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N-Acetyl-4-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-yl)-2-carboxybenzenesulfonamide ID: ALA571852
Chembl Id: CHEMBL571852
PubChem CID: 45487114
Max Phase: Preclinical
Molecular Formula: C15H12F2N2O6S
Molecular Weight: 386.33
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: CC(=O)NS(=O)(=O)c1ccc(-c2ccn(C(F)F)c(=O)c2)cc1C(=O)O
Standard InChI: InChI=1S/C15H12F2N2O6S/c1-8(20)18-26(24,25)12-3-2-9(6-11(12)14(22)23)10-4-5-19(15(16)17)13(21)7-10/h2-7,15H,1H3,(H,18,20)(H,22,23)
Standard InChI Key: QWGFBJWNBZWBPO-UHFFFAOYSA-N
Associated Targets(Human) Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 386.33Molecular Weight (Monoisotopic): 386.0384AlogP: 1.43#Rotatable Bonds: 5Polar Surface Area: 122.54Molecular Species: ACIDHBA: 6HBD: 2#RO5 Violations: ┄HBA (Lipinski): 8HBD (Lipinski): 2#RO5 Violations (Lipinski): ┄CX Acidic pKa: 2.05CX Basic pKa: ┄CX LogP: 0.94CX LogD: -3.53Aromatic Rings: 2Heavy Atoms: 26QED Weighted: 0.80Np Likeness Score: -0.97
References 1. Chowdhury MA, Abdellatif KR, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE.. (2009) Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity., 19 (24): [PMID:19884005 ] [10.1016/j.bmcl.2009.10.083 ]