| 1. Kingsbury WD, Boehm JC, Jakas DR, Holden KG, Hecht SM, Gallagher G, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK.. (1991) Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity., 34 (1): [PMID:1846923] [10.1021/jm00105a017] |
| 2. Kim DK, Ryu DH, Lee JY, Lee N, Kim YW, Kim JS, Chang K, Im GJ, Kim TK, Choi WS.. (2001) Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues., 44 (10): [PMID:11334569] [10.1021/jm0004751] |
| 3. Fan Y, Weinstein JN, Kohn KW, Shi LM, Pommier Y.. (1998) Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin., 41 (13): [PMID:9632354] [10.1021/jm9605445] |
| 4. Sugimori M, Ejima A, Ohsuki S, Uoto K, Mitsui I, Kawato Y, Hirota Y, Sato K, Terasawa H.. (1998) Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues., 41 (13): [PMID:9632364] [10.1021/jm970765q] |
| 5. Burke TG, Mi Z.. (1993) Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin., 36 (17): [PMID:8355258] [10.1021/jm00069a020] |
| 6. Lavergne O, Harnett J, Rolland A, Lanco C, Lesueur-Ginot L, Demarquay D, Huchet M, Coulomb H, Bigg DC.. (1999) BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II., 9 (17): [PMID:10498216] [10.1016/s0960-894x(99)00428-x] |
| 7. Sugimori M, Ejima A, Ohsuki S, Uoto K, Mitsui I, Matsumoto K, Kawato Y, Yasuoka M, Sato K, Tagawa H.. (1994) Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues., 37 (19): [PMID:7932525] [10.1021/jm00045a007] |
| 8. Dallavalle S, Ferrari A, Biasotti B, Merlini L, Penco S, Gallo G, Marzi M, Tinti MO, Martinelli R, Pisano C, Carminati P, Carenini N, Beretta G, Perego P, De Cesare M, Pratesi G, Zunino F.. (2001) Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity., 44 (20): [PMID:11563925] [10.1021/jm0108092] |
| 9. Bom D, Curran DP, Kruszewski S, Zimmer SG, Thompson Strode J, Kohlhagen G, Du W, Chavan AJ, Fraley KA, Bingcang AL, Latus LJ, Pommier Y, Burke TG.. (2000) The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity., 43 (21): [PMID:11052802] [10.1021/jm000144o] |
| 10. Burke TG, Mi Z.. (1994) The structural basis of camptothecin interactions with human serum albumin: impact on drug stability., 37 (1): [PMID:8289200] [10.1021/jm00027a005] |
| 11. Angenault S, Thirot S, Schmidt F, Monneret C, Pfeiffer B, Renard P.. (2003) Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy., 13 (5): [PMID:12617927] [10.1016/s0960-894x(02)01080-6] |
| 12. Van Quaquebeke E, Simon G, André A, Dewelle J, El Yazidi M, Bruyneel F, Tuti J, Nacoulma O, Guissou P, Decaestecker C, Braekman JC, Kiss R, Darro F.. (2005) Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses., 48 (3): [PMID:15689169] [10.1021/jm049405a] |
| 13. Manikumar G, Wadkins RM, Bearss D, Von Hoff DD, Wani MC, Wall ME.. (2004) Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction., 14 (21): [PMID:15454230] [10.1016/j.bmcl.2004.08.010] |
| 14. Manikumar G, Wadkins RM, Bearss D, Von Hoff DD, Wani MC, Wall ME.. (2004) Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction., 14 (21): [PMID:15454230] [10.1016/j.bmcl.2004.08.010] |
| 15. Dallavalle S, Merlini L, Beretta GL, Tinelli S, Zunino F.. (2004) Synthesis and cytotoxic activity of substituted luotonin A derivatives., 14 (23): [PMID:15501036] [10.1016/j.bmcl.2004.09.039] |
| 16. Gao H, Zhang X, Chen Y, Shen H, Pang T, Sun J, Xu C, Ding J, Li C, Lu W.. (2005) Synthesis and antitumor activity of the hexacyclic camptothecin derivatives., 15 (13): [PMID:15913996] [10.1016/j.bmcl.2005.04.063] |
| 17. Gao H, Zhang X, Chen Y, Shen H, Sun J, Huang M, Ding J, Li C, Lu W.. (2005) Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin., 15 (8): [PMID:15808456] [10.1016/j.bmcl.2005.02.072] |
| 18. Dallavalle S, Giannini G, Alloatti D, Casati A, Marastoni E, Musso L, Merlini L, Morini G, Penco S, Pisano C, Tinelli S, De Cesare M, Beretta GL, Zunino F.. (2006) Synthesis and cytotoxic activity of polyamine analogues of camptothecin., 49 (17): [PMID:16913706] [10.1021/jm060285b] |
| 19. Grillet F, Baumlová B, Prévost G, Constant JF, Chaumeron S, Bigg DC, Greene AE, Kanazawa A.. (2008) Synthesis and bioevaluation of 22-hydroxyacuminatine analogs., 18 (6): [PMID:18276141] [10.1016/j.bmcl.2008.01.082] |
| 20. Giannini G, Marzi M, Cabri W, Marastoni E, Battistuzzi G, Vesci L, Pisano C, Beretta GL, De Cesare M, Zunino F.. (2008) E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation., 18 (9): [PMID:18424133] [10.1016/j.bmcl.2008.03.074] |
| 21. Dallavalle S, Rocchetta DG, Musso L, Merlini L, Morini G, Penco S, Tinelli S, Beretta GL, Zunino F.. (2008) Synthesis and cytotoxic activity of new 9-substituted camptothecins., 18 (9): [PMID:18434153] [10.1016/j.bmcl.2008.04.016] |
| 22. Li M, Tang W, Zeng F, Lou L, You T.. (2008) Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin., 18 (24): [PMID:18986807] [10.1016/j.bmcl.2008.10.074] |
| 23. Samorì C, Guerrini A, Varchi G, Fontana G, Bombardelli E, Tinelli S, Beretta GL, Basili S, Moro S, Zunino F, Battaglia A.. (2009) Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins., 52 (4): [PMID:19530720] [10.1021/jm801153y] |
| 24. Clericuzio M, Tabasso S, Bianco MA, Pratesi G, Beretta G, Tinelli S, Zunino F, Vidari G.. (2006) Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus., 69 (12): [PMID:17190463] [10.1021/np060213n] |
| 25. Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ.. (2009) 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents., 17 (7): [PMID:19303306] [10.1016/j.bmc.2009.02.023] |
| 26. Niizuma S, Tsukazaki M, Suda H, Murata T, Ohwada J, Ozawa S, Fukuda H, Murasaki C, Kohchi M, Morikami K, Yoshinari K, Endo M, Ura M, Tanimura H, Miyazaki Y, Takasuka T, Kawashima A, Nanba E, Nakano K, Ogawa K, Kobayashi K, Okabe H, Umeda I, Shimma N.. (2009) Synthesis of new camptothecin analogs with improved antitumor activities., 19 (7): [PMID:19254843] [10.1016/j.bmcl.2009.02.031] |
| 27. Li M, Jin W, Jiang C, Zheng C, Tang W, You T, Lou L.. (2009) 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation., 19 (15): [PMID:19541483] [10.1016/j.bmcl.2009.06.010] |
| 28. Galal SA, Hegab KH, Hashem AM, Youssef NS.. (2010) Synthesis and antitumor activity of novel benzimidazole-5-carboxylic acid derivatives and their transition metal complexes as topoisomerease II inhibitors., 45 (12): [PMID:20884089] [10.1016/j.ejmech.2010.09.023] |
| 29. (2008) Casarett and Doull's Toxicology The Basic Science of Poisons, 7th edition, |
| 30. Fontana E, Dansette PM, Poli SM.. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity., 6 (1): [PMID:16248836] [10.2174/138920005774330639] |
| 31. Aoyagi Y, Hitotsuyanagi Y, Hasuda T, Fukaya H, Takeya K, Aiyama R, Matsuzaki T, Hashimoto S.. (2011) Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities., 21 (10): [PMID:21470864] [10.1016/j.bmcl.2011.03.025] |
| 32. Cananzi S, Merlini L, Artali R, Beretta GL, Zaffaroni N, Dallavalle S.. (2011) Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D., 19 (16): [PMID:21783369] [10.1016/j.bmc.2011.06.056] |
| 33. Kiang TK, Ensom MH, Chang TK.. (2005) UDP-glucuronosyltransferases and clinical drug-drug interactions., 106 (1): [PMID:15781124] [10.1016/j.pharmthera.2004.10.013] |
| 34. PubChem BioAssay data set, |
| 35. Luo Y, Yu S, Tong L, Huang Q, Lu W, Chen Y.. (2012) Synthesis and biological evaluation of new homocamptothecin analogs., 54 [PMID:22647222] [10.1016/j.ejmech.2012.05.002] |
| 36. Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y.. (2003) Breast cancer resistance protein exports sulfated estrogens but not free estrogens., 64 (1): [PMID:12920197] [10.1124/mol.64.3.610] |
| 37. Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I.. (2005) Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms., 33 (1): [PMID:15608127] [10.1124/dmd.104.001909] |
| 38. Nakatomi K, Yoshikawa M, Oka M, Ikegami Y, Hayasaka S, Sano K, Shiozawa K, Kawabata S, Soda H, Ishikawa T, Tanabe S, Kohno S.. (2001) Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells., 288 (1): [PMID:11688982] [10.1006/bbrc.2001.5850] |
| 39. Maliepaard M, van Gastelen MA, Tohgo A, Hausheer FH, van Waardenburg RC, de Jong LA, Pluim D, Beijnen JH, Schellens JH.. (2001) Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918., 7 (1): [PMID:11309344] |
| 40. Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S.. (2001) Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells., 280 (1): [PMID:11162657] [10.1006/bbrc.2001.4267] |
| 41. Chen ZS, Furukawa T, Sumizawa T, Ono K, Ueda K, Seto K, Akiyama SI.. (1999) ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P., 55 (1): [PMID:10220571] |
| 42. Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P.. (2004) Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro., 64 (1): [PMID:15059881] [10.1158/0008-5472.can-03-3344] |
| 43. Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M.. (2003) Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors., 63 (1): [PMID:12488537] [10.1124/mol.63.1.65] |
| 44. Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T.. (2003) Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists., 2 (1): [PMID:12533678] |
| 45. Miwa M, Tsukahara S, Ishikawa E, Asada S, Imai Y, Sugimoto Y.. (2003) Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants., 107 (1): [PMID:14566825] [10.1002/ijc.11484] |
| 46. Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, Oka M, Kohno S, Sawada S, Ishikawa T, Tanabe S.. (2004) Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells., 110 (1): [PMID:15170677] [10.1002/ijc.20216] |
| 47. Alloatti D, Giannini G, Vesci L, Castorina M, Pisano C, Badaloni E, Cabri W.. (2012) Camptothecins in tumor homing via an RGD sequence mimetic., 22 (20): [PMID:22959246] [10.1016/j.bmcl.2012.07.061] |
| 48. Huang Q, Wang L, Lu W.. (2013) Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents., 63 [PMID:23578545] [10.1016/j.ejmech.2013.01.058] |
| 49. Guerrant W, Patil V, Canzoneri JC, Yao LP, Hood R, Oyelere AK.. (2013) Dual-acting histone deacetylase-topoisomerase I inhibitors., 23 (11): [PMID:23622981] [10.1016/j.bmcl.2013.03.108] |
| 50. Wang L, Huang Y, Zhang J, Tong L, Chen Y, Lu W, Huang Q.. (2014) Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs., 24 (6): [PMID:24529870] [10.1016/j.bmcl.2014.01.049] |
| 51. Mark Wenlock and Nicholas Tomkinson. Experimental in vitro DMPK and physicochemical data on a set of publicly disclosed compounds, [10.6019/CHEMBL3301361] |
| 52. Jabor Gozzi G, Bouaziz Z, Winter E, Daflon-Yunes N, Aichele D, Nacereddine A, Marminon C, Valdameri G, Zeinyeh W, Bollacke A, Guillon J, Lacoudre A, Pinaud N, Cadena SM, Jose J, Le Borgne M, Di Pietro A.. (2015) Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2., 58 (1): [PMID:25272055] [10.1021/jm500943z] |
| 53. Wang MJ, Liu YQ, Chang LC, Wang CY, Zhao YL, Zhao XB, Qian K, Nan X, Yang L, Yang XM, Hung HY, Yang JS, Kuo DH, Goto M, Morris-Natschke SL, Pan SL, Teng CM, Kuo SC, Wu TS, Wu YC, Lee KH.. (2014) Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents., 57 (14): [PMID:25003995] [10.1021/jm5003588] |
| 54. Karthikeyan C, Lee C, Moore J, Mittal R, Suswam EA, Abbott KL, Pondugula SR, Manne U, Narayanan NK, Trivedi P, Tiwari AK, Tiwari AK.. (2015) IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells., 23 (3): [PMID:25537531] [10.1016/j.bmc.2014.11.043] |
| 55. Wang L, Xie S, Ma L, Chen Y, Lu W.. (2015) Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents., 23 (9): [PMID:25835359] [10.1016/j.bmc.2015.03.031] |
| 56. Parrino B, Carbone A, Ciancimino C, Spanò V, Montalbano A, Barraja P, Cirrincione G, Diana P, Sissi C, Palumbo M, Pinato O, Pennati M, Beretta G, Folini M, Matyus P, Balogh B, Zaffaroni N.. (2015) Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., 94 [PMID:25768699] [10.1016/j.ejmech.2015.03.005] |
| 57. Zhou J, Tracy TS, Remmel RP.. (2011) Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors., 39 (2): [PMID:21030469] [10.1124/dmd.110.035030] |
| 58. Fujita K, Sunakawa Y, Miwa K, Akiyama Y, Sugiyama M, Kawara K, Ishida H, Yamashita K, Mizuno K, Saji S, Ichikawa W, Yamamoto W, Nagashima F, Miya T, Narabayashi M, Ando Y, Hirose T, Sasaki Y.. (2011) Delayed elimination of SN-38 in cancer patients with severe renal failure., 39 (2): [PMID:20980446] [10.1124/dmd.110.035451] |
| 59. Wang L, Xie S, Ma L, Chen Y, Lu W.. (2016) 10-Boronic acid substituted camptothecin as prodrug of SN-38., 116 [PMID:27060760] [10.1016/j.ejmech.2016.03.063] |
| 60. (2009) Multikinase inhibitors for use in the treatment of cancer, |
| 61. Martino E, Della Volpe S, Terribile E, Benetti E, Sakaj M, Centamore A, Sala A, Collina S.. (2017) The long story of camptothecin: From traditional medicine to drugs., 27 (4): [PMID:28073672] [10.1016/j.bmcl.2016.12.085] |
| 62. Wei Y, Qiu G, Lei B, Qin L, Chu H, Lu Y, Zhu G, Gao Q, Huang Q, Qian G, Liao P, Luo X, Zhang X, Zhang C, Li Y, Zheng S, Yu Y, Tang P, Ni J, Yan P, Zhou Y, Li P, Huang X, Gong A, Liu J.. (2017) Oral Delivery of Propofol with Methoxymethylphosphonic Acid as the Delivery Vehicle., 60 (20): [PMID:28968087] [10.1021/acs.jmedchem.7b01133] |
| 63. Jin C, Zhang Q, Lu W.. (2017) Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38., 132 [PMID:28350997] [10.1016/j.ejmech.2017.03.040] |
| 64. Jin C, Wen S, Zhang Q, Zhu Q, Yu J, Lu W.. (2017) Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole., 8 (7): [PMID:28740613] [10.1021/acsmedchemlett.7b00189] |
| 65. Cai YS, Sarotti AM, Zhou TL, Huang R, Qiu G, Tian C, Miao ZH, Mándi A, Kurtán T, Cao S, Yang SP.. (2018) Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata., 81 (9): [PMID:30169038] [10.1021/acs.jnatprod.8b00191] |
| 66. Zhu Q, Yu X, Shen Q, Zhang Q, Su M, Zhou Y, Li J, Chen Y, Lu W.. (2018) A series of camptothecin prodrugs exhibit HDAC inhibition activity., 26 (16): [PMID:30115492] [10.1016/j.bmc.2018.08.008] |
| 67. Unpublished dataset, |
| 68. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
| 69. Katie Heiser, Peter F. McLean, Chadwick T. Davis, Ben Fogelson, Hannah B. Gordon, Pamela Jacobson, Brett Hurst, Ben Miller, Ronald W. Alfa, Berton A. Earnshaw, Mason L. Victors, Yolanda T. Chong, Imran S. Haque, Adeline S. Low, Christopher C. Gibson. (2020) Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2, [10.1101/2020.04.21.054387] |
| 70. Fukuda T, Nanjo Y, Fujimoto M, Yoshida K, Natsui Y, Ishibashi F, Okazaki F, To H, Iwao M.. (2019) Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold., 27 (2): [PMID:30553626] [10.1016/j.bmc.2018.11.037] |
| 71. Deng T, Mao X, Xiao Y, Yang Z, Zheng X, Jiang ZX.. (2019) Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs., 29 (4): [PMID:30600208] [10.1016/j.bmcl.2018.12.059] |
| 72. Patil S, Ghosh D, Radhakrishna M, Basu S.. (2020) Mitochondrial Impairment by Cyanine-Based Small Molecules Induces Apoptosis in Cancer Cells., 11 (1): [PMID:31938458] [10.1021/acsmedchemlett.9b00304] |
| 73. Zhu S, Shen Q, Gao Y, Wang L, Fang Y, Chen Y, Lu W.. (2020) Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation., 63 (10): [PMID:32352777] [10.1021/acs.jmedchem.0c00305] |
| 74. Kusakabe Y, Mizutani S, Kamo S, Yoshimoto T, Tomoshige S, Kawasaki T, Takasawa R, Tsubaki K, Kuramochi K.. (2019) Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives., 29 (11): [PMID:30935798] [10.1016/j.bmcl.2019.03.034] |
| 75. Coviello V, Marchi B, Sartini S, Quattrini L, Marini AM, Simorini F, Taliani S, Salerno S, Orlandi P, Fioravanti A, Desidero TD, Vullo D, Da Settimo F, Supuran CT, Bocci G, La Motta C.. (2016) 1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions., 59 (13): [PMID:27305384] [10.1021/acs.jmedchem.6b00616] |
| 76. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 77. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 78. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 79. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 80. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 81. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 82. Valero T, Baillache DJ, Fraser C, Myers SH, Unciti-Broceta A.. (2020) Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway., 28 (1): [PMID:31787462] [10.1016/j.bmc.2019.115215] |
| 83. Botta L, Filippi S, Zippilli C, Cesarini S, Bizzarri BM, Cirigliano A, Rinaldi T, Paiardini A, Fiorucci D, Saladino R, Negri R, Benedetti P.. (2020) Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1., 11 (5): [PMID:32435422] [10.1021/acsmedchemlett.0c00131] |
| 84. Jin X, Zhang J, Jin X, Liu L, Tian X.. (2020) Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging., 11 (8): [PMID:32832017] [10.1021/acsmedchemlett.0c00031] |
| 85. Unpublished dataset, |
| 86. Ellen Van Damme. (2021) Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity, [10.6019/CHEMBL4651402] |
| 87. Fan S,Cao YX,Li GY,Lei H,Attiogbe MKI,Yao JC,Yang XY,Liu YJ,Hei YY,Zhang H,Cao L,Zhang XY,Du SS,Zhang GM,Zhang SQ. (2020) F10, a new camptothecin derivative, was identified as a new orally-bioavailable, potent antitumor agent., 202 [PMID:32650182] [10.1016/j.ejmech.2020.112528] |
| 88. Silbermann K,Li J,Namasivayam V,Stefan SM,Wiese M. (2021) Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site., 212 [PMID:33454462] [10.1016/j.ejmech.2020.113045] |
| 89. Hsueh WY,Lee YE,Huang MS,Lai CH,Gao YS,Lin JC,Chen YF,Chang CL,Chou SY,Chen SF,Lu YY,Chang LH,Lin SF,Lin YH,Hsu PC,Wei WY,Huang YC,Kao YF,Teng LW,Liu HH,Chen YC,Yuan TT,Chan YW,Huang PH,Chao YT,Huang SY,Jian BH,Huang HY,Yang SC,Lo TH,Huang GR,Wang SY,Lin HS,Chuang SH,Huang JJ. (2021) Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors., 64 (3.0): [PMID:33492141] [10.1021/acs.jmedchem.0c00727] |
| 90. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |
| 91. Naumczuk B, Górecki M, Wiktorska K, Urbanowicz M, Sitkowski J, Lubelska K, Milczarek M, Bednarek E, Bocian W, Kozerski L.. (2021) New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology., 46 [PMID:34048881] [10.1016/j.bmcl.2021.128146] |
| 92. Baldo S, Antunes P, Felicidade JF, Santos FMF, Arteaga JF, Fernandes F, Pischel U, Pinto SN, Gois PMP.. (2022) The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib-GV1001 Conjugate., 13 (1.0): [PMID:35059132] [10.1021/acsmedchemlett.1c00615] |
| 93. Zhou Z, Feng S, Zhou J, Ji X, Long YQ.. (2022) On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo., 65 (1.0): [PMID:34963283] [10.1021/acs.jmedchem.1c01493] |
| 94. Fan W, Zhang L, Jiang Q, Song W, Yan F, Zhang L.. (2020) Histone deacetylase inhibitor based prodrugs., 203 [PMID:32679451] [10.1016/j.ejmech.2020.112628] |
| 95. Zhang R, Luo Y, Du C, Wu L, Wang Y, Chen Y, Li S, Jiang X, Xie Y.. (2023) Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment., 81 [PMID:36639036] [10.1016/j.bmcl.2023.129128] |
| 96. Stefan K, Schmitt SM, Wiese M.. (2017) 9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein., 60 (21): [PMID:29016119] [10.1021/acs.jmedchem.7b00788] |
| 97. Institute for Molecular Medicine Finland - High Throughput Biomedicine Unit. (2023) ECBD screening data for assay EOS300108, [10.6019/EOS300108] |
