3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine

ID: ALA92279

Chembl Id: CHEMBL92279

PubChem CID: 5329454

Max Phase: Preclinical

Molecular Formula: C16H11N5

Molecular Weight: 273.30

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  c1cc(-c2cnc3c(-c4ccncc4)cnn3c2)ccn1

Standard InChI:  InChI=1S/C16H11N5/c1-5-17-6-2-12(1)14-9-19-16-15(10-20-21(16)11-14)13-3-7-18-8-4-13/h1-11H

Standard InChI Key:  ZLISHOMLHVNDJG-UHFFFAOYSA-N

Alternative Forms

1. Parent:

   

   ALA92279

   Pyrazolo[1,5-a]pyrimidine 1a

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 273.30

Molecular Weight (Monoisotopic): 273.1014

AlogP: 2.85

#Rotatable Bonds: 2

Polar Surface Area: 55.97

Molecular Species: NEUTRAL

HBA: 5

HBD: ┄

#RO5 Violations: ┄

HBA (Lipinski): 5

HBD (Lipinski): ┄

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: ┄

CX Basic pKa: 4.61

CX LogP: 1.51

CX LogD: 1.51

Aromatic Rings: 4

Heavy Atoms: 21

QED Weighted: 0.56

Np Likeness Score: -1.29

References

1. Fraley ME, Hoffman WF, Rubino RS, Hungate RW, Tebben AJ, Rutledge RZ, McFall RC, Huckle WR, Kendall RL, Coll KE, Thomas KA..  (2002)  Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.,  12  (19): [PMID:12217372] [10.1016/s0960-894x(02)00525-5]

2. Fraley ME, Rubino RS, Hoffman WF, Hambaugh SR, Arrington KL, Hungate RW, Bilodeau MT, Tebben AJ, Rutledge RZ, Kendall RL, McFall RC, Huckle WR, Coll KE, Thomas KA..  (2002)  Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.,  12  (24): [PMID:12443771] [10.1016/s0960-894x(02)00827-2]

3. Cherukupalli S, Karpoormath R, Chandrasekaran B, Hampannavar GA, Thapliyal N, Palakollu VN..  (2017)  An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.,  126  [PMID:27894044] [10.1016/j.ejmech.2016.11.019]

Source

Source(1):

• Scientific Literature