CuSO4.5H2O

ID: ALA604

Max Phase: Approved

First Approval: 1987

Molecular Formula: CuO4S

Molecular Weight: 159.61

Molecule Type: Small molecule

Associated Items:

Alternative Forms

  1. Parent:

Associated Targets(Human)

TET1 Tbio Methylcytosine dioxygenase TET1 (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TET2 Tchem Methylcytosine dioxygenase TET2 (57 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mycoplasmoides gallisepticum (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hyaloperonospora parasitica (23 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Microcystis aeruginosa (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Synechocystis sp. PCC 6803 (30 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: Yes
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: YesAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 159.61Molecular Weight (Monoisotopic): 158.8813AlogP: #Rotatable Bonds:
Polar Surface Area: Molecular Species: HBA: HBD:
#RO5 Violations: HBA (Lipinski): HBD (Lipinski): #RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: CX LogP: CX LogD:
Aromatic Rings: Heavy Atoms: QED Weighted: Np Likeness Score:

References

1. de Zwart MA, Bastiaans HM, van der Goot H, Timmerman H..  (1991)  Synthesis and copper-dependent antimycoplasmal activity of amides and amidines derived from 2-amino-1,10-phenanthroline.,  34  (3): [PMID:2002460] [10.1021/jm00107a045]
2. Carter JP, Noronha-Blob L, Audia VH, Dupont AC, McPherson DW, Natalie KJ, Rzeszotarski WJ, Spagnuolo CJ, Waid PP, Kaiser C..  (1991)  Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds.,  34  (10): [PMID:1920357] [10.1021/jm00114a016]
3. de Zwart MA, van der Goot H, Timmerman H..  (1989)  Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines.,  32  (2): [PMID:2913309] [10.1021/jm00122a033]
4. de Zwart MA, van der Goot H, Timmerman H..  (1988)  Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides.,  31  (4): [PMID:3351847] [10.1021/jm00399a005]
5. Unpublished dataset, 
6. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, 
7. van der Wolf JM, Michta A, van der Zouwen PS, de Boer WJ, Davelaar E, Stevens LH..  (2012)  Seed and leaf treatments with natural compounds to induce resistance against Peronospora parasitica in Brassica oleracea,  35  [10.1016/j.cropro.2012.01.008]
8. WHO Anatomical Therapeutic Chemical Classification, 
9. Feng J, He H, Zhou Y, Guo X, Liu H, Cai M, Wang F, Feng L, He H..  (2019)  Design, synthesis and biological evaluation of novel inhibitors against cyanobacterial pyruvate dehydrogenase multienzyme complex E1.,  27  (12): [PMID:30692021] [10.1016/j.bmc.2019.01.021]
10. Weirath NA, Hurben AK, Chao C, Pujari SS, Cheng T, Liu S, Tretyakova NY..  (2022)  Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II).,  13  (5.0): [PMID:35586434] [10.1021/acsmedchemlett.1c00677]