1. Yoshikawa M, Xu F, Morikawa T, Ninomiya K, Matsuda H.. (2003) Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica., 13 (6): [PMID:12643908] [10.1016/s0960-894x(03)00088-x] |
2. Kilkuskie RE, Kashiwada Y, Nonaka G, Nishioka I, Bodner AJ, Cheng Y, Lee K. (1992) HIV and reverse transcriptase inhibition by tannins, 2 (12): [10.1016/S0960-894X(00)80422-9] |
3. Maitrejean M, Comte G, Barron D, El Kirat K, Conseil G, Di Pietro A.. (2000) The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein., 10 (2): [PMID:10673101] [10.1016/s0960-894x(99)00636-8] |
4. Kashiwada Y, Nonaka G, Nishioka I, Ballas LM, Jiang JB, Janzen WP, Lee K. (1992) Tannins as selective inhibitors of protein kinase C, 2 (3): [10.1016/S0960-894X(01)81072-6] |
5. Matsuda H, Ishikado A, Nishida N, Ninomiya K, Fujiwara H, Kobayashi Y, Yoshikawa M.. (1998) Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica., 8 (21): [PMID:9873651] [10.1016/s0960-894x(98)00528-9] |
6. Moro S, van Rhee AM, Sanders LH, Jacobson KA.. (1998) Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model., 41 (1): [PMID:9438021] [10.1021/jm970446z] |
7. Hashimoto F, Kashiwada Y, Nonaka G, Nishioka I, Nohara T, Cosentino L, Lee K. (1996) Evaluation of tea polyphenols as anti-HIV agents, 6 (6): [10.1016/0960-894X(96)00095-9] |
8. Franke L, Schwarz O, Müller-Kuhrt L, Hoernig C, Fischer L, George S, Tanrikulu Y, Schneider P, Werz O, Steinhilber D, Schneider G.. (2007) Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening., 50 (11): [PMID:17461565] [10.1021/jm060655w] |
9. Katavic PL, Lamb K, Navarro H, Prisinzano TE.. (2007) Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships., 70 (8): [PMID:17685652] [10.1021/np070194x] |
10. Wada S, Yasui Y, Hitomi T, Tanaka R.. (2007) Structures and radical-scavenging activities of phenolic constituents from the bark of Picea jezoensis var. jezoensis., 70 (10): [PMID:17907781] [10.1021/np070104o] |
11. Hayashi T, Sawa K, Kawasaki M, Arisawa M, Shimizu M, Morita N.. (1988) Inhibition of cow's milk xanthine oxidase by flavonoids., 51 (2): [PMID:3379415] [10.1021/np50056a030] |
12. De Bruyne T, Pieters L, Witvrouw M, De Clercq E, Vanden Berghe D, Vlietinck AJ.. (1999) Biological evaluation of proanthocyanidin dimers and related polyphenols., 62 (7): [PMID:10425115] [10.1021/np980481o] |
13. Habtemariam S.. (1997) Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells., 60 (8): [PMID:9287415] [10.1021/np960581z] |
14. Konstantinopoulou M, Karioti A, Skaltsas S, Skaltsa H.. (2003) Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity., 66 (5): [PMID:12762812] [10.1021/np020472m] |
15. Malterud KE, Bremnes TE, Faegri A, Moe T, Dugstad EKS, Anthonsen T, Henriksen LM. (1985) Flavonoids from the Wood of Salix caprea as Inhibitors of Wood-Destroying Fungi, 48 (4): [10.1021/np50040a007] |
16. Geahlen RL, Koonchanok NM, McLaughlin JL, Pratt DE.. (1989) Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds., 52 (5): [PMID:2607357] [10.1021/np50065a011] |
17. Chang CJ, Geahlen RL.. (1992) Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents., 55 (11): [PMID:1479375] [10.1021/np50089a001] |
18. Pedersen JM, Matsson P, Bergström CA, Norinder U, Hoogstraate J, Artursson P.. (2008) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)., 51 (11): [PMID:18457386] [10.1021/jm7015683] |
19. Lale A, Herbert JM, Augereau JM, Billon M, Leconte M, Gleye J.. (1996) Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes., 59 (3): [PMID:8882428] [10.1021/np960057s] |
20. Bohmont C, Aaronson LM, Mann K, Pardini RS.. (1987) Inhibition of mitochondrial NADH oxidase, succinoxidase, and ATPase by naturally occurring flavonoids., 50 (3): [PMID:2959755] [10.1021/np50051a014] |
21. Jeong KW, Lee JY, Kang DI, Lee JU, Shin SY, Kim Y.. (2009) Screening of flavonoids as candidate antibiotics against Enterococcus faecalis., 72 (4): [PMID:19236029] [10.1021/np800698d] |
22. Vasilevsky SF, Govdi AI, Shults EE, Shakirov MM, Sorokina IV, Tolstikova TG, Baev DS, Tolstikov GA, Alabugin IV.. (2009) Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity., 17 (14): [PMID:19524443] [10.1016/j.bmc.2009.05.059] |
23. Wada S, Yasui Y, Tokuda H, Tanaka R.. (2009) Anti-tumor-initiating effects of phenolic compounds isolated from the bark of Picea jezoensis var. jezoensis., 17 (17): [PMID:19646881] [10.1016/j.bmc.2009.07.016] |
24. Nakashima S, Matsuda H, Oda Y, Nakamura S, Xu F, Yoshikawa M.. (2010) Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells., 18 (6): [PMID:20189399] [10.1016/j.bmc.2010.01.046] |
25. Carver JA, Duggan PJ, Ecroyd H, Liu Y, Meyer AG, Tranberg CE.. (2010) Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation., 18 (1): [PMID:19931462] [10.1016/j.bmc.2009.10.063] |
26. Amić D, Lucić B.. (2010) Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids., 18 (1): [PMID:19944611] [10.1016/j.bmc.2009.11.015] |
27. Chimenti F, Fioravanti R, Bolasco A, Chimenti P, Secci D, Rossi F, Yáñez M, Orallo F, Ortuso F, Alcaro S, Cirilli R, Ferretti R, Sanna ML.. (2010) A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors., 18 (3): [PMID:20045650] [10.1016/j.bmc.2009.12.029] |
28. Reinke AA, Seh HY, Gestwicki JE.. (2009) A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta., 19 (17): [PMID:19640715] [10.1016/j.bmcl.2009.07.082] |
29. Smejkal K, Svacinová J, Slapetová T, Schneiderová K, Dall'acqua S, Innocenti G, Závalová V, Kollár P, Chudík S, Marek R, Julínek O, Urbanová M, Kartal M, Csöllei M, Dolezal K.. (2010) Cytotoxic activities of several geranyl-substituted flavanones., 73 (4): [PMID:20192247] [10.1021/np900681y] |
30. PubChem BioAssay data set, |
31. PubChem BioAssay data set, |
32. Vasilevsky SF, Govdi AI, Sorokina IV, Tolstikova TG, Baev DS, Tolstikov GA, Mamatuyk VI, Alabugin IV.. (2011) Rapid access to new bioconjugates of betulonic acid via click chemistry., 21 (1): [PMID:21159508] [10.1016/j.bmcl.2010.11.072] |
33. Pandurangan N, Bose C, Banerji A.. (2011) Synthesis and antioxygenic activities of seabuckthorn flavone-3-ols and analogs., 21 (18): [PMID:21821414] [10.1016/j.bmcl.2011.07.008] |
34. PubChem BioAssay data set, |
35. Wang L, Li X, Zhang S, Lu W, Liao S, Liu X, Shan L, Shen X, Jiang H, Zhang W, Huang J, Li H.. (2012) Natural products as a gold mine for selective matrix metalloproteinases inhibitors., 20 (13): [PMID:22658537] [10.1016/j.bmc.2012.04.063] |
36. Zhang D, Xie L, Jia G, Cai S, Ji B, Liu Y, Wu W, Zhou F, Wang A, Chu L, Wei Y, Liu J, Gao F.. (2011) Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro., 46 (9): [PMID:21824690] [10.1016/j.ejmech.2011.07.031] |
37. Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.. (2012) Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine., 20 (22): [PMID:23062825] [10.1016/j.bmc.2012.09.040] |
38. Pasha FA, Cho SJ, Beg Y, Tripathi YB. (2007) Quantum chemical QSAR study of flavones and their radical-scavenging activity, 16 (7): [10.1007/s00044-007-9060-5] |
39. Anand P, Singh B. (2013) Flavonoids as lead compounds modulating the enzyme targets in Alzheimers disease, 22 (7): [10.1007/s00044-012-0353-y] |
40. Chin YW, Kong JY, Han SY.. (2013) Flavonoids as receptor tyrosine kinase FLT3 inhibitors., 23 (6): [PMID:23411073] [10.1016/j.bmcl.2013.01.049] |
41. Vrba J, Gažák R, Kuzma M, Papoušková B, Vacek J, Weiszenstein M, Křen V, Ulrichová J.. (2013) A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway., 56 (3): [PMID:23294286] [10.1021/jm3013344] |
42. Ahn JH, Kim ES, Lee C, Kim S, Cho SH, Hwang BY, Lee MK.. (2013) Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects., 23 (12): [PMID:23642481] [10.1016/j.bmcl.2013.04.013] |
43. Ribeiro D, Freitas M, Tomé SM, Silva AM, Porto G, Fernandes E.. (2013) Modulation of human neutrophils' oxidative burst by flavonoids., 67 [PMID:23871908] [10.1016/j.ejmech.2013.06.019] |
44. Ribeiro D, Freitas M, Tomé SM, Silva AM, Porto G, Cabrita EJ, Marques MM, Fernandes E.. (2014) Inhibition of LOX by flavonoids: a structure-activity relationship study., 72 [PMID:24368208] [10.1016/j.ejmech.2013.11.030] |
45. Park MH, Kim IS, Kim SA, Na CS, Hong CY, Dong MS, Yoo HH.. (2014) Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component., 24 (7): [PMID:24630560] [10.1016/j.bmcl.2014.02.039] |
46. Pferschy-Wenzig EM, Atanasov AG, Malainer C, Noha SM, Kunert O, Schuster D, Heiss EH, Oberlies NH, Wagner H, Bauer R, Dirsch VM.. (2014) Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma., 77 (4): [PMID:24597776] [10.1021/np400943b] |
47. Loers G, Yashunsky DV, Nifantiev NE, Schachner M.. (2014) Neural cell activation by phenolic compounds from the Siberian larch (Larix sibirica)., 77 (7): [PMID:24963869] [10.1021/np4009738] |
48. Stark TD, Salger M, Frank O, Balemba OB, Wakamatsu J, Hofmann T.. (2015) Antioxidative compounds from Garcinia buchananii stem bark., 78 (2): [PMID:25625705] [10.1021/np5007873] |
49. Karioti A, Ceruso M, Carta F, Bilia AR, Supuran CT.. (2015) New natural product carbonic anhydrase inhibitors incorporating phenol moieties., 23 (22): [PMID:26498393] [10.1016/j.bmc.2015.10.018] |
50. Beck S, Muellers SN, Benzie AL, Parkin DW, Stockman BJ.. (2015) Adenosine/guanosine preferring nucleoside ribohydrolase is a distinct, druggable antitrichomonal target., 25 (22): [PMID:26592812] [10.1016/j.bmcl.2015.10.030] |
51. Jiang WJ, Ishiuchi K, Furukawa M, Takamiya T, Kitanaka S, Iijima H.. (2015) Stereospecific inhibition of nitric oxide production in macrophage cells by flavanonols: Synthesis and the structure-activity relationship., 23 (21): [PMID:26481151] [10.1016/j.bmc.2015.09.042] |
52. Swioklo S, Watson KA, Williamson EM, Farrimond JA, Putnam SE, Bicknell KA.. (2015) Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids., 78 (11): [PMID:26517554] [10.1021/acs.jnatprod.5b00075] |
53. Zemanova L, Hofman J, Novotna E, Musilek K, Lundova T, Havrankova J, Hostalkova A, Chlebek J, Cahlikova L, Wsol V.. (2015) Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment., 78 (11): [PMID:26529431] [10.1021/acs.jnatprod.5b00616] |
54. Hanaki M, Murakami K, Akagi K, Irie K.. (2016) Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids., 24 (2): [PMID:26719209] [10.1016/j.bmc.2015.12.021] |
55. Park H, Lee S, Hong S.. (2016) Discovery of Dual Inhibitors for Wild Type and D816V Mutant of c-KIT Kinase through Virtual and Biochemical Screening of Natural Products., 79 (2): [PMID:26807861] [10.1021/acs.jnatprod.5b00851] |
56. Guan LP, Liu BY.. (2016) Antidepressant-like effects and mechanisms of flavonoids and related analogues., 121 [PMID:27214511] [10.1016/j.ejmech.2016.05.026] |
57. Karhu E, Isojärvi J, Vuorela P, Hanski L, Fallarero A.. (2017) Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy., 80 (10): [PMID:29043803] [10.1021/acs.jnatprod.6b01052] |
58. Li J, Dong J, Ouyang J, Cui J, Chen Y, Wang F, Wang J.. (2017) Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin., 8 (2): [PMID:30108751] [10.1039/C6MD00496B] |
59. Hendra R, Keller PA.. (2017) Phytochemical Studies on Two Australian Anigozanthos Plant Species., 80 (7): [PMID:28682615] [10.1021/acs.jnatprod.7b00063] |
60. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
61. Spinello A, Martini S, Berti F, Pennati M, Pavlin M, Sgrignani J, Grazioso G, Colombo G, Zaffaroni N, Magistrato A.. (2019) Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer., 168 [PMID:30822713] [10.1016/j.ejmech.2019.02.045] |
62. Kim JY, Kim JY, Jenis J, Li ZP, Ban YJ, Baiseitova A, Park KH.. (2019) Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle)., 27 (12): [PMID:30871862] [10.1016/j.bmc.2019.03.013] |
63. Maruca A, Catalano R, Bagetta D, Mesiti F, Ambrosio FA, Romeo I, Moraca F, Rocca R, Ortuso F, Artese A, Costa G, Alcaro S, Lupia A.. (2019) The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile., 181 [PMID:31398616] [10.1016/j.ejmech.2019.111579] |
64. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
65. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
66. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
67. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
68. Johannes Zuegg, Alysha Elliott, Maite Amado, Emma Cowie, Ali Hinton, Geraldine Kaeslin, Angela Kavanagh, Anne Kunert, Gabriell Lowe, Soumya Ramu, Janet Reid, Robin Trauer, Mathilde Desselle, Ruth Neale, Karl Hansford, Mark Blascovich, Matthew Cooper. CO-ADD screening of NIH (USA) - Clinical Collection, [10.6019/CHEMBL4513141] |
69. Jo MS, Lee S, Yu JS, Baek SC, Cho YC, Kim KH.. (2020) Megastigmane Derivatives from the Cladodes of Opuntia humifusa and Their Nitric Oxide Inhibitory Activities in Macrophages., 83 (3): [PMID:32118424] [10.1021/acs.jnatprod.9b01120] |
70. Proença C, Oliveira A, Freitas M, Ribeiro D, Sousa JLC, Ramos MJ, Silva AMS, Fernandes PA, Fernandes E.. (2020) Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase., 83 (5): [PMID:32364726] [10.1021/acs.jnatprod.0c00014] |
71. Majik MS,Gawas UB,Mandrekar VK. (2020) Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities., 28 (21): [PMID:33065436] [10.1016/j.bmc.2020.115728] |
72. Zima V,Radilová K,Kožíšek M,Albiñana CB,Karlukova E,Brynda J,Fanfrlík J,Flieger M,Hodek J,Weber J,Majer P,Konvalinka J,Machara A. (2020) Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors., 208 [PMID:32883638] [10.1016/j.ejmech.2020.112754] |
73. Rice M,Wong B,Oja M,Samuels K,Williams AK,Fong J,Sapse AM,Maran U,Korobkova EA. (2021) A role of flavonoids in cytochrome c-cardiolipin interactions., 33 [PMID:33530021] [10.1016/j.bmc.2021.116043] |
74. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |
75. Singh YP, Rai H, Singh G, Singh GK, Mishra S, Kumar S, Srikrishna S, Modi G.. (2021) A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease., 215 [PMID:33662757] [10.1016/j.ejmech.2021.113278] |
76. Arora S, Joshi G, Chaturvedi A, Heuser M, Patil S, Kumar R.. (2022) A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2., 65 (2.0): [PMID:34726055] [10.1021/acs.jmedchem.1c00981] |
77. Rathod B, Chak S, Patel S, Shard A.. (2021) Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents., 12 (7.0): [PMID:34355179] [10.1039/D1MD00045D] |