4-Amino-3-bromo-benzenesulfonamide

ID: ALA6724

Chembl Id: CHEMBL6724

Cas Number: 53297-69-1

PubChem CID: 3526523

Max Phase: Preclinical

Molecular Formula: C6H7BrN2O2S

Molecular Weight: 251.10

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  Nc1ccc(S(N)(=O)=O)cc1Br

Standard InChI:  InChI=1S/C6H7BrN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11)

Standard InChI Key:  KQEVQYJWCZRLTJ-UHFFFAOYSA-N

Alternative Forms

Associated Targets(Human)

CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA4 Tclin Carbonic anhydrase IV (2163 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA7 Tclin Carbonic anhydrase VII (2318 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ca13 Carbonic anhydrase XIII (322 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA4 Carbonic anhydrase IV (1713 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonic anhydrase (197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonic anhydrase (69 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
cynT Carbonic anhydrase 1 (82 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCE103 Carbonic anhydrase (85 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ca15 Carbonic anhydrase 15 (173 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
mtcA1 Uncharacterized protein Rv1284/MT1322 (182 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) (107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCE103 Carbonic anhydrase (253 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA Alpha carbonic anhydrase (93 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
mtcA2 Carbonic anhydrase (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Carbonic anhydrase (56 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAN2 Carbonic anhydrase 2 (140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCE103 Carbonic anhydrase (137 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ca1 Delta carbonic anhydrase (40 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
1272966 AGAP002992-PA (40 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonate dehydratase (40 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonic anhydrase, alpha family (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 251.10Molecular Weight (Monoisotopic): 249.9412AlogP: 0.68#Rotatable Bonds: 1
Polar Surface Area: 86.18Molecular Species: NEUTRALHBA: 3HBD: 2
#RO5 Violations: HBA (Lipinski): 4HBD (Lipinski): 4#RO5 Violations (Lipinski):
CX Acidic pKa: 10.32CX Basic pKa: 1.26CX LogP: 0.52CX LogD: 0.52
Aromatic Rings: 1Heavy Atoms: 12QED Weighted: 0.72Np Likeness Score: -1.52

References

1. Vullo D, Franchi M, Gallori E, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT..  (2003)  Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.,  13  (6): [PMID:12643899] [10.1016/s0960-894x(03)00091-x]
2. Scozzafava A, Supuran CT..  (2000)  Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.,  10  (10): [PMID:10843231] [10.1016/s0960-894x(00)00178-5]
3. Scozzafava A, Menabuoni L, Mincione F, Supuran CT..  (2002)  Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.,  45  (7): [PMID:11906288] [10.1021/jm0108202]
4. Ilies MA, Vullo D, Pastorek J, Scozzafava A, Ilies M, Caproiu MT, Pastorekova S, Supuran CT..  (2003)  Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.,  46  (11): [PMID:12747790] [10.1021/jm021123s]
5. Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT..  (1999)  Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?,  42  (14): [PMID:10411484] [10.1021/jm9900523]
6. Scozzafava A, Briganti F, Ilies MA, Supuran CT..  (2000)  Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.,  43  (2): [PMID:10649985] [10.1021/jm990479+]
7. Jaiswal M, Khadikar PV, Scozzafava A, Supuran CT..  (2004)  Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.,  14  (12): [PMID:15149691] [10.1016/j.bmcl.2004.03.099]
8. Scozzafava A, Briganti F, Mincione G, Menabuoni L, Mincione F, Supuran CT..  (1999)  Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.,  42  (18): [PMID:10479300] [10.1021/jm9901879]
9. Lehtonen JM, Parkkila S, Vullo D, Casini A, Scozzafava A, Supuran CT..  (2004)  Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.,  14  (14): [PMID:15203157] [10.1016/j.bmcl.2004.04.106]
10. Agrawal VK, Khadikar PV..  (2003)  Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.,  13  (3): [PMID:12565948] [10.1016/s0960-894x(02)00954-x]
11. Scozzafava A, Menabuoni L, Mincione F, Mincione G, Supuran CT..  (2001)  Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.,  11  (4): [PMID:11229775] [10.1016/s0960-894x(00)00722-8]
12. Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT..  (2005)  Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.,  15  (4): [PMID:15686895] [10.1016/j.bmcl.2004.12.052]
13. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT..  (2005)  Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.,  15  (17): [PMID:16039848] [10.1016/j.bmcl.2005.06.055]
14. Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastoreková S, Supuran CT..  (2005)  Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?,  15  (4): [PMID:15686894] [10.1016/j.bmcl.2004.12.053]
15. Innocenti A, Firnges MA, Antel J, Wurl M, Scozzafava A, Supuran CT..  (2005)  Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.,  15  (4): [PMID:15686931] [10.1016/j.bmcl.2004.12.009]
16. Innocenti A, Antel J, Wurl M, Scozzafava A, Supuran CT..  (2004)  Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.,  14  (22): [PMID:15482952] [10.1016/j.bmcl.2004.07.085]
17. Zimmerman S, Innocenti A, Casini A, Ferry JG, Scozzafava A, Supuran CT..  (2004)  Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.,  14  (24): [PMID:15546717] [10.1016/j.bmcl.2004.09.085]
18. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT..  (2005)  Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.,  48  (24): [PMID:16302824] [10.1021/jm050483n]
19. Nishimori I, Minakuchi T, Morimoto K, Sano S, Onishi S, Takeuchi H, Vullo D, Scozzafava A, Supuran CT..  (2006)  Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.,  49  (6): [PMID:16539401] [10.1021/jm0512600]
20. Agrawal VK, Singh J, Khadikar PV, Supuran CT..  (2006)  QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.,  16  (7): [PMID:16458003] [10.1016/j.bmcl.2005.08.071]
21. Nishimori I, Vullo D, Minakuchi T, Morimoto K, Onishi S, Scozzafava A, Supuran CT..  (2006)  Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.,  16  (8): [PMID:16459077] [10.1016/j.bmcl.2006.01.044]
22. Nishimori I, Minakuchi T, Onishi S, Vullo D, Scozzafava A, Supuran CT..  (2007)  Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.,  50  (2): [PMID:17228881] [10.1021/jm0612057]
23. Nishimori I, Minakuchi T, Kohsaki T, Onishi S, Takeuchi H, Vullo D, Scozzafava A, Supuran CT..  (2007)  Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.,  17  (13): [PMID:17482815] [10.1016/j.bmcl.2007.04.063]
24. Isik S, Kockar F, Aydin M, Arslan O, Guler OO, Innocenti A, Scozzafava A, Supuran CT..  (2009)  Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.,  17  (3): [PMID:19124253] [10.1016/j.bmc.2008.12.035]
25. Güzel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT..  (2009)  Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.,  52  (13): [PMID:19438226] [10.1021/jm9004016]
26. Hilvo M, Salzano AM, Innocenti A, Kulomaa MS, Scozzafava A, Scaloni A, Parkkila S, Supuran CT..  (2009)  Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.,  52  (3): [PMID:19193158] [10.1021/jm801267c]
27. Minakuchi T, Nishimori I, Vullo D, Scozzafava A, Supuran CT..  (2009)  Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.,  52  (8): [PMID:19317447] [10.1021/jm9000488]
28. Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Innocenti A, Supuran CT..  (2009)  Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.,  52  (9): [PMID:19338333] [10.1021/jm9003126]
29. Innocenti A, Hall RA, Schlicker C, Scozzafava A, Steegborn C, Mühlschlegel FA, Supuran CT..  (2009)  Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.,  17  (13): [PMID:19450983] [10.1016/j.bmc.2009.05.002]
30. Bertucci A, Innocenti A, Zoccola D, Scozzafava A, Tambutté S, Supuran CT..  (2009)  Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.,  17  (14): [PMID:19520577] [10.1016/j.bmc.2009.05.063]
31. Carta F, Maresca A, Covarrubias AS, Mowbray SL, Jones TA, Supuran CT..  (2009)  Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.,  19  (23): [PMID:19846301] [10.1016/j.bmcl.2009.10.009]
32. Sethi KK, Verma SM, Prasanthi N, Sahoo SK, Parhi RN, Suresh P..  (2010)  3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors.,  20  (10): [PMID:20443227] [10.1016/j.bmcl.2010.03.104]
33. Bertucci A, Innocenti A, Scozzafava A, Tambutté S, Zoccola D, Supuran CT..  (2011)  Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.,  21  (2): [PMID:21208801] [10.1016/j.bmcl.2010.11.124]
34. Hewitson KS, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran CT..  (2012)  Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.,  55  (7): [PMID:22424239] [10.1021/jm300203r]
35. Del Prete S, Isik S, Vullo D, De Luca V, Carginale V, Scozzafava A, Supuran CT, Capasso C..  (2012)  DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.,  55  (23): [PMID:23181552] [10.1021/jm301611m]
36. Pan P, Vermelho AB, Capaci Rodrigues G, Scozzafava A, Tolvanen ME, Parkkila S, Capasso C, Supuran CT..  (2013)  Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.,  56  (4): [PMID:23391336] [10.1021/jm4000616]
37. Vullo D, Luca VD, Scozzafava A, Carginale V, Rossi M, Supuran CT, Capasso C..  (2013)  The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.,  21  (6): [PMID:22883029] [10.1016/j.bmc.2012.07.024]
38. Vullo D, Leewattanapasuk W, Mühlschlegel FA, Mastrolorenzo A, Capasso C, Supuran CT..  (2013)  Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.,  23  (9): [PMID:23511020] [10.1016/j.bmcl.2013.02.092]
39. Syrjänen L, Vermelho AB, Rodrigues Ide A, Corte-Real S, Salonen T, Pan P, Vullo D, Parkkila S, Capasso C, Supuran CT..  (2013)  Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.,  56  (18): [PMID:23977960] [10.1021/jm400939k]
40. Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C..  (2014)  Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.,  24  (1): [PMID:24314394] [10.1016/j.bmcl.2013.11.021]
41. Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C..  (2014)  Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.,  24  (1): [PMID:24316122] [10.1016/j.bmcl.2013.11.030]
42. Nishimori I, Vullo D, Minakuchi T, Scozzafava A, Capasso C, Supuran CT..  (2014)  Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.,  22  (11): [PMID:24792813] [10.1016/j.bmc.2014.04.006]
43. Prete SD, Vullo D, Osman SM, Scozzafava A, AlOthman Z, Capasso C, Supuran CT..  (2014)  Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.,  22  (17): [PMID:25129169] [10.1016/j.bmc.2014.07.048]
44. Vullo D, Del Prete S, Fisher GM, Andrews KT, Poulsen SA, Capasso C, Supuran CT..  (2015)  Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.,  23  (3): [PMID:25533402] [10.1016/j.bmc.2014.12.009]
45. Syrjänen L, Kuuslahti M, Tolvanen M, Vullo D, Parkkila S, Supuran CT..  (2015)  The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.,  23  (10): [PMID:25882523] [10.1016/j.bmc.2015.03.081]
46. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT..  (2015)  Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.,  23  (8): [PMID:25773015] [10.1016/j.bmc.2015.02.045]
47. Dedeoglu N, DeLuca V, Isik S, Yildirim H, Kockar F, Capasso C, Supuran CT..  (2015)  Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans.,  25  (11): [PMID:25913199] [10.1016/j.bmcl.2015.04.037]
48. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT..  (2015)  Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.,  25  (17): [PMID:26174556] [10.1016/j.bmcl.2015.06.079]
49. Vullo D, Bhatt A, Mahon BP, McKenna R, Supuran CT..  (2016)  Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.,  26  (2): [PMID:26691758] [10.1016/j.bmcl.2015.11.104]
50. Del Prete S, Vullo D, De Luca V, Carginale V, Ferraroni M, Osman SM, AlOthman Z, Supuran CT, Capasso C..  (2016)  Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.,  24  (5): [PMID:26850377] [10.1016/j.bmc.2016.01.037]
51. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Osman SM, AlOthman Z, Capasso C, Supuran CT..  (2016)  Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.,  26  (4): [PMID:26832216] [10.1016/j.bmcl.2016.01.023]
52. Eminoğlu A, Vullo D, Aşık A, Çolak DN, Çanakçı S, Beldüz AO, Supuran CT..  (2016)  Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.,  26  (7): [PMID:26920803] [10.1016/j.bmcl.2016.02.032]
53. Del Prete S, Vullo D, De Luca V, Carginale V, Osman SM, AlOthman Z, Supuran CT, Capasso C..  (2016)  Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.,  26  (8): [PMID:26972117] [10.1016/j.bmcl.2016.03.014]
54. Del Prete S, Vullo D, Di Fonzo P, Osman SM, AlOthman Z, Donald WA, Supuran CT, Capasso C..  (2017)  Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis.,  27  (3): [PMID:28025002] [10.1016/j.bmcl.2016.12.035]
55. Del Prete S, Vullo D, Osman SM, AlOthman Z, Supuran CT, Capasso C..  (2017)  Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia.,  25  (13): [PMID:28511911] [10.1016/j.bmc.2017.05.007]
56. Del Prete S, Vullo D, De Luca V, Carginale V, Osman SM, AlOthman Z, Supuran CT, Capasso C..  (2016)  Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.,  26  (17): [PMID:27485387] [10.1016/j.bmcl.2016.07.060]

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