| 1. Kim CU, Misco PF, Haynes UJ, McGregor DN.. (1984) Synthesis and antibacterial activity of 2-[(methoxycarbonyl)methylene]cephalosporins., 27 (9): [PMID:6471077] [10.1021/jm00375a026] |
| 2. Indelicato JM, Pasini CE.. (1988) The acylating potential of gamma-lactam antibacterials: base hydrolysis of bicyclic pyrazolidinones., 31 (6): [PMID:3373491] [10.1021/jm00401a026] |
| 3. Sol V, Branland P, Granet R, Kaldapa C, Verneuil B, Krausz P.. (1998) Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria., 8 (21): [PMID:9873665] [10.1016/s0960-894x(98)00536-8] |
| 4. Adediran SA, Cabaret D, Pratt RF, Wakselman M.. (1999) A "cephalosporin-like" cyclic depsipeptide: synthesis and reaction with beta-lactam-recognizing enzymes., 9 (3): [PMID:10091681] [10.1016/s0960-894x(98)00739-2] |
| 5. Böhme EH, Bambury RE, Baumann RJ, Erickson RC, Harrison BL, Hoffman PF, McCarty FJ, Schnettler RA, Vaal MJ, Wenstrup DL.. (1980) Orally active cephalosporins and penicillins., 23 (4): [PMID:7381838] [10.1021/jm00178a011] |
| 6. Hannah J, Johnson CR, Wagner AF, Walton E.. (1982) Quaternary heterocyclylamino beta-lactams: a generic alternative to the classical acylamino side chain., 25 (4): [PMID:7069725] [10.1021/jm00346a024] |
| 7. Bounkhala Z, Renard C, Baurain R, Marchand-Brynaert J, Ghosez L, Tulkens PM.. (1988) Coupling products of amino acids to penicillin V and cephalothin: synthesis and susceptibility to carboxypeptidases and lysosomal enzymes., 31 (5): [PMID:3129562] [10.1021/jm00400a015] |
| 8. Díaz N, Suárez D, Merz KM, Sordo TL.. (2005) Molecular dynamics simulations of the TEM-1 beta-lactamase complexed with cephalothin., 48 (3): [PMID:15689162] [10.1021/jm0493663] |
| 9. Adediran SA, Cabaret D, Lohier JF, Wakselman M, Pratt RF.. (2004) Benzopyranones with retro-amide side chains as (inhibitory) beta-lactamase substrates., 14 (20): [PMID:15380211] [10.1016/j.bmcl.2004.07.067] |
| 10. Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I.. (2005) Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1., 48 (13): [PMID:15974593] [10.1021/jm048982w] |
| 11. Chen S, Cui S, McDermott PF, Zhao S, White DG, Paulsen I, Meng J.. (2007) Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials., 51 (2): [PMID:17043131] [10.1128/aac.00600-06] |
| 12. Poirel L, Cattoir V, Soares A, Soussy CJ, Nordmann P.. (2007) Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1., 51 (2): [PMID:17116662] [10.1128/aac.01082-06] |
| 13. Robin F, Delmas J, Schweitzer C, Tournilhac O, Lesens O, Chanal C, Bonnet R.. (2007) Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient., 51 (4): [PMID:17220412] [10.1128/aac.01058-06] |
| 14. Wu JJ, Ko WC, Tsai SH, Yan JJ.. (2007) Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital., 51 (4): [PMID:17242140] [10.1128/aac.01195-06] |
| 15. Naas T, Aubert D, Ozcan A, Nordmann P.. (2007) Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii., 51 (4): [PMID:17242148] [10.1128/aac.01152-06] |
| 16. Morandi S, Morandi F, Caselli E, Shoichet BK, Prati F.. (2008) Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors., 16 (3): [PMID:17997318] [10.1016/j.bmc.2007.10.075] |
| 17. Mendonça N, Leitão J, Manageiro V, Ferreira E, Caniça M.. (2007) Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal., 51 (6): [PMID:17371815] [10.1128/aac.01412-06] |
| 18. Poirel L, Corvec S, Rapoport M, Mugnier P, Petroni A, Pasteran F, Faccone D, Galas M, Drugeon H, Cattoir V, Nordmann P.. (2007) Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina., 51 (6): [PMID:17420213] [10.1128/aac.01600-06] |
| 19. Kwon DH, Lu CD.. (2007) Polyamine effects on antibiotic susceptibility in bacteria., 51 (6): [PMID:17438056] [10.1128/aac.01472-06] |
| 20. Papagiannitsis CC, Loli A, Tzouvelekis LS, Tzelepi E, Arlet G, Miriagou V.. (2007) SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli., 51 (6): [PMID:17353248] [10.1128/aac.01439-06] |
| 21. Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.. (2008) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors., 51 (21): [PMID:18834112] [10.1021/jm800656v] |
| 22. Papagiannitsis CC, Tzouvelekis LS, Tzelepi E, Miriagou V.. (2007) Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli., 51 (10): [PMID:17664321] [10.1128/aac.00389-07] |
| 23. Lartigue MF, Zinsius C, Wenger A, Bille J, Poirel L, Nordmann P.. (2007) Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland., 51 (8): [PMID:17470647] [10.1128/aac.01614-06] |
| 24. Suvorov M, Vakulenko SB, Mobashery S.. (2007) Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance., 51 (8): [PMID:17502412] [10.1128/aac.00011-07] |
| 25. Pérez A, Canle D, Latasa C, Poza M, Beceiro A, Tomás Mdel M, Fernández A, Mallo S, Pérez S, Molina F, Villanueva R, Lasa I, Bou G.. (2007) Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate., 51 (9): [PMID:17638702] [10.1128/aac.00072-07] |
| 26. Girlich D, Leclercq R, Naas T, Nordmann P.. (2007) Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii., 51 (11): [PMID:17846134] [10.1128/aac.00537-07] |
| 27. Neuwirth C, Siebor E, Robin F, Bonnet R.. (2007) First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France., 51 (12): [PMID:17938180] [10.1128/aac.01462-06] |
| 28. Fonseca F, Sarmento AC, Henriques I, Samyn B, van Beeumen J, Domingues P, Domingues MR, Saavedra MJ, Correia A.. (2007) Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase., 51 (12): [PMID:17875998] [10.1128/aac.00491-07] |
| 29. Robin F, Delmas J, Brebion A, Dubois D, Constantin JM, Bonnet R.. (2007) TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases., 51 (11): [PMID:17709463] [10.1128/aac.00614-07] |
| 30. Power P, Di Conza J, Rodríguez MM, Ghiglione B, Ayala JA, Casellas JM, Radice M, Gutkind G.. (2007) Biochemical characterization of PER-2 and genetic environment of blaPER-2., 51 (7): [PMID:17438050] [10.1128/aac.01395-06] |
| 31. Morio F, Jean-Pierre H, Dubreuil L, Jumas-Bilak E, Calvet L, Mercier G, Devine R, Marchandin H.. (2007) Antimicrobial susceptibilities and clinical sources of Dialister species., 51 (12): [PMID:17923492] [10.1128/aac.00538-07] |
| 32. Meziane-Cherif D, Decré D, Høiby EA, Courvalin P, Périchon B.. (2008) Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens., 52 (2): [PMID:18070972] [10.1128/aac.01145-07] |
| 33. Zong Z, Partridge SR, Iredell JR.. (2008) RmtC 16S rRNA methyltransferase in Australia., 52 (2): [PMID:18025117] [10.1128/aac.01399-07] |
| 34. Cuzon G, Naas T, Demachy MC, Nordmann P.. (2008) Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece., 52 (2): [PMID:18056283] [10.1128/aac.01180-07] |
| 35. Miguet L, Zervosen A, Gerards T, Pasha FA, Luxen A, Distèche-Nguyen M, Thomas A.. (2009) Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening., 52 (19): [PMID:19746934] [10.1021/jm900625q] |
| 36. Pohlmann J, Vasilevich NI, Glushkov AI, Kellenberger L, Shapiro S, Caspers P, Page MG, Danel F.. (2010) Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams., 20 (15): [PMID:20576430] [10.1016/j.bmcl.2010.05.110] |
| 37. Girlich D, Poirel L, Nordmann P.. (2010) Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France., 54 (1): [PMID:19901091] [10.1128/aac.00961-09] |
| 38. Doublet B, Robin F, Casin I, Fabre L, Le Fleche A, Bonnet R, Weill FX.. (2010) Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola., 54 (1): [PMID:19884377] [10.1128/aac.00427-09] |
| 39. Robin F, Aggoune-Khinache N, Delmas J, Naim M, Bonnet R.. (2010) Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria., 54 (1): [PMID:19901092] [10.1128/aac.00017-09] |
| 40. Girlich D, Poirel L, Nordmann P.. (2010) First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate., 54 (1): [PMID:19884362] [10.1128/aac.00861-09] |
| 41. Poirel L, Docquier JD, De Luca F, Verlinde A, Ide L, Rossolini GM, Nordmann P.. (2010) BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa., 54 (1): [PMID:19884378] [10.1128/aac.00859-09] |
| 42. Kotsakis SD, Papagiannitsis CC, Tzelepi E, Legakis NJ, Miriagou V, Tzouvelekis LS.. (2010) GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa., 54 (3): [PMID:20065056] [10.1128/aac.01561-09] |
| 43. Bondock S, Fadaly W, Metwally MA.. (2010) Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety., 45 (9): [PMID:20605657] [10.1016/j.ejmech.2010.05.018] |
| 44. Gozalbes R, Pineda-Lucena A.. (2010) QSAR-based solubility model for drug-like compounds., 18 (19): [PMID:20810286] [10.1016/j.bmc.2010.08.003] |
| 45. Mendonça N, Manageiro V, Bonnet R, Caniça M.. (2008) Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae., 52 (5): [PMID:18316524] [10.1128/aac.01525-07] |
| 46. Carrër A, Poirel L, Yilmaz M, Akan OA, Feriha C, Cuzon G, Matar G, Honderlick P, Nordmann P.. (2010) Spread of OXA-48-encoding plasmid in Turkey and beyond., 54 (3): [PMID:20086157] [10.1128/aac.01312-09] |
| 47. De Luca F, Giraud-Morin C, Rossolini GM, Docquier JD, Fosse T.. (2010) Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes., 54 (4): [PMID:20124004] [10.1128/aac.01252-09] |
| 48. Nannini EC, Stryjewski ME, Singh KV, Rude TH, Corey GR, Fowler VG, Murray BE.. (2010) Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus., 54 (5): [PMID:20211890] [10.1128/aac.01325-09] |
| 49. Poirel L, Rodríguez-Martínez JM, Al Naiemi N, Debets-Ossenkopp YJ, Nordmann P.. (2010) Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands., 54 (6): [PMID:20308383] [10.1128/aac.01456-09] |
| 50. Mendonça N, Manageiro V, Robin F, Salgado MJ, Ferreira E, Caniça M, Bonnet R.. (2008) The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition., 52 (5): [PMID:18316518] [10.1128/aac.01381-07] |
| 51. Naas T, Cuzon G, Villegas MV, Lartigue MF, Quinn JP, Nordmann P.. (2008) Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene., 52 (4): [PMID:18227185] [10.1128/aac.01451-07] |
| 52. Poirel L, Mansour W, Bouallegue O, Nordmann P.. (2008) Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97., 52 (5): [PMID:18299404] [10.1128/aac.00978-07] |
| 53. Marchiaro P, Tomatis PE, Mussi MA, Pasteran F, Viale AM, Limansky AS, Vila AJ.. (2008) Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain., 52 (6): [PMID:18362187] [10.1128/aac.01025-07] |
| 54. Manageiro V, Ferreira E, Albuquerque L, Bonnet R, Caniça M.. (2010) Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain., 54 (5): [PMID:20211886] [10.1128/aac.01442-09] |
| 55. Guillon H, Eb F, Mammeri H.. (2010) Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena., 54 (5): [PMID:20308380] [10.1128/aac.00791-09] |
| 56. Meziane-Cherif D, Lambert T, Dupêchez M, Courvalin P, Galimand M.. (2008) Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442., 52 (4): [PMID:18212108] [10.1128/aac.00684-07] |
| 57. Doi Y, Poirel L, Paterson DL, Nordmann P.. (2008) Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans., 52 (6): [PMID:18362192] [10.1128/aac.01463-07] |
| 58. Stoczko M, Frère JM, Rossolini GM, Docquier JD.. (2008) Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora., 52 (7): [PMID:18443127] [10.1128/aac.01062-07] |
| 59. Marti S, Sánchez-Céspedes J, Blasco MD, Ruiz M, Espinal P, Alba V, Fernández-Cuenca F, Pascual A, Vila J.. (2008) Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate., 52 (8): [PMID:18505859] [10.1128/aac.00072-08] |
| 60. Pränting M, Negrea A, Rhen M, Andersson DI.. (2008) Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2., 52 (8): [PMID:18519732] [10.1128/aac.00205-08] |
| 61. Samuelsen Ø, Castanheira M, Walsh TR, Spencer J.. (2008) Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family., 52 (8): [PMID:18559652] [10.1128/aac.00166-08] |
| 62. Petrella S, Ziental-Gelus N, Mayer C, Renard M, Jarlier V, Sougakoff W.. (2008) Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France., 52 (10): [PMID:18625772] [10.1128/aac.00163-08] |
| 63. Dubois V, Poirel L, Demarthe F, Arpin C, Coulange L, Minarini LA, Bezian MC, Nordmann P, Quentin C.. (2008) Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae., 52 (10): [PMID:18663019] [10.1128/aac.00387-08] |
| 64. Picão RC, Poirel L, Demarta A, Petrini O, Corvaglia AR, Nordmann P.. (2008) Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland., 52 (9): [PMID:18644966] [10.1128/aac.00770-08] |
| 65. Mammeri H, Galleni M, Nordmann P.. (2009) Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli., 53 (1): [PMID:19001118] [10.1128/aac.00608-08] |
| 66. Cattoir V, Poirel L, Nordmann P.. (2008) Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France., 52 (10): [PMID:18644958] [10.1128/aac.00638-08] |
| 67. Rodríguez MM, Power P, Sader H, Galleni M, Gutkind G.. (2010) Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup., 54 (7): [PMID:20421403] [10.1128/aac.01615-09] |
| 68. Cuzon G, Naas T, Bogaerts P, Glupczynski Y, Huang TD, Nordmann P.. (2008) Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium., 52 (9): [PMID:18644970] [10.1128/aac.00543-08] |
| 69. Juan C, Beceiro A, Gutiérrez O, Albertí S, Garau M, Pérez JL, Bou G, Oliver A.. (2008) Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain., 52 (10): [PMID:18644957] [10.1128/aac.00465-08] |
| 70. PubChem BioAssay data set, |
| 71. PubChem BioAssay data set, |
| 72. Obach RS, Lombardo F, Waters NJ.. (2008) Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds., 36 (7): [PMID:18426954] [10.1124/dmd.108.020479] |
| 73. Wolter DJ, Kurpiel PM, Woodford N, Palepou MF, Goering RV, Hanson ND.. (2009) Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4., 53 (2): [PMID:19015357] [10.1128/aac.00734-08] |
| 74. Cui L, Neoh HM, Shoji M, Hiramatsu K.. (2009) Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus., 53 (3): [PMID:19124662] [10.1128/aac.01173-08] |
| 75. Nagano Y, Nagano N, Wachino J, Ishikawa K, Arakawa Y.. (2009) Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime., 53 (1): [PMID:18955524] [10.1128/aac.00227-08] |
| 76. Rodríguez-Martínez JM, Poirel L, Nordmann P.. (2009) Extended-spectrum cephalosporinases in Pseudomonas aeruginosa., 53 (5): [PMID:19258272] [10.1128/aac.01410-08] |
| 77. Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.. (2010) Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase., 54 (7): [PMID:20421396] [10.1128/aac.00197-10] |
| 78. Pradel N, Delmas J, Wu LF, Santini CL, Bonnet R.. (2009) Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane., 53 (1): [PMID:18981261] [10.1128/aac.00642-08] |
| 79. Poirel L, Rodriguez-Martinez JM, Plésiat P, Nordmann P.. (2009) Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex., 53 (3): [PMID:19075063] [10.1128/aac.00946-08] |
| 80. Zioga A, Whichard JM, Kotsakis SD, Tzouvelekis LS, Tzelepi E, Miriagou V.. (2009) CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids., 53 (3): [PMID:19104021] [10.1128/aac.01284-08] |
| 81. Zeba B, De Luca F, Dubus A, Delmarcelle M, Simporé J, Nacoulma OG, Rossolini GM, Frère JM, Docquier JD.. (2009) IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso., 53 (10): [PMID:19651915] [10.1128/aac.01607-08] |
| 82. Duval V, Nicoloff H, Levy SB.. (2009) Combined inactivation of lon and ycgE decreases multidrug susceptibility by reducing the amount of OmpF porin in Escherichia coli., 53 (11): [PMID:19721064] [10.1128/aac.00787-09] |
| 83. Dalley AJ, Deans R, Lipman J, Venkatesh B, Rudd M, Roberts MS, Cross SE.. (2009) Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury., 53 (12): [PMID:19752272] [10.1128/aac.01600-08] |
| 84. Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR.. (2009) Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India., 53 (12): [PMID:19770275] [10.1128/aac.00774-09] |
| 85. Higgins PG, Poirel L, Lehmann M, Nordmann P, Seifert H.. (2009) OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii., 53 (12): [PMID:19770279] [10.1128/aac.00856-09] |
| 86. Nakao K, Tanaka K, Ichiishi S, Mikamo H, Shibata T, Watanabe K.. (2009) Susceptibilities of 23 Desulfovibrio isolates from humans., 53 (12): [PMID:19786606] [10.1128/aac.00630-09] |
| 87. Rodríguez-Martínez JM, Nordmann P, Ronco E, Poirel L.. (2010) Extended-spectrum cephalosporinase in Acinetobacter baumannii., 54 (8): [PMID:20547808] [10.1128/aac.00050-10] |
| 88. Dalley AJ, Lipman J, Deans R, Venkatesh B, Rudd M, Roberts MS, Cross SE.. (2009) Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers., 53 (1): [PMID:18955521] [10.1128/aac.00718-08] |
| 89. Beceiro A, Pérez A, Fernández-Cuenca F, Martínez-Martínez L, Pascual A, Vila J, Rodríguez-Baño J, Cisneros JM, Pachón J, Bou G, Spanish Group for Nosocomial Infection (GEIH).. (2009) Genetic variability among ampC genes from acinetobacter genomic species 3., 53 (3): [PMID:19029333] [10.1128/aac.00485-08] |
| 90. Doublet B, Granier SA, Robin F, Bonnet R, Fabre L, Brisabois A, Cloeckaert A, Weill FX.. (2009) Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg., 53 (5): [PMID:19273683] [10.1128/aac.01581-08] |
| 91. Potron A, Poirel L, Croizé J, Chanteperdrix V, Nordmann P.. (2009) Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii., 53 (7): [PMID:19380596] [10.1128/aac.01164-08] |
| 92. Hu WS, Lin JF, Lin YH, Chang HY.. (2009) Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium., 53 (8): [PMID:19470505] [10.1128/aac.00079-09] |
| 93. Kotsakis SD, Papagiannitsis CC, Tzelepi E, Tzouvelekis LS, Miriagou V.. (2009) Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase., 53 (8): [PMID:19470510] [10.1128/aac.00219-09] |
| 94. Griggs DJ, Peake L, Johnson MM, Ghori S, Mott A, Piddock LJ.. (2009) Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni., 53 (8): [PMID:19506058] [10.1128/aac.01655-08] |
| 95. Collins B, Curtis N, Cotter PD, Hill C, Ross RP.. (2010) The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics., 54 (10): [PMID:20643901] [10.1128/aac.00503-10] |
| 96. Girlich D, Poirel L, Nordmann P.. (2010) PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila., 54 (4): [PMID:20145085] [10.1128/aac.01585-09] |
| 97. Borgianni L, Vandenameele J, Matagne A, Bini L, Bonomo RA, Frère JM, Rossolini GM, Docquier JD.. (2010) Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding., 54 (8): [PMID:20498317] [10.1128/aac.01336-09] |
| 98. Kotsakis SD, Miriagou V, Tzelepi E, Tzouvelekis LS.. (2010) Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases., 54 (11): [PMID:20696873] [10.1128/aac.00771-10] |
| 99. Docquier JD, Benvenuti M, Calderone V, Stoczko M, Menciassi N, Rossolini GM, Mangani S.. (2010) High-resolution crystal structure of the subclass B3 metallo-beta-lactamase BJP-1: rational basis for substrate specificity and interaction with sulfonamides., 54 (10): [PMID:20696874] [10.1128/aac.00409-10] |
| 100. Borgianni L, Prandi S, Salden L, Santella G, Hanson ND, Rossolini GM, Docquier JD.. (2011) Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States., 55 (1): [PMID:21041509] [10.1128/aac.00858-10] |
| 101. Shimizu-Ibuka A, Oishi M, Yamada S, Ishii Y, Mura K, Sakai H, Matsuzawa H.. (2011) Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1., 55 (1): [PMID:21078949] [10.1128/aac.00098-10] |
| 102. Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.. (2010) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species., 23 (1): [PMID:20014752] [10.1021/tx900326k] |
| 103. PubChem BioAssay data set, |
| 104. Bondock S, Khalifa W, Fadda AA.. (2011) Synthesis and antimicrobial activity of some new 4-hetarylpyrazole and furo[2,3-c]pyrazole derivatives., 46 (6): [PMID:21489661] [10.1016/j.ejmech.2011.03.045] |
| 105. Pedretti A, De Luca L, Marconi C, Regazzoni L, Aldini G, Vistoli G.. (2011) Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping., 19 (15): [PMID:21741846] [10.1016/j.bmc.2011.06.027] |
| 106. Sarkar A, Anderson KC, Kellogg GE.. (2012) Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics., 52 [PMID:22483632] [10.1016/j.ejmech.2012.03.008] |
| 107. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H.. (1999) The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1., 290 (1): [PMID:10411577] |
| 108. Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H.. (2002) Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1., 70 (1): [PMID:12005172] [10.1016/s0024-3205(02)01500-x] |
| 109. Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H.. (2003) Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics., 465 (1): [PMID:12650826] [10.1016/s0014-2999(03)01381-5] |
| 110. Luckner P, Brandsch M.. (2005) Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1., 59 (1): [PMID:15567297] [10.1016/j.ejpb.2004.07.008] |
| 111. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A.. (1999) Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance., 291 (1): [PMID:10525100] |
| 112. Takeda M, Babu E, Narikawa S, Endou H.. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics., 438 (1): [PMID:11909604] [10.1016/s0014-2999(02)01306-7] |
| 113. Patel MA, Bhila VG, Patel NH, Patel AK, Brahmbhatt DI. (2012) Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives, 21 (12): [10.1007/s00044-012-9978-0] |
| 114. Habib OMO, Hassan HM, El-Mekabaty A. (2013) Novel quinazolinone derivatives: synthesis and antimicrobial activity, 22 (2): [10.1007/s00044-012-0079-x] |
| 115. Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA.. (2013) Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase., 56 (3): [PMID:23252553] [10.1021/jm301490d] |
| 116. Fadda AA, Afsah el-SM, Awad RS.. (2013) Synthesis and antimicrobial activity of some new benzo and naphthonitrile derivatives., 60 [PMID:23318903] [10.1016/j.ejmech.2012.11.017] |
| 117. Unpublished dataset, |
| 118. Unpublished dataset, |
| 119. Unpublished dataset, |
| 120. Dave K, Palzkill T, Pratt RF.. (2014) Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA., 5 (2): [PMID:24900789] [10.1021/ml400408c] |
| 121. Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.. (2004) [Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs]., 28 (8-9): [PMID:15646539] [10.1016/s0399-8320(04)95062-2] |
| 122. PubChem BioAssay data set, |
| 123. PubChem BioAssay data set, |
| 124. Narisada M, Yoshida T, Onoue H, Ohtani M, Okada T, Tsuji T, Kikkawa I, Haga N, Satoh H, Itani H, Nagata W.. (1979) Synthetic studies on beta-lactam antibiotics. Part 101. Synthesis of 7beta-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems., 22 (7): [PMID:448673] [10.1021/jm00193a001] |
| 125. Kim CU, Misco PF, McGregor DN.. (1979) Synthesis and antibacterial activity of 2-oxocephalosporins., 22 (6): [PMID:458825] [10.1021/jm00192a025] |
| 126. DeMarinis RM, Boehm JC, Dunn GL, Hoover JR, Uri JV, Guarini JR, Phillips L, Actor P, Weisbach JA.. (1977) Semisynthetic cephalosporins. Synthesis and structure-activity relationships of analogues with 7-acyl groups derived from 2-(cyanomethylthio)acetic acid or 2-[(2,2,2-trifluoroethyl)thio]acetic acid and their sulfoxides and sulfones., 20 (1): [PMID:319233] [10.1021/jm00211a006] |
| 127. Indelicato JM, Dinner A, Peters LR, Wilham WL.. (1977) Hydrolysis of 3-chloro-3-cephems. Intramolecular nucleophilic attack in cefaclor., 20 (7): [PMID:874971] [10.1021/jm00217a021] |
| 128. Nudelman A, Karoly H, Braun F, Böhme EH, Erickson RC.. (1978) Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives., 21 (9): [PMID:722761] [10.1021/jm00207a022] |
| 129. Beeby PJ.. (1977) Synthesis of cephalosporin-4-aldehydes., 20 (1): [PMID:833822] [10.1021/jm00211a041] |
| 130. DeMarinis RM, Hoover JR, Lam LL, Uri JV, Guarini JR, Phillips L, Actor P, Weisbach JA.. (1976) Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-sulfonylacetamido-3-cephem-4-carboxylic acids., 19 (6): [PMID:781242] [10.1021/jm00228a003] |
| 131. DeMarinis RM, Boehm JC, Uri JV, Guarini JR, Phillips L, Dunn GL.. (1977) Synthesis and biological activity of some broad-spectrum N-acylphenyglycine cephalosporins., 20 (9): [PMID:411932] [10.1021/jm00219a010] |
| 132. Brain EG, Eglington AJ, Nayler JH, Osborne NF, Pearson MJ, Smale TC, Southgate R, Tolliday P, Basker MJ, Sutherland R.. (1977) Structure--activity relationships in cephalosporins prepared from penicillins. 1. 7beta-Acylamino derivatives of 3-benzyl- and 3-(3-pyridylmethyl)ceph-3-em-4-carboxylic acids., 20 (8): [PMID:894679] [10.1021/jm00218a018] |
| 133. Huffman WF, Hall RF, Grant JA, Holden KG.. (1978) Nuclear analogues of beta-lactam antibiotics. 4. Total synthesis of bisnorisopenicillins from beta-lactam precursors., 21 (5): [PMID:660583] [10.1021/jm00203a001] |
| 134. Trippier PC, McGuigan C. (2010) Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications, 1 (3): [10.1039/C0MD00119H] |
| 135. Wolman AT, Gionfriddo MR, Heindel GA, Mukhija P, Witkowski S, Bommareddy A, Vanwert AL.. (2013) Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., 41 (4): [PMID:23344796] [10.1124/dmd.112.049569] |
| 136. Zampieri D, Mamolo MG, Vio L, Romano M, Skoko N, Baralle M, Pau V, De Logu A.. (2016) Antimycobacterial activity of new N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives., 26 (14): [PMID:27241693] [10.1016/j.bmcl.2016.05.053] |
| 137. WHO Anatomical Therapeutic Chemical Classification, |
| 138. British National Formulary (72nd edition), |
| 139. Open TG-GATES, [10.6019/CHEMBL3885861] |
| 140. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
| 141. Katie Heiser, Peter F. McLean, Chadwick T. Davis, Ben Fogelson, Hannah B. Gordon, Pamela Jacobson, Brett Hurst, Ben Miller, Ronald W. Alfa, Berton A. Earnshaw, Mason L. Victors, Yolanda T. Chong, Imran S. Haque, Adeline S. Low, Christopher C. Gibson. (2020) Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2, [10.1101/2020.04.21.054387] |
| 142. Evans LE, Krishna A, Ma Y, Webb TE, Marshall DC, Tooke CL, Spencer J, Clarke TB, Armstrong A, Edwards AM.. (2019) Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug., 62 (9): [PMID:31009558] [10.1021/acs.jmedchem.8b01923] |
| 143. Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezada L, Somersan S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson P, Mitscher LA, Porubsky P, Rogers S, Schoenen FJ, Nathan C, Aubé J.. (2016) Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis., 59 (13): [PMID:27144688] [10.1021/acs.jmedchem.5b01833] |
| 144. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 145. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 146. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 147. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 148. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |
| 149. Hu L, Yang H, Yu T, Chen F, Liu R, Xue S, Zhang S, Mao W, Ji C, Wang H, Xie H.. (2022) Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases., 232 [PMID:35152091] [10.1016/j.ejmech.2022.114174] |
| 150. Sutherland JJ, Yonchev D, Fekete A, Urban L.. (2023) A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs., 14 (1): [PMID:37468498] [10.1038/s41467-023-40064-9] |
