(S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide

ID: ALA569280

Chembl Id: CHEMBL569280

PubChem CID: 45486346

Max Phase: Preclinical

Molecular Formula: C30H53N13O4

Molecular Weight: 659.84

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCNC(=N)N

Standard InChI:  InChI=1S/C30H53N13O4/c1-19(2)24(27(47)42-21(12-8-16-39-29(33)34)25(45)37-14-6-7-15-38-28(31)32)43-26(46)22(13-9-17-40-30(35)36)41-23(44)18-20-10-4-3-5-11-20/h3-5,10-11,19,21-22,24H,6-9,12-18H2,1-2H3,(H,37,45)(H,41,44)(H,42,47)(H,43,46)(H4,31,32,38)(H4,33,34,39)(H4,35,36,40)/t21-,22-,24-/m0/s1

Standard InChI Key:  ACPMDCNBPZRQGO-FIXSFTCYSA-N

Associated Targets(Human)

FURIN Tchem Furin (909 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK6 Tchem Subtilisin/kexin type 6 (163 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK1 Tchem Prohormone convertase 1 (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK5 Tchem Subtilisin/kexin type 5 (16 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F10 Tclin Coagulation factor X (9693 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLG Tclin Plasminogen (2339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK7 Tchem Subtilisin/kexin type 7 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PCSK2 Tchem Prohormone convertase 2 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 659.84Molecular Weight (Monoisotopic): 659.4343AlogP: -1.75#Rotatable Bonds: 22
Polar Surface Area: 302.10Molecular Species: BASEHBA: 7HBD: 13
#RO5 Violations: 2HBA (Lipinski): 17HBD (Lipinski): 16#RO5 Violations (Lipinski): 3
CX Acidic pKa: 12.09CX Basic pKa: 11.83CX LogP: -2.76CX LogD: -9.30
Aromatic Rings: 1Heavy Atoms: 47QED Weighted: 0.04Np Likeness Score: -0.10

References

1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T..  (2010)  Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.,  53  (3): [PMID:20038105] [10.1021/jm9012455]

Source