, Lee KK, Yi W, Kwak JA, Park SG, Kim H, Lee K, Kang JS, Han SB, Hwang BY, Hong JT, Jung JK, Kim Y, Cho J, Lee H..  (2010)  Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives.,  20  (15): [PMID:20579876] [10.1016/j.bmcl.2010.06.004]

653. Logrado LP, Santos CO, Romeiro LA, Costa AM, Ferreira JR, Cavalcanti BC, Manoel de Moraes O, Costa-Lotufo LV, Pessoa C, Dos Santos ML..  (2010)  Synthesis and cytotoxicity screening of substituted isobenzofuranones designed from anacardic acids.,  45  (8): [PMID:20537433] [10.1016/j.ejmech.2010.05.015]

654. Longeon A, Copp BR, Roué M, Dubois J, Valentin A, Petek S, Debitus C, Bourguet-Kondracki ML..  (2010)  New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.,  18  (16): [PMID:20634081] [10.1016/j.bmc.2010.06.066]

655. Casano G, Dumètre A, Pannecouque C, Hutter S, Azas N, Robin M..  (2010)  Anti-HIV and antiplasmodial activity of original flavonoid derivatives.,  18  (16): [PMID:20638854] [10.1016/j.bmc.2010.06.067]

656. Lakshmi NV, Thirumurugan P, Noorulla KM, Perumal PT..  (2010)  InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.,  20  (17): [PMID:20675130] [10.1016/j.bmcl.2010.07.039]

657. Liu CM, Li B, Shen YH, Zhang WD..  (2010)  Heterocyclic compounds and aromatic diglycosides from Bretschneidera sinensis.,  73  (9): [PMID:20722446] [10.1021/np1002934]

658. Chao CH, Chou KJ, Wang GH, Wu YC, Wang LH, Chen JP, Sheu JH, Sung PJ..  (2010)  Norterpenoids and related peroxides from the formosan marine sponge Negombata corticata.,  73  (9): [PMID:20718475] [10.1021/np100353x]

659. Kim KH, Noh HJ, Choi SU, Park KM, Seok SJ, Lee KR..  (2010)  Lactarane sesquiterpenoids from Lactarius subvellereus and their cytotoxicity.,  20  (18): [PMID:20719504] [10.1016/j.bmcl.2010.07.119]

660. Trisuwan K, Khamthong N, Rukachaisirikul V, Phongpaichit S, Preedanon S, Sakayaroj J..  (2010)  Anthraquinone, cyclopentanone, and naphthoquinone derivatives from the sea fan-derived fungi Fusarium spp. PSU-F14 and PSU-F135.,  73  (9): [PMID:20815366] [10.1021/np100282k]

661. Kamal A, Dastagiri D, Ramaiah MJ, Bharathi EV, Reddy JS, Balakishan G, Sarma P, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S..  (2010)  Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates.,  18  (18): [PMID:20732817] [10.1016/j.bmc.2010.07.067]

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819. Kamal A, Mallareddy A, Suresh P, Lakshma Nayak V, Shetti RV, Sankara Rao N, Tamboli JR, Shaik TB, Vishnuvardhan MV, Ramakrishna S..  (2012)  Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents.,  47  [PMID:22136907] [10.1016/j.ejmech.2011.11.024]

820. Lee CC, Huang KF, Lin PY, Huang FC, Chen CL, Chen TC, Guh JH, Lin JJ, Huang HS..  (2012)  Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.,  47  [PMID:22100139] [10.1016/j.ejmech.2011.10.059]

821. Lee JH, Jang KH, Lee YJ, Lee HS, Sim CJ, Oh KB, Shin J..  (2011)  Triterpene galactosides of the pouoside class and corresponding aglycones from the sponge Lipastrotethya sp.,  74  (12): [PMID:22148280] [10.1021/np200748g]

822. Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR..  (2011)  Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.,  19  (22): [PMID:22000949] [10.1016/j.bmc.2011.09.025]

823. Neves MP, Cravo S, Lima RT, Vasconcelos MH, Nascimento MS, Silva AM, Pinto M, Cidade H, Corrêa AG..  (2012)  Solid-phase synthesis of 2'-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines.,  20  (1): [PMID:22177409] [10.1016/j.bmc.2011.11.042]

824. Shi DK, Zhang W, Ding N, Li M, Li YX..  (2012)  Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors.,  47  [PMID:22119124] [10.1016/j.ejmech.2011.11.011]

825. Girgis AS, Stawinski J, Ismail NS, Farag H..  (2012)  Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-3,2'(1'H)-pyrrolo[3,4-c]pyrrole]-2,3',5'(1H,2'aH,4'H)-triones.,  47  [PMID:22119131] [10.1016/j.ejmech.2011.10.058]

826. George RF..  (2012)  Stereoselective synthesis and QSAR study of cytotoxic 2-(4-oxo-thiazolidin-2-ylidene)-2-cyano-N-arylacetamides.,  47  [PMID:22119132] [10.1016/j.ejmech.2011.11.006]

827. Kamal A, Ramakrishna G, Lakshma Nayak V, Raju P, Subba Rao AV, Viswanath A, Vishnuvardhan MV, Ramakrishna S, Srinivas G..  (2012)  Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents.,  20  (2): [PMID:22209733] [10.1016/j.bmc.2011.12.003]

828. Rao VK, Chhikara BS, Tiwari R, Shirazi AN, Parang K, Kumar A..  (2012)  One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities.,  22  (1): [PMID:22119472] [10.1016/j.bmcl.2011.10.124]

829. Kumar D, Maruthi Kumar N, Ghosh S, Shah K..  (2012)  Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents.,  22  (1): [PMID:22123320] [10.1016/j.bmcl.2011.11.031]

830. Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Saxena AK, Singh J, Taneja SC..  (2012)  Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.,  22  (1): [PMID:22123322] [10.1016/j.bmcl.2011.10.112]

831. Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LB, Bjeldanes LF, Crews P..  (2011)  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.,  74  (12): [PMID:22129061] [10.1021/np200673b]

832. El-borai MA, Rizk HF, Abd-Aal MF, El-Deeb IY..  (2012)  Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities - Part 1.,  48  [PMID:22178093] [10.1016/j.ejmech.2011.11.038]

833. Zhang Y, Zhong H, Wang T, Geng D, Zhang M, Li K..  (2012)  Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity.,  48  [PMID:22182926] [10.1016/j.ejmech.2011.11.036]

834. Jang KH, Lee Y, Sim CJ, Oh KB, Shin J..  (2012)  Bioactive lipids from the sponge Spirastrella abata.,  22  (2): [PMID:22182501] [10.1016/j.bmcl.2011.11.105]

835. Mielcke TR, Mascarello A, Filippi-Chiela E, Zanin RF, Lenz G, Leal PC, Chiaradia LD, Yunes RA, Nunes RJ, Battastini AM, Morrone FB, Campos MM..  (2012)  Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation.,  48  [PMID:22209415] [10.1016/j.ejmech.2011.12.023]

836. Kamal A, Srikanth YV, Ramaiah MJ, Khan MN, Kashi Reddy M, Ashraf M, Lavanya A, Pushpavalli SN, Pal-Bhadra M..  (2012)  Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.,  22  (1): [PMID:22104151] [10.1016/j.bmcl.2011.10.080]

837. Panthama N, Kanokmedhakul S, Kanokmedhakul K, Soytong K..  (2011)  Cytotoxic and antimalarial azaphilones from Chaetomium longirostre.,  74  (11): [PMID:22004007] [10.1021/np2004903]

838. Thuong PT, Pham TH, Le TV, Dao TT, Dang TT, Nguyen QT, Oh WK..  (2012)  Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis.,  22  (2): [PMID:22197145] [10.1016/j.bmcl.2011.11.116]

839. La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R..  (2011)  Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.,  54  (24): [PMID:22044164] [10.1021/jm2012886]

840. Lewin G, Aubert G, Thoret S, Dubois J, Cresteil T..  (2012)  Influence of the skeleton on the cytotoxicity of flavonoids.,  20  (3): [PMID:22257529] [10.1016/j.bmc.2011.12.038]

841. Pradidphol N, Kongkathip N, Sittikul P, Boonyalai N, Kongkathip B..  (2012)  First synthesis and anticancer activity of novel naphthoquinone amides.,  49  [PMID:22280818] [10.1016/j.ejmech.2012.01.020]

842. Soudy R, Wang L, Kaur K..  (2012)  Synthetic peptides derived from the sequence of a lasso peptide microcin J25 show antibacterial activity.,  20  (5): [PMID:22304849] [10.1016/j.bmc.2011.12.061]

843. Karki R, Thapa P, Yoo HY, Kadayat TM, Park PH, Na Y, Lee E, Jeon KH, Cho WJ, Choi H, Kwon Y, Lee ES..  (2012)  Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.,  49  [PMID:22318164] [10.1016/j.ejmech.2012.01.015]

844. Majeed R, Reddy MV, Chinthakindi PK, Sangwan PL, Hamid A, Chashoo G, Saxena AK, Koul S..  (2012)  Bakuchiol derivatives as novel and potent cytotoxic agents: a report.,  49  [PMID:22245048] [10.1016/j.ejmech.2011.12.018]

845. Saidu NE, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M..  (2012)  Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.,  20  (4): [PMID:22264758] [10.1016/j.bmc.2011.12.032]

846. Maiti M, Nauwelaerts K, Herdewijn P..  (2012)  Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.,  22  (4): [PMID:22257890] [10.1016/j.bmcl.2011.12.103]

847. Lee CC, Huang KF, Chang DM, Hsu JJ, Huang FC, Shih KN, Chen CL, Chen TC, Chen RH, Lin JJ, Huang HS..  (2012)  Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones.,  50  [PMID:22357112] [10.1016/j.ejmech.2012.01.044]

848. Kamal A, Reddy MK, Shaik TB, Rajender, Srikanth YV, Reddy VS, Kumar GB, Kalivendi SV..  (2012)  Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors.,  50  [PMID:22361684] [10.1016/j.ejmech.2012.01.004]

849. Khatik GL, Kaur J, Kumar V, Tikoo K, Nair VA..  (2012)  1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents.,  22  (5): [PMID:22326399] [10.1016/j.bmcl.2012.01.059]

850. Reddy BV, Divya B, Swain M, Rao TP, Yadav JS, Vishnu Vardhan MV..  (2012)  A domino Knoevenagel hetero-Diels-Alder reaction for the synthesis of polycyclic chromene derivatives and evaluation of their cytotoxicity.,  22  (5): [PMID:22330634] [10.1016/j.bmcl.2012.01.033]

851. Chhikara BS, St Jean N, Mandal D, Kumar A, Parang K..  (2011)  Fatty acyl amide derivatives of doxorubicin: synthesis and in vitro anticancer activities.,  46  (6): [PMID:21420207] [10.1016/j.ejmech.2011.02.056]

852. Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, Tsukuda S, Takada K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F..  (2011)  Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.,  19  (24): [PMID:22071521] [10.1016/j.bmc.2011.09.059]

853. Abdel-Megeed MF, Badr BE, Azaam MM, El-Hiti GA..  (2012)  Synthesis, antimicrobial and anticancer activities of a novel series of diphenyl 1-(pyridin-3-yl)ethylphosphonates.,  20  (7): [PMID:22370339] [10.1016/j.bmc.2012.02.015]

854. Kamal A, Suresh P, Ramaiah MJ, Mallareddy A, Imthiajali S, Pushpavalli SN, Lavanya A, Pal-Bhadra M..  (2012)  Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.,  20  (6): [PMID:22364746] [10.1016/j.bmc.2012.01.039]

855. Kamel AA, Geronikaki A, Abdou WM..  (2012)  Inhibitory effect of novel S,N-bisphosphonates on some carcinoma cell lines, osteoarthritis, and chronic inflammation.,  51  [PMID:22444025] [10.1016/j.ejmech.2012.02.047]

856. Shen CC, Cheng JJ, Lay HL, Wu SY, Ni CL, Teng CM, Chen CC..  (2012)  Cytotoxic apigenin derivatives from Chrysopogon aciculatis.,  75  (2): [PMID:22272829] [10.1021/np2007796]

857. Li G, Wang H, Zhu R, Sun L, Wang L, Li M, Li Y, Liu Y, Zhao Z, Lou H..  (2012)  Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp.,  75  (2): [PMID:22276650] [10.1021/np200614h]

858. Sun HF, Li XM, Meng L, Cui CM, Gao SS, Li CS, Huang CG, Wang BG..  (2012)  Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48.,  75  (2): [PMID:22283451] [10.1021/np2006742]

859. Huang H, Yang T, Ren X, Liu J, Song Y, Sun A, Ma J, Wang B, Zhang Y, Huang C, Zhang C, Ju J..  (2012)  Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.,  75  (2): [PMID:22304344] [10.1021/np2008335]

860. Subba Reddy BV, Rajeswari N, Sarangapani M, Prashanthi Y, Ganji RJ, Addlagatta A..  (2012)  Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.,  22  (7): [PMID:22386528] [10.1016/j.bmcl.2012.02.011]

861. Gu X, Ren Z, Tang X, Peng H, Zhao Q, Lai Y, Peng S, Zhang Y..  (2012)  Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.,  51  [PMID:22405646] [10.1016/j.ejmech.2012.02.034]

862. da Silva DL, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A..  (2012)  Free radical scavenging and antiproliferative properties of Biginelli adducts.,  20  (8): [PMID:22410248] [10.1016/j.bmc.2012.02.036]

863. Sanphanya K, Wattanapitayakul SK, Prangsaengtong O, Jo M, Koizumi K, Shibahara N, Priprem A, Fokin VV, Vajragupta O..  (2012)  Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents.,  22  (8): [PMID:22414612] [10.1016/j.bmcl.2012.02.029]

864. Alvala M, Bhatnagar S, Ravi A, Jeankumar VU, Manjashetty TH, Yogeeswari P, Sriram D..  (2012)  Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.,  22  (9): [PMID:22464458] [10.1016/j.bmcl.2012.03.030]

865. Lang KL, Silva IT, Zimmermann LA, Machado VR, Teixeira MR, Lapuh MI, Galetti MA, Palermo JA, Cabrera GM, Bernardes LS, Simões CM, Schenkel EP, Caro MS, Durán FJ..  (2012)  Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives.,  20  (9): [PMID:22472043] [10.1016/j.bmc.2012.03.001]

866. Prakasham AP, Saxena AK, Luqman S, Chanda D, Kaur T, Gupta A, Yadav DK, Chanotiya CS, Shanker K, Khan F, Negi AS..  (2012)  Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization.,  20  (9): [PMID:22472045] [10.1016/j.bmc.2012.02.057]

867. Gu X, Ren Z, Tang X, Peng H, Ma Y, Lai Y, Peng S, Zhang Y..  (2012)  Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.,  20  (8): [PMID:22429509] [10.1016/j.bmc.2012.02.050]

868. Kim EL, Li JL, Dang HT, Hong J, Lee CO, Kim DK, Yoon WD, Kim E, Liu Y, Jung JH..  (2012)  Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai.,  22  (9): [PMID:22483395] [10.1016/j.bmcl.2012.03.058]

869. Lal J, Gupta SK, Thavaselvam D, Agarwal DD..  (2012)  Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin.,  22  (8): [PMID:22440624] [10.1016/j.bmcl.2012.02.056]

870. Wijeratne EM, Bashyal BP, Liu MX, Rocha DD, Gunaherath GM, U'Ren JM, Gunatilaka MK, Arnold AE, Whitesell L, Gunatilaka AA..  (2012)  Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.,  75  (3): [PMID:22264149] [10.1021/np200769q]

871. Breiner-Goldstein E, Evron Z, Frenkel M, Cohen K, Meiron KN, Peer D, Roichman Y, Flescher E, Fridman M..  (2011)  Targeting anthracycline-resistant tumor cells with synthetic aloe-emodin glycosides.,  2  (7): [PMID:24900344] [10.1021/ml2001104]

872. Araya JJ, Kindscher K, Timmermann BN..  (2012)  Cytotoxic cardiac glycosides and other compounds from Asclepias syriaca.,  75  (3): [PMID:22316168] [10.1021/np2008076]

873. Chhikara BS, Mandal D, Parang K..  (2012)  Synthesis, anticancer activities, and cellular uptake studies of lipophilic derivatives of doxorubicin succinate.,  55  (4): [PMID:22276998] [10.1021/jm201653u]

874. Sousa Tda S, Jimenez PC, Ferreira EG, Silveira ER, Braz-Filho R, Pessoa OD, Costa-Lotufo LV..  (2012)  Anthracyclinones from Micromonospora sp.,  75  (3): [PMID:22250891] [10.1021/np200795p]

875. Zhang F, Wang JS, Gu YC, Kong LY..  (2012)  Cytotoxic and anti-inflammatory triterpenoids from Toona ciliata.,  75  (4): [PMID:22537362] [10.1021/np200579b]

876. Barcelos RC, Pastre JC, Caixeta V, Vendramini-Costa DB, de Carvalho JE, Pilli RA..  (2012)  Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells.,  20  (11): [PMID:22537680] [10.1016/j.bmc.2012.03.059]

877. Ghorab MM, Shaaban MA, Refaat HM, Heiba HI, Ibrahim SS..  (2012)  Anticancer and radiosensitizing evaluation of some new pyranothiazole-Schiff bases bearing the biologically active sulfonamide moiety.,  53  [PMID:22583778] [10.1016/j.ejmech.2012.04.009]

878. Yen CT, Lee CL, Chang FR, Hwang TL, Yen HF, Chen CJ, Chen SL, Wu YC..  (2012)  Indiosides G-K: steroidal glycosides with cytotoxic and anti-inflammatory activities from Solanum violaceum.,  75  (4): [PMID:22413887] [10.1021/np200877u]

879. Puthiyapurayil P, Poojary B, Chikkanna C, Buridipad SK..  (2012)  Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents.,  53  [PMID:22542958] [10.1016/j.ejmech.2012.03.056]

880. Wittine K, Stipković Babić M, Makuc D, Plavec J, Kraljević Pavelić S, Sedić M, Pavelić K, Leyssen P, Neyts J, Balzarini J, Mintas M..  (2012)  Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.,  20  (11): [PMID:22555152] [10.1016/j.bmc.2012.01.054]

881. Maneerat W, Ritthiwigrom T, Cheenpracha S, Promgool T, Yossathera K, Deachathai S, Phakhodee W, Laphookhieo S..  (2012)  Bioactive carbazole alkaloids from Clausena wallichii roots.,  75  (4): [PMID:22482432] [10.1021/np3000365]

882. Haddach M, Michaux J, Schwaebe MK, Pierre F, O'Brien SE, Borsan C, Tran J, Raffaele N, Ravula S, Drygin D, Siddiqui-Jain A, Darjania L, Stansfield R, Proffitt C, Macalino D, Streiner N, Bliesath J, Omori M, Whitten JP, Anderes K, Rice WG, Ryckman DM..  (2012)  Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.,  3  (2): [PMID:24900437] [10.1021/ml200259q]

883. Alafeefy AM, Alqasoumi SI, Ashour AE, Masand V, Al-Jaber NA, Ben Hadda T, Mohamed MA..  (2012)  Quinazoline-tyrphostin as a new class of antitumor agents, molecular properties prediction, synthesis and biological testing.,  53  [PMID:22520152] [10.1016/j.ejmech.2012.03.044]

884. Djurendić EA, Ajduković JJ, Sakač MN, Csanádi JJ, Kojić VV, Bogdanović GM, Penov Gaši KM..  (2012)  Synthesis and cytotoxic activity of some 17-picolyl and 17-picolinylidene androstane derivatives.,  54  [PMID:22770744] [10.1016/j.ejmech.2012.06.030]

885. Yeshak MY, Burman R, Asres K, Göransson U..  (2011)  Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands.,  74  (4): [PMID:21434649] [10.1021/np100790f]

886. Li X, Zheng SL, Li X, Li JL, Qiang O, Liu R, He L..  (2012)  Synthesis and anti-breast cancer activity of new indolylquinone derivatives.,  54  [PMID:22658083] [10.1016/j.ejmech.2012.04.019]

887. Nagaraju M, Gnana Deepthi E, Ashwini C, Vishnuvardhan MV, Lakshma Nayak V, Chandra R, Ramakrishna S, Gawali BB..  (2012)  Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells.,  22  (13): [PMID:22668451] [10.1016/j.bmcl.2012.05.016]

888. Verhaeghe P, Dumètre A, Castera-Ducros C, Hutter S, Laget M, Fersing C, Prieri M, Yzombard J, Sifredi F, Rault S, Rathelot P, Vanelle P, Azas N..  (2011)  4-Thiophenoxy-2-trichloromethyquinazolines display in vitro selective antiplasmodial activity against the human malaria parasite Plasmodium falciparum.,  21  (19): [PMID:21852132] [10.1016/j.bmcl.2011.06.113]

889. Abu-Aisheh MN, Mustafa MS, El-Abadelah MM, Naffa RG, Ismail SI, Zihlif MA, Taha MO, Mubarak MS..  (2012)  Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners.,  54  [PMID:22677031] [10.1016/j.ejmech.2012.04.028]

890. Tuncbilek M, Guven EB, Onder T, Cetin Atalay R..  (2012)  Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.,  55  (7): [PMID:22409771] [10.1021/jm3001532]

891. Paloque L, Verhaeghe P, Casanova M, Castera-Ducros C, Dumètre A, Mbatchi L, Hutter S, Kraiem-M'rabet M, Laget M, Remusat V, Rault S, Rathelot P, Azas N, Vanelle P..  (2012)  Discovery of a new antileishmanial hit in 8-nitroquinoline series.,  54  [PMID:22608675] [10.1016/j.ejmech.2012.04.029]

892. Nakhi A, Adepu R, Rambabu D, Kishore R, Vanaja GR, Kalle AM, Pal M..  (2012)  Thieno[3,2-c]pyran-4-one based novel small molecules: their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents.,  22  (13): [PMID:22632935] [10.1016/j.bmcl.2012.04.109]

893. Sumangala V, Poojary B, Chidananda N, Arulmoli T, Shenoy S..  (2012)  Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines.,  54  [PMID:22633832] [10.1016/j.ejmech.2012.04.024]

894. Li C, La MP, Tang H, Pan WH, Sun P, Krohn K, Yi YH, Li L, Zhang W..  (2012)  Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.,  22  (13): [PMID:22647719] [10.1016/j.bmcl.2012.05.001]

895. Zhao PL, Duan AN, Zou M, Yang HK, You WW, Wu SG..  (2012)  Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety.,  22  (13): [PMID:22647723] [10.1016/j.bmcl.2012.03.023]

896. Tang X, Gu X, Ren Z, Ma Y, Lai Y, Peng H, Peng S, Zhang Y..  (2012)  Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents.,  22  (8): [PMID:22450134] [10.1016/j.bmcl.2012.03.005]

897. Venkateswararao E, Anh Hle T, Sharma VK, Lee KC, Sharma N, Kim Y, Jung SH..  (2012)  Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells.,  22  (14): [PMID:22738641] [10.1016/j.bmcl.2012.06.001]

898. Kumarihamy M, Khan SI, Jacob M, Tekwani BL, Duke SO, Ferreira D, Nanayakkara NP..  (2012)  Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.,  75  (5): [PMID:22530813] [10.1021/np200940b]

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986. Refaat HM.  (2012)  Synthesis of potential anticancer derivatives of pyrido[1,2-a]benzimidazoles,  21  (7): [10.1007/s00044-011-9636-y]

987. Ghorab MM, Ragab FA, Heiba HI, Youssef HA, El-Gazzar MG.  (2012)  Synthesis of novel pyrazole and pyrimidine derivatives bearing sulfonamide moiety as antitumor and radiosensitizing agents,  21  (7): [10.1007/s00044-011-9653-x]

988. Ghorab MM, Ragab FA, Heiba HI, Arafa RK, El-Hossary EM.  (2011)  Docking study, in vitro anticancer screening and radiosensitizing evaluation of some new fluorine-containing quinoline and pyrimidoquinoline derivatives bearing a sulfonamide moiety,  20  (3): [10.1007/s00044-010-9332-3]

989. Lin C, Lu P, Yang C, Hulme C, Shaw AY.  (2013)  Structureactivity relationship study of growth inhibitory 2-styrylchromones against carcinoma cells,  22  (5): [10.1007/s00044-012-0232-6]

990. da Rocha Pitta MG, Souza ES, Barros FWA, Moraes Filho MO, Pessoa CO, Hernandes MZ, do Carmo Alves de Lima M, Galdino SL, da Rocha Pitta I.  (2013)  Synthesis and in vitro anticancer activity of novel thiazacridine derivatives,  22  (5): [10.1007/s00044-012-0236-2]

991. Zaharia V, Ignat A, Ngameni B, Kuete V, Moungang ML, Fokunang CN, Vasilescu M, Palibroda N, Cristea C, Silaghi-Dumitrescu L, Ngadjui BT.  (2013)  Heterocycles 23: Synthesis, characterization and anticancer activity of new hydrazinoselenazole derivatives,  22  (12): [10.1007/s00044-013-0558-8]

992. Fathalla OAEM, Ismail MAH, Anwar MM, Abouzid KAM, Ramadan AAK.  (2013)  Novel 2-thiopyrimidine derivatives as CDK2 inhibitors: molecular modeling, synthesis, and anti-tumor activity evaluation,  22  (2): [10.1007/s00044-012-0051-9]

993. Masoud GN, Youssef AM, Abdel Khalek MM, Abdel Wahab AE, Labouta IM, Hazzaa AAB.  (2013)  Design, synthesis, and biological evaluation of new 4-thiazolidinone derivatives substituted with benzimidazole ring as potential chemotherapeutic agents,  22  (2): [10.1007/s00044-012-0057-3]

994. Jagadeesh Kumar G, Sriramkumar Bomma HVS, Srihari E, Shrivastava S, Naidu VGM, Srinivas K, Jayathirtha Rao V.  (2013)  Synthesis and anticancer activity of some new s-triazine derivatives,  22  (12): [10.1007/s00044-013-0584-6]

995. Rajguru D, Keshwal BS, Jain S.  (2013)  Solvent-free, green and efficient synthesis of pyrano[4, 3-b]pyrans by grinding and their biological evaluation as antitumor and antioxidant agents,  22  (12): [10.1007/s00044-013-0586-4]

996. Isloor AM, Sunil D, Shetty P, Malladi S, Pai KSR, Maliyakkl N.  (2013)  Synthesis, characterization, anticancer, and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells,  22  (2): [10.1007/s00044-012-0071-5]

997. Shukla S, Srivastava RS, Shrivastava SK, Sodhi A, Kumar P.  (2013)  Synthesis, characterization, in vitro anticancer activity, and docking of Schiff bases of 4-amino-1,2-naphthoquinone,  22  (4): [10.1007/s00044-012-0150-7]

998. Devarakonda M, Doonaboina R, Vanga S, Vemu J, Boni S, Mailavaram RP.  (2013)  Synthesis of novel 2-alkyl-4-substituted-amino-pyrazolo[3,4-d]pyrimidines as new leads for anti-bacterial and anti-cancer activity,  22  (3): [10.1007/s00044-012-0084-0]

999. Sambasiva Rao P, Kurumurthy C, Veeraswamy B, Santhosh kumar G, Narsaiah B, Pranay Kumar K, Murthy USN, Karnewar S, Kotamraju S.  (2013)  Synthesis, antimicrobial and cytotoxic activities of novel 4-trifluoromethyl-(1,2,3)-thiadiazolo-5-carboxylic acid hydrazide Schiffs bases,  22  (4): [10.1007/s00044-012-0168-x]

1000. Nagarapua L, Gaikwad HK, Manikonda SR, Bantu R, Manda KM, Kalivendi SV.  (2013)  Synthesis of novel building blocks of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one and evaluation of their antitumor activity,  22  (1): [10.1007/s00044-012-0018-x]

1001. Khalil NA, Ahmed EM, El-Nassan HB.  (2013)  Synthesis, characterization, and biological evaluation of certain 1,3-thiazolone derivatives bearing pyrazoline moiety as potential anti-breast cancer agents,  22  (2): [10.1007/s00044-012-0098-7]

1002. Pingaew R, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.  (2013)  Synthesis and cytotoxicity of novel N-sulfonyl-1,2,3,4-tetrahydroisoquinoline thiosemicarbazone derivatives,  22  (1): [10.1007/s00044-012-0025-y]

1003. Garg V, Kumar A, Chaudhary A, Agrawal S, Tomar P, Sreenivasan KK.  (2013)  Synthesis, biological evaluation and molecular docking studies of 1,3-benzoxazine derivatives as potential anticancer agents,  22  (11): [10.1007/s00044-013-0534-3]

1004. Eskander J, Sakka OK, Harakat D, Lavaud C.  (2013)  Steroidal saponins from the leaves of Yucca de-smetiana and their in vitro antitumor activity: structure activity relationships through a molecular modeling approach,  22  (10): [10.1007/s00044-013-0497-4]

1005. El-Ashmawy MB, El-Sherbeny MA, El-Gohary NS.  (2013)  Synthesis and antitumor screening of new series of pyrimido-[4,5-b]quinolines and [1,2,4]triazolo[2,3:3,4]pyrimido[6,5-b]quinolines,  22  (6): [10.1007/s00044-012-0272-y]

1006. Metwally K, Khalil A, Sallam A, Pratsinis H, Kletsas D, El Sayed K.  (2013)  Structureactivity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones,  22  (9): [10.1007/s00044-012-0428-9]

1007. Fleita DH, Mohareb RM, Sakka OK.  (2013)  Antitumor and antileishmanial evaluation of novel heterocycles derived from quinazoline scaffold: a molecular modeling approach,  22  (5): [10.1007/s00044-012-0213-9]

1008. Sumangala V, Poojary B, Chidananda N, Arulmoli T, Shenoy S.  (2013)  Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione,  22  (6): [10.1007/s00044-012-0294-5]

1009. Sasidhar BS, Biradar JS.  (2013)  Synthesis of some bisindolyl analogs for in vitro cytotoxic and DNA cleavage studies,  22  (7): [10.1007/s00044-012-0370-x]

1010. Miralinaghi P, Salimi M, Amirhamzeh A, Norouzi M, Kandelousi HM, Shafiee A, Amini M.  (2013)  Synthesis, molecular docking study, and anticancer activity of triaryl-1,2,4-oxadiazole,  22  (9): [10.1007/s00044-012-0436-9]

1011. Avula S, Komsani JR, Koppireddi S, Yadla R, Kanugula AK, Kotamraju S.  (2013)  Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives,  22  (8): [10.1007/s00044-012-0373-7]

1012. Mohini Y, Prasad RBN, Karuna MSL, Ganesh Kumar C, Poornima M, Sujitha P.  (2013)  Synthesis of fatty acid Schiff base esters as potential antimicrobial and chemotherapeutic agents,  22  (9): [10.1007/s00044-012-0450-y]

1013. Pingaew R, Tongraung P, Worachartcheewan A, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.  (2013)  Cytotoxicity and QSAR study of (thio)ureas derived from phenylalkylamines and pyridylalkylamines,  22  (8): [10.1007/s00044-012-0402-6]

1014. Kongkathip B, Akkarasamiyo S, Hasitapan K, Sittikul P, Boonyalai N, Kongkathip N..  (2013)  Synthesis of novel naphthoquinone aliphatic amides and esters and their anticancer evaluation.,  60  [PMID:23313636] [10.1016/j.ejmech.2012.12.006]

1015. Wang Y, Wang WJ, Su C, Zhang DM, Xu LP, He RR, Wang L, Zhang J, Zhang XQ, Ye WC..  (2013)  Cytotoxic quassinoids from Ailanthus altissima.,  23  (3): [PMID:23290052] [10.1016/j.bmcl.2012.11.116]

1016. Manohar S, Khan SI, Kandi SK, Raj K, Sun G, Yang X, Calderon Molina AD, Ni N, Wang B, Rawat DS..  (2013)  Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin.,  23  (1): [PMID:23218718] [10.1016/j.bmcl.2012.11.004]

1017. Orlandi F, Coronnello M, Bellucci C, Dei S, Guandalini L, Manetti D, Martelli C, Romanelli MN, Scapecchi S, Salerno M, Menif H, Bello I, Mini E, Teodori E..  (2013)  New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).,  21  (2): [PMID:23245571] [10.1016/j.bmc.2012.11.019]

1018. Amin KM, Eissa AA, Abou-Seri SM, Awadallah FM, Hassan GS..  (2013)  Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.,  60  [PMID:23291120] [10.1016/j.ejmech.2012.12.004]

1019. Álvarez R, Puebla P, Díaz JF, Bento AC, García-Navas R, de la Iglesia-Vicente J, Mollinedo F, Andreu JM, Medarde M, Peláez R..  (2013)  Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.,  56  (7): [PMID:23470139] [10.1021/jm3015603]

1020. Shaul P, Frenkel M, Goldstein EB, Mittelman L, Grunwald A, Ebenstein Y, Tsarfaty I, Fridman M..  (2013)  The structure of anthracycline derivatives determines their subcellular localization and cytotoxic activity.,  4  (3): [PMID:24900668] [10.1021/ml3002852]

1021. Chaniyara R, Tala S, Chen CW, Zang X, Kakadiya R, Lin LF, Chen CH, Chien SI, Chou TC, Tsai TH, Lee TC, Shah A, Su TL..  (2013)  Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.,  56  (4): [PMID:23360284] [10.1021/jm301788a]

1022. Romagnoli R, Baraldi PG, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, Brancale A, Hamel E, Castagliuolo I, Bortolozzi R, Basso G, Viola G..  (2013)  Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.,  56  (6): [PMID:23445496] [10.1021/jm400043d]

1023. Cheenpracha S, Ritthiwigrom T, Laphookhieo S..  (2013)  Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla.,  76  (4): [PMID:23806072] [10.1021/np3006937]

1024. Liu HX, Chen K, Sun QY, Yang FM, Hu GW, Wang YH, Long CL..  (2013)  Nudibaccatumone, a trimer comprising a phenylpropanoid and two sesquiterpene moieties from Piper nudibaccatum.,  76  (4): [PMID:23544451] [10.1021/np300703u]

1025. Vansteelandt M, Blanchet E, Egorov M, Petit F, Toupet L, Bondon A, Monteau F, Le Bizec B, Thomas OP, Pouchus YF, Le Bot R, Grovel O..  (2013)  Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived Penicillium strain.,  76  (2): [PMID:23360521] [10.1021/np3007364]

1026. Sunassee SN, Veale CG, Shunmoogam-Gounden N, Osoniyi O, Hendricks DT, Caira MR, de la Mare JA, Edkins AL, Pinto AV, da Silva Júnior EN, Davies-Coleman MT..  (2013)  Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.,  62  [PMID:23353747] [10.1016/j.ejmech.2012.12.048]

1027. Rogez-Florent T, Meignan S, Foulon C, Six P, Gros A, Bal-Mahieu C, Supuran CT, Scozzafava A, Frédérick R, Masereel B, Depreux P, Lansiaux A, Goossens JF, Gluszok S, Goossens L..  (2013)  New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.,  21  (6): [PMID:23168081] [10.1016/j.bmc.2012.10.029]

1028. Zaki MA, Balachandran P, Khan S, Wang M, Mohammed R, Hetta MH, Pasco DS, Muhammad I..  (2013)  Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.,  76  (4): [PMID:23547843] [10.1021/np300893n]

1029. Hao J, Liu J, Wen X, Sun H..  (2013)  Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.,  23  (7): [PMID:23434227] [10.1016/j.bmcl.2013.01.129]

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1031. Kim KH, Moon E, Choi SU, Kim SY, Lee KR..  (2013)  Lanostane triterpenoids from the mushroom Naematoloma fasciculare.,  76  (5): [PMID:23634786] [10.1021/np300801x]

1032. Khazir J, Singh PP, Reddy DM, Hyder I, Shafi S, Sawant SD, Chashoo G, Mahajan A, Alam MS, Saxena AK, Arvinda S, Gupta BD, Kumar HM..  (2013)  Synthesis and anticancer activity of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of α-santonin.,  63  [PMID:23501113] [10.1016/j.ejmech.2013.01.003]

1033. Chang FR, Yen CT, El-Shazly M, Yu CY, Yen MH, Cheng YB, Chen SL, Wu YC..  (2013)  Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.,  23  (9): [PMID:23511021] [10.1016/j.bmcl.2013.02.060]

1034. Liu AH, Liu DQ, Liang TJ, Yu XQ, Feng MT, Yao LG, Fang Y, Wang B, Feng LH, Zhang MX, Mao SC..  (2013)  Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa.,  23  (9): [PMID:23548547] [10.1016/j.bmcl.2013.03.038]

1035. Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, Georg GI..  (2013)  Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.,  56  (10): [PMID:23600925] [10.1021/jm301234k]

1036. Bell-Horwath TR, Vadukoot AK, Thowfeik FS, Li G, Wunderlich M, Mulloy JC, Merino EJ..  (2013)  Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia.,  23  (10): [PMID:23578690] [10.1016/j.bmcl.2013.03.048]

1037. Kim SH, Lee E, Baek KH, Kwon HB, Woo H, Lee ES, Kwon Y, Na Y..  (2013)  Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.,  23  (11): [PMID:23608763] [10.1016/j.bmcl.2013.03.106]

1038. Ma G, Yuan J, Wu H, Cao L, Zhang X, Xu L, Wei H, Wu L, Zheng Q, Li L, Zhang L, Yang J, Xu X..  (2013)  Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax.,  76  (6): [PMID:23806110] [10.1021/np300918q]

1039. Bulic B, Pickhardt M, Mandelkow E..  (2013)  Progress and developments in tau aggregation inhibitors for Alzheimer disease.,  56  (11): [PMID:23484434] [10.1021/jm3017317]

1040. Azevedo CM, Afonso CM, Sousa D, Lima RT, Vasconcelos MH, Pedro M, Barbosa J, Corrêa AG, Reis S, Pinto MM..  (2013)  Multidimensional optimization of promising antitumor xanthone derivatives.,  21  (11): [PMID:23623253] [10.1016/j.bmc.2013.03.079]

1041. Lal J, Gupta SK, Thavaselvam D, Agarwal DD..  (2013)  Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides.,  64  [PMID:23685942] [10.1016/j.ejmech.2013.03.012]

1042. Liu Q, Liu H, Zhang L, Guo T, Wang P, Geng M, Li Y..  (2013)  Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.,  64  [PMID:23639650] [10.1016/j.ejmech.2013.04.016]

1043. Zhang Y, Wang JS, Wei DD, Gu YC, Wang XB, Kong LY..  (2013)  Bioactive terpenoids from the fruits of Aphanamixis grandifolia.,  76  (6): [PMID:23772699] [10.1021/np400126q]

1044. Chai B, Wang S, Yu W, Li H, Song C, Xu Y, Liu C, Chang J..  (2013)  Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines.,  23  (12): [PMID:23664877] [10.1016/j.bmcl.2013.04.045]

1045. Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH..  (2013)  Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.,  21  (13): [PMID:23673218] [10.1016/j.bmc.2013.04.027]

1046. Ali I, Haque A, Saleem K, Hsieh MF..  (2013)  Curcumin-I Knoevenagel's condensates and their Schiff's bases as anticancer agents: synthesis, pharmacological and simulation studies.,  21  (13): [PMID:23643901] [10.1016/j.bmc.2013.04.018]

1047. Bertamino A, Soprano M, Musella S, Rusciano MR, Sala M, Vernieri E, Di Sarno V, Limatola A, Carotenuto A, Cosconati S, Grieco P, Novellino E, Illario M, Campiglia P, Gomez-Monterrey I..  (2013)  Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators.,  56  (13): [PMID:23802716] [10.1021/jm400311n]

1048. Kumar JA, Saidachary G, Mallesham G, Sridhar B, Jain N, Kalivendi SV, Rao VJ, Raju BC..  (2013)  Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates.,  65  [PMID:23748152] [10.1016/j.ejmech.2013.03.042]

1049. Abbas SE, Abdel Gawad NM, George RF, Akar YA..  (2013)  Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives.,  65  [PMID:23708013] [10.1016/j.ejmech.2013.04.055]

1050. Bejjanki NK, Venkatesham A, Madda J, Kommu N, Pombala S, Kumar CG, Prasad KR, Nanubolu JB..  (2013)  Synthesis of new chromeno-annulated cis-fused pyrano[4,3-c]isoxazole derivatives via intramolecular nitrone cycloaddition and their cytotoxicity evaluation.,  23  (14): [PMID:23764302] [10.1016/j.bmcl.2013.05.060]

1051. Kim KH, Choi SU, Son MW, Choi SZ, Clardy J, Lee KR..  (2013)  Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil).,  76  (7): [PMID:23815260] [10.1021/np400326e]

1052. Tan KC, Wakimoto T, Takada K, Ohtsuki T, Uchiyama N, Goda Y, Abe I..  (2013)  Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.,  76  (7): [PMID:23848233] [10.1021/np400404r]

1053. Wang ZC, Qin YJ, Wang PF, Yang YA, Wen Q, Zhang X, Qiu HY, Duan YT, Wang YT, Sang YL, Zhu HL..  (2013)  Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis.,  66  [PMID:23777898] [10.1016/j.ejmech.2013.04.035]

1054. El-Borai MA, Rizk HF, Beltagy DM, El-Deeb IY..  (2013)  Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities.,  66  [PMID:23831694] [10.1016/j.ejmech.2013.04.043]

1055. Soares FA, Sesti-Costa R, da Silva JS, de Souza MC, Ferreira VF, Santos Fda C, Monteiro PA, Leitão A, Montanari CA..  (2013)  Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity.,  23  (16): [PMID:23850203] [10.1016/j.bmcl.2013.06.029]

1056. Font M, Lizarraga E, Ibáñez E, Plano D, Sanmartín C, Palop JA..  (2013)  Structural variations on antitumour agents derived from bisacylimidoselenocarbamate. A proposal for structure-activity relationships based on the analysis of conformational behaviour.,  66  [PMID:23831811] [10.1016/j.ejmech.2013.06.001]

1057. Moosophon P, Kanokmedhakul S, Kanokmedhakul K, Buayairaksa M, Noichan J, Poopasit K..  (2013)  Antiplasmodial and cytotoxic flavans and diarylpropanes from the stems of Combretum griffithii.,  76  (7): [PMID:23795891] [10.1021/np400266h]

1058. Woo JK, Jeon JE, Kim CK, Sim CJ, Oh DC, Oh KB, Shin J..  (2013)  Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis.,  76  (7): [PMID:23799303] [10.1021/np4003367]

1059. Seephonkai P, Pyne SG, Willis AC, Lie W..  (2013)  Bioactive compounds from the roots of Strophioblachia fimbricalyx.,  76  (7): [PMID:23806014] [10.1021/np400268d]

1060. dos Santos Edos A, Hamel E, Bai R, Burnett JC, Tozatti CS, Bogo D, Perdomo RT, Antunes AM, Marques MM, Matos Mde F, de Lima DP..  (2013)  Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.,  23  (16): [PMID:23810282] [10.1016/j.bmcl.2013.06.009]

1061. Hassan GS, El-Messery SM, Al-Omary FA, Al-Rashood ST, Shabayek MI, Abulfadl YS, Habib el-SE, El-Hallouty SM, Fayad W, Mohamed KM, El-Menshawi BS, El-Subbagh HI..  (2013)  Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.,  66  [PMID:23792351] [10.1016/j.ejmech.2013.05.039]

1062. Wu L, Zhang C, Li W..  (2013)  Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents.,  23  (17): [PMID:23871222] [10.1016/j.bmcl.2013.06.040]

1063. Bruder M, Vendramini-Costa DB, de Carvalho JE, Pilli RA..  (2013)  Design, synthesis and in vitro evaluation against human cancer cells of 5-methyl-5-styryl-2,5-dihydrofuran-2-ones, a new series of goniothalamin analogues.,  21  (17): [PMID:23876338] [10.1016/j.bmc.2013.06.044]

1064. Cavalluzzi MM, Viale M, Bruno C, Carocci A, Catalano A, Carrieri A, Franchini C, Lentini G..  (2013)  A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells.,  23  (17): [PMID:23886686] [10.1016/j.bmcl.2013.06.077]

1065. Emmerich J, Hu Q, Hanke N, Hartmann RW..  (2013)  Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.,  56  (15): [PMID:23869452] [10.1021/jm400240r]

1066. Insuasty B, Montoya A, Becerra D, Quiroga J, Abonia R, Robledo S, Vélez ID, Upegui Y, Nogueras M, Cobo J..  (2013)  Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.,  67  [PMID:23871905] [10.1016/j.ejmech.2013.06.049]

1067. Kumar JN, Reddy PR, Das B, Kumar CG, Sujitha P..  (2013)  A new strategy for the synthesis of crucigasterin A, and cytotoxic activity of this compound and its related analogues.,  23  (18): [PMID:23932340] [10.1016/j.bmcl.2013.07.007]

1068. Ravu RR, Chen YL, Jacob MR, Pan X, Agarwal AK, Khan SI, Heitman J, Clark AM, Li XC..  (2013)  Synthesis and antifungal activities of miltefosine analogs.,  23  (17): [PMID:23891181] [10.1016/j.bmcl.2013.06.096]

1069. Lee YJ, Han S, Lee HS, Kang JS, Yun J, Sim CJ, Shin HJ, Lee JS..  (2013)  Cytotoxic psammaplysin analogues from a Suberea sp. marine sponge and the role of the spirooxepinisoxazoline in their activity.,  76  (9): [PMID:23964644] [10.1021/np400448y]

1070. Desai NC, Bhatt N, Somani H, Trivedi A..  (2013)  Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles.,  67  [PMID:23835482] [10.1016/j.ejmech.2013.06.029]

1071. Jeon JE, Liao L, Kim H, Sim CJ, Oh DC, Oh KB, Shin J..  (2013)  Cytotoxic diterpenoid pseudodimers from the Korean sponge Phorbas gukhulensis.,  76  (9): [PMID:24025124] [10.1021/np400389c]

1072. Kamal A, Suresh P, Ramaiah MJ, Srinivasa Reddy T, Kapavarapu RK, Rao BN, Imthiajali S, Lakshminarayan Reddy T, Pushpavalli SN, Shankaraiah N, Pal-Bhadra M..  (2013)  4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.,  21  (17): [PMID:23849207] [10.1016/j.bmc.2013.06.033]

1073. Vijai Kumar Reddy T, Prabhavathi Devi BL, Prasad RB, Sujitha P, Ganesh Kumar C..  (2013)  Total synthesis and biological evaluation of clavaminol-G and its analogs.,  67  [PMID:23911578] [10.1016/j.ejmech.2013.07.001]

1074. Chegaev K, Riganti C, Rolando B, Lazzarato L, Gazzano E, Guglielmo S, Ghigo D, Fruttero R, Gasco A..  (2013)  Doxorubicin-antioxidant co-drugs.,  23  (19): [PMID:23973213] [10.1016/j.bmcl.2013.07.070]

1075. Marganakop SB, Kamble RR, Hoskeri J, Prasad DJ, Meti GY.  (2013)  Facile synthesis of novel quinoline derivatives as anticancer agents,  [10.1007/s00044-013-0855-2]

1076. Leepasert T, Shahabi M, Shanab K, Schirmer E, Holzer W, Spreitzer H, Aicher B, Müller G, Günther E..  (2013)  Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.,  23  (19): [PMID:23988351] [10.1016/j.bmcl.2013.08.021]

1077. George RF, Ismail NS, Stawinski J, Girgis AS..  (2013)  Design, synthesis and QSAR studies of dispiroindole derivatives as new antiproliferative agents.,  68  [PMID:23994327] [10.1016/j.ejmech.2013.07.035]

1078. Li YB, Zhao WL, Wang YX, Zhang CX, Jiang JD, Bi CW, Tang S, Chen RX, Shao RG, Song DQ..  (2013)  Discovery, synthesis and biological evaluation of cycloprotoberberine derivatives as potential antitumor agents.,  68  [PMID:24012683] [10.1016/j.ejmech.2013.07.026]

1079. Qin JJ, Jin HZ, Huang Y, Zhang SD, Shan L, Voruganti S, Nag S, Wang W, Zhang WD, Zhang R..  (2013)  Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz.,  68  [PMID:24044895] [10.1016/j.ejmech.2013.07.018]

1080. Al-Omran F, Mohareb RM, El-Khair AA.  (2013)  New route for synthesis, spectroscopy, and X-ray studies of 2-[aryl-(6-hydroxy-4,4-dimethyl-2-oxocyclohex-6-enyl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone and 1,8-dioxo-octahydroxanthenes and antitumor evaluation,  [10.1007/s00044-013-0712-3]

1081. Leite ACL, Barbosa FF, Cardoso MVdO, Moreira DRM, Coelho LCD, da Silva EB, Filho GBdO, de Souza VMO, Pereira VRA, de C. Reis L, Ferreira PMP, Pessoa C, Wanderley AG, Mota FVB, da Silva TG.  (2013)  Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes,  [10.1007/s00044-013-0730-1]

1082. Wang XY, Gao H, Zhang W, Li Y, Cheng G, Sun XL, Tang HF..  (2013)  Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis.,  23  (20): [PMID:23992864] [10.1016/j.bmcl.2013.08.006]

1083. Pingaew R, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.  (2013)  Synthesis and cytotoxicity of novel 4-(4-(substituted)-1H-1,2,3-triazol-1-yl)-N-phenethylbenzenesulfonamides,  [10.1007/s00044-013-0777-z]

1084. Madabhushi S, Chinthala N, Kanwal A, Kaur G, Banerjee SK.  (2013)  Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity,  [10.1007/s00044-013-0784-0]

1085. Yao J, Ye W, Liu J, Liu J, Wang C.  (2013)  Synthesis and cytotoxicity of (3)-3-acetyloxy-5(6)-androsten-7-one oxime and 3,5(6)-androstadien-7-one oxime,  [10.1007/s00044-013-0788-9]

1086. Alam M, Nami SAA, Rehman S, Lee D, Park S.  (2013)  Synthesis, characterization, and cytotoxicity of N-2-hydroxyethyl-substituted azastigmastanes,  [10.1007/s00044-013-0795-x]

1087. Luo H, Yang S, Zhao Q, Xiang H.  (2013)  Synthesis and antitumor properties of novel curcumin analogs,  [10.1007/s00044-013-0854-3]

1088. Popsavin V, Francuz J, Srećo Zelenović B, Benedeković G, Popsavin M, Kojić V, Bogdanović G..  (2013)  Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.,  23  (20): [PMID:24021462] [10.1016/j.bmcl.2013.08.069]

1089. Soudy R, Chen C, Kaur K..  (2013)  Novel peptide-doxorubucin conjugates for targeting breast cancer cells including the multidrug resistant cells.,  56  (19): [PMID:24028446] [10.1021/jm400647r]

1090. Tian HY, Luo SL, Liu JS, Wang L, Wang Y, Zhang DM, Zhang XQ, Jiang RW, Ye WC..  (2013)  C23 steroids from the venom of Bufo bufo gargarizans.,  76  (10): [PMID:24050254] [10.1021/np400174f]

1091. Zhang G, Wu G, Zhu T, Kurtán T, Mándi A, Jiao J, Li J, Qi X, Gu Q, Li D..  (2013)  Meroterpenoids with diverse ring systems from the sponge-associated fungus Alternaria sp. JJY-32.,  76  (10): [PMID:24128115] [10.1021/np4005757]

1092. Al-Dosari MS, Ghorab MM, Alsaid MS, Nissan YM, Ahmed AB..  (2013)  Synthesis and anticancer activity of some novel trifluoromethylquinolines carrying a biologically active benzenesulfonamide moiety.,  69  [PMID:24077528] [10.1016/j.ejmech.2013.08.048]

1093. Galal SA, Abdelsamie AS, Soliman SM, Mortier J, Wolber G, Ali MM, Tokuda H, Suzuki N, Lida A, Ramadan RA, El Diwani HI..  (2013)  Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor.,  69  [PMID:24013411] [10.1016/j.ejmech.2013.07.049]

1094. Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y..  (2013)  3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.,  69  [PMID:24013413] [10.1016/j.ejmech.2013.07.048]

1095. Arafa RK, Nour MS, El-Sayed NA..  (2013)  Novel heterocyclic-fused pyrimidine derivatives: synthesis, molecular modeling and pharmacological screening.,  69  [PMID:24090920] [10.1016/j.ejmech.2013.08.042]

1096. Shamroukh AH, El-Shahat M, Drabowicz J, Ali MM, Rashad AE, Ali HS..  (2013)  Anticancer evaluation of some newly synthesized N-nicotinonitrile derivative.,  69  [PMID:24095746] [10.1016/j.ejmech.2013.09.005]

1097. Di Salvo A, Dugois P, Tandeo D, Peltekian M, Kong Thoo Lin P..  (2013)  Synthesis, cytotoxicity and DNA binding of oxoazabenzo[de]anthracenes derivatives in colon cancer Caco-2 cells.,  69  [PMID:24099994] [10.1016/j.ejmech.2013.08.038]

1098. Azevedo CM, Afonso CM, Soares JX, Reis S, Sousa D, Lima RT, Vasconcelos MH, Pedro M, Barbosa J, Gales L, Pinto MM..  (2013)  Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models.,  69  [PMID:24113365] [10.1016/j.ejmech.2013.09.012]

1099. Nagarapu L, Vanaparthi S, Bantu R, Ganesh Kumar C..  (2013)  Synthesis of novel benzo[4,5]thiazolo[1,2-a]pyrimidine-3-carboxylate derivatives and biological evaluation as potential anticancer agents.,  69  [PMID:24113366] [10.1016/j.ejmech.2013.08.024]

1100. Castera-Ducros C, Paloque L, Verhaeghe P, Casanova M, Cantelli C, Hutter S, Tanguy F, Laget M, Remusat V, Cohen A, Crozet MD, Rathelot P, Azas N, Vanelle P..  (2013)  Targeting the human parasite Leishmania donovani: discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series.,  21  (22): [PMID:24080103] [10.1016/j.bmc.2013.09.002]

1101. Budovská M, Pilátová M, Varinská L, Mojžiš J, Mezencev R..  (2013)  The synthesis and anticancer activity of analogs of the indole phytoalexins brassinin, 1-methoxyspirobrassinol methyl ether and cyclobrassinin.,  21  (21): [PMID:24012378] [10.1016/j.bmc.2013.08.020]

1102. Sangthong S, Ha H, Teerawattananon T, Ngamrojanavanich N, Neamati N, Muangsin N..  (2013)  Overcoming doxorubicin-resistance in the NCI/ADR-RES model cancer cell line by novel anthracene-9,10-dione derivatives.,  23  (22): [PMID:24095089] [10.1016/j.bmcl.2013.09.004]

1103. Ding YH, Fan HX, Long J, Zhang Q, Chen Y..  (2013)  The application of Heck reaction in the synthesis of guaianolide sesquiterpene lactones derivatives selectively inhibiting resistant acute leukemic cells.,  23  (22): [PMID:24095093] [10.1016/j.bmcl.2013.09.028]

1104. Unpublished dataset, 

1105. Unpublished dataset, 

1106. Valdivielso ÁM, Ventosa-Andrés P, Tato F, Fernández-Ibañez MÁ, Pappos I, Tsopanoglou NE, García-López MT, Gutiérrez-Rodríguez M, Herranz R..  (2013)  Highly functionalized 2-oxopiperazine-based peptidomimetics: an approach to PAR1 antagonists.,  70  [PMID:24158013] [10.1016/j.ejmech.2013.09.058]

1107. Bolden S, Zhu XY, Etukala JR, Boateng C, Mazu T, Flores-Rozas H, Jacob MR, Khan SI, Walker LA, Ablordeppey SY..  (2013)  Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents.,  70  [PMID:24141203] [10.1016/j.ejmech.2013.09.044]

1108. Suresh N, Nagesh HN, Sekhar KV, Kumar A, Shirazi AN, Parang K..  (2013)  Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines.,  23  (23): [PMID:24138941] [10.1016/j.bmcl.2013.09.077]

1109. Awadallah FM, Piazza GA, Gary BD, Keeton AB, Canzoneri JC..  (2013)  Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.,  70  [PMID:24161704] [10.1016/j.ejmech.2013.10.003]

1110. Chinthala Y, Kumar Domatti A, Sarfaraz A, Singh SP, Kumar Arigari N, Gupta N, Satya SK, Kotesh Kumar J, Khan F, Tiwari AK, Paramjit G..  (2013)  Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring.,  70  [PMID:24177357] [10.1016/j.ejmech.2013.10.005]

1111. Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY..  (2013)  Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.,  56  (21): [PMID:24128000] [10.1021/jm4009532]

1112. Zhang J, Jiang Y, Cao Y, Liu J, Zheng D, Chen X, Han L, Jiang C, Huang X..  (2013)  Violapyrones A-G, α-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces.,  76  (11): [PMID:24182355] [10.1021/np4003417]

1113. Meng LH, Li XM, Lv CT, Li CS, Xu GM, Huang CG, Wang BG..  (2013)  Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.,  76  (11): [PMID:24195466] [10.1021/np400614f]

1114. Dawood KM, Eldebss TM, El-Zahabi HS, Yousef MH, Metz P..  (2013)  Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents.,  70  [PMID:24231309] [10.1016/j.ejmech.2013.10.042]

1115. Pérez BC, Fernandes I, Mateus N, Teixeira C, Gomes P..  (2013)  Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues.,  23  (24): [PMID:24184076] [10.1016/j.bmcl.2013.10.025]

1116. Xu YM, Espinosa-Artiles P, Liu MX, Arnold AE, Gunatilaka AA..  (2013)  Secoemestrin D, a cytotoxic epitetrathiodioxopiperizine, and emericellenes A-E, five sesterterpenoids from Emericella sp. AST0036, a fungal endophyte of Astragalus lentiginosus1.,  76  (12): [PMID:24251417] [10.1021/np400762k]

1117. Mareddy J, Nallapati SB, Anireddy J, Devi YP, Mangamoori LN, Kapavarapu R, Pal S..  (2013)  Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells.,  23  (24): [PMID:24215890] [10.1016/j.bmcl.2013.10.035]

1118. Ajduković JJ, Djurendić EA, Petri ET, Klisurić OR, Celić AS, Sakač MN, Jakimov DS, Gaši KM..  (2013)  17(E)-picolinylidene androstane derivatives as potential inhibitors of prostate cancer cell growth: antiproliferative activity and molecular docking studies.,  21  (23): [PMID:24148837] [10.1016/j.bmc.2013.09.063]

1119. Lam KH, Gambari R, Lee KK, Chen YX, Kok SH, Wong RS, Lau FY, Cheng CH, Wong WY, Bian ZX, Chan AS, Tang JC, Chui CH..  (2014)  Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus.,  24  (1): [PMID:24269165] [10.1016/j.bmcl.2013.10.072]

1120. Nagarapu L, Yadagiri B, Bantu R, Kumar CG, Pombala S, Nanubolu J..  (2014)  Studies on the synthetic and structural aspects of benzosuberones bearing 2, 4-thiazolidenone moiety as potential anti-cancer agents.,  71  [PMID:24287557] [10.1016/j.ejmech.2013.10.078]

1121. Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V..  (2014)  Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.,  71  [PMID:24287561] [10.1016/j.ejmech.2013.10.079]

1122. Jangili P, Kashanna J, Kumar CG, Poornachandra Y, Das B..  (2014)  Stereoselective total synthesis of a novel regiomer of herbarumin I and its cytotoxic and antimicrobial activities.,  24  (1): [PMID:24300737] [10.1016/j.bmcl.2013.11.010]

1123. Buragohain P, Saikia B, Surineni N, Barua NC, Saxena AK, Suri N..  (2014)  Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction.,  24  (1): [PMID:24332623] [10.1016/j.bmcl.2013.11.032]

1124. Fernandes C, Masawang K, Tiritan ME, Sousa E, de Lima V, Afonso C, Bousbaa H, Sudprasert W, Pedro M, Pinto MM..  (2014)  New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines.,  22  (3): [PMID:24411197] [10.1016/j.bmc.2013.12.042]

1125. Kong F, Wang Y, Liu P, Dong T, Zhu W..  (2014)  Thiodiketopiperazines from the marine-derived fungus Phoma sp. OUCMDZ-1847.,  77  (1): [PMID:24370114] [10.1021/np400802d]

1126. Andrioli WJ, Conti R, Araújo MJ, Zanasi R, Cavalcanti BC, Manfrim V, Toledo JS, Tedesco D, de Moraes MO, Pessoa C, Cruz AK, Bertucci C, Sabino J, Nanayakkara DN, Pupo MT, Bastos JK..  (2014)  Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus.,  77  (1): [PMID:24387625] [10.1021/np4006822]

1127. Liao L, Lee JH, You M, Choi TJ, Park W, Lee SK, Oh DC, Oh KB, Shin J..  (2014)  Penicillipyrones A and B, meroterpenoids from a marine-derived Penicillium sp. fungus.,  77  (2): [PMID:24437979] [10.1021/np400826p]

1128. Bhattacharya AK, Raut DS, Rana KC, Polanki IK, Khan MS, Iram S..  (2013)  Diversity-oriented synthesis of α-aminophosphonates: a new class of potential anticancer agents.,  66  [PMID:23792352] [10.1016/j.ejmech.2013.05.036]

1129. Mallavadhani UV, Vanga NR, Jeengar MK, Naidu VG..  (2014)  Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells.,  74  [PMID:24487188] [10.1016/j.ejmech.2013.12.040]

1130. Rodrigues FA, Bomfim Ida S, Cavalcanti BC, Pessoa Cdo Ó, Wardell JL, Wardell SM, Pinheiro AC, Kaiser CR, Nogueira TC, Low JN, Gomes LR, de Souza MV..  (2014)  Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl)quinoxalines, a promising and potent new class of anticancer agents.,  24  (3): [PMID:24398294] [10.1016/j.bmcl.2013.12.074]

1131. da Cruz EH, Hussene CM, Dias GG, Diogo EB, de Melo IM, Rodrigues BL, da Silva MG, Valença WO, Camara CA, de Oliveira RN, de Paiva YG, Goulart MO, Cavalcanti BC, Pessoa C, da Silva Júnior EN..  (2014)  1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.,  22  (5): [PMID:24530030] [10.1016/j.bmc.2014.01.033]

1132. Shahrisa A, Esmati S, Miri R, Firuzi O, Edraki N, Nejati M..  (2013)  Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction.,  66  [PMID:23827179] [10.1016/j.ejmech.2013.05.049]

1133. Zhang W, Li Z, Zhou M, Wu F, Hou X, Luo H, Liu H, Han X, Yan G, Ding Z, Li R..  (2014)  Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents.,  24  (3): [PMID:24418772] [10.1016/j.bmcl.2013.12.095]

1134. de Assis PA, Theodoro PN, de Paula JE, Araújo AJ, Costa-Lotufo LV, Michel S, Grougnet R, Kritsanida M, Espindola LS..  (2014)  Antifungal ether diglycosides from Matayba guianensis Aublet.,  24  (5): [PMID:24485783] [10.1016/j.bmcl.2014.01.022]

1135. Reddy Chamakura U, Sailaja E, Dulla B, Kalle AM, Bhavani S, Rambabu D, Kapavarapu R, Rao MV, Pal M..  (2014)  Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines.,  24  (5): [PMID:24513041] [10.1016/j.bmcl.2014.01.044]

1136. Chen TC, Yu DS, Huang KF, Fu YC, Lee CC, Chen CL, Huang FC, Hsieh HH, Lin JJ, Huang HS..  (2013)  Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents.,  69  [PMID:24051300] [10.1016/j.ejmech.2013.06.058]

1137. Calderón C, De Ford C, Castro V, Merfort I, Murillo R..  (2014)  Cytotoxic clerodane diterpenes from Zuelania guidonia.,  77  (3): [PMID:24484281] [10.1021/np400672g]

1138. Reiter C, Capcı Karagöz A, Fröhlich T, Klein V, Zeino M, Viertel K, Held J, Mordmüller B, Emirdağ Öztürk S, Anıl H, Efferth T, Tsogoeva SB..  (2014)  Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.,  75  [PMID:24561670] [10.1016/j.ejmech.2014.01.043]

1139. Wu L, Zhang C, Li W..  (2014)  Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones.,  24  (6): [PMID:24582982] [10.1016/j.bmcl.2014.02.018]

1140. Barros ME, Freitas JC, Oliveira JM, da Cruz CH, da Silva PB, de Araújo LC, Militão GC, da Silva TG, Oliveira RA, Menezes PH..  (2014)  Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents.,  76  [PMID:24589485] [10.1016/j.ejmech.2014.02.013]

1141. Kiselev E, Sooryakumar D, Agama K, Cushman M, Pommier Y..  (2014)  Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells.,  57  (4): [PMID:24502276] [10.1021/jm401471v]

1142. Sambasiva Rao P, Kurumurthy C, Veeraswamy B, Poornachandra Y, Ganesh Kumar C, Narsaiah B..  (2014)  Synthesis of novel 5-(3-alkylquinolin-2-yl)-3-aryl isoxazole derivatives and their cytotoxic activity.,  24  (5): [PMID:24507927] [10.1016/j.bmcl.2014.01.038]

1143. Saidachary G, Veera Prasad K, Divya D, Singh A, Ramesh U, Sridhar B, China Raju B..  (2014)  Convenient one-pot synthesis, anti-mycobacterial and anticancer activities of novel benzoxepinoisoxazolones and pyrazolones.,  76  [PMID:24607876] [10.1016/j.ejmech.2014.02.042]

1144. Prabha K, Prasad KJR.  (2013)  Dinaphthonaphthyridines a class of novel molecules with potent antioxidant and anticancer activity,  4  (2): [10.1039/C2MD20270K]

1145. Bharate SB, Yadav RR, Khan SI, Tekwani BL, Jacob MR, Khan IA, Vishwakarma RA.  (2013)  Meridianin G and its analogs as antimalarial agents,  4  (6): [10.1039/C3MD00097D]

1146. Chen J, Kassenbrock A, Li BX, Xiao X..  (2013)  Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine.,  4  (9): [PMID:24163729] [10.1039/c3md00134b]

1147. Rana P, Naven R, Narayanan A, Will Y, Jones LH.  (2013)  Chemical motifs that redox cycle and their associated toxicity,  4  (8): [10.1039/C3MD00149K]

1148. Prachyawarakorn V, Sangpetsiripan S, Surawatanawong P, Mahidol C, Ruchirawat S, Kittakoop P.  (2013)  Flavans from Desmos cochinchinensis as potent aromatase inhibitors,  4  (12): [10.1039/C3MD00166K]

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1150. PubChem BioAssay data set, 

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1234. Chen HZ, Chen YB, Lv YP, Zeng F, Zhang J, Zhou YL, Li HB, Chen LF, Zhou BJ, Gao JR, Xia CN..  (2014)  Synthesis and antitumor activity of feruloyl and caffeoyl derivatives.,  24  (18): [PMID:25160837] [10.1016/j.bmcl.2014.08.024]

1235. Tabélé C, Cohen A, Curti C, Bouhlel A, Hutter S, Remusat V, Primas N, Terme T, Azas N, Vanelle P..  (2014)  New series of monoamidoxime derivatives displaying versatile antiparasitic activity.,  87  [PMID:25282267] [10.1016/j.ejmech.2014.07.113]

1236. Fan BY, Gu YC, He Y, Li ZR, Luo JG, Kong LY..  (2014)  Cytotoxic resin glycosides from Ipomoea aquatica and their effects on intracellular Ca2+ concentrations.,  77  (10): [PMID:25314138] [10.1021/np5005246]

1237. Yang P, Liu DQ, Liang TJ, Li J, Zhang HY, Liu AH, Guo YW, Mao SC..  (2015)  Bioactive constituents from the green alga Caulerpa racemosa.,  23  (1): [PMID:25497963] [10.1016/j.bmc.2014.11.031]

1238. Wang Y, Islam MA, Davis RA, McAlpine SR..  (2015)  The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents.,  25  (2): [PMID:25499433] [10.1016/j.bmcl.2014.11.055]

1239. Romagnoli R, Baraldi PG, Salvador MK, Prencipe F, Bertolasi V, Cancellieri M, Brancale A, Hamel E, Castagliuolo I, Consolaro F, Porcù E, Basso G, Viola G..  (2014)  Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.,  57  (15): [PMID:25025853] [10.1021/jm5008193]

1240. Takemoto K, Kamisuki S, Chia PT, Kuriyama I, Mizushina Y, Sugawara F..  (2014)  Bioactive dihydronaphthoquinone derivatives from Fusarium solani.,  77  (9): [PMID:25163667] [10.1021/np500175j]

1241. Benedeković G, Popsavin M, Francuz J, Kovačević I, Kojić V, Bogdanović G, Divjaković V, Popsavin V..  (2014)  Design, synthesis and SAR analysis of antitumour styryl lactones related to (+)-crassalactones B and C.,  87  [PMID:25259516] [10.1016/j.ejmech.2014.09.064]

1242. Dutra LM, Bomfim LM, Rocha SL, Nepel A, Soares MB, Barison A, Costa EV, Bezerra DP..  (2014)  ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.,  24  (15): [PMID:24969014] [10.1016/j.bmcl.2014.06.005]

1243. Parrino B, Carbone A, Muscarella M, Spanò V, Montalbano A, Barraja P, Salvador A, Vedaldi D, Cirrincione G, Diana P..  (2014)  11H-Pyrido[3',2':4,5]pyrrolo[3,2-c]cinnoline and pyrido[3',2':4,5]pyrrolo[1,2-c][1,2,3]benzotriazine: two new ring systems with antitumor activity.,  57  (22): [PMID:25317694] [10.1021/jm501244f]

1244. Manda BR, Alla M, Ganji RJ, Addlagatta A..  (2014)  Discovery of Tröger's base analogues as selective inhibitors against human breast cancer cell line: design, synthesis and cytotoxic evaluation.,  86  [PMID:25140752] [10.1016/j.ejmech.2014.08.044]

1245. Lindgren EB, de Brito MA, Vasconcelos TR, de Moraes MO, Montenegro RC, Yoneda JD, Leal KZ..  (2014)  Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.,  86  [PMID:25147145] [10.1016/j.ejmech.2014.08.039]

1246. Xia G, Chen W, Zhang J, Shao J, Zhang Y, Huang W, Zhang L, Qi W, Sun X, Li B, Xiang Z, Ma C, Xu J, Deng H, Li Y, Li P, Miao H, Han J, Liu Y, Shen J, Yu Y..  (2014)  A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.,  57  (23): [PMID:25409491] [10.1021/jm5014659]

1247. Kozakai Y, Kamada R, Kiyota Y, Yoshimura F, Tanino K, Sakaguchi K..  (2014)  Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.,  24  (24): [PMID:25466181] [10.1016/j.bmcl.2014.10.093]

1248. Khokhar S, Feng Y, Campitelli MR, Ekins MG, Hooper JN, Beattie KD, Sadowski MC, Nelson CC, Davis RA..  (2014)  Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.,  24  (15): [PMID:24973030] [10.1016/j.bmcl.2014.05.104]

1249. Chen S, Wang Y, Zhou W, Li S, Peng J, Shi Z, Hu J, Liu YC, Ding H, Lin Y, Li L, Cheng S, Liu J, Lu T, Jiang H, Liu B, Zheng M, Luo C..  (2014)  Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.,  57  (21): [PMID:25333769] [10.1021/jm501134e]

1250. Kishore N, Binneman B, Mahapatra A, van de Venter M, du Plessis-Stoman D, Boukes G, Houghton P, Marion Meyer JJ, Lall N..  (2014)  Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines.,  22  (17): [PMID:25059501] [10.1016/j.bmc.2014.06.013]

1251. Kumaraswamy G, Kumar RS, Sampath B, Poornachandra Y, Ganesh Kumar C, Vemulapalli SP, Bharatam J..  (2014)  A concise diastereoselective approach to enantioenriched substituted piperidines and their in vitro cytotoxicity evaluation.,  24  (18): [PMID:25172418] [10.1016/j.bmcl.2014.08.003]

1252. Madda J, Venkatesham A, Naveen Kumar B, Nagaiah K, Sujitha P, Ganesh Kumar C, Rao TP, Jagadeesh Babu N..  (2014)  Synthesis of novel chromeno-annulated cis-fused pyrano[3,4-c]benzopyran and naphtho pyran derivatives via domino aldol-type/hetero Diels-Alder reaction and their cytotoxicity evaluation.,  24  (18): [PMID:25172420] [10.1016/j.bmcl.2014.08.005]

1253. Yadagiri B, Holagunda UD, Bantu R, Nagarapu L, Guguloth V, Polepally S, Jain N..  (2014)  Rational design, synthesis and anti-proliferative evaluation of novel benzosuberone tethered with hydrazide-hydrazones.,  24  (21): [PMID:25264072] [10.1016/j.bmcl.2014.09.018]

1254. Liou JR, Wu TY, Thang TD, Hwang TL, Wu CC, Cheng YB, Chiang MY, Lan YH, El-Shazly M, Wu SL, Beerhues L, Yuan SS, Hou MF, Chen SL, Chang FR, Wu YC..  (2014)  Bioactive 6S-styryllactone constituents of Polyalthia parviflora.,  77  (12): [PMID:25419616] [10.1021/np5004577]

1255. Ganihigama DU, Sureram S, Sangher S, Hongmanee P, Aree T, Mahidol C, Ruchirawat S, Kittakoop P..  (2015)  Antimycobacterial activity of natural products and synthetic agents: pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis.,  89  [PMID:25462220] [10.1016/j.ejmech.2014.10.026]

1256. Sirajuddin M, Ali S, McKee V, Sohail M, Pasha H..  (2014)  Potentially bioactive organotin(IV) compounds: synthesis, characterization, in vitro bioactivities and interaction with SS-DNA.,  84  [PMID:25036793] [10.1016/j.ejmech.2014.07.028]

1257. Horikawa M, Inai M, Oguri Y, Kuroda E, Tanaka M, Suzuki S, Ito T, Takahashi S, Kaku H, Tsunoda T..  (2014)  Isolation and total syntheses of cytotoxic cryptolactones A1, A2, B1, and B2: α,β-unsaturated δ-lactones from a Cryptomyzus sp. aphid.,  77  (11): [PMID:25353976] [10.1021/np500542x]

1258. Kwak JH, Park JY, Lee D, Kwak JY, Park EH, Kim KH, Park HJ, Kim HY, Jang HJ, Ham J, Hwang GS, Yamabe N, Kang KS..  (2014)  Inhibitory effects of ginseng sapogenins on the proliferation of triple negative breast cancer MDA-MB-231 cells.,  24  (23): [PMID:25453798] [10.1016/j.bmcl.2014.10.041]

1259. Shankaraiah N, Nekkanti S, Chudasama KJ, Senwar KR, Sharma P, Jeengar MK, Naidu VG, Srinivasulu V, Srinivasulu G, Kamal A..  (2014)  Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids.,  24  (23): [PMID:25453799] [10.1016/j.bmcl.2014.10.038]

1260. Koppireddi S, Chilaka DR, Avula S, Komsani JR, Kotamraju S, Yadla R..  (2014)  Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo [2,1-b]thiazoles.,  24  (23): [PMID:25453802] [10.1016/j.bmcl.2014.10.030]

1261. Nisha, Gut J, Rosenthal PJ, Kumar V..  (2014)  β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation.,  84  [PMID:25062007] [10.1016/j.ejmech.2014.07.064]

1262. Freitas LB, Borgati TF, de Freitas RP, Ruiz AL, Marchetti GM, de Carvalho JE, da Cunha EF, Ramalho TC, Alves RB..  (2014)  Synthesis and antiproliferative activity of 8-hydroxyquinoline derivatives containing a 1,2,3-triazole moiety.,  84  [PMID:25062010] [10.1016/j.ejmech.2014.07.061]

1263. Shareef MA, Duscharla D, Ramasatyaveni G, Dhoke NR, Das A, Ummanni R, Srivastava AK..  (2015)  Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.,  89  [PMID:25462233] [10.1016/j.ejmech.2014.10.050]

1264. Yao S, To KK, Wang YZ, Yin C, Tang C, Chai S, Ke CQ, Lin G, Ye Y..  (2014)  Polyoxypregnane steroids from the stems of Marsdenia tenacissima.,  77  (9): [PMID:25215856] [10.1021/np500385b]

1265. Madabhushi S, Mallu KK, Vangipuram VS, Kurva S, Poornachandra Y, Ganesh Kumar C..  (2014)  Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities.,  24  (20): [PMID:25241926] [10.1016/j.bmcl.2014.08.064]

1266. Kumbhare RM, Kosurkar UB, Bagul PK, Kanwal A, Appalanaidu K, Dadmal TL, Banerjee SK..  (2014)  Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin converting enzyme (ACE) inhibitors.,  22  (21): [PMID:25300819] [10.1016/j.bmc.2014.09.027]

1267. Ayan D, Maltais R, Hospital A, Poirier D..  (2014)  Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives.,  22  (21): [PMID:25300820] [10.1016/j.bmc.2014.09.026]

1268. Slanina J, Páchniková G, Carnecká M, Porubová Koubíková L, Adámková L, Humpa O, Smejkal K, Slaninová I..  (2014)  Identification of key structural characteristics of Schisandra chinensis lignans involved in P-glycoprotein inhibition.,  77  (10): [PMID:25302569] [10.1021/np500521v]

1269. Bollu R, Palem JD, Bantu R, Guguloth V, Nagarapu L, Polepalli S, Jain N..  (2015)  Rational design, synthesis and anti-proliferative evaluation of novel 1,4-benzoxazine-[1,2,3]triazole hybrids.,  89  [PMID:25462234] [10.1016/j.ejmech.2014.10.051]

1270. Quintana J, Bayona LM, Castellanos L, Puyana M, Camargo P, Aristizábal F, Edwards C, Tabudravu JN, Jaspars M, Ramos FA..  (2014)  Almiramide D, cytotoxic peptide from the marine cyanobacterium Oscillatoria nigroviridis.,  22  (24): [PMID:25468043] [10.1016/j.bmc.2014.10.039]

1271. Zhang H, Zhu P, Liu J, Lin Y, Yao H, Jiang J, Ye W, Wu X, Xu J..  (2015)  Synthesis, in vitro and in vivo antitumor activity of pyrazole-fused 23-hydroxybetulinic acid derivatives.,  25  (3): [PMID:25529742] [10.1016/j.bmcl.2014.11.058]

1272. Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Buyanov VN, Treshalina HM, Lesnaya NA, Romanenko VI, Kaluzhny DN, Balzarini J, Agama K, Pommier Y, Shtil AA, Preobrazhenskaya MN..  (2014)  Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.,  86  [PMID:25244612] [10.1016/j.ejmech.2014.09.021]

1273. Mabkhot YN, Barakat A, Yousuf S, Choudhary MI, Frey W, Ben Hadda T, Mubarak MS..  (2014)  Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.,  22  (23): [PMID:25245672] [10.1016/j.bmc.2014.08.014]

1274. Kong X, Chen L, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C..  (2014)  Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.,  57  (22): [PMID:25369470] [10.1021/jm501230c]

1275. Macabeo AP, Martinez FP, Kurtán T, Tóth L, Mándi A, Schmidt S, Heilmann J, Alejandro GJ, Knorn M, Dahse HM, Franzblau SG..  (2014)  Tetrahydroxanthene-1,3(2H)-dione derivatives from Uvaria valderramensis.,  77  (12): [PMID:25372601] [10.1021/np500538c]

1276. Nirma C, Eparvier V, Stien D..  (2015)  Antibacterial ilicicolinic acids C and D and ilicicolinal from Neonectria discophora SNB-CN63 isolated from a termite nest.,  78  (1): [PMID:25478997] [10.1021/np500080m]

1277. Gu W, Hao Y, Zhang G, Wang SF, Miao TT, Zhang KP..  (2015)  Synthesis, in vitro antimicrobial and cytotoxic activities of new carbazole derivatives of ursolic acid.,  25  (3): [PMID:25537271] [10.1016/j.bmcl.2014.12.021]

1278. Bozorov K, Ma HR, Zhao JY, Zhao HQ, Chen H, Bobakulov K, Xin XL, Elmuradov B, Shakhidoyatov K, Aisa HA..  (2014)  Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.,  84  [PMID:25064350] [10.1016/j.ejmech.2014.07.065]

1279. Sieveking I, Thomas P, Estévez JC, Quiñones N, Cuéllar MA, Villena J, Espinosa-Bustos C, Fierro A, Tapia RA, Maya JD, López-Muñoz R, Cassels BK, Estévez RJ, Salas CO..  (2014)  2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.,  22  (17): [PMID:25127463] [10.1016/j.bmc.2014.07.030]

1280. Singh K, Verma V, Yadav K, Sreekanth V, Kumar D, Bajaj A, Kumar V..  (2014)  Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole-quinoline hybrids against cancer and primary endothelial cells.,  87  [PMID:25247771] [10.1016/j.ejmech.2014.09.055]

1281. Zhang H, Zhu P, Liu J, Yang X, Xu S, Yao H, Jiang J, Ye W, Wu X, Xu J..  (2014)  Synthesis and antitumor activity of novel 3-oxo-23-hydroxybetulinic acid derivatives.,  87  [PMID:25247772] [10.1016/j.ejmech.2014.09.058]

1282. Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X..  (2014)  Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.,  57  (15): [PMID:25061803] [10.1021/jm500024v]

1283. Amin KM, Abou-Seri SM, Awadallah FM, Eissa AA, Hassan GS, Abdulla MM..  (2015)  Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells.,  90  [PMID:25461322] [10.1016/j.ejmech.2014.11.027]

1284. dos Santos DS, Piovesan LA, D'Oca CR, Hack CR, Treptow TG, Rodrigues MO, Vendramini-Costa DB, Ruiz AL, de Carvalho JE, D'Oca MG..  (2015)  Antiproliferative activity of synthetic fatty acid amides from renewable resources.,  23  (2): [PMID:25510639] [10.1016/j.bmc.2014.11.019]

1285. Kumagai K, Minamida M, Akakabe M, Tsuda M, Konishi Y, Tominaga A, Tsuda M, Fukushi E, Kawabata J..  (2015)  Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species.,  25  (3): [PMID:25534608] [10.1016/j.bmcl.2014.12.003]

1286. Kumbhare RM, Dadmal TL, Ramaiah MJ, Kishore KS, Pushpa Valli SN, Tiwari SK, Appalanaidu K, Rao YK, Bhadra MP..  (2015)  Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.,  25  (3): [PMID:25563891] [10.1016/j.bmcl.2014.11.083]

1287. Kurbakova SY, Il'ina IV, Mikhalchenko OS, Pokrovsky MA, Korchagina DV, Volcho KP, Pokrovsky AG, Salakhutdinov NF..  (2015)  The short way to chiral compounds with hexahydrofluoreno[9,1-bc]furan framework: synthesis and cytotoxic activity.,  23  (7): [PMID:25737086] [10.1016/j.bmc.2015.02.013]

1288. Kieffer C, Cohen A, Verhaeghe P, Paloque L, Hutter S, Castera-Ducros C, Laget M, Rault S, Valentin A, Rathelot P, Azas N, Vanelle P..  (2015)  Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series.,  23  (10): [PMID:25846065] [10.1016/j.bmc.2015.03.064]

1289. Nikolić AR, Petri ET, Klisurić OR, Ćelić AS, Jakimov DS, Djurendić EA, Penov Gaši KM, Sakač MN..  (2015)  Synthesis and anticancer cell potential of steroidal 16,17-seco-16,17a-dinitriles: identification of a selective inhibitor of hormone-independent breast cancer cells.,  23  (4): [PMID:25619894] [10.1016/j.bmc.2014.12.069]

1290. Polkam N, Rayam P, Anireddy JS, Yennam S, Anantaraju HS, Dharmarajan S, Perumal Y, Kotapalli SS, Ummanni R, Balasubramanian S..  (2015)  Synthesis, in vitro anticancer and antimycobacterial evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivatives.,  25  (7): [PMID:25765907] [10.1016/j.bmcl.2015.02.052]

1291. Yadagiri B, Gurrala S, Bantu R, Nagarapu L, Polepalli S, Srujana G, Jain N..  (2015)  Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents.,  25  (10): [PMID:25827522] [10.1016/j.bmcl.2015.03.032]

1292. Feng XH, Wang ZH, Meng DL, Li X..  (2015)  Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.,  25  (10): [PMID:25862199] [10.1016/j.bmcl.2015.03.058]

1293. Kamiński K, Rapacz A, Łuszczki JJ, Latacz G, Obniska J, Kieć-Kononowicz K, Filipek B..  (2015)  Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.,  23  (10): [PMID:25868743] [10.1016/j.bmc.2015.03.038]

1294. Kim EL, Wang H, Park JH, Hong J, Choi JS, Im DS, Chung HY, Jung JH..  (2015)  Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.,  25  (10): [PMID:25881821] [10.1016/j.bmcl.2015.03.080]

1295. Ajduković JJ, Penov Gaši KM, Jakimov DS, Klisurić OR, Jovanović-Šanta SS, Sakač MN, Aleksić LD, Djurendić EA..  (2015)  Synthesis, structural analysis and antitumor activity of novel 17α-picolyl and 17(E)-picolinylidene A-modified androstane derivatives.,  23  (7): [PMID:25737400] [10.1016/j.bmc.2015.02.001]

1296. Poornima B, Siva B, Shankaraiah G, Venkanna A, Nayak VL, Ramakrishna S, Venkat Rao C, Babu KS..  (2015)  Novel sesquiterpenes from Schisandra grandiflora: isolation, cytotoxic activity and synthesis of their triazole derivatives using "click" reaction.,  92  [PMID:25594739] [10.1016/j.ejmech.2014.12.040]

1297. Zhang B, Chen K, Wang N, Gao C, Sun Q, Li L, Chen Y, Tan C, Liu H, Jiang Y..  (2015)  Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents.,  93  [PMID:25686590] [10.1016/j.ejmech.2015.02.003]

1298. Irfan M, Aneja B, Yadava U, Khan SI, Manzoor N, Daniliuc CG, Abid M..  (2015)  Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds.,  93  [PMID:25686593] [10.1016/j.ejmech.2015.02.007]

1299. Bisi A, Gobbi S, Merolle L, Farruggia G, Belluti F, Rampa A, Molnar J, Malucelli E, Cappadone C..  (2015)  Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold.,  92  [PMID:25596478] [10.1016/j.ejmech.2015.01.004]

1300. Li L, Zhao P, Hu J, Liu J, Liu Y, Wang Z, Xia Y, Dai Y, Chen L..  (2015)  Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids.,  93  [PMID:25703298] [10.1016/j.ejmech.2015.01.040]

1301. Ramanivas T, Sushma B, Nayak VL, Chandra Shekar K, Srivastava AK..  (2015)  Design, synthesis and biological evaluations of chirally pure 1,2,3,4-tertrahydroisoquinoline analogs as anti-cancer agents.,  92  [PMID:25615796] [10.1016/j.ejmech.2015.01.030]

1302. Ghorab MM, Ragab FA, Heiba HI, El-Gazzar MG, Zahran SS..  (2015)  Synthesis, anticancer and radiosensitizing evaluation of some novel sulfonamide derivatives.,  92  [PMID:25618015] [10.1016/j.ejmech.2015.01.036]

1303. Kieffer C, Cohen A, Verhaeghe P, Hutter S, Castera-Ducros C, Laget M, Remusat V, M'Rabet MK, Rault S, Rathelot P, Azas N, Vanelle P..  (2015)  Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series.,  92  [PMID:25559208] [10.1016/j.ejmech.2014.12.056]

1304. Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y..  (2015)  Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.,  92  [PMID:25618019] [10.1016/j.ejmech.2015.01.011]

1305. Li S, Wang Y, Zhao M, Wu J, Peng S..  (2015)  BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals.,  25  (5): [PMID:25648297] [10.1016/j.bmcl.2014.12.013]

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1386. Qin XY, Chen BY, Fu JJ, Shan L, Lei XG, Zhang WD..  (2015)  Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues.,  102  [PMID:26280922] [10.1016/j.ejmech.2015.07.051]

1387. Davidovich P, Aksenova V, Petrova V, Tentler D, Orlova D, Smirnov S, Gurzhiy V, Okorokov AL, Garabadzhiu A, Melino G, Barlev N, Tribulovich V..  (2015)  Discovery of Novel Isatin-Based p53 Inducers.,  6  (8): [PMID:26288684] [10.1021/acsmedchemlett.5b00011]

1388. Lee YR, Chen TC, Lee CC, Chen CL, Ahmed Ali AA, Tikhomirov A, Guh JH, Yu DS, Huang HS..  (2015)  Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.,  102  [PMID:26344783] [10.1016/j.ejmech.2015.07.052]

1389. Jardim GAM, Guimaraes TT, Pinto MdCFR, Cavalcanti BC, de Farias KM, Pessoa C, Gatto CC, Nair DK, Namboothiri INN, da Silva Junior EN.  (2015)  Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines,  6  (1): [10.1039/C4MD00371C]

1390. Bertamino A, Musella S, Di Sarno V, Ostacolo C, Manfra M, Vanacore D, Stiuso P, Novellino E, Campiglia P, Gomez-Monterrey IM..  (2015)  Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies.,  102  [PMID:26253231] [10.1016/j.ejmech.2015.07.044]

1391. Hao H, Chen W, Zhu J, Lu C, Shen Y..  (2015)  Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents.,  102  [PMID:26291037] [10.1016/j.ejmech.2015.07.048]

1392. Chen TC, Wu CL, Lee CC, Chen CL, Yu DS, Huang HS..  (2015)  Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.,  103  [PMID:25799376] [10.1016/j.ejmech.2014.09.050]

1393. Reddy CN, Nayak VL, Mani GS, Kapure JS, Adiyala PR, Maurya RA, Kamal A..  (2015)  Synthesis and biological evaluation of spiro[cyclopropane-1,3'-indolin]-2'-ones as potential anticancer agents.,  25  (20): [PMID:26330077] [10.1016/j.bmcl.2015.08.056]

1394. Pingaew R, Prachayasittikul V, Worachartcheewan A, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V..  (2015)  Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies.,  103  [PMID:26397393] [10.1016/j.ejmech.2015.09.001]

1395. Parker EN, Song J, Kishore Kumar GD, Odutola SO, Chavarria GE, Charlton-Sevcik AK, Strecker TE, Barnes AL, Sudhan DR, Wittenborn TR, Siemann DW, Horsman MR, Chaplin DJ, Trawick ML, Pinney KG..  (2015)  Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.,  23  (21): [PMID:26462052] [10.1016/j.bmc.2015.09.036]

1396. Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K..  (2015)  (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.,  103  [PMID:26360048] [10.1016/j.ejmech.2015.08.014]

1397. Khadka DB, Tran GH, Shin S, Nguyen HT, Cao HT, Zhao C, Jin Y, Van HT, Chau MV, Kwon Y, Le TN, Cho WJ..  (2015)  Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases.,  103  [PMID:26334499] [10.1016/j.ejmech.2015.08.040]

1398. Islam MA, Zhang Y, Wang Y, McAlpine SR.  (2015)  Design, synthesis and anticancer mechanistic studies of linked azoles,  6  (2): [10.1039/C4MD00387J]

1399. Ma G, Wu H, Chen D, Zhu N, Zhu Y, Sun Z, Li P, Yang J, Yuan J, Xu X..  (2015)  Antimalarial and Antiproliferative Cassane Diterpenes of Caesalpinia sappan.,  78  (10): [PMID:26398312] [10.1021/acs.jnatprod.5b00317]

1400. Jakimov DS, Kojić VV, Aleksić LD, Bogdanović GM, Ajduković JJ, Djurendić EA, Penov Gaši KM, Sakač MN, Jovanović-Šanta SS..  (2015)  Androstane derivatives induce apoptotic death in MDA-MB-231 breast cancer cells.,  23  (22): [PMID:26494582] [10.1016/j.bmc.2015.10.015]

1401. Unpublished dataset, 

1402. Wang Y, Katzenmeyer JB, Arriaga EA..  (2011)  Combination of micellar electrokinetic and high-performance liquid chromatographies to assess age-related changes in the in vitro metabolism of Fischer 344 rat liver.,  66  (9): [PMID:21746738] [10.1093/gerona/glr074]

1403. de Oliveira JF, da Silva AL, Vendramini-Costa DB, da Cruz Amorim CA, Campos JF, Ribeiro AG, Olímpio de Moura R, Neves JL, Ruiz AL, Ernesto de Carvalho J, Alves de Lima Mdo C..  (2015)  Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities.,  104  [PMID:26454648] [10.1016/j.ejmech.2015.09.036]

1404. Sidoryk K, Świtalska M, Jaromin A, Cmoch P, Bujak I, Kaczmarska M, Wietrzyk J, Dominguez EG, Żarnowski R, Andes DR, Bańkowski K, Cybulski M, Kaczmarek Ł..  (2015)  The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: highly selective cytotoxic agents.,  105  [PMID:26496013] [10.1016/j.ejmech.2015.10.022]

1405. Dinesha, Viveka S, Priya BK, Pai KS, Naveen S, Lokanath NK, Nagaraja GK..  (2015)  Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents.,  104  [PMID:26433616] [10.1016/j.ejmech.2015.09.029]

1406. Yu Q, Ravu RR, Xu QM, Ganji S, Jacob MR, Khan SI, Yu BY, Li XC..  (2015)  Antibacterial Prenylated Acylphloroglucinols from Psorothamnus fremontii.,  78  (11): [PMID:26469557] [10.1021/acs.jnatprod.5b00721]

1407. Aeluri R, Ganji RJ, Marapaka AK, Pillalamarri V, Alla M, Addlagatta A..  (2015)  Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase.,  106  [PMID:26513642] [10.1016/j.ejmech.2015.10.026]

1408. Devendar P, Nayak VL, Yadav DK, Kumar AN, Kumar JK, Satya Srinivas K, Sridhar B, Khan F, Sastry KP, Ramakrishna S.  (2015)  Synthesis and evaluation of anticancer activity of novel andrographolide derivatives,  6  (5): [10.1039/C4MD00566J]

1409. Vaarla K, Kesharwani RK, Santosh K, Vedula RR, Kotamraju S, Toopurani MK..  (2015)  Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.,  25  (24): [PMID:26542964] [10.1016/j.bmcl.2015.10.042]

1410. Gunia-Krzyżak A, Żesławska E, Słoczyńska K, Koczurkiewicz P, Nitek W, Żelaszczyk D, Szkaradek N, Waszkielewicz AM, Pękala E, Marona H..  (2016)  Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.,  107  [PMID:26560050] [10.1016/j.ejmech.2015.10.051]

1411. He X, Zhang Z, Chen Y, Che Q, Zhu T, Gu Q, Li D..  (2015)  Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor.,  78  (11): [PMID:26561719] [10.1021/acs.jnatprod.5b00742]

1412. Kuder K, Łażewska D, Latacz G, Schwed JS, Karcz T, Stark H, Karolak-Wojciechowska J, Kieć-Kononowicz K..  (2016)  Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.,  24  (2): [PMID:26690914] [10.1016/j.bmc.2015.11.021]

1413. Abdjul DB, Kanno S, Yamazaki H, Ukai K, Namikoshi M..  (2016)  A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.,  26  (2): [PMID:26711144] [10.1016/j.bmcl.2015.12.022]

1414. Kim CK, Woo JK, Kim SH, Cho E, Lee YJ, Lee HS, Sim CJ, Oh DC, Oh KB, Shin J..  (2015)  Meroterpenoids from a Tropical Dysidea sp. Sponge.,  78  (11): [PMID:26551342] [10.1021/acs.jnatprod.5b00867]

1415. Venepally V, Prasad RB, Poornachandra Y, Kumar CG, Jala RC..  (2016)  Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation.,  26  (2): [PMID:26646219] [10.1016/j.bmcl.2015.11.063]

1416. Cândido-Bacani Pde M, Figueiredo Pde O, Matos Mde F, Garcez FR, Garcez WS..  (2015)  Cytotoxic Orbitide from the Latex of Croton urucurana.,  78  (11): [PMID:26561866] [10.1021/acs.jnatprod.5b00724]

1417. Kaki SS, Arukali S, Korlipara PV, Prasad RB, Yedla P, Ganesh Kumar C..  (2016)  Synthesis and biological evaluation of novel lipoamino acid derivatives.,  26  (1): [PMID:26586599] [10.1016/j.bmcl.2015.10.086]

1418. Tikhomirov AS, Shchekotikhin AE, Lee YH, Chen YA, Yeh CA, Tatarskiy VV, Dezhenkova LG, Glazunova VA, Balzarini J, Shtil AA, Preobrazhenskaya MN, Chueh PJ..  (2015)  Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.,  58  (24): [PMID:26633734] [10.1021/acs.jmedchem.5b00859]

1419. Fomani M, Ngeufa Happi E, Nouga Bisoue A, Ndom JC, Kamdem Waffo AF, Sewald N, Wansi JD..  (2016)  Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco).,  26  (2): [PMID:26711890] [10.1016/j.bmcl.2015.12.028]

1420. Thida M, Kim DW, Tran TT, Pham MQ, Lee H, Kim I, Lee JW..  (2016)  Gambogic acid induces apoptotic cell death in T98G glioma cells.,  26  (3): [PMID:26631318] [10.1016/j.bmcl.2015.11.043]

1421. Grzywa R, Winiarski Ł, Psurski M, Rudnicka A, Wietrzyk J, Gajda T, Oleksyszyn J..  (2016)  Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.,  26  (2): [PMID:26639764] [10.1016/j.bmcl.2015.11.045]

1422. Wang S, Chen C, Lo C, Feng J, Lin H, Chang P, Yang L, Chen L, Liu Y, Kuo C, Wu J.  (2015)  Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents,  6  (10): [10.1039/C5MD00163C]

1423. Abdou NS, Serya RAT, Esmat A, Tolba MF, Ismail NSM, Abouzid KAM.  (2015)  Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivatives,  6  (8): [10.1039/C5MD00127G]

1424. Kuntala N, Telu JR, Banothu V, Nallapati SB, Anireddy JS, Pal S.  (2015)  Novel benzoxepine-1,2,3-triazole hybrids: synthesis and pharmacological evaluation as potential antibacterial and anticancer agents,  6  (9): [10.1039/C5MD00224A]

1425. Roa-Linares VC, Brand YM, Agudelo-Gomez LS, Tangarife-Castaño V, Betancur-Galvis LA, Gallego-Gomez JC, González MA..  (2016)  Anti-herpetic and anti-dengue activity of abietane ferruginol analogues synthesized from (+)-dehydroabietylamine.,  108  [PMID:26638041] [10.1016/j.ejmech.2015.11.009]

1426. de Souza Fernandes F, Fernandes TS, da Silveira LS, Caneschi W, Lourenço MC, Diniz CG, de Oliveira PF, Martins Sde P, Pereira DE, Tavares DC, Le Hyaric M, de Almeida MV, Couri MR..  (2016)  Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols.,  108  [PMID:26649907] [10.1016/j.ejmech.2015.11.037]

1427. Ibrahim HS, Abou-Seri SM, Ismail NS, Elaasser MM, Aly MH, Abdel-Aziz HA..  (2016)  Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents.,  108  [PMID:26706352] [10.1016/j.ejmech.2015.11.047]

1428. Srikanth V, Prasad RB, Poornachandra Y, Phani Babu VS, Ganesh Kumar C, Jagadeesh B, Jala RC..  (2016)  Synthesis of dihydrosterculic acid-based monoglucosyl diacylglycerol and its analogues and their biological evaluation.,  109  [PMID:26774921] [10.1016/j.ejmech.2015.12.048]

1429. Kamal A, Mahesh R, Nayak VL, Babu KS, Kumar GB, Shaik AB, Kapure JS, Alarifi A..  (2016)  Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach.,  108  [PMID:26708114] [10.1016/j.ejmech.2015.11.046]

1430. Šarlauskas J, Pečiukaitytė-Alksnė M, Misevičienė L, Marozienė A, Polmickaitė E, Staniulytė Z, Čėnas N, Anusevičius Ž..  (2016)  Naphtho[1',2':4,5]imidazo[1,2-a]pyridine-5,6-diones: Synthesis, enzymatic reduction and cytotoxic activity.,  26  (2): [PMID:26681508] [10.1016/j.bmcl.2015.11.084]

1431. Santos GB, Krogh R, Magalhaes LG, Andricopulo AD, Pupo MT, Emery FS..  (2016)  Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi.,  26  (4): [PMID:26810263] [10.1016/j.bmcl.2016.01.033]

1432. AlQudah DA, Zihlif MA, Taha MO..  (2016)  Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors.,  110  [PMID:26840362] [10.1016/j.ejmech.2016.01.034]

1433. George RF, Fouad MA, Gomaa IE..  (2016)  Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers.,  112  [PMID:26874744] [10.1016/j.ejmech.2016.01.048]

1434. Alnabulsi S, Santina E, Russo I, Hussein B, Kadirvel M, Chadwick A, Bichenkova EV, Bryce RA, Nolan K, Demonacos C, Stratford IJ, Freeman S..  (2016)  Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.,  111  [PMID:26854376] [10.1016/j.ejmech.2016.01.022]

1435. Guimarães KG, de Freitas RP, Ruiz AL, Fiorito GF, de Carvalho JE, da Cunha EF, Ramalho TC, Alves RB..  (2016)  Synthesis, antiproliferative activities, and computational evaluation of novel isocoumarin and 3,4-dihydroisocoumarin derivatives.,  111  [PMID:26859070] [10.1016/j.ejmech.2016.01.051]

1436. Islam MS, Barakat A, Al-Majid AM, Ghabbour HA, Rahman AF, Javaid K, Imad R, Yousuf S, Choudhary MI..  (2016)  A concise synthesis and evaluation of new malonamide derivatives as potential α-glucosidase inhibitors.,  24  (8): [PMID:26972921] [10.1016/j.bmc.2016.02.037]

1437. Buduma K, Chinde S, Dommati AK, Sharma P, Shukla A, Srinivas KV, Arigari NK, Khan F, Tiwari AK, Grover P, Jonnala KK..  (2016)  Synthesis and evaluation of anticancer and antiobesity activity of 1-ethoxy carbonyl-3,5-bis (3'-indolyl methylene)-4-pyperidone analogs.,  26  (6): [PMID:26873414] [10.1016/j.bmcl.2016.01.073]

1438. Gao F, Liu H, Li L, Guo J, Wang Y, Zhao M, Peng S..  (2015)  Design, synthesis, and testing of an isoquinoline-3-carboxylic-based novel anti-tumor lead.,  25  (20): [PMID:26386603] [10.1016/j.bmcl.2015.09.014]

1439. Kovačević I, Popsavin M, Benedeković G, Kojić V, Jakimov D, Rodić MV, Srdić-Rajić T, Bogdanović G, Divjaković V, Popsavin V..  (2016)  Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers.,  108  [PMID:26720155] [10.1016/j.ejmech.2015.12.011]

1440. Shchekotikhin AE, Dezhenkova LG, Tsvetkov VB, Luzikov YN, Volodina YL, Tatarskiy VV, Kalinina AA, Treshalin MI, Treshalina HM, Romanenko VI, Kaluzhny DN, Kubbutat M, Schols D, Pommier Y, Shtil AA, Preobrazhenskaya MN..  (2016)  Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.,  112  [PMID:26890118] [10.1016/j.ejmech.2016.01.050]

1441. Pastuch-Gawołek G, Malarz K, Mrozek-Wilczkiewicz A, Musioł M, Serda M, Czaplinska B, Musiol R..  (2016)  Small molecule glycoconjugates with anticancer activity.,  112  [PMID:26890119] [10.1016/j.ejmech.2016.01.061]

1442. Pereira UA, Moreira TA, Barbosa LCA, Maltha CRA, Bomfim IS, Maranhao SS, Moraes MO, Pessoa C, Barros-Nepomuceno FWA.  (2016)  Rubrolide analogues and their derived lactams as potential anticancer agents,  7  (2): [10.1039/C5MD00459D]

1443. Li L, Cai Y, Jiang Y, Liu J, Ma J, Yuan C, Mu Y, Han L, Huang X..  (2016)  A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus.,  26  (6): [PMID:26874404] [10.1016/j.bmcl.2016.02.002]

1444. Zhu H, Song Y, Wang Y, Zhao M, Ren Y, Wang Y, Zhao S, Wu J, Peng S.  (2016)  Design, synthesis and evaluation of a novel stacking nano-intercalator as an anti-tumor agent,  7  (2): [10.1039/C5MD00507H]

1445. Chen YY, Wu XQ, Tang WJ, Shi JB, Li J, Liu XH..  (2016)  Novel dihydropyrazole-chromen: Design and modulates hTERT inhibition proliferation of MGC-803.,  110  [PMID:26807545] [10.1016/j.ejmech.2016.01.014]

1446. Wang Y, Cheng FX, Yuan XL, Tang WJ, Shi JB, Liao CZ, Liu XH..  (2016)  Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo.,  112  [PMID:26900656] [10.1016/j.ejmech.2016.02.009]

1447. Abdu-Allah HH, Abdel-Moty SG, El-Awady R, El-Shorbagi AN..  (2016)  Design and synthesis of novel 5-aminosalicylate (5-ASA)-4-thiazolinone hybrid derivatives with promising antiproliferative activity.,  26  (7): [PMID:26947606] [10.1016/j.bmcl.2016.02.073]

1448. Kamal A, Faazil S, Hussaini SM, Ramaiah MJ, Balakrishna M, Patel N, Pushpavalli SN, Pal-Bhadra M..  (2016)  Synthesis and mechanistic aspects of 2-anilinonicotinyl-pyrazolo[1,5-a]pyrimidine conjugates that regulate cell proliferation in MCF-7 cells via estrogen signaling.,  26  (8): [PMID:26948540] [10.1016/j.bmcl.2016.02.072]

1449. Suja TD, Divya KV, Naik LV, Ravi Kumar A, Kamal A..  (2016)  Copper-catalyzed three-component synthesis of aminonaphthoquinone-sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity.,  26  (8): [PMID:26948541] [10.1016/j.bmcl.2016.02.071]

1450. Wu S, Li Y, Xu G, Chen S, Zhang Y, Liu N, Dong G, Miao C, Su H, Zhang W, Sheng C..  (2016)  Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure-activity relationship.,  115  [PMID:27016707] [10.1016/j.ejmech.2016.03.039]

1451. Chandrashekhar M, Nayak VL, Ramakrishna S, Mallavadhani UV..  (2016)  Novel triazole hybrids of myrrhanone C, a natural polypodane triterpene: Synthesis, cytotoxic activity and cell based studies.,  114  [PMID:27015609] [10.1016/j.ejmech.2016.03.013]

1452. Pedada SR, Yarla NS, Tambade PJ, Dhananjaya BL, Bishayee A, Arunasree KM, Philip GH, Dharmapuri G, Aliev G, Putta S, Rangaiah G..  (2016)  Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents.,  112  [PMID:26907155] [10.1016/j.ejmech.2016.02.025]

1453. Polkam N, Ramaswamy VR, Rayam P, Allaka TR, Anantaraju HS, Dharmarajan S, Perumal Y, Gandamalla D, Yellu NR, Balasubramanian S, Anireddy JS..  (2016)  Synthesis, molecular properties prediction and anticancer, antioxidant evaluation of new edaravone derivatives.,  26  (10): [PMID:27055942] [10.1016/j.bmcl.2016.03.024]

1454. Zhang W, Zhang B, Zhang W, Yang T, Wang N, Gao C, Tan C, Liu H, Jiang Y..  (2016)  Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.,  116  [PMID:27060757] [10.1016/j.ejmech.2016.03.066]

1455. Narva S, Chitti S, Bala BR, Alvala M, Jain N, Kondapalli VG..  (2016)  Synthesis and biological evaluation of pyrrolo[2,3-b]pyridine analogues as antiproliferative agents and their interaction with calf thymus DNA.,  114  [PMID:26994690] [10.1016/j.ejmech.2016.02.059]

1456. Gardelly M, Trimech B, Belkacem MA, Harbach M, Abdelwahed S, Mosbah A, Bouajila J, Ben Jannet H..  (2016)  Synthesis of novel diazaphosphinanes coumarin derivatives with promoted cytotoxic and anti-tyrosinase activities.,  26  (10): [PMID:27080182] [10.1016/j.bmcl.2016.03.108]

1457. Hafez HN, El-Gazzar AR, Al-Hussain SA..  (2016)  Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents.,  26  (10): [PMID:27080187] [10.1016/j.bmcl.2016.03.117]

1458. Nagarsenkar A, Prajapti SK, Guggilapu SD, Birineni S, Sravanti Kotapalli S, Ummanni R, Babu BN.  (2016)  Investigation of triazole-linked indole and oxindole glycoconjugates as potential anticancer agents: novel Akt/PKB signaling pathway inhibitors,  7  (4): [10.1039/C5MD00513B]

1459. Princival IM, Ferreira JG, Silva TG, Aguiar JS, Princival JL..  (2016)  Synthesis and in vitro evaluation of (R), (S) and (R/S)-2-hexyne-1,4-diol, a natural product produced by fungus Clitocybe catinus, and related analogs as potential anticancer agents.,  26  (12): [PMID:27142752] [10.1016/j.bmcl.2016.04.060]

1460. Quintana M, Alegre-Requena JV, Marques-Lopez E, Herrera RP, Triola G.  (2016)  Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action,  7  (3): [10.1039/C5MD00515A]

1461. Buduma K, Chinde S, Arigari NK, Grover P, Srinivas KV, Kotesh Kumar J..  (2016)  Iodine catalyzed simple and efficient synthesis of antiproliferative 2-pyridones.,  26  (9): [PMID:27036521] [10.1016/j.bmcl.2016.03.071]

1462. Du H, Gu H, Li N, Wang J.  (2016)  Synthesis and biological evaluation of bivalent -carbolines as potential anticancer agents,  7  (4): [10.1039/C5MD00581G]

1463. Zhao LM, Cao FX, Jin HS, Zhang JH, Szwaya J, Wang G..  (2016)  One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities.,  26  (11): [PMID:27080175] [10.1016/j.bmcl.2016.04.006]

1464. Senkiv J, Finiuk N, Kaminskyy D, Havrylyuk D, Wojtyra M, Kril I, Gzella A, Stoika R, Lesyk R..  (2016)  5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.,  117  [PMID:27089210] [10.1016/j.ejmech.2016.03.089]

1465. Khan I, Zaib S, Batool S, Abbas N, Ashraf Z, Iqbal J, Saeed A..  (2016)  Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification.,  24  (11): [PMID:27112448] [10.1016/j.bmc.2016.03.031]

1466. Ghorab MM, Ragab FA, Heiba HI, Soliman AM..  (2016)  Design and synthesis of some novel 4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide derivatives as anticancer and radiosensitizing agents.,  117  [PMID:27085944] [10.1016/j.ejmech.2016.04.009]

1467. Tantak MP, Gupta V, Nikhil K, Arun V, Singh RP, Jha PN, Shah K, Kumar D..  (2016)  Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities.,  26  (13): [PMID:27173802] [10.1016/j.bmcl.2016.04.080]

1468. Jo H, Choi M, Kumar AS, Jung Y, Kim S, Yun J, Kang JS, Kim Y, Han SB, Jung JK, Cho J, Lee K, Kwak JH, Lee H..  (2016)  Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-κB Inhibitors and Cytotoxic Agents.,  7  (4): [PMID:27096046] [10.1021/acsmedchemlett.6b00004]

1469. Palem JD, Alugubelli GR, Bantu R, Nagarapu L, Polepalli S, Jain SN, Bathini R, Manga V..  (2016)  Quinazolinones-Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents.,  26  (13): [PMID:27209232] [10.1016/j.bmcl.2016.05.021]

1470. Malhotra R, Rarhi C, Diveshkumar KV, Barik R, D'cunha R, Dhar P, Kundu M, Chattopadhyay S, Roy S, Basu S, Pradeepkumar PI, Hajra S..  (2016)  Dihydrochelerythrine and its derivatives: Synthesis and their application as potential G-quadruplex DNA stabilizing agents.,  24  (13): [PMID:27234888] [10.1016/j.bmc.2016.04.059]

1471. Hahn D, Kim H, Yang I, Chin J, Hwang H, Won DH, Lee B, Nam SJ, Ekins M, Choi H, Kang H..  (2016)  The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea.,  79  (3): [PMID:26821210] [10.1021/acs.jnatprod.5b00871]

1472. Tran TD, Pham NB, Quinn RJ..  (2016)  Unique Polybrominated Hydrocarbons from the Australian Endemic Red Alga Ptilonia australasica.,  79  (3): [PMID:26904921] [10.1021/acs.jnatprod.5b00989]

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1474. Benedeković G, Kovačević I, Popsavin M, Francuz J, Kojić V, Bogdanović G, Popsavin V..  (2016)  New antitumour agents with α,β-unsaturated δ-lactone scaffold: Synthesis and antiproliferative activity of (-)-cleistenolide and analogues.,  26  (14): [PMID:27231128] [10.1016/j.bmcl.2016.05.044]

1475. Gurrapu S, Jonnalagadda SK, Alam MA, Ronayne CT, Nelson GL, Solano LN, Lueth EA, Drewes LR, Mereddy VR..  (2016)  Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents.,  26  (14): [PMID:27241692] [10.1016/j.bmcl.2016.05.054]

1476. Tseng WR, Huang CY, Tsai YY, Lin YS, Hwang TL, Su JH, Sung PJ, Dai CF, Sheu JH..  (2016)  New cytotoxic and anti-inflammatory steroids from the soft coral Klyxum flaccidum.,  26  (14): [PMID:27256910] [10.1016/j.bmcl.2016.05.060]

1477. Vucicevic J, Srdic-Rajic T, Pieroni M, Laurila JM, Perovic V, Tassini S, Azzali E, Costantino G, Glisic S, Agbaba D, Scheinin M, Nikolic K, Radi M, Veljkovic N..  (2016)  A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.,  24  (14): [PMID:27265687] [10.1016/j.bmc.2016.05.043]

1478. Venkanna A, Kumar CP, Poornima B, Siva B, Jain N, Suresh Babu K.  (2016)  Design, synthesis and anti-proliferative activities of novel 7-O-substituted schisantherin A derivatives,  7  (6): [10.1039/C6MD00097E]

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1480. Yan J, Chen J, Zhang S, Hu J, Huang L, Li X..  (2016)  Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo.,  59  (11): [PMID:27149641] [10.1021/acs.jmedchem.6b00021]

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1483. Fortes MP, da Silva PB, da Silva TG, Kaufman TS, Militão GC, Silveira CC..  (2016)  Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.,  118  [PMID:27116711] [10.1016/j.ejmech.2016.04.039]

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1501. Moussa Z, El-Sharief MAMS, Abbas SY..  (2016)  New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities.,  122  [PMID:27393950] [10.1016/j.ejmech.2016.06.051]

1502. Chen JY, Huang CY, Lin YS, Hwang TL, Wang WL, Chiou SF, Sheu JH..  (2016)  Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan.,  79  (9): [PMID:27536968] [10.1021/acs.jnatprod.6b00452]

1503. Yu Q, Ravu RR, Jacob MR, Khan SI, Agarwal AK, Yu BY, Li XC..  (2016)  Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species.,  79  (9): [PMID:27584935] [10.1021/acs.jnatprod.6b00224]

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1507. Theppawong A, De Vreese R, Vannecke L, Grootaert C, Van Camp J, D'hooghe M..  (2016)  Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids.,  26  (23): [PMID:27843113] [10.1016/j.bmcl.2016.10.068]

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1514. Kumar S, Aggarwal R, Kumar V, Sadana R, Patel B, Kaushik P, Kaushik D..  (2016)  Solvent-free synthesis of bacillamide analogues as novel cytotoxic and anti-inflammatory agents.,  123  [PMID:27521588] [10.1016/j.ejmech.2016.07.033]

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1546. Shaik SP, Nayak VL, Sultana F, Rao AVS, Shaik AB, Babu KS, Kamal A..  (2017)  Design and synthesis of imidazo[2,1-b]thiazole linked triazole conjugates: Microtubule-destabilizing agents.,  126  [PMID:27744185] [10.1016/j.ejmech.2016.09.060]

1547. Wang C, Wu P, Tian S, Xue J, Xu L, Li H, Wei X..  (2016)  Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus.,  79  (11): [PMID:27797185] [10.1021/acs.jnatprod.6b00715]

1548. Qin JM, Huang RZ, Yao GY, Liao ZX, Pan YM, Wang HS..  (2017)  Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation.,  126  [PMID:27889629] [10.1016/j.ejmech.2016.11.024]

1549. Ravi C, Qayum A, Chandra Mohan D, Singh SK, Adimurthy S..  (2017)  Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives.,  126  [PMID:27889631] [10.1016/j.ejmech.2016.11.037]

1550. Chen Y, Li C, Zheng Y, Gao Y, Hu J, Chen H..  (2017)  Discovery of FZU-03,010 as a self-assembling anticancer amphiphile for acute myeloid leukemia.,  27  (4): [PMID:28073673] [10.1016/j.bmcl.2016.12.071]

1551. Ronayne CT, Solano LN, Nelson GL, Lueth EA, Hubbard SL, Schumacher TJ, Gardner ZS, Jonnalagadda SK, Gurrapu S, Holy J, Mereddy VR..  (2017)  Synthesis and biological evaluation of 2-alkoxycarbonylallyl esters as potential anticancer agents.,  27  (4): [PMID:28129978] [10.1016/j.bmcl.2017.01.037]

1552. Francuz J, Kovačević I, Popsavin M, Benedeković G, Zelenović BS, Kojić V, Jakimov D, Aleksić L, Bogdanović G, Srdić-Rajić T, Lončar E, Rodić MV, Divjaković V, Popsavin V..  (2017)  Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.,  128  [PMID:28135634] [10.1016/j.ejmech.2017.01.024]

1553. Samundeeswari S, Chougala B, Holiyachi M, Shastri L, Kulkarni M, Dodamani S, Jalalpur S, Joshi S, Dixit S, Sunagar V, Hunnur R..  (2017)  Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.,  128  [PMID:28171832] [10.1016/j.ejmech.2017.01.014]

1554. Santos JAM, Santos CS, Almeida CLA, Silva TDS, Freitas Filho JR, Militão GCG, da Silva TG, da Cruz CHB, Freitas JCR, Menezes PH..  (2017)  Structure-based design, synthesis and antitumoral evaluation of enulosides.,  128  [PMID:28189083] [10.1016/j.ejmech.2017.01.036]

1555. Arasakumar T, Mathusalini S, Gopalan S, Shyamsivappan S, Ata A, Mohan PS..  (2017)  Biologically active perspective synthesis of heteroannulated 8-nitroquinolines with green chemistry approach.,  27  (7): [PMID:28262524] [10.1016/j.bmcl.2017.02.042]

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1562. Amin KM, Syam YM, Anwar MM, Ali HI, Abdel-Ghani TM, Serry AM..  (2017)  Synthesis and molecular docking studies of new furochromone derivatives as p38α MAPK inhibitors targeting human breast cancer MCF-7 cells.,  25  (8): [PMID:28291685] [10.1016/j.bmc.2017.02.065]

1563. Liu HY, Chen AC, Yin QK, Li Z, Huang SM, Du G, He JH, Zan LP, Wang SK, Xu YH, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS..  (2017)  New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.,  60  (13): [PMID:28603988] [10.1021/acs.jmedchem.7b00099]

1564. Zhao JX, Fan YY, Xu JB, Gan LS, Xu CH, Ding J, Yue JM..  (2017)  Diterpenoids and Lignans from Cephalotaxus fortunei.,  80  (2): [PMID:28139925] [10.1021/acs.jnatprod.6b00802]

1565. Jain M, Harburn JJ, Gill JH, Loadman PM, Falconer RA, Mooney CA, Cobb SL, Berry DJ..  (2017)  Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs.,  60  (10): [PMID:28471664] [10.1021/acs.jmedchem.6b01472]

1566. Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM..  (2017)  Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.,  60  (13): [PMID:28514170] [10.1021/acs.jmedchem.7b00016]

1567. Wang SK, Wu Y, Wang XQ, Kuang GT, Zhang Q, Lin SL, Liu HY, Tan JH, Huang ZS, Ou TM..  (2017)  Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents.,  60  (13): [PMID:28530833] [10.1021/acs.jmedchem.6b01444]

1568. Zoidis G, Sosic A, Da Ros S, Gatto B, Sissi C, Palluotto F, Carotti A, Catto M..  (2017)  Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents.,  25  (9): [PMID:28342691] [10.1016/j.bmc.2017.03.019]

1569. Wang YQ, Huang ZL, Chen SB, Wang CX, Shan C, Yin QK, Ou TM, Li D, Gu LQ, Tan JH, Huang ZS..  (2017)  Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.,  60  (16): [PMID:28714689] [10.1021/acs.jmedchem.7b00421]

1570. Wijesekera K, Mahidol C, Ruchirawat S, Kittakoop P..  (2017)  Metabolite diversification by cultivation of the endophytic fungus Dothideomycete sp. in halogen containing media: Cultivation of terrestrial fungus in seawater.,  25  (11): [PMID:28366267] [10.1016/j.bmc.2017.03.040]

1571. Zhao Y, Zhang J, Zhuang R, He R, Xi J, Pan X, Shao Y, Pan J, Sun J, Cai Z, Liu S, Huang W, Lv X..  (2017)  Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.,  25  (12): [PMID:28412159] [10.1016/j.bmc.2017.04.003]

1572. Ashok Yadav P, Pavan Kumar C, Siva B, Suresh Babu K, Allanki AD, Sijwali PS, Jain N, Veerabhadra Rao A..  (2017)  Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives.,  134  [PMID:28419927] [10.1016/j.ejmech.2017.04.016]

1573. Letis AS, Seo EJ, Nikolaropoulos SS, Efferth T, Giannis A, Fousteris MA..  (2017)  Synthesis and cytotoxic activity of new artemisinin hybrid molecules against human leukemia cells.,  25  (13): [PMID:28456567] [10.1016/j.bmc.2017.04.021]

1574. Shaik SP, Vishnuvardhan MVPS, Sultana F, Subba Rao AV, Bagul C, Bhattacharjee D, Kapure JS, Jain N, Kamal A..  (2017)  Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors.,  25  (13): [PMID:28462842] [10.1016/j.bmc.2017.04.013]

1575. Badolato M, Carullo G, Armentano B, Panza S, Malivindi R, Aiello F..  (2017)  Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives.,  27  (14): [PMID:28549734] [10.1016/j.bmcl.2017.05.046]

1576. Amata E, Dichiara M, Arena E, Pittalà V, Pistarà V, Cardile V, Graziano ACE, Fraix A, Marrazzo A, Sortino S, Prezzavento O..  (2017)  Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.,  60  (23): [PMID:29172528] [10.1021/acs.jmedchem.7b00791]

1577. An B, Wang B, Hu J, Xu S, Huang L, Li X, Chan ASC..  (2018)  Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents.,  61  (6): [PMID:29509413] [10.1021/acs.jmedchem.8b00128]

1578. Muralidharan VP, Alagumuthu M, Iyer SK..  (2017)  Iodine catalyzed three component synthesis of 1-((2-hydroxy naphthalen-1-yl)(phenyl)(methyl))pyrrolidin-2-one derivatives: Rationale as potent PI3K inhibitors and anticancer agents.,  27  (11): [PMID:28462836] [10.1016/j.bmcl.2017.03.093]

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1580. Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W..  (2016)  DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.,  21  (4): [PMID:26948801] [10.1016/j.drudis.2016.02.015]

1581. Psurski M, Janczewski Ł, Świtalska M, Gajda A, Goszczyński TM, Oleksyszyn J, Wietrzyk J, Gajda T..  (2017)  Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.,  132  [PMID:28342398] [10.1016/j.ejmech.2017.03.028]

1582. Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR..  (2017)  Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.,  60  (19): [PMID:28858511] [10.1021/acs.jmedchem.7b00916]

1583. Singh U, Chashoo G, Khan SU, Mahajan P, Nargotra A, Mahajan G, Singh A, Sharma A, Mintoo MJ, Guru SK, Aruri H, Thatikonda T, Sahu P, Chibber P, Kumar V, Mir SA, Bharate SS, Madishetti S, Nandi U, Singh G, Mondhe DM, Bhushan S, Malik F, Mignani S, Vishwakarma RA, Singh PP..  (2017)  Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.,  60  (23): [PMID:29144137] [10.1021/acs.jmedchem.7b00663]

1584. Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH..  (2017)  Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium.,  80  (3): [PMID:28055219] [10.1021/acs.jnatprod.6b00907]

1585. Bashyal BP, Wijeratne EM, Tillotson J, Arnold AE, Chapman E, Gunatilaka AA..  (2017)  Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus.,  80  (2): [PMID:28139929] [10.1021/acs.jnatprod.6b00960]

1586. Urda C, Fernández R, Pérez M, Rodríguez J, Jiménez C, Cuevas C..  (2017)  Protoxenicins A and B, Cytotoxic Long-Chain Acylated Xenicanes from the Soft Coral Protodendron repens.,  80  (3): [PMID:28256841] [10.1021/acs.jnatprod.7b00046]

1587. Kovačević I, Popsavin M, Benedeković G, Kesić J, Kojić V, Jakimov D, Srdić-Rajić T, Bogdanović G, Divjaković V, Popsavin V..  (2017)  Synthesis and in vitro antitumour activity of crassalactone D, its stereoisomers and novel cinnamic ester derivatives.,  134  [PMID:28427016] [10.1016/j.ejmech.2017.03.088]

1588. Ghorab MM, Alsaid MS, Samir N, Abdel-Latif GA, Soliman AM, Ragab FA, Abou El Ella DA..  (2017)  Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.,  134  [PMID:28427017] [10.1016/j.ejmech.2017.04.028]

1589. Galal SA, Abdelsamie AS, Shouman SA, Attia YM, Ali HI, Tabll A, El-Shenawy R, El Abd YS, Ali MM, Mahmoud AE, Abdel-Halim AH, Fyiad AA, Girgis AS, El-Diwani HI..  (2017)  Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.,  134  [PMID:28433679] [10.1016/j.ejmech.2017.03.090]

1590. Gulipalli KC, Bodige S, Ravula P, Endoori S, Vanaja GR, Suresh Babu G, Narendra Sharath Chandra JN, Seelam N..  (2017)  Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.,  27  (15): [PMID:28579122] [10.1016/j.bmcl.2017.05.047]

1591. Vudhgiri S, Koude D, Veeragoni DK, Misra S, Prasad RBN, Jala RCR..  (2017)  Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides.,  27  (15): [PMID:28615134] [10.1016/j.bmcl.2017.06.004]

1592. Kandela IK, McAuliffe KJ, Cochran LE, Barrett AGM, Hoffman BM, Mazar AP, Trivedi ER..  (2017)  Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice.,  8  (7): [PMID:28740602] [10.1021/acsmedchemlett.7b00063]

1593. Hu MH, Wang YQ, Yu ZY, Hu LN, Ou TM, Chen SB, Huang ZS, Tan JH..  (2018)  Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.,  61  (6): [PMID:29474069] [10.1021/acs.jmedchem.7b01697]

1594. Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC, Lee KH..  (2017)  New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo.,  131  [PMID:28319780] [10.1016/j.ejmech.2017.03.006]

1595. Ramírez-Prada J, Robledo SM, Vélez ID, Crespo MDP, Quiroga J, Abonia R, Montoya A, Svetaz L, Zacchino S, Insuasty B..  (2017)  Synthesis of novel quinoline-based 4,5-dihydro-1H-pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents.,  131  [PMID:28329730] [10.1016/j.ejmech.2017.03.016]

1596. Desai V, Desai S, Gaonkar SN, Palyekar U, Joshi SD, Dixit SK..  (2017)  Novel quinoxalinyl chalcone hybrid scaffolds as enoyl ACP reductase inhibitors: Synthesis, molecular docking and biological evaluation.,  27  (10): [PMID:28372908] [10.1016/j.bmcl.2017.03.059]

1597. Liu QX, Yang YX, Zhang JP, Chen LP, Shen YH, Li HL, Zhang WD..  (2016)  Isolation, Structure Elucidation, and Absolute Configuration of Highly Oxygenated Germacranolides from Carpesium cernuum.,  79  (10): [PMID:27668963] [10.1021/acs.jnatprod.6b00315]

1598. Boraei AT, Gomaa MS, El Ashry ES, Duerkop A..  (2017)  Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents.,  125  [PMID:27688190] [10.1016/j.ejmech.2016.09.046]

1599. Dcona MM, Sheldon JE, Mitra D, Hartman MC..  (2017)  Light induced drug release from a folic acid-drug conjugate.,  27  (3): [PMID:28040391] [10.1016/j.bmcl.2016.12.036]

1600. Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, de Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MR, Vicente F, Genilloud O, Tormo JR, Reyes F..  (2017)  Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus.,  80  (4): [PMID:28277681] [10.1021/acs.jnatprod.6b00680]

1601. Jiang H, Zhang GJ, Liu YF, Wang HS, Liang D..  (2017)  Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis.,  80  (4): [PMID:28358196] [10.1021/acs.jnatprod.6b00976]

1602. Kaur R, Manjal SK, Rawal RK, Kumar K..  (2017)  Recent synthetic and medicinal perspectives of tryptanthrin.,  25  (17): [PMID:28720329] [10.1016/j.bmc.2017.07.003]

1603. Yeon Park J, Young Kim H, Shibamoto T, Su Jang T, Cheon Lee S, Suk Shim J, Hahm DH, Lee HJ, Lee S, Sung Kang K..  (2017)  Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells.,  27  (17): [PMID:28784292] [10.1016/j.bmcl.2017.07.070]

1604. Gontijo TB, de Freitas RP, Emery FS, Pedrosa LF, Vieira Neto JB, Cavalcanti BC, Pessoa C, King A, de Moliner F, Vendrell M, da Silva Júnior EN..  (2017)  On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells.,  27  (18): [PMID:28818447] [10.1016/j.bmcl.2017.08.007]

1605. Arepalli SK, Park B, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H..  (2017)  Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f][1,7]naphthyrdines.,  25  (20): [PMID:28870801] [10.1016/j.bmc.2017.08.030]

1606. Gouda AM, Abdelazeem AH, Omar HA, Abdalla AN, Abourehab MAS, Ali HI..  (2017)  Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.,  25  (20): [PMID:28916158] [10.1016/j.bmc.2017.08.039]

1607. Song JL, Zhang J, Liu CL, Liu C, Zhu KK, Yang FF, Liu XG, Figueiró Longo JP, Alexandre Muehlmann L, Azevedo RB, Zhang YY, Guo YW, Jiang CS, Zhang H..  (2017)  Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-κB inhibitory and anti-proliferative activities.,  27  (20): [PMID:28919340] [10.1016/j.bmcl.2017.09.013]

1608. Toviwek B, Suphakun P, Choowongkomon K, Hannongbua S, Gleeson MP..  (2017)  Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines.,  27  (20): [PMID:28927795] [10.1016/j.bmcl.2017.08.063]

1609. Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T..  (2017)  Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.,  27  (22): [PMID:29037947] [10.1016/j.bmcl.2017.10.008]

1610. Qiu Q, Liu B, Cui J, Li Z, Deng X, Qiang H, Li J, Liao C, Zhang B, Shi W, Pan M, Huang W, Qian H..  (2017)  Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.,  60  (8): [PMID:28355069] [10.1021/acs.jmedchem.6b01787]

1611. Li J, Seupel R, Feineis D, Mudogo V, Kaiser M, Brun R, Brünnert D, Chatterjee M, Seo EJ, Efferth T, Bringmann G..  (2017)  Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.,  80  (2): [PMID:28121440] [10.1021/acs.jnatprod.6b00967]

1612. Wen Z, Zhang Y, Wang X, Zeng X, Hu Z, Liu Y, Xie Y, Liang G, Zhu J, Luo H, Xu B..  (2017)  Novel 3',5'-diprenylated chalcones inhibited the proliferation of cancer cells in vitro by inducing cell apoptosis and arresting cell cycle phase.,  133  [PMID:28390228] [10.1016/j.ejmech.2017.03.077]

1613. Mohamed KO, Nissan YM, El-Malah AA, Ahmed WA, Ibrahim DM, Sakr TM, Motaleb MA..  (2017)  Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptosis inducers.,  135  [PMID:28463785] [10.1016/j.ejmech.2017.04.069]

1614. Picconi P, Prabaharan P, Auer JL, Sandiford S, Cascio F, Chowdhury M, Hind C, Wand ME, Sutton JM, Rahman KM..  (2017)  Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species.,  25  (15): [PMID:28600080] [10.1016/j.bmc.2017.05.037]

1615. Idowu T, Samadder P, Arthur G, Schweizer F..  (2017)  Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells.,  60  (23): [PMID:29043812] [10.1021/acs.jmedchem.7b01198]

1616. Li J, Gu BB, Sun F, Xu JR, Jiao WH, Yu HB, Han BN, Yang F, Zhang XC, Lin HW..  (2017)  Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper.,  80  (5): [PMID:28398051] [10.1021/acs.jnatprod.6b01105]

1617. Son S, Ko SK, Jang M, Lee JK, Kwon MC, Kang DH, Ryoo IJ, Lee JS, Hong YS, Kim BY, Jang JH, Ahn JS..  (2017)  Polyketides and Anthranilic Acid Possessing 6-Deoxy-α-l-talopyranose from a Streptomyces Species.,  80  (5): [PMID:28406643] [10.1021/acs.jnatprod.6b01059]

1618. Kim CK, Riswanto R, Won TH, Kim H, Elya B, Sim CJ, Oh DC, Oh KB, Shin J..  (2017)  Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge.,  80  (5): [PMID:28452477] [10.1021/acs.jnatprod.7b00121]

1619. Chamni S, Sirimangkalakitti N, Chanvorachote P, Saito N, Suwanborirux K..  (2017)  Chemistry of Renieramycins. 17. A New Generation of Renieramycins: Hydroquinone 5-O-Monoester Analogues of Renieramycin M as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells.,  80  (5): [PMID:28459574] [10.1021/acs.jnatprod.7b00068]

1620. Sriyatep T, Andersen RJ, Patrick BO, Pyne SG, Muanprasat C, Seemakhan S, Borwornpinyo S, Laphookhieo S..  (2017)  Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua.,  80  (5): [PMID:28489373] [10.1021/acs.jnatprod.7b00240]

1621. Chen L, Chai W, Wang W, Song T, Lian XY, Zhang Z..  (2017)  Cytotoxic Bagremycins from Mangrove-Derived Streptomyces sp. Q22.,  80  (5): [PMID:28504888] [10.1021/acs.jnatprod.6b01136]

1622. El-Gohary NS, Shaaban MI..  (2017)  Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs.,  137  [PMID:28623814] [10.1016/j.ejmech.2017.05.064]

1623. Łażewska D, Kaleta M, Hagenow S, Mogilski S, Latacz G, Karcz T, Lubelska A, Honkisz E, Handzlik J, Reiner D, Satała G, Filipek B, Stark H, Kieć-Kononowicz K..  (2018)  Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.,  26  (9): [PMID:29681486] [10.1016/j.bmc.2018.04.023]

1624. Gao M, Li J, Nie C, Song B, Yan L, Qian H..  (2018)  Design, synthesis and biological evaluation of novel hydrogen sulfide releasing capsaicin derivatives.,  26  (9): [PMID:29685681] [10.1016/j.bmc.2018.04.031]

1625. Li S, Li G, Yang X, Meng Q, Yuan S, He Y, Sun D..  (2018)  Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents.,  28  (13): [PMID:29789258] [10.1016/j.bmcl.2018.05.035]

1626. Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM..  (2018)  Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.,  26  (12): [PMID:29793751] [10.1016/j.bmc.2018.05.022]

1627. Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB..  (2018)  Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.,  26  (12): [PMID:29887512] [10.1016/j.bmc.2018.05.041]

1628. Samara P, Christoforidou N, Lemus C, Argyropoulou A, Ioannou K, Vougogiannopoulou K, Aligiannis N, Paronis E, Gaboriaud-Kolar N, Tsitsilonis O, Skaltsounis AL..  (2017)  New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo.,  137  [PMID:28551177] [10.1016/j.ejmech.2017.05.029]

1629. Xu XL, Yang YR, Mo XF, Wei JL, Zhang XJ, You QD..  (2017)  Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.,  137  [PMID:28554092] [10.1016/j.ejmech.2017.05.042]

1630. Hassan GS, Abdel Rahman DE, Nissan YM, Abdelmajeed EA, Abdelghany TM..  (2017)  Novel pyrazolopyrimidines: Synthesis, in vitro cytotoxic activity and mechanistic investigation.,  138  [PMID:28704759] [10.1016/j.ejmech.2017.07.003]

1631. Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V..  (2017)  4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation.,  138  [PMID:28756265] [10.1016/j.ejmech.2017.07.041]

1632. Omar HA, Zaher DM, Srinivasulu V, Hersi F, Tarazi H, Al-Tel TH..  (2017)  Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma.,  139  [PMID:28865276] [10.1016/j.ejmech.2017.08.054]

1633. Murahari M, Prakash KV, Peters GJ, Mayur YC..  (2017)  Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies.,  139  [PMID:28886509] [10.1016/j.ejmech.2017.08.023]

1634. Manikandan A, Moharil P, Sathishkumar M, Muñoz-Garay C, Sivakumar A..  (2017)  Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.,  141  [PMID:29032034] [10.1016/j.ejmech.2017.09.076]

1635. Jiang B, Zhao W, Li S, Liu H, Yu L, Zhang Y, He H, Wu L..  (2017)  Cytotoxic Dibohemamines D-F from a Streptomyces Species.,  80  (10): [PMID:29035560] [10.1021/acs.jnatprod.7b00136]

1636. Kruakaew S, Seeka C, Lhinhatrakool T, Thongnest S, Yahuafai J, Piyaviriyakul S, Siripong P, Sutthivaiyakit S..  (2017)  Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves.,  80  (11): [PMID:29072457] [10.1021/acs.jnatprod.7b00554]

1637. Urda C, Fernández R, Rodríguez J, Pérez M, Jiménez C, Cuevas C..  (2017)  Daedophamide, a Cytotoxic Cyclodepsipeptide from a Daedalopelta sp. Sponge Collected in Indonesia.,  80  (11): [PMID:29112820] [10.1021/acs.jnatprod.7b00678]

1638. Zhang Z, He X, Zhang G, Che Q, Zhu T, Gu Q, Li D..  (2017)  Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile.,  80  (12): [PMID:29144133] [10.1021/acs.jnatprod.7b00417]

1639. Bian T, Chandagirikoppal Vijendra K, Wang Y, Meacham A, Hati S, Cogle CR, Sun H, Xing C..  (2018)  Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells.,  61  (15): [PMID:29995404] [10.1021/acs.jmedchem.8b00813]

1640. Reddy SD, Siva B, Phani Babu VS, Vijaya M, Nayak VL, Mandal R, Tiwari AK, Shashikala P, Babu KS..  (2017)  New cycloartane type-triterpenoids from the areal parts of Caragana sukiensis and their biological activities.,  136  [PMID:28482219] [10.1016/j.ejmech.2017.04.065]

1641. Tantak MP, Klingler L, Arun V, Kumar A, Sadana R, Kumar D..  (2017)  Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.,  136  [PMID:28494255] [10.1016/j.ejmech.2017.04.078]

1642. de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SCB, Lafayette EA, da Silva RMF, de Almeida SMV, de Moura RO, Ruiz ALTG, de Carvalho JE, de Lima MDCA..  (2017)  Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.,  136  [PMID:28505535] [10.1016/j.ejmech.2017.05.023]

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1644. Pluta K, Jeleń M, Morak-Młodawska B, Zimecki M, Artym J, Kocięba M, Zaczyńska E..  (2017)  Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.,  138  [PMID:28734245] [10.1016/j.ejmech.2017.07.009]

1645. Insuasty D, Robledo SM, Vélez ID, Cuervo P, Insuasty B, Quiroga J, Nogueras M, Cobo J, Abonia R..  (2017)  A Schmidt rearrangement-mediated synthesis of novel tetrahydro-benzo[1,4]diazepin-5-ones as potential anticancer and antiprotozoal agents.,  141  [PMID:29102177] [10.1016/j.ejmech.2017.10.024]

1646. Kovvuri J, Nagaraju B, Nayak VL, Akunuri R, Rao MPN, Ajitha A, Nagesh N, Kamal A..  (2018)  Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors.,  143  [PMID:29129513] [10.1016/j.ejmech.2017.10.054]

1647. Nadysev GY, Tikhomirov AS, Lin MH, Yang YT, Dezhenkova LG, Chen HY, Kaluzhny DN, Schols D, Shtil AA, Shchekotikhin AE, Chueh PJ..  (2018)  Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.,  143  [PMID:29137865] [10.1016/j.ejmech.2017.10.055]

1648. El Gaafary M, Ezzat SM, El Sayed AM, Sabry OM, Hafner S, Lang S, Schmiech M, Syrovets T, Simmet T..  (2017)  Acovenoside A Induces Mitotic Catastrophe Followed by Apoptosis in Non-Small-Cell Lung Cancer Cells.,  80  (12): [PMID:29190084] [10.1021/acs.jnatprod.7b00546]

1649. Ansari MF, Idrees D, Hassan MI, Ahmad K, Avecilla F, Azam A..  (2018)  Design, synthesis and biological evaluation of novel pyridine-thiazolidinone derivatives as anticancer agents: Targeting human carbonic anhydrase IX.,  144  [PMID:29289880] [10.1016/j.ejmech.2017.12.049]

1650. Vágvölgyi M, Martins A, Kulmány Á, Zupkó I, Gáti T, Simon A, Tóth G, Hunyadi A..  (2018)  Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam.,  144  [PMID:29291440] [10.1016/j.ejmech.2017.12.032]

1651. Galal SA, Khairat SHM, Ali HI, Shouman SA, Attia YM, Ali MM, Mahmoud AE, Abdel-Halim AH, Fyiad AA, Tabll A, El-Shenawy R, El Abd YS, Ramdan R, El Diwani HI..  (2018)  Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors.,  144  [PMID:29316526] [10.1016/j.ejmech.2017.12.023]

1652. Zhao F, Wang W, Lu W, Xu L, Yang S, Cai XM, Zhou M, Lei M, Ma M, Xu HJ, Cao F..  (2018)  High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex.,  146  [PMID:29407970] [10.1016/j.ejmech.2018.01.041]

1653. Galal SA, Khattab M, Shouman SA, Ramadan R, Kandil OM, Kandil OM, Tabll A, El Abd YS, El-Shenawy R, Attia YM, El-Rashedy AA, El Diwani HI..  (2018)  Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates.,  146  [PMID:29407991] [10.1016/j.ejmech.2018.01.072]

1654. Li N, Xin WY, Yao BR, Wang CH, Cong W, Zhao F, Li HJ, Hou Y, Meng QG, Hou GG..  (2018)  Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo.,  147  [PMID:29421568] [10.1016/j.ejmech.2018.01.088]

1655. Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C..  (2018)  Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.,  147  [PMID:29421570] [10.1016/j.ejmech.2018.01.066]

1656. Pinto MEF, Najas JZG, Magalhães LG, Bobey AF, Mendonça JN, Lopes NP, Leme FM, Teixeira SP, Trovó M, Andricopulo AD, Koehbach J, Gruber CW, Cilli EM, Bolzani VS..  (2018)  Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria.,  81  (5): [PMID:29757646] [10.1021/acs.jnatprod.7b00969]

1657. Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O..  (2018)  Non-geminal Aliphatic Dihalogenation Pattern in Dichlorinated Diaporthins from Hamigera fusca NRRL 35721.,  81  (6): [PMID:29792325] [10.1021/acs.jnatprod.8b00041]

1658. Guo Y, Wang Y, Li H, Wang K, Wan Q, Li J, Zhou Y, Chen Y..  (2018)  Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents.,  9  (5): [PMID:29795767] [10.1021/acsmedchemlett.8b00125]

1659. Fröhlich T, Reiter C, Saeed MEM, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva SB..  (2018)  Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.,  9  (6): [PMID:29937978] [10.1021/acsmedchemlett.7b00412]

1660. Chang FR, Li PS, Huang Liu R, Hu HC, Hwang TL, Lee JC, Chen SL, Wu YC, Cheng YB..  (2018)  Bioactive Phenolic Components from the Twigs of Atalantia buxifolia.,  81  (7): [PMID:29975532] [10.1021/acs.jnatprod.7b00938]

1661. Addepalli Y, Yang X, Zhou M, Reddy DP, Zhang SL, Wang Z, He Y..  (2018)  Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines.,  151  [PMID:29614418] [10.1016/j.ejmech.2018.02.079]

1662. Yu H, Hou Z, Tian Y, Mou Y, Guo C..  (2018)  Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents.,  151  [PMID:29649740] [10.1016/j.ejmech.2018.04.005]

1663. Baiju TV, Almeida RG, Sivanandan ST, de Simone CA, Brito LM, Cavalcanti BC, Pessoa C, Namboothiri INN, da Silva Júnior EN..  (2018)  Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.,  151  [PMID:29660689] [10.1016/j.ejmech.2018.03.079]

1664. Nasr T, Bondock S, Rashed HM, Fayad W, Youns M, Sakr TM..  (2018)  Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies.,  151  [PMID:29665526] [10.1016/j.ejmech.2018.04.014]

1665. Ibrahim HS, Allam HA, Mahmoud WR, Bonardi A, Nocentini A, Gratteri P, Ibrahim ES, Abdel-Aziz HA, Supuran CT..  (2018)  Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.,  152  [PMID:29684705] [10.1016/j.ejmech.2018.04.016]

1666. Yu XH, Peng CC, Sun XX, Chen WH..  (2018)  Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters.,  152  [PMID:29702447] [10.1016/j.ejmech.2018.04.036]

1667. Crespo I, Giménez-Dejoz J, Porté S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Parés X, Ruiz FX, Metwally K, Farrés J..  (2018)  Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.,  152  [PMID:29705708] [10.1016/j.ejmech.2018.04.015]

1668. Yu Q, Yang H, Zhu TW, Yu LM, Chen JW, Gu LQ, Huang ZS, An LK..  (2018)  Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.,  152  [PMID:29705710] [10.1016/j.ejmech.2018.04.040]

1669. Peerzada MN, Khan P, Ahmad K, Hassan MI, Azam A..  (2018)  Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.,  155  [PMID:29852328] [10.1016/j.ejmech.2018.05.034]

1670. Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani JL, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P..  (2018)  Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.,  155  [PMID:29885575] [10.1016/j.ejmech.2018.06.001]

1671. Wu GR, Xu B, Yang YQ, Zhang XY, Fang K, Ma T, Wang H, Xue NN, Chen M, Guo WB, Jia XH, Wang PL, Lei HM..  (2018)  Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.,  155  [PMID:29886322] [10.1016/j.ejmech.2018.05.052]

1672. Li N, Xin WY, Yao BR, Cong W, Wang CH, Hou GG..  (2018)  N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines.,  155  [PMID:29909338] [10.1016/j.ejmech.2018.06.027]

1673. Szulczyk D, Dobrowolski MA, Roszkowski P, Bielenica A, Stefańska J, Koliński M, Kmiecik S, Jóźwiak M, Wrzosek M, Olejarz W, Struga M..  (2018)  Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies.,  156  [PMID:30031974] [10.1016/j.ejmech.2018.07.041]

1674. Sathish M, Chetan Dushantrao S, Nekkanti S, Tokala R, Thatikonda S, Tangella Y, Srinivas G, Cherukommu S, Hari Krishna N, Shankaraiah N, Nagesh N, Kamal A..  (2018)  Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors.,  26  (17): [PMID:30172625] [10.1016/j.bmc.2018.08.031]

1675. Zhang XR, Wang HW, Tang WL, Zhang Y, Yang H, Hu DX, Ravji A, Marchand C, Kiselev E, Ofori-Atta K, Agama K, Pommier Y, An LK..  (2018)  Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.,  61  (22): [PMID:30336023] [10.1021/acs.jmedchem.8b00639]

1676. Chowdhury NS, Sohrab MH, Rana MS, Hasan CM, Jamshidi S, Rahman KM..  (2017)  Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani.,  80  (4): [PMID:28257197] [10.1021/acs.jnatprod.6b00610]

1677. Vasu KK, Digwal CS, Pandya AN, Pandya DH, Sharma JA, Patel S, Agarwal M..  (2017)  Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.,  27  (24): [PMID:29138027] [10.1016/j.bmcl.2017.10.060]

1678. Che T, Chen SB, Tu JL, Wang B, Wang YQ, Zhang Y, Wang J, Wang ZQ, Zhang ZP, Ou TM, Zhao Y, Tan JH, Huang ZS..  (2018)  Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.,  61  (8): [PMID:29618208] [10.1021/acs.jmedchem.7b01615]

1679. Xiao J, Hu JY, Sun HD, Zhao X, Zhong WT, Duan DZ, Wang L, Wang XL..  (2018)  Sinopestalotiollides A-D, cytotoxic diphenyl ether derivatives from plant endophytic fungus Pestalotiopsis palmarum.,  28  (3): [PMID:29295796] [10.1016/j.bmcl.2017.11.044]

1680. Ma X, Laramie M, Henary M..  (2018)  Synthesis, optical properties and cytotoxicity of meso-heteroatom substituted IR-786 analogs.,  28  (3): [PMID:29249562] [10.1016/j.bmcl.2017.12.001]

1681. Anuchapreeda S, Khumpirapang N, Rupitiwiriya K, Tho-Iam L, Saiai A, Okonogi S, Usuki T..  (2018)  Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.).,  28  (3): [PMID:29274817] [10.1016/j.bmcl.2017.12.029]

1682. Goli N, Mainkar PS, Kotapalli SS, K T, Ummanni R, Chandrasekhar S..  (2017)  Expanding the tetrahydroquinoline pharmacophore.,  27  (8): [PMID:28318941] [10.1016/j.bmcl.2017.02.077]

1683. Ibrahim SRM, Mohamed GA, Al Haidari RA, Zayed MF, El-Kholy AA, Elkhayat ES, Ross SA..  (2018)  Fusarithioamide B, a new benzamide derivative from the endophytic fungus Fusarium chlamydosporium with potent cytotoxic and antimicrobial activities.,  26  (3): [PMID:29317147] [10.1016/j.bmc.2017.12.049]

1684. Romero JA, Acosta ME, Gamboa ND, Mijares MR, De Sanctis JB, Charris JE..  (2018)  Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate.,  26  (4): [PMID:29398445] [10.1016/j.bmc.2017.12.022]

1685. Kasaboina S, Ramineni V, Banu S, Bandi Y, Nagarapu L, Dumala N, Grover P..  (2018)  Iodine mediated pyrazolo-quinoline derivatives as potent anti-proliferative agents.,  28  (4): [PMID:29409753] [10.1016/j.bmcl.2018.01.023]

1686. Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Kucwaj-Brysz K, Wesołowska A, Kieć-Kononowicz K, Handzlik J..  (2018)  MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.,  28  (5): [PMID:29439902] [10.1016/j.bmcl.2018.02.003]

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1690. Romo-Pérez A, Miranda LD, Chávez-Blanco AD, Dueñas-González A, Camacho-Corona MDR, Acosta-Huerta A, García A..  (2017)  Mild C(sp3)-H functionalization of dihydrosanguinarine and dihydrochelerythrine for development of highly cytotoxic derivatives.,  138  [PMID:28641156] [10.1016/j.ejmech.2017.06.021]

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1693. Eldehna WM, Abo-Ashour MF, Nocentini A, Gratteri P, Eissa IH, Fares M, Ismael OE, Ghabbour HA, Elaasser MM, Abdel-Aziz HA, Supuran CT..  (2017)  Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.,  139  [PMID:28802125] [10.1016/j.ejmech.2017.07.073]

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1695. Kumar NP, Sharma P, Kumari SS, Brahma U, Nekkanti S, Shankaraiah N, Kamal A..  (2017)  Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies.,  140  [PMID:28923381] [10.1016/j.ejmech.2017.09.006]

1696. Gazieva GA, Anikina LV, Nechaeva TV, Pukhov SA, Karpova TB, Popkov SV, Nelyubina YV, Kolotyrkina NG, Kravchenko AN..  (2017)  Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives.,  140  [PMID:28923382] [10.1016/j.ejmech.2017.09.009]

1697. Abdel-Rahman SA, El-Gohary NS, El-Bendary ER, El-Ashry SM, Shaaban MI..  (2017)  Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs.,  140  [PMID:28926764] [10.1016/j.ejmech.2017.08.066]

1698. Lin Y, Liu R, Zhao P, Ye J, Zheng Z, Huang J, Zhang Y, Gao Y, Chen H, Liu S, Zhou J, Chen C, Chen H..  (2018)  Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer.,  146  [PMID:29407962] [10.1016/j.ejmech.2018.01.056]

1699. Tikhomirov AS, Lin CY, Volodina YL, Dezhenkova LG, Tatarskiy VV, Schols D, Shtil AA, Kaur P, Chueh PJ, Shchekotikhin AE..  (2018)  New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship.,  148  [PMID:29459273] [10.1016/j.ejmech.2018.02.027]

1700. Borie C, Mondal S, Arif T, Briand M, Lingua H, Dumur F, Gigmes D, Stocker P, Barbarat B, Robert V, Nicoletti C, Olive D, Maresca M, Nechab M..  (2018)  Enediynes bearing polyfluoroaryl sulfoxide as new antiproliferative agents with dual targeting of microtubules and DNA.,  148  [PMID:29471119] [10.1016/j.ejmech.2018.02.030]

1701. Amujuri D, Siva B, Poornima B, Sirisha K, Sarma AVS, Lakshma Nayak V, Tiwari AK, Purushotham U, Suresh Babu K..  (2018)  Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents.,  149  [PMID:29501940] [10.1016/j.ejmech.2018.02.066]

1702. Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W..  (2018)  Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.,  149  [PMID:29501942] [10.1016/j.ejmech.2018.02.045]

1703. Kassab AE, Gedawy EM..  (2018)  Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.,  150  [PMID:29547830] [10.1016/j.ejmech.2018.03.026]

1704. Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K..  (2018)  Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.,  81  (8): [PMID:30106296] [10.1021/acs.jnatprod.8b00411]

1705. Tang D, Liu LL, He QR, Yan W, Li D, Gao JM..  (2018)  Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5.,  81  (9): [PMID:30132670] [10.1021/acs.jnatprod.8b00203]

1706. Xiong J, Wang LJ, Qian J, Wang PP, Wang XJ, Ma GL, Zeng H, Li J, Hu JF..  (2018)  Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia shiluensis.,  81  (10): [PMID:30289713] [10.1021/acs.jnatprod.8b00386]

1707. Kuder KJ, Łażewska D, Kaleta M, Latacz G, Kottke T, Olejarz A, Karcz T, Fruziński A, Szczepańska K, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K..  (2017)  Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.,  25  (10): [PMID:28372935] [10.1016/j.bmc.2017.03.031]

1708. Sun J, Shao J, Sun C, Song Y, Li Q, Lu L, Hu Y, Gui C, Zhang H, Ju J..  (2018)  Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.,  26  (8): [PMID:29452840] [10.1016/j.bmc.2018.01.010]

1709. Jin L, Huang R, Huang X, Zhang B, Ji M, Wang H..  (2018)  Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.,  26  (8): [PMID:29486954] [10.1016/j.bmc.2018.02.021]

1710. Venkataramana Reddy PO, Hridhay M, Nikhil K, Khan S, Jha PN, Shah K, Kumar D..  (2018)  Synthesis and investigations into the anticancer and antibacterial activity studies of β-carboline chalcones and their bromide salts.,  28  (8): [PMID:29573910] [10.1016/j.bmcl.2018.03.033]

1711. Zhang N, Yu Z, Yang X, Hu P, He Y..  (2018)  Synthesis of novel ring-contracted artemisinin dimers with potent anticancer activities.,  150  [PMID:29597166] [10.1016/j.ejmech.2018.03.010]

1712. Psurski M, Janczewski Ł, Świtalska M, Gajda A, Goszczyński TM, Ciekot J, Winiarski Ł, Oleksyszyn J, Wietrzyk J, Gajda T..  (2018)  Phosphorus-containing isothiocyanate-derived mercapturic acids as a useful alternative for parental isothiocyanates in experimental oncology.,  28  (15): [PMID:29945793] [10.1016/j.bmcl.2018.06.042]

1713. Stanojković T, Marković V, Matić IZ, Mladenović MP, Petrović N, Krivokuća A, Petković M, Joksović MD..  (2018)  Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents.,  28  (15): [PMID:29970309] [10.1016/j.bmcl.2018.06.048]

1714. Chaitanya MVSK, Reddy POV, Nikhil K, Kumar A, Shah K, Kumar D..  (2018)  Synthesis and anticancer activity studies of indolylisoxazoline analogues.,  28  (17): [PMID:30072225] [10.1016/j.bmcl.2018.07.035]

1715. Okolotowicz KJ, Dwyer M, Ryan D, Cheng J, Cashman EA, Moore S, Mercola M, Cashman JR..  (2018)  Novel tertiary sulfonamides as potent anti-cancer agents.,  26  (15): [PMID:30075999] [10.1016/j.bmc.2018.07.042]

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1717. Yang R, Chen Y, Pan L, Yang Y, Zheng Q, Hu Y, Wang Y, Zhang L, Sun Y, Li Z, Meng X..  (2018)  Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors.,  26  (17): [PMID:30170925] [10.1016/j.bmc.2018.08.028]

1718. Arepalli SK, Lee C, Sim S, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H..  (2018)  Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors.,  26  (18): [PMID:30253887] [10.1016/j.bmc.2018.09.019]

1719. Santos CCF, Paradela LS, Novaes LFT, Dias SMG, Pastre JC..  (2017)  Design and synthesis of cenocladamide analogues and their evaluation against breast cancer cell lines.,  8  (4): [PMID:30108794] [10.1039/C6MD00577B]

1720. Nasr T, Bondock S, Youns M, Fayad W, Zaghary W..  (2017)  Synthesis, antitumor evaluation and microarray study of some new pyrazolo[3,4-d][1,2,3]triazine derivatives.,  141  [PMID:29107422] [10.1016/j.ejmech.2017.10.016]

1721. Abdelhaleem EF, Abdelhameid MK, Kassab AE, Kandeel MM..  (2018)  Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.,  143  [PMID:29133058] [10.1016/j.ejmech.2017.10.075]

1722. Qi J, Dong H, Huang J, Zhang S, Niu L, Zhang Y, Wang J..  (2018)  Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors.,  143  [PMID:29172084] [10.1016/j.ejmech.2017.08.018]

1723. Hossam M, Lasheen DS, Ismail NSM, Esmat A, Mansour AM, Singab ANB, Abouzid KAM..  (2018)  Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity.,  144  [PMID:29275232] [10.1016/j.ejmech.2017.12.022]

1724. Park S, Kim EH, Kim J, Kim SH, Kim I..  (2018)  Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.,  144  [PMID:29288944] [10.1016/j.ejmech.2017.12.056]

1725. Sathish M, Kavitha B, Nayak VL, Tangella Y, Ajitha A, Nekkanti S, Alarifi A, Shankaraiah N, Nagesh N, Kamal A..  (2018)  Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.,  144  [PMID:29289881] [10.1016/j.ejmech.2017.12.055]

1726. de Santana TI, Barbosa MO, Gomes PATM, da Cruz ACN, da Silva TG, Leite ACL..  (2018)  Synthesis, anticancer activity and mechanism of action of new thiazole derivatives.,  144  [PMID:29329071] [10.1016/j.ejmech.2017.12.040]

1727. Padumadasa C, Xu YM, Wijeratne EMK, Espinosa-Artiles P, U'Ren JM, Arnold AE, Gunatilaka AAL..  (2018)  Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa.,  81  (3): [PMID:29373790] [10.1021/acs.jnatprod.7b00838]

1728. Ojima I, Wang X, Jing Y, Wang C..  (2018)  Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.,  81  (3): [PMID:29468872] [10.1021/acs.jnatprod.7b01012]

1729. Nadaradjane C, Yang CH, Rodriguez-Gabin A, Ye K, Sugasawa K, Atasoylu O, Smith AB, Horwitz SB, McDaid HM..  (2018)  Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners.,  81  (3): [PMID:29522336] [10.1021/acs.jnatprod.8b00111]

1730. Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Seo EJ, Efferth T, Bringmann G..  (2018)  Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.,  81  (4): [PMID:29560715] [10.1021/acs.jnatprod.7b01041]

1731. Garnica P, Encío I, Plano D, Palop JA, Sanmartín C..  (2018)  Combined Acylselenourea-Diselenide Structures: New Potent and Selective Antitumoral Agents as Autophagy Activators.,  9  (4): [PMID:29670691] [10.1021/acsmedchemlett.7b00482]

1732. Załuski M, Stanuch K, Karcz T, Hinz S, Latacz G, Szymańska E, Schabikowski J, Doroż-Płonka A, Handzlik J, Drabczyńska A, Müller CE, Kieć-Kononowicz K..  (2018)  Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.,  9  (6): [PMID:30108984] [10.1039/C8MD00070K]

1733. Savić MP, Ajduković JJ, Plavša JJ, Bekić SS, Ćelić AS, Klisurić OR, Jakimov DS, Petri ET, Djurendić EA..  (2018)  Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo-keto reductase 1C3 inhibitory activity.,  9  (6): [PMID:30108986] [10.1039/C8MD00077H]

1734. Kucwaj-Brysz K, Kurczab R, Żesławska E, Lubelska A, Marć MA, Latacz G, Satała G, Nitek W, Kieć-Kononowicz K, Handzlik J..  (2018)  The role of aryl-topology in balancing between selective and dual 5-HT₇R/5-HT_1A actions of 3,5-substituted hydantoins.,  9  (6): [PMID:30108992] [10.1039/C8MD00168E]

1735. Vendrusculo V, de Souza VP, M Fontoura LA, M D'Oca MG, Banzato TP, Monteiro PA, Pilli RA, de Carvalho JE, Russowsky D..  (2018)  Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activity.,  9  (9): [PMID:30288229] [10.1039/C8MD00270C]

1736. Kurek J, Kwaśniewska-Sip P, Myszkowski K, Cofta G, Murias M, Barczyński P, Jasiewicz B, Kurczab R..  (2018)  7-Deacetyl-10-alkylthiocolchicine derivatives - new compounds with potent anticancer and fungicidal activity.,  9  (10): [PMID:30429975] [10.1039/C8MD00352A]

1737. Eroshenko DV, Krainova GF, Konysheva AV, Dmitriev MV, Grishko VV..  (2018)  Synthesis, modification, and cytotoxic evaluation of 2,3-secotriterpenic β-ketoesters.,  28  (23-24): [PMID:30340899] [10.1016/j.bmcl.2018.10.014]

1738. Wu Q, Zheng K, Huang X, Li L, Mei W..  (2018)  Tanshinone-IIA-Based Analogues of Imidazole Alkaloid Act as Potent Inhibitors To Block Breast Cancer Invasion and Metastasis in Vivo.,  61  (23): [PMID:30398868] [10.1021/acs.jmedchem.8b01018]

1739. Liu X, Li B, Zhang Z, Wei Y, Xu Z, Qin S, Liu N, Zhao R, Peng J, Yang G, Qi M, Liu T, Xie M, Liu S, Gao X, Lu C, Zhu L, Long X, Kang H, Sun T, Zhou H, Wei M, Yang G, Yang C..  (2018)  Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.,  61  (23): [PMID:30433783] [10.1021/acs.jmedchem.8b01445]

1740. Rapacz A, Waszkielewicz AM, Pańczyk K, Pytka K, Koczurkiewicz P, Piska K, Pękala E, Budziszewska B, Starek-Świechowicz B, Marona H..  (2017)  Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols.,  8  (1): [PMID:30108708] [10.1039/C6MD00537C]

1741. Huang RZ, Hua SX, Liao ZX, Huang XC, Wang HS..  (2017)  Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-κB) pathway and cell proliferation.,  8  (7): [PMID:30108853] [10.1039/C7MD00105C]

1742. Costa MP, Feitosa ACS, Oliveira FCE, Cavalcanti BC, Dias GG, Caetano EWS, Sales FAM, Freire VN, Di Fiore S, Fischer R, Ladeira LO, da Silva Júnior EN, Pessoa C..  (2017)  Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines.,  8  (10): [PMID:30108718] [10.1039/C7MD00196G]

1743. Tikhomirov AS, Tsvetkov VB, Kaluzhny DN, Volodina YL, Zatonsky GV, Schols D, Shchekotikhin AE..  (2018)  Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.,  159  [PMID:30268824] [10.1016/j.ejmech.2018.09.054]

1744. Pavelyev RS, Bondar OV, Nguyen TNT, Ziganshina AA, Al Farroukh M, Karwt R, Alekbaeva GD, Pugachev MV, Yamaleeva ZR, Kataeva ON, Balakin KV, Shtyrlin YG..  (2018)  Synthesis and in vitro antitumor activity of novel alkenyl derivatives of pyridoxine, bioisosteric analogs of feruloyl methane.,  26  (22): [PMID:30429098] [10.1016/j.bmc.2018.10.031]

1745. El-Husseiny WM, El-Sayed MA, Abdel-Aziz NI, El-Azab AS, Asiri YA, Abdel-Aziz AA..  (2018)  Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking.,  158  [PMID:30216848] [10.1016/j.ejmech.2018.09.007]

1746. Zhang Q, Shen Q, Gao L, Tong L, Li J, Chen Y, Lu W..  (2018)  Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR.,  158  [PMID:30241010] [10.1016/j.ejmech.2018.09.032]

1747. Zhang N, Yu Z, Yang X, Zhou Y, Wang J, Zhang SL, Wang MW, He Y..  (2018)  Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors.,  158  [PMID:30245395] [10.1016/j.ejmech.2018.09.002]

1748. Maestro A, Martín-Encinas E, Alonso C, Martinez de Marigorta E, Rubiales G, Vicario J, Palacios F..  (2018)  Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives.,  158  [PMID:30253344] [10.1016/j.ejmech.2018.09.011]

1749. Zhang SL, Yang Z, Hu X, Tam KY..  (2018)  Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships.,  28  (21): [PMID:30266541] [10.1016/j.bmcl.2018.09.026]

1750. Yao H, Wei G, Liu Y, Yao H, Zhu Z, Ye W, Wu X, Xu J, Xu S..  (2018)  Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies.,  9  (10): [PMID:30344912] [10.1021/acsmedchemlett.8b00321]

1751. Metwally K, Pratsinis H, Kletsas D..  (2017)  Novel 2,4- thiazolidinediones: Synthesis, in vitro cytotoxic activity, and mechanistic investigation.,  133  [PMID:28395220] [10.1016/j.ejmech.2017.03.052]

1752. Salvador JAR, Leal AS, Valdeira AS, Gonçalves BMF, Alho DPS, Figueiredo SAC, Silvestre SM, Mendes VIS..  (2017)  Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.,  142  [PMID:28754470] [10.1016/j.ejmech.2017.07.013]

1753. El-Gohary NS, Shaaban MI..  (2018)  New pyrazolopyridine analogs: Synthesis, antimicrobial, antiquorum-sensing and antitumor screening.,  152  [PMID:29702448] [10.1016/j.ejmech.2018.04.025]

1754. Melo TRF, Kumkhaek C, Fernandes GFDS, Lopes Pires ME, Chelucci RC, Barbieri KP, Coelho F, Capote TSO, Lanaro C, Carlos IZ, Marcondes S, Chegaev K, Guglielmo S, Fruttero R, Chung MC, Costa FF, Rodgers GP, Dos Santos JL..  (2018)  Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation.,  154  [PMID:29852459] [10.1016/j.ejmech.2018.05.008]

1755. Ibrahim MK, Taghour MS, Metwaly AM, Belal A, Mehany ABM, Elhendawy MA, Radwan MM, Yassin AM, El-Deeb NM, Hafez EE, ElSohly MA, Eissa IH..  (2018)  Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.,  155  [PMID:29885574] [10.1016/j.ejmech.2018.06.004]

1756. Mostafa AS, Selim KB..  (2018)  Synthesis and anticancer activity of new dihydropyrimidinone derivatives.,  156  [PMID:30015070] [10.1016/j.ejmech.2018.07.004]

1757. Wang JQ, Wang X, Wang Y, Tang WJ, Shi JB, Liu XH..  (2018)  Novel curcumin analogue hybrids: Synthesis and anticancer activity.,  156  [PMID:30025345] [10.1016/j.ejmech.2018.07.013]

1758. Antoszczak M, Urbaniak A, Delgado M, Maj E, Borgström B, Wietrzyk J, Huczyński A, Yuan Y, Chambers TC, Strand D..  (2018)  Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.,  156  [PMID:30025346] [10.1016/j.ejmech.2018.07.021]

1759. Ruberte AC, Plano D, Encío I, Aydillo C, Sharma AK, Sanmartín C..  (2018)  Novel selenadiazole derivatives as selective antitumor and radical scavenging agents.,  157  [PMID:30071406] [10.1016/j.ejmech.2018.07.063]

1760. Zhang N, Yu Z, Yang X, Zhou Y, Tang Q, Hu P, Wang J, Zhang SL, Wang MW, He Y..  (2018)  Difuran-substituted quinoxalines as a novel class of PI3Kα H1047R mutant inhibitors: Synthesis, biological evaluation and structure-activity relationship.,  157  [PMID:30071408] [10.1016/j.ejmech.2018.07.061]

1761. Pontes O, Costa M, Santos F, Sampaio-Marques B, Dias T, Ludovico P, Baltazar F, Proença F..  (2018)  Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment.,  157  [PMID:30081238] [10.1016/j.ejmech.2018.07.058]

1762. Fersing C, Boudot C, Pedron J, Hutter S, Primas N, Castera-Ducros C, Bourgeade-Delmas S, Sournia-Saquet A, Moreau A, Cohen A, Stigliani JL, Pratviel G, Crozet MD, Wyllie S, Fairlamb A, Valentin A, Rathelot P, Azas N, Courtioux B, Verhaeghe P, Vanelle P..  (2018)  8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.,  157  [PMID:30092366] [10.1016/j.ejmech.2018.07.064]

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1764. Pan L, Zheng Q, Chen Y, Yang R, Yang Y, Li Z, Meng X..  (2018)  Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors.,  157  [PMID:30103191] [10.1016/j.ejmech.2018.08.013]

1765. El-Gohary NS, Shaaban MI..  (2018)  Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives.,  157  [PMID:30138804] [10.1016/j.ejmech.2018.08.008]

1766. Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja B..  (2018)  Benzothiazole carbamates and amides as antiproliferative species.,  157  [PMID:30179747] [10.1016/j.ejmech.2018.08.067]

1767. Unpublished dataset, 

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1769. El-Sayed NA, Nour MS, Salem MA, Arafa RK..  (2019)  New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.,  183  [PMID:31539778] [10.1016/j.ejmech.2019.111693]

1770. Zengin Kurt B, Sonmez F, Ozturk D, Akdemir A, Angeli A, Supuran CT..  (2019)  Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.,  183  [PMID:31542715] [10.1016/j.ejmech.2019.111702]

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1772. Soumyanarayanan U, Ramanujulu PM, Mustafa N, Haider S, Fang Nee AH, Tong JX, Tan KSW, Chng WJ, Dymock BW..  (2019)  Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.,  184  [PMID:31627059] [10.1016/j.ejmech.2019.111755]

1773. Carramiñana V, Ochoa de Retana AM, de Los Santos JM, Palacios F..  (2020)  First synthesis of merged hybrids phosphorylated azirino[2,1-b]benzo[e][1,3]oxazine derivatives as anticancer agents.,  185  [PMID:31671309] [10.1016/j.ejmech.2019.111771]

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1775. Torres Hernandez AX, Weeramange CJ, Desman P, Fatino A, Haney O, Rafferty RJ..  (2019)  Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy.,  10  (1): [PMID:30774864] [10.1039/C8MD00463C]

1776. Shi C, Zhang Y, Wang T, Lu W, Zhang S, Guo B, Chen Q, Luo C, Zhou X, Yang Y..  (2019)  Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.,  62  (6): [PMID:30698430] [10.1021/acs.jmedchem.8b01750]

1777. Sreenivasulu R, Reddy KT, Sujitha P, Kumar CG, Raju RR..  (2019)  Synthesis, antiproliferative and apoptosis induction potential activities of novel bis(indolyl)hydrazide-hydrazone derivatives.,  27  (6): [PMID:30773423] [10.1016/j.bmc.2019.02.002]

1778. Liu Y, Liang Y, Jiang J, Qin Q, Wang L, Liu X..  (2019)  Design, synthesis and biological evaluation of 1,4-dihydroxyanthraquinone derivatives as anticancer agents.,  29  (9): [PMID:30846253] [10.1016/j.bmcl.2019.02.026]

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1785. Nagaraju B, Kovvuri J, Kumar CG, Routhu SR, Shareef MA, Kadagathur M, Adiyala PR, Alavala S, Nagesh N, Kamal A..  (2019)  Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.,  27  (5): [PMID:30679134] [10.1016/j.bmc.2019.01.011]

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1787. Hammons JC, Trzoss L, Jimenez PC, Hirata AS, Costa-Lotufo LV, La Clair JJ, Fenical W..  (2019)  Advance of Seriniquinone Analogues as Melanoma Agents.,  10  (2): [PMID:30783501] [10.1021/acsmedchemlett.8b00391]

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1789. Yu HB, Glukhov E, Li Y, Iwasaki A, Gerwick L, Dorrestein PC, Jiao BH, Gerwick WH..  (2019)  Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens.,  82  (9): [PMID:31468974] [10.1021/acs.jnatprod.9b00549]

1790. Orabi MAA, Orabi EA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T..  (2019)  Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl (m-GO-m-GOG)-Type Ellagitannins from the Galls of Tamarix aphylla.,  82  (10): [PMID:31532650] [10.1021/acs.jnatprod.9b00073]

1791. Wang D, Wang Y, Ouyang Y, Fu P, Zhu W..  (2019)  Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species.,  82  (12): [PMID:31820976] [10.1021/acs.jnatprod.9b00963]

1792. Patil S, Ghosh D, Radhakrishna M, Basu S..  (2020)  Mitochondrial Impairment by Cyanine-Based Small Molecules Induces Apoptosis in Cancer Cells.,  11  (1): [PMID:31938458] [10.1021/acsmedchemlett.9b00304]

1793. Yao BR, Sun Y, Chen SL, Suo HD, Zhang YL, Wei H, Wang CH, Zhao F, Cong W, Xin WY, Hou GG..  (2019)  Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.,  167  [PMID:30771605] [10.1016/j.ejmech.2019.02.020]

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1795. Ali EMH, Abdel-Maksoud MS, Oh CH..  (2019)  Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.,  27  (7): [PMID:30826188] [10.1016/j.bmc.2019.02.044]

1796. Czopek A, Bucki A, Kołaczkowski M, Zagórska A, Drop M, Pawłowski M, Siwek A, Głuch-Lutwin M, Pękala E, Chrzanowska A, Struga M, Partyka A, Wesołowska A..  (2019)  Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.,  27  (18): [PMID:31383628] [10.1016/j.bmc.2019.07.046]

1797. Rueda-Zubiaurre A, Yahiya S, Fischer OJ, Hu X, Saunders CN, Sharma S, Straschil U, Shen J, Tate EW, Delves MJ, Baum J, Barnard A, Fuchter MJ..  (2020)  Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes.,  63  (5): [PMID:31490680] [10.1021/acs.jmedchem.9b00898]

1798. Xu Z, Zhao SJ, Liu Y..  (2019)  1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.,  183  [PMID:31546197] [10.1016/j.ejmech.2019.111700]

1799. Sittihan S, Jumpathong W, Sopha P, Ruchirawat S..  (2020)  Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives.,  30  (1): [PMID:31704206] [10.1016/j.bmcl.2019.126776]

1800. Wang L, Yang Z, Ni T, Shi W, Guo Y, Li K, Shi A, Wu S, Sheng C..  (2020)  Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity.,  30  (1): [PMID:31784322] [10.1016/j.bmcl.2019.126662]

1801. Pedron J, Boudot C, Brossas JY, Pinault E, Bourgeade-Delmas S, Sournia-Saquet A, Boutet-Robinet E, Destere A, Tronnet A, Bergé J, Bonduelle C, Deraeve C, Pratviel G, Stigliani JL, Paris L, Mazier D, Corvaisier S, Since M, Malzert-Fréon A, Wyllie S, Milne R, Fairlamb AH, Valentin A, Courtioux B, Verhaeghe P..  (2020)  New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.,  11  (4): [PMID:32292551] [10.1021/acsmedchemlett.9b00566]

1802. Liu Q, Yang X, Ji J, Zhang SL, He Y..  (2019)  Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structure-activity relationship studies.,  170  [PMID:30878835] [10.1016/j.ejmech.2019.03.011]

1803. Mrozek-Wilczkiewicz A, Malarz K, Rejmund M, Polanski J, Musiol R..  (2019)  Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety.,  171  [PMID:30921758] [10.1016/j.ejmech.2019.03.027]

1804. Draganov AB, Yang X, Anifowose A, De La Cruz LKC, Dai C, Ni N, Chen W, De Los Santos Z, Gu L, Zhou M, Wang B..  (2019)  Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.,  27  (17): [PMID:31324563] [10.1016/j.bmc.2019.07.019]

1805. Niu H, Strecker TE, Gerberich JL, Campbell JW, Saha D, Mondal D, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG..  (2019)  Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.,  62  (11): [PMID:31059248] [10.1021/acs.jmedchem.9b00551]

1806. Mrozek-Wilczkiewicz A, Kuczak M, Malarz K, Cieślik W, Spaczyńska E, Musiol R..  (2019)  The synthesis and anticancer activity of 2-styrylquinoline derivatives. A p53 independent mechanism of action.,  177  [PMID:31158748] [10.1016/j.ejmech.2019.05.061]

1807. Panice MR, Lopes SMM, Figueiredo MC, Goes Ruiz ALT, Foglio MA, Nazari Formagio AS, Sarragiotto MH, Pinho E Melo TMVD..  (2019)  New 3-tetrazolyl-β-carbolines and β-carboline-3-carboxylates with anti-cancer activity.,  179  [PMID:31247374] [10.1016/j.ejmech.2019.05.085]

1808. Allam HA, Fahim SH, F Abo-Ashour M, Nocentini A, Elbakry ME, Abdelrahman MA, Eldehna WM, Ibrahim HS, Supuran CT..  (2019)  Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.,  179  [PMID:31276899] [10.1016/j.ejmech.2019.06.081]

1809. Li ZZ, Tangadanchu VKR, Battini N, Bheemanaboina RRY, Zang ZL, Zhang SL, Zhou CH..  (2019)  Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus.,  179  [PMID:31284082] [10.1016/j.ejmech.2019.06.093]

1810. Sangshetti J, Pathan SK, Patil R, Akber Ansari S, Chhajed S, Arote R, Shinde DB..  (2019)  Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.,  27  (18): [PMID:31401008] [10.1016/j.bmc.2019.07.050]

1811. D'Ascenzio M, Secci D, Carradori S, Zara S, Guglielmi P, Cirilli R, Pierini M, Poli G, Tuccinardi T, Angeli A, Supuran CT..  (2020)  1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.,  63  (5): [PMID:31972093] [10.1021/acs.jmedchem.9b01434]

1812. Yin H, Dong J, Cai Y, Shi X, Wang H, Liu G, Tang Y, Liu J, Ma L..  (2019)  Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.,  180  [PMID:31325783] [10.1016/j.ejmech.2019.05.053]

1813. Leechaisit R, Pingaew R, Prachayasittikul V, Worachartcheewan A, Prachayasittikul S, Ruchirawat S, Prachayasittikul V..  (2019)  Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors.,  27  (19): [PMID:31416738] [10.1016/j.bmc.2019.08.001]

1814. Lu L, Zhang H, Liu J, Liu Y, Wang Y, Xu S, Zhu Z, Xu J..  (2019)  Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents.,  182  [PMID:31491611] [10.1016/j.ejmech.2019.111659]

1815. Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A..  (2019)  Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.,  27  (23): [PMID:31653441] [10.1016/j.bmc.2019.115144]

1816. Rodrigues FC, Anil Kumar NV, Thakur G..  (2019)  Developments in the anticancer activity of structurally modified curcumin: An up-to-date review.,  177  [PMID:31129455] [10.1016/j.ejmech.2019.04.058]

1817. Tang WL, Zhang Y, Hu DX, Yang H, Yu Q, Chen JW, Agama K, Pommier Y, An LK..  (2019)  Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.,  178  [PMID:31176097] [10.1016/j.ejmech.2019.05.074]

1818. Zhang J, Wang S, Ba Y, Xu Z..  (2019)  Tetrazole hybrids with potential anticancer activity.,  178  [PMID:31200236] [10.1016/j.ejmech.2019.05.071]

1819. Wang J, Li T, Zhao T, Wu T, Liu C, Ding H, Li Z, Bian J..  (2019)  Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.,  178  [PMID:31238183] [10.1016/j.ejmech.2019.06.024]

1820. Zhang J, Zhang J, Hao G, Xin W, Yang F, Zhu M, Zhou H..  (2019)  Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents.,  62  (14): [PMID:31264855] [10.1021/acs.jmedchem.9b00736]

1821. Ewies EF, El-Hussieny M, El-Sayed NF, Fouad MA..  (2019)  Design, synthesis and biological evaluation of novel α-aminophosphonate oxadiazoles via optimized iron triflate catalyzed reaction as apoptotic inducers.,  180  [PMID:31323616] [10.1016/j.ejmech.2019.07.029]

1822. Li Q, Meng L, Zhou S, Deng X, Wang N, Ji Y, Peng Y, Xing J, Yao G..  (2019)  Rapid generation of novel benzoic acid-based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study.,  180  [PMID:31336309] [10.1016/j.ejmech.2019.07.045]

1823. Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ..  (2018)  Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists.,  9  (11): [PMID:30568756] [10.1039/C8MD00313K]

1824. Francuz J, Popsavin M, Djokić S, Kojić V, Srdić-Rajić T, Rodić MV, Jakimov D, Popsavin V..  (2018)  Novel O-methyl goniofufurone and 7-epi-goniofufurone derivatives: synthesis, in vitro cytotoxicity and SAR analysis.,  9  (12): [PMID:30746062] [10.1039/C8MD00431E]

1825. Shyamsivappan S, Vivek R, Saravanan A, Arasakumar T, Subashini G, Suresh T, Shankar R, Mohan PS..  (2019)  Synthesis and X-ray study of dispiro 8-nitroquinolone analogues and their cytotoxic properties against human cervical cancer HeLa cells.,  10  (3): [PMID:31015907] [10.1039/C8MD00482J]

1826. Lee SR, Seok S, Ryoo R, Choi SU, Kim KH..  (2019)  Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.,  82  (1): [PMID:30457333] [10.1021/acs.jnatprod.8b00823]

1827. Liu W, Liang L, Zhao L, Tan H, Wu J, Qin Q, Gou X, Sun X..  (2019)  Synthesis and characterization of a photoresponsive doxorubicin/combretastatin A4 hybrid prodrug.,  29  (3): [PMID:30553736] [10.1016/j.bmcl.2018.12.017]

1828. Maguire CJ, Carlson GJ, Ford JW, Strecker TE, Hamel E, Trawick ML, Pinney KG..  (2019)  Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.,  10  (8): [PMID:31534659] [10.1039/C9MD00127A]

1829. Nichol RJO, Khalaf AI, Sooda K, Hussain O, Griffiths HBS, Phillips R, Javid FA, Suckling CJ, Allison SJ, Scott FJ..  (2019)  Selective in vitro anti-cancer activity of non-alkylating minor groove binders.,  10  (9): [PMID:32952999] [10.1039/C9MD00268E]

1830. Zhang L, Xu Z..  (2019)  Coumarin-containing hybrids and their anticancer activities.,  181  [PMID:31404864] [10.1016/j.ejmech.2019.111587]

1831. Skok Ž, Zidar N, Kikelj D, Ilaš J..  (2020)  Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets.,  63  (3): [PMID:31592646] [10.1021/acs.jmedchem.9b00726]

1832. Galiana-Roselló C, Aceves-Luquero C, González J, Martínez-Camarena Á, Villalonga R, Fernández de Mattos S, Soriano C, Llinares J, García-España E, Villalonga P, González-Rosende ME..  (2020)  Toward a Rational Design of Polyamine-Based Zinc-Chelating Agents for Cancer Therapies.,  63  (3): [PMID:31935092] [10.1021/acs.jmedchem.9b01554]

1833. Huang R, Jing X, Huang X, Pan Y, Fang Y, Liang G, Liao Z, Wang H, Chen Z, Zhang Y..  (2020)  Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.,  63  (4): [PMID:31999451] [10.1021/acs.jmedchem.9b01386]

1834. Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA, Supuran CT..  (2019)  Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.,  162  [PMID:30445264] [10.1016/j.ejmech.2018.10.068]

1835. Szczepańska K, Karcz T, Kotańska M, Siwek A, Kuder KJ, Latacz G, Mogilski S, Hagenow S, Lubelska A, Sobolewski M, Stark H, Kieć-Kononowicz K..  (2018)  Optimization and preclinical evaluation of novel histamine H₃receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives.,  26  (23-24): [PMID:30448256] [10.1016/j.bmc.2018.11.010]

1836. Xiao X, Xu M, Yang C, Yao Y, Liang LN, Ed Chung P, Long Q, Zacksenhaus E, He Z, Liu S, Ben-David Y..  (2018)  Novel racemosin B derivatives as new therapeutic agents for aggressive breast cancer.,  26  (23-24): [PMID:30471828] [10.1016/j.bmc.2018.11.014]

1837. Lin X, Tian D, Fu Y, Li Y, Huang L, Gu W, Song J, Li Y, Ben-David Y, Wen M, Yuan C, Hao X..  (2019)  Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase.,  162  [PMID:30500683] [10.1016/j.ejmech.2018.11.046]

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2033. Yuan J, Liu Z, Zhang Z, Yan D, Zhang W..  (2021)  Synthesis and biological evaluation of naphthoquinone phenacylimidazolium derivatives.,  41  [PMID:33766771] [10.1016/j.bmcl.2021.127977]

2034. Zhou S, Huang G, Chen G..  (2021)  Synthesis and anti-tumor activity of marine alkaloids.,  41  [PMID:33831559] [10.1016/j.bmcl.2021.128009]

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2038. Shawky AM, Abdalla AN, Ibrahim NA, Abourehab MAS, Gouda AM..  (2021)  Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: Design, synthesis, cytotoxicity, and MDR reversal activities.,  218  [PMID:33823396] [10.1016/j.ejmech.2021.113403]

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2041. Patle R, Shinde S, Patel S, Maheshwari R, Jariyal H, Srivastava A, Chauhan N, Globisch C, Jain A, Tekade RK, Shard A..  (2021)  Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.,  42  [PMID:33901643] [10.1016/j.bmcl.2021.128062]

2042. Cheng M, Li P, Jiang Y, Tang X, Zhang W, Wang Q, Li G..  (2021)  Penitol A and Penicitols E-I: Citrinin Derivatives from Penicillium citrinum and the Structure Revision of Previously Proposed Analogues.,  84  (4.0): [PMID:33847126] [10.1021/acs.jnatprod.1c00082]

2043. ElZahabi HSA, Nafie MS, Osman D, Elghazawy NH, Soliman DH, El-Helby AAH, Arafa RK..  (2021)  Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity.,  222  [PMID:34119830] [10.1016/j.ejmech.2021.113609]

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2046. Tikhomirov AS, Abdelhamid MAS, Nadysev GY, Zatonsky GV, Bykov EE, Chueh PJ, Waller ZAE, Shchekotikhin AE..  (2021)  Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.,  84  (5.0): [PMID:33974416] [10.1021/acs.jnatprod.1c00162]

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2048. Fairhall JM, Camilli JC, Gibson BH, Hook S, Gamble AB..  (2021)  EGFR-targeted prodrug activation using bioorthogonal alkene-azide click-and-release chemistry.,  46  [PMID:34411983] [10.1016/j.bmc.2021.116361]

2049. Uttekar PS, Yadav VD, Bhagwat DA..  (2021)  1, 2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamin (DPPE), doxorubicin and folic acid conjugated micelles for cancer management in tumor bearing BALB/c mice.,  50  [PMID:34438013] [10.1016/j.bmcl.2021.128337]

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2051. Zhou YQ, Sun Y, Luo HL, Gao ZF, Zhang HQ, Meng QG, Bai XY, Hou GG, Hou Y..  (2021)  Discovery of anti-hepatoma agents from 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine by inhibiting PI3K/AKT/NF-κB pathway activation.,  225  [PMID:34450496] [10.1016/j.ejmech.2021.113796]

2052. Saepua S, Kornsakulkarn J, Choowong W, Suriyachadkun C, Boonlarppradab C, Thongpanchang C..  (2021)  Antimicrobial and Cytotoxic Angucyclic Quinones from Actinomadura miaoliensis.,  84  (11.0): [PMID:34748348] [10.1021/acs.jnatprod.1c00232]

2053. El-Shershaby MH, Ghiaty A, Bayoumi AH, Al-Karmalawy AA, Husseiny EM, El-Zoghbi MS, Abulkhair HS..  (2021)  From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.,  42  [PMID:34126285] [10.1016/j.bmc.2021.116266]

2054. Ariztia J, Chateau A, Boura C, Didierjean C, Lamandé-Langle S, Pellegrini Moïse N..  (2021)  Synthesis of anti-proliferative [3.3.0]furofuranone derivatives by lactonization and functionalization of C-glycosyl compounds.,  45  [PMID:34325324] [10.1016/j.bmc.2021.116313]

2055. Sun J, Wang J, Wang X, Hu X, Cao H, Bai J, Li D, Hua H..  (2021)  Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer.,  45  [PMID:34365102] [10.1016/j.bmc.2021.116341]

2056. Ayoup MS, Abu-Serie MM, Abdel-Hamid H, Teleb M..  (2021)  Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.,  220  [PMID:33901898] [10.1016/j.ejmech.2021.113475]

2057. Volodina YL, Tikhomirov AS, Dezhenkova LG, Ramonova AA, Kononova AV, Andreeva DV, Kaluzhny DN, Schols D, Moisenovich MM, Shchekotikhin AE, Shtil AA..  (2021)  Thiophene-2-carboxamide derivatives of anthraquinone: A new potent antitumor chemotype.,  221  [PMID:34082225] [10.1016/j.ejmech.2021.113521]

2058. Shen Q, Dai G, Ravichandran V, Liu Y, Zhong L, Sui H, Ren X, Jiao N, Zhang Y, Zhou H, Bian X..  (2021)  Saccharochelins A-H, Cytotoxic Amphiphilic Siderophores from the Rare Marine Actinomycete Saccharothrix sp. D09.,  84  (8.0): [PMID:34323485] [10.1021/acs.jnatprod.1c00155]

2059. Li Q, Deng X, Jiang N, Meng L, Xing J, Jiang W, Xu Y..  (2021)  Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.,  225  [PMID:34399391] [10.1016/j.ejmech.2021.113765]

2060. Song H, Xing W, Shi X, Zhang T, Lou H, Fan P..  (2021)  Antitumor and toxicity study of mitochondria-targeted triptolide derivatives using triphenylphosphine (TPP⁺) as a carrier.,  50  [PMID:34700239] [10.1016/j.bmc.2021.116466]

2061. Kithsiri Wijeratne EM, Xu YM, Liu MX, Inacio MC, Brooks AD, Tewary P, Sayers TJ, Gunatilaka AAL..  (2021)  Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma.,  84  (12.0): [PMID:34851111] [10.1021/acs.jnatprod.1c00724]

2062. Melo de Oliveira VN, Flávia do Amaral Moura C, Peixoto ADS, Gonçalves Ferreira VP, Araújo HM, Lapa Montenegro Pimentel LM, Pessoa CDÓ, Nicolete R, Versiani Dos Anjos J, Sharma PP, Rathi B, Pena LJ, Rollin P, Tatibouët A, Nascimento de Oliveira R..  (2021)  Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis.,  220  [PMID:33940463] [10.1016/j.ejmech.2021.113472]

2063. Güngör T, Ozleyen A, Yılmaz YB, Siyah P, Ay M, Durdağı S, Tumer TB..  (2021)  New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects.,  221  [PMID:34077833] [10.1016/j.ejmech.2021.113566]

2064. Yu N, Li N, Wang K, Deng Q, Lei Z, Sun J, Chen L..  (2021)  Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo.,  224  [PMID:34315044] [10.1016/j.ejmech.2021.113701]

2065. Lemos BC, Westphal R, Filho EV, Fiorot RG, Carneiro JWM, Gomes ACC, Guimarães CJ, de Oliveira FCE, Costa PMS, Pessoa C, Greco SJ..  (2021)  Synthetic enamine naphthoquinone derived from lawsone as cytotoxic agents assessed by in vitro and in silico evaluations.,  53  [PMID:34715305] [10.1016/j.bmcl.2021.128419]

2066. Hu C, Li G, Mu Y, Wu W, Cao B, Wang Z, Yu H, Guan P, Han L, Li L, Huang X..  (2021)  Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones.,  64  (9.0): [PMID:33860662] [10.1021/acs.jmedchem.1c00085]

2067. Czerwonka D, Maj E, Wietrzyk J, Huczyński A..  (2021)  Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity.,  52  [PMID:34592435] [10.1016/j.bmcl.2021.128382]

2068. Murthy AVR, Narendar V, Sampath Kumar N, Aparna P, Bhavani AKD, Solhi H, Le Guevel R, Roul J, Gautier F, Juin P, Reddy CR, Mosset P, Levoin N, Grée R..  (2021)  Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.,  52  [PMID:34601029] [10.1016/j.bmcl.2021.128390]

2069. Zhang JH, Xie HX, Li Y, Wang KM, Song Z, Zhu KK, Fang L, Zhang J, Jiang CS..  (2021)  Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors.,  52  [PMID:34634473] [10.1016/j.bmcl.2021.128413]

2070. Hu MH, Lin JH..  (2021)  New Dibenzoquinoxalines Inhibit Triple-Negative Breast Cancer Growth by Dual Targeting of Topoisomerase 1 and the c-MYC G-Quadruplex.,  64  (10.0): [PMID:33961424] [10.1021/acs.jmedchem.0c02202]

2071. Mlostoń G, Kowalczyk M, Celeda M, Gach-Janczak K, Janecka A, Jasiński M..  (2021)  Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones.,  84  (12.0): [PMID:34808062] [10.1021/acs.jnatprod.1c00797]

2072. Pouny I, Long C, Batut M, Aussagues Y, Jean Valère N, Achoundong G, David B, Lavaud C, Massiot G..  (2021)  Quinolizidine Alkaloids from Cylicomorpha solmsii.,  84  (4.0): [PMID:33606529] [10.1021/acs.jnatprod.0c01261]

2073. Fan RZ, Chen L, Su T, Li W, Huang JL, Sang J, Tang GH, Yin S..  (2021)  Discovery of 8,9-seco-ent-Kaurane Diterpenoids as Potential Leads for the Treatment of Triple-Negative Breast Cancer.,  64  (14.0): [PMID:34236840] [10.1021/acs.jmedchem.1c00166]

2074. Mozaffari S, Salehi D, Mahdipoor P, Beuttler R, Tiwari R, Aliabadi HM, Parang K..  (2021)  Design and application of hybrid cyclic-linear peptide-doxorubicin conjugates as a strategy to overcome doxorubicin resistance and toxicity.,  226  [PMID:34537446] [10.1016/j.ejmech.2021.113836]

2075. Zeng Q, Nie X, Li L, Liu HF, Peng YY, Zhou WT, Hu XJ, Xu XY, Chen XL..  (2022)  Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins.,  85  (1.0): [PMID:34978808] [10.1021/acs.jnatprod.1c00950]

2076. Baldo S, Antunes P, Felicidade JF, Santos FMF, Arteaga JF, Fernandes F, Pischel U, Pinto SN, Gois PMP..  (2022)  The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib-GV1001 Conjugate.,  13  (1.0): [PMID:35059132] [10.1021/acsmedchemlett.1c00615]

2077. Ntungwe EN, Stojanov SJ, Duarte NM, Candeias NR, Díaz-Lanza AM, Vágvölgyi M, Hunyadi A, Pešić M, Rijo P..  (2022)  C₂₀-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.,  13  (4.0): [PMID:35450348] [10.1021/acsmedchemlett.1c00711]

2078. Tilekar K, Hess JD, Upadhyay N, Bianco AL, Schweipert M, Laghezza A, Loiodice F, Meyer-Almes FJ, Aguilera RJ, Lavecchia A, C S R..  (2021)  Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects.,  64  (10.0): [PMID:34006099] [10.1021/acs.jmedchem.1c00491]

2079. Feng Y, Wang W, Zhang Y, Fu X, Ping K, Zhao J, Lei Y, Mou Y, Wang S..  (2022)  Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis.,  229  [PMID:34968902] [10.1016/j.ejmech.2021.114070]

2080. Dewa AA, Elbanna AH, Khalil ZG, Capon RJ..  (2022)  Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.,  65  (3.0): [PMID:35067062] [10.1021/acs.jmedchem.1c01989]

2081. Krymov SK, Scherbakov AM, Salnikova DI, Sorokin DV, Dezhenkova LG, Ivanov IV, Vullo D, De Luca V, Capasso C, Supuran CT, Shchekotikhin AE..  (2022)  Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.,  228  [PMID:34902732] [10.1016/j.ejmech.2021.113997]

2082. Yang Q, Qiu X, Zhang X, Yu Y, Li N, Wei X, Feng G, Li Y, Zhao Y, Wang R..  (2021)  Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells.,  64  (18.0): [PMID:34506131] [10.1021/acs.jmedchem.1c00870]

2083. Fallica AN, Barbaraci C, Amata E, Pasquinucci L, Turnaturi R, Dichiara M, Intagliata S, Gariboldi MB, Marras E, Orlandi VT, Ferroni C, Martini C, Rescifina A, Gentile D, Varchi G, Marrazzo A..  (2021)  Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents.,  64  (15.0): [PMID:34319100] [10.1021/acs.jmedchem.1c00917]

2084. Qu W, Kithsiri Wijeratne EM, Bashyal BP, Xu J, Xu YM, Liu MX, Inácio MC, Arnold AE, U'Ren JM, Leslie Gunatilaka AA..  (2021)  Strobiloscyphones A-F, 6-Isopentylsphaeropsidones and Other Metabolites from Strobiloscypha sp. AZ0266, a Leaf-Associated Fungus of Douglas Fir.,  84  (9.0): [PMID:34495663] [10.1021/acs.jnatprod.1c00662]

2085. Kryshchyshyn-Dylevych A, Radko L, Finiuk N, Garazd M, Kashchak N, Posyniak A, Niemczuk K, Stoika R, Lesyk R..  (2021)  Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential.,  50  [PMID:34634616] [10.1016/j.bmc.2021.116453]

2086. Zhang K, Song W, Wei M, Sun Y, Wang N, Ma L, Yu X, Gao R, Wang R, Zhang Y, Zheng N, Li N, Mu L, Tang Z, Li X, Yang C, Yang G..  (2021)  A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells.,  64  (21.0): [PMID:34704758] [10.1021/acs.jmedchem.1c01123]

2087. Tantawy AH, El-Behairy MF, Abd-Allah WH, Jiang H, Wang MQ, Marzouk AA..  (2021)  Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites.,  64  (23.0): [PMID:34791873] [10.1021/acs.jmedchem.1c01674]

2088. Naaz F, Ahmad F, Lone BA, Khan A, Sharma K, IntzarAli, ShaharYar M, Pokharel YR, Shafi S..  (2021)  Apoptosis Inducing 1,3,4-Oxadiazole Conjugates of Capsaicin: Their In Vitro Antiproliferative and In Silico Studies.,  12  (11.0): [PMID:34795858] [10.1021/acsmedchemlett.1c00304]

2089. Sbenati RM, Semreen MH, Semreen AM, Shehata MK, Alsaghir FM, El-Gamal MI..  (2021)  Evaluation of imidazo[2,1-b]thiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects.,  29  [PMID:33316752] [10.1016/j.bmc.2020.115897]

2090. Arya GC, Kaur K, Jaitak V..  (2021)  Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.,  221  [PMID:34000484] [10.1016/j.ejmech.2021.113511]

2091. Pradhan T, Gupta O, Singh G, Monga V..  (2021)  Aurora kinase inhibitors as potential anticancer agents: Recent advances.,  221  [PMID:34020340] [10.1016/j.ejmech.2021.113495]

2092. Gong Q, Hu J, Wang P, Li X, Zhang X..  (2021)  A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.,  210  [PMID:33158575] [10.1016/j.ejmech.2020.112962]

2093. Li ML, Yuan JM, Yuan H, Wu BH, Huang SL, Li QJ, Ou TM, Wang HG, Tan JH, Li D, Chen SB, Huang ZS..  (2022)  Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex.,  65  (19.0): [PMID:36121464] [10.1021/acs.jmedchem.2c00467]

2094. Badiger KB, Khatavi SY, Kamanna K..  (2022)  Green synthesis of 3-methyl-4-(hetero)aryl methylene isoxazole-5(4H)-ones using WEOFPA/glycerol: evaluation of anticancer and electrochemical behaviour properties.,  13  (11.0): [PMID:36439979] [10.1039/d2md00191h]

2095. Lima DJB, Almeida RG, Jardim GAM, Barbosa BPA, Santos ACC, Valença WO, Scheide MR, Gatto CC, de Carvalho GGC, Costa PMS, Pessoa C, Pereira CLM, Jacob C, Braga AL, da Silva Júnior EN..  (2021)  It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.,  12  (10.0): [PMID:34778772] [10.1039/D1MD00168J]

2096. Łowicki D, Przybylski P..  (2022)  Cascade synthetic strategies opening access to medicinal-relevant aliphatic 3- and 4-membered N-heterocyclic scaffolds.,  238  [PMID:35567964] [10.1016/j.ejmech.2022.114438]

2097. Zhang G, Yin R, Dai X, Wu G, Qi X, Yu R, Li J, Jiang T..  (2022)  Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.,  241  [PMID:35932565] [10.1016/j.ejmech.2022.114610]

2098. Wei MX, Zhou YX, Lin M, Zhang J, Sun X..  (2022)  Design, synthesis and biological evaluation of rhein-piperazine-dithiocarbamate hybrids as potential anticancer agents.,  241  [PMID:35963130] [10.1016/j.ejmech.2022.114651]

2099. Sabry MA, Ghaly MA, Maarouf AR, El-Subbagh HI..  (2022)  New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity.,  241  [PMID:35964425] [10.1016/j.ejmech.2022.114661]

2100. Pokhodylo N, Finiuk N, Klyuchivska O, Тupychak MA, Matiychuk V, Goreshnik E, Stoika R..  (2022)  Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells.,  241  [PMID:35973342] [10.1016/j.ejmech.2022.114633]

2101. Venkateswara Rao B, Pavan Kumar P, Ramalingam V, Karthik G, Andugulapati SB, Suresh Babu K..  (2022)  Piperazine tethered bergenin heterocyclic hybrids: design, synthesis, anticancer activity, and molecular docking studies.,  13  (8.0): [PMID:36092140] [10.1039/d2md00116k]

2102. Popović-Djordjević J, Quispe C, Giordo R, Kostić A, Katanić Stanković JS, Tsouh Fokou PV, Carbone K, Martorell M, Kumar M, Pintus G, Sharifi-Rad J, Docea AO, Calina D..  (2022)  Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs.,  233  [PMID:35276425] [10.1016/j.ejmech.2022.114217]

2103. Finiuk N, Kryshchyshyn-Dylevych A, Holota S, Klyuchivska O, Kozytskiy A, Karpenko O, Manko N, Ivasechko I, Stoika R, Lesyk R..  (2022)  Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation.,  238  [PMID:35533562] [10.1016/j.ejmech.2022.114422]

2104. Elbadawi MM, Eldehna WM, Nocentini A, Somaa WR, Al-Rashood ST, Elkaeed EB, El Hassab MA, Abdel-Aziz HA, Supuran CT, Fares M..  (2022)  Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.,  238  [PMID:35551035] [10.1016/j.ejmech.2022.114412]

2105. Zhu H, Lu L, Zhu W, Tan Y, Duan Y, Liu J, Ye W, Zhu Z, Xu J, Xu S..  (2022)  Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties.,  240  [PMID:35803175] [10.1016/j.ejmech.2022.114575]

2106. Eissa AG, Barrow D, Gee J, Powell LE, Foster PA, Simons C..  (2022)  4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors.,  240  [PMID:35834906] [10.1016/j.ejmech.2022.114569]

2107. Jiang YY, Gao Y, Liu JY, Xu Y, Wei MY, Wang CY, Gu YC, Shao CL..  (2022)  Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo.,  65  (18.0): [PMID:36089748] [10.1021/acs.jmedchem.2c00532]

2108. Wang H, Qi H, Zhang SY, Song WS, Zhang LQ, Xiang WS, Wang JD..  (2022)  Sarubicinols A-C, Cytotoxic Benzoxazoles from a Streptomyces.,  85  (4.0): [PMID:35213166] [10.1021/acs.jnatprod.1c00820]

2109. Fu X, Mao Q, Zhang B, Lv J, Ping K, Zhang P, Lin F, Zhao J, Feng Y, Yang J, Wang H, Zhang L, Mou Y, Wang S..  (2022)  Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.,  85  (4.0): [PMID:35255689] [10.1021/acs.jnatprod.2c00104]

2110. Yazdani M, Béni Z, Dékány M, Szemerédi N, Spengler G, Hohmann J, Ványolós A..  (2022)  Triterpenes from Pholiota populnea as Cytotoxic Agents and Chemosensitizers to Overcome Multidrug Resistance of Cancer Cells.,  85  (4.0): [PMID:35293752] [10.1021/acs.jnatprod.1c01024]

2111. Moya-Garzon MD, Rodriguez-Rodriguez B, Martin-Higueras C, Franco-Montalban F, Fernandes MX, Gomez-Vidal JA, Pey AL, Salido E, Diaz-Gavilan M..  (2022)  New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.,  237  [PMID:35500475] [10.1016/j.ejmech.2022.114396]

2112. Miceli RT, Corr DT, Barroso M, Dogra N, Gross RA..  (2022)  Sophorolipids: Anti-cancer activities and mechanisms.,  65  [PMID:35526504] [10.1016/j.bmc.2022.116787]

2113. Ul Karim MR, Fukaya K, In Y, Sharma AR, Harunari E, Oku N, Urabe D, Trianto A, Igarashi Y..  (2022)  Marinoquinolones and Marinobactoic Acid: Antimicrobial and Cytotoxic ortho-Dialkylbenzene-Class Metabolites Produced by a Marine Obligate Gammaproteobacterium of the Genus Marinobacterium.,  85  (7.0): [PMID:35802519] [10.1021/acs.jnatprod.2c00281]

2114. Huang D, Liu Q, Zhang M, Guo Y, Cui Z, Li T, Luo D, Xu B, Huang C, Guo J, Tam KY, Zhang M, Zhang SL, He Y..  (2022)  A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities.,  65  (14.0): [PMID:35818137] [10.1021/acs.jmedchem.2c00640]

2115. Zhang H, Wu J, Wang J, Xiao S, Zhao L, Yan R, Wu X, Wang Z, Fan L, Jin Y..  (2022)  Novel Isoindolinone-Based Analogs of the Natural Cyclic Peptide Fenestin A: Synthesis and Antitumor Activity.,  13  (7.0): [PMID:35859879] [10.1021/acsmedchemlett.2c00149]

2116. Wang G, Sun S, Guo H..  (2022)  Current status of carbazole hybrids as anticancer agents.,  229  [PMID:34838335] [10.1016/j.ejmech.2021.113999]

2117. Łowicki D, Przybylski P..  (2022)  Tandem construction of biological relevant aliphatic 5-membered N-heterocycles.,  235  [PMID:35344904] [10.1016/j.ejmech.2022.114303]

2118. Pósa SP, Dargó G, Nagy S, Kisszékelyi P, Garádi Z, Hámori L, Szakács G, Kupai J, Tóth S..  (2022)  Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.,  67  [PMID:35640378] [10.1016/j.bmc.2022.116855]

2119. He S, Liu Y, Chu X, Li Q, Lyu W, Liu Y, Xing S, Feng F, Liu W, Guo Q, Zhao L, Sun H..  (2022)  Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance.,  13  (8.0): [PMID:35978698] [10.1021/acsmedchemlett.2c00175]

2120. Abd El-Meguid EA, Naglah AM, Moustafa GO, Awad HM, El Kerdawy AM..  (2022)  Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies.,  58  [PMID:35007724] [10.1016/j.bmcl.2022.128529]

2121. Wu T, Salim AA, Cui H, Khalil ZG, Bernhardt PV, Capon RJ..  (2022)  Glenthenamines A-F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived Streptomyces sp. CMB-PB042.,  85  (2.0): [PMID:35073486] [10.1021/acs.jnatprod.1c00821]

2122. Valipour M..  (2022)  Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.,  235  [PMID:35367708] [10.1016/j.ejmech.2022.114314]

2123. Kadagathur M, Patra S, Devabattula G, George J, Phanindranath R, Shaikh AS, Sigalapalli DK, Godugu C, Nagesh N, Tangellamudi ND, Shankaraiah N..  (2022)  Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors.,  238  [PMID:35635947] [10.1016/j.ejmech.2022.114465]

2124. Fernández-Bobey A, Pinto MEF, de Almeida LC, de Souza BM, Dias NB, de Paula-Souza J, Cilli EM, Lopes NP, Costa-Lotufo LV, Palma MS, da Silva Bolzani V..  (2022)  Cytotoxic Cyclotides from Anchietea pyrifolia, a South American Plant Species.,  85  (9.0): [PMID:36044031] [10.1021/acs.jnatprod.1c01129]

2125. Jin J, Holland DC, Carroll AR, Zunk M..  (2022)  Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse (Echium plantagineum).,  85  (10.0): [PMID:36126331] [10.1021/acs.jnatprod.2c00151]

2126. Chen C, Luo Y, Yin H, Zhong Q, Zheng S, Liu R, Zhao C, Wang G, He L..  (2022)  Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones.,  60  [PMID:35255412] [10.1016/j.bmc.2022.116626]

2127. Çiçek SS, Galarza Pérez M, Wenzel-Storjohann A, Bezerra RM, Segovia JFO, Girreser U, Kanzaki I, Tasdemir D..  (2022)  Antimicrobial Prenylated Isoflavones from the Leaves of the Amazonian Medicinal Plant Vatairea guianensis Aubl.,  85  (4.0): [PMID:35271771] [10.1021/acs.jnatprod.1c01035]

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2137. Waly OM, Saad KM, El-Subbagh HI, Bayomi SM, Ghaly MA..  (2022)  Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.,  231  [PMID:35101650] [10.1016/j.ejmech.2022.114152]

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2180. Huang X, Chen Y, Zhong W, Liu Z, Zhang H, Zhang B, Wang H..  (2022)  Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment.,  244  [PMID:36252396] [10.1016/j.ejmech.2022.114817]

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Source

Source(18):

• Scientific Literature
• Sanger Institute Genomics of Drug Sensitivity in Cancer
• PubChem BioAssays
• Clinical Candidates
• Open TG-GATEs
• USP Dictionary of USAN and International Drug Names
• DrugMatrix
• TP-search Transporter Database
• Harvard Malaria Screening
• Gene Expression Atlas Compounds
• FDA Approval Packages
• Curated Drug Metabolism Pathways
• HeCaToS Compounds
• Patent Bioactivity Data
• WHO Anatomical Therapeutic Chemical Classification
• Active Ingredient of a Prodrug
• IMI-CARE SARS-CoV-2 Data
• Fraunhofer HDAC6