1. Kung HF, Kasliwal R, Pan SG, Kung MP, Mach RH, Guo YZ.. (1988) Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide., 31 (5): [PMID:2966245] [10.1021/jm00400a027] |
2. Tamagnan G, Baldwin RM, Kula NS, Baldessarini RJ, Innis RB.. (2000) Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity., 10 (10): [PMID:10843230] [10.1016/s0960-894x(00)00185-2] |
3. Chumpradit S, Kung HF, Billings J, Kung MP, Pan S.. (1989) (+/-)-7-chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent., 32 (7): [PMID:2525621] [10.1021/jm00127a005] |
4. Maryanoff BE, McComsey DF, Gardocki JF, Shank RP, Costanzo MJ, Nortey SO, Schneider CR, Setler PE.. (1987) Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships., 30 (8): [PMID:3039136] [10.1021/jm00391a028] |
5. Foulon C, Kung MP, Kung HF.. (1993) Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand., 36 (10): [PMID:8098771] [10.1021/jm00062a025] |
6. Brewster WK, Nichols DE, Riggs RM, Mottola DM, Lovenberg TW, Lewis MH, Mailman RB.. (1990) trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist., 33 (6): [PMID:1971308] [10.1021/jm00168a034] |
7. Murphy RA, Kung HF, Kung MP, Billings J.. (1990) Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents., 33 (1): [PMID:2136916] [10.1021/jm00163a029] |
8. Carroll FI.. (2003) 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy., 46 (10): [PMID:12723940] [10.1021/jm030092d] |
9. Riggs RM, Nichols DE, Foreman MM, Truex LL.. (1987) Evaluation of isomeric 4-(chlorohydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines as dopamine D-1 antagonists., 30 (10): [PMID:3656362] [10.1021/jm00393a033] |
10. Berger JG, Chang WK, Clader JW, Hou D, Chipkin RE, McPhail AT.. (1989) Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol., 32 (8): [PMID:2666667] [10.1021/jm00128a038] |
11. Charifson PS, Wyrick SD, Hoffman AJ, Simmons RM, Bowen JP, McDougald DL, Mailman RB.. (1988) Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands., 31 (10): [PMID:3050089] [10.1021/jm00118a012] |
12. de Paulis T, Janowsky A, Kessler RM, Clanton JA, Smith HE.. (1988) (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors., 31 (10): [PMID:3172140] [10.1021/jm00118a031] |
13. Charifson PS, Bowen JP, Wyrick SD, Hoffman AJ, Cory M, McPhail AT, Mailman RB.. (1989) Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands., 32 (9): [PMID:2527994] [10.1021/jm00129a006] |
14. Baindur N, Neumeyer JL, Niznik HB, Bzowej NH, Jarvie KR, Seeman P, Garlick RK, Miller JJ.. (1988) A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]Iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor., 31 (11): [PMID:3263503] [10.1021/jm00119a003] |
15. Negash K, Nichols DE, Watts VJ, Mailman RB.. (1997) Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine., 40 (14): [PMID:9216832] [10.1021/jm970157a] |
16. Pettersson I, Liljefors T, Bøgesø K.. (1990) Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series., 33 (8): [PMID:1973733] [10.1021/jm00170a025] |
17. Knoerzer TA, Nichols DE, Brewster WK, Watts VJ, Mottola D, Mailman RB.. (1994) Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist., 37 (15): [PMID:7914538] [10.1021/jm00041a025] |
18. Raviña E, Negreira J, Cid J, Masaguer CF, Rosa E, Rivas ME, Fontenla JA, Loza MI, Tristán H, Cadavid MI, Sanz F, Lozoya E, Carotti A, Carrieri A.. (1999) Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics., 42 (15): [PMID:10425088] [10.1021/jm981094e] |
19. Michaelides MR, Schoenleber R, Thomas S, Yamamoto DM, Britton DR, MacKenzie R, Kebabian JW.. (1991) Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands., 34 (10): [PMID:1833546] [10.1021/jm00114a002] |
20. Mottola DM, Laiter S, Watts VJ, Tropsha A, Wyrick SD, Nichols DE, Mailman RB.. (1996) Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping., 39 (1): [PMID:8568818] [10.1021/jm9502100] |
21. Bucholtz EC, Brown RL, Tropsha A, Booth RG, Wyrick SD.. (1999) Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors., 42 (16): [PMID:10447948] [10.1021/jm980428x] |
22. Knoerzer TA, Watts VJ, Nichols DE, Mailman RB.. (1995) Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors., 38 (16): [PMID:7636869] [10.1021/jm00016a009] |
23. Hoffman B, Cho SJ, Zheng W, Wyrick S, Nichols DE, Mailman RB, Tropsha A.. (1999) Quantitative structure-activity relationship modeling of dopamine D(1) antagonists using comparative molecular field analysis, genetic algorithms-partial least-squares, and K nearest neighbor methods., 42 (17): [PMID:10464009] [10.1021/jm980415j] |
24. Brewster WK, Nichols DE, Watts VJ, Riggs RM, Mottola D, Mailman RB.. (1995) Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands., 38 (2): [PMID:7830274] [10.1021/jm00002a013] |
25. Chang WK, Peters M, Fevig VP, Kozlowski JA, Zhou G, Lowe DB, Guzik H, McQuade RD, Duffy R, Coffin VL, Berger JG. (1992) Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position, 2 (5): [10.1016/S0960-894X(00)80155-9] |
26. Myers AM, Charifson PS, Owens CE, Kula NS, McPhail AT, Baldessarini RJ, Booth RG, Wyrick SD.. (1994) Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor., 37 (24): [PMID:7990111] [10.1021/jm00050a008] |
27. Claudi F, Cingolani GM, Di Stefano A, Giorgioni G, Amenta F, Barili P, Ferrari F, Giuliani D.. (1996) Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands., 39 (21): [PMID:8863801] [10.1021/jm960318v] |
28. Shah JH, Izenwasser S, Geter-Douglass B, Witkin JM, Newman AH.. (1995) (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists., 38 (21): [PMID:7473556] [10.1021/jm00021a018] |
29. Minor DL, Wyrick SD, Charifson PS, Watts VJ, Nichols DE, Mailman RB.. (1994) Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists., 37 (25): [PMID:7996543] [10.1021/jm00051a008] |
30. Efange SM, Mash DC, Khare AB, Ouyang Q.. (1998) Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes., 41 (23): [PMID:9804688] [10.1021/jm980156y] |
31. Pettersson I, Gundertofte K, Palm J, Liljefors T.. (1992) A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine D-1 receptor activity., 35 (3): [PMID:1531365] [10.1021/jm00081a010] |
32. Neumeyer JL, Baindur N, Yuan J, Booth G, Seeman P, Niznik HB.. (1990) Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine., 33 (2): [PMID:2405157] [10.1021/jm00164a009] |
33. Neumeyer JL, Baindur N, Yuan J, Booth G, Seeman P, Niznik HB.. (1990) Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine., 33 (2): [PMID:2405157] [10.1021/jm00164a009] |
34. Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE.. (1996) 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore., 39 (2): [PMID:8558526] [10.1021/jm950707+] |
35. Schaus JM, Titus RD, Foreman MM, Mason NR, Truex LL.. (1990) Aporphines as antagonists of dopamine D-1 receptors., 33 (2): [PMID:2405158] [10.1021/jm00164a022] |
36. Claudi F, Di Stefano A, Napolitani F, Cingolani GM, Giorgioni G, Fontenla JA, Montenegro GY, Rivas ME, Rosa E, Michelotto B, Orlando G, Brunetti L.. (2000) Binding and preliminary evaluation of 5-hydroxy- and 10-hydroxy-2,3, 12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as dopamine receptor ligands., 43 (4): [PMID:10691686] [10.1021/jm991034o] |
37. Chumpradit S, Kung MP, Billings JJ, Kung HF.. (1991) Synthesis and resolution of (+-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro- 1H-3- benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor., 34 (3): [PMID:1825848] [10.1021/jm00107a002] |
38. Doll MK, Nichols DE, Kilts JD, Prioleau C, Lawler CP, Lewis MM, Mailman RB.. (1999) Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane., 42 (5): [PMID:10072690] [10.1021/jm9804533] |
39. Wu WL, Burnett DA, Spring R, Greenlee WJ, Smith M, Favreau L, Fawzi A, Zhang H, Lachowicz JE.. (2005) Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists., 48 (3): [PMID:15689153] [10.1021/jm030614p] |
40. Di Stefano A, Sozio P, Cacciatore I, Cocco A, Giorgioni G, Costa B, Montali M, Lucacchini A, Martini C, Spoto G, Di Pietrantonio F, Di Matteo E, Pinnen F.. (2005) Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists., 48 (7): [PMID:15801855] [10.1021/jm040889k] |
41. Minetti P, Tinti MO, Carminati P, Castorina M, Di Cesare MA, Di Serio S, Gallo G, Ghirardi O, Giorgi F, Giorgi L, Piersanti G, Bartoccini F, Tarzia G.. (2005) 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization., 48 (22): [PMID:16250647] [10.1021/jm058018d] |
42. Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE.. (2006) trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist., 49 (23): [PMID:17154515] [10.1021/jm0604979] |
43. Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP.. (2008) Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity., 51 (14): [PMID:18588282] [10.1021/jm701575k] |
44. Liu Z, Chen X, Yu L, Zhen X, Zhang A.. (2008) Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines., 16 (14): [PMID:18562201] [10.1016/j.bmc.2008.05.077] |
45. Zhu Z, Sun ZY, Ye Y, McKittrick B, Greenlee W, Czarniecki M, Fawzi A, Zhang H, Lachowicz JE.. (2009) Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists., 19 (17): [PMID:19643610] [10.1016/j.bmcl.2009.07.012] |
46. Qiang L, Sasikumar TK, Burnett DA, Su J, Tang H, Ye Y, Mazzola RD, Zhu Z, McKittrick BA, Greenlee WJ, Fawzi A, Smith M, Zhang H, Lachowicz JE.. (2010) Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists., 20 (3): [PMID:20061148] [10.1016/j.bmcl.2009.12.100] |
47. Bonner LA, Chemel BR, Watts VJ, Nichols DE.. (2010) Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists., 18 (18): [PMID:20709559] [10.1016/j.bmc.2010.07.052] |
48. PubChem BioAssay data set, |
49. PubChem BioAssay data set, |
50. Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD.. (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia., 51 (22): [PMID:18983139] [10.1021/jm8007618] |
51. Hayashi S, Nakata E, Morita A, Mizuno K, Yamamura K, Kato A, Ohashi K.. (2010) Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships., 18 (21): [PMID:20875743] [10.1016/j.bmc.2010.07.034] |
52. Dolusić E, Larrieu P, Moineaux L, Stroobant V, Pilotte L, Colau D, Pochet L, Van den Eynde B, Masereel B, Wouters J, Frédérick R.. (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators., 54 (15): [PMID:21726069] [10.1021/jm2006782] |
53. PubChem BioAssay data set, |
54. Tukey RH, Strassburg CP.. (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease., 40 (1): [PMID:10836148] [10.1146/annurev.pharmtox.40.1.581] |
55. Qian W, Lu W, Sun H, Li Z, Zhu L, Zhao R, Zhang L, Zhou S, Zhou Y, Jiang H, Zhen X, Liu H.. (2012) Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D₁ receptor., 20 (15): [PMID:22748706] [10.1016/j.bmc.2012.05.057] |
56. Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.. (2013) Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells., 23 (6): [PMID:23403082] [10.1016/j.bmcl.2013.01.025] |
57. Wen W, Wu W, Romaine IM, Kaufmann K, Du Y, Sulikowski GA, Weaver CD, Lindsley CW.. (2013) Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors., 23 (16): [PMID:23838260] [10.1016/j.bmcl.2013.06.023] |
58. Mark Wenlock and Nicholas Tomkinson. Experimental in vitro DMPK and physicochemical data on a set of publicly disclosed compounds, [10.6019/CHEMBL3301361] |
59. Deng X, Guo L, Xu L, Zhen X, Yu K, Zhao W, Fu W.. (2015) Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold., 25 (18): [PMID:26227779] [10.1016/j.bmcl.2015.07.030] |
60. Cao X, Zhang Y, Chen Y, Qiu Y, Yu M, Xu X, Liu X, Liu BF, Zhang L, Zhang G.. (2018) Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics., 61 (22): [PMID:30383372] [10.1021/acs.jmedchem.8b01096] |
61. Ge H, Zhang Y, Yang Z, Qiang K, Chen C, Sun L, Chen M, Zhang J.. (2019) Chemical synthesis, microbial transformation and biological evaluation of tetrahydroprotoberberines as dopamine D1/D2 receptor ligands., 27 (10): [PMID:30981605] [10.1016/j.bmc.2019.04.014] |
62. Park H, Urs AN, Zimmerman J, Liu C, Wang Q, Urs NM.. (2020) Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands., 11 (3): [PMID:32184974] [10.1021/acsmedchemlett.9b00575] |
63. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
64. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
65. Giri R, Namballa HK, Sarker A, Alberts I, Harding WW.. (2020) Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines., 30 (16): [PMID:32631525] [10.1016/j.bmcl.2020.127305] |
66. Ellen Van Damme. (2021) Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity, [10.6019/CHEMBL4651402] |
67. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |