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Melatonin receptor 1A

Name And Classification

ID:  ALA1945

Type:  SINGLE PROTEIN

Synonyms:   Mel-1A-R | Mel1a receptor | Melatonin receptor type 1A | MTNR1A

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine-derivative receptor (family A GPCR) / Melatonin receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2094268SUBSET OFMelatonin receptorPROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
Melatonin receptor type 1APROTEINP48039

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA7713

    Name:
    Cyclopropanecarboxylic acid [4-(3-methoxy-phenylamino)-phenyl]-amide

    Mol. Formula:
    C17H18N2O2

    M.W.:
    282.34

    Type:
    Small molecule

    AlogP:
    3.79

    Polar Surface Area:
    50.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  2. Tetrahydrouridine
    ALA7874

    Name:
    N-[4-(3-Methoxy-phenylamino)-phenyl]-isobutyramide

    Mol. Formula:
    C17H20N2O2

    M.W.:
    284.36

    Type:
    Small molecule

    AlogP:
    4.03

    Polar Surface Area:
    50.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  3. Tetrahydrouridine
    ALA7229

    Name:
    N-[4-(3-Methoxy-phenylamino)-phenyl]-butyramide

    Mol. Formula:
    C17H20N2O2

    M.W.:
    284.36

    Type:
    Small molecule

    AlogP:
    4.18

    Polar Surface Area:
    50.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  4. Tetrahydrouridine
    ALA7215

    Name:
    N-[4-(3-Methoxy-phenylamino)-phenyl]-propionamide

    Mol. Formula:
    C16H18N2O2

    M.W.:
    270.33

    Type:
    Small molecule

    AlogP:
    3.79

    Polar Surface Area:
    50.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  5. Tetrahydrouridine
    ALA268165

    Name:
    N-[4-(3-Methoxy-phenylamino)-phenyl]-acetamide

    Mol. Formula:
    C15H16N2O2

    M.W.:
    256.31

    Type:
    Small molecule

    AlogP:
    3.40

    Polar Surface Area:
    50.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  6. Tetrahydrouridine
    ALA266549

    Name:
    N-{4-[(3-Methoxy-phenyl)-methyl-amino]-phenyl}-butyramide

    Mol. Formula:
    C18H22N2O2

    M.W.:
    298.39

    Type:
    Small molecule

    AlogP:
    4.20

    Polar Surface Area:
    41.57

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  7. Tetrahydrouridine
    ALA7867

    Name:
    N-[4-(3-Methoxy-benzyl)-phenyl]-butyramide

    Mol. Formula:
    C18H21NO2

    M.W.:
    283.37

    Type:
    Small molecule

    AlogP:
    4.02

    Polar Surface Area:
    38.33

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  8. Tetrahydrouridine
    ALA7556

    Name:
    {4-[(3-Methoxy-phenyl)-methyl-amino]-phenyl}-carbamic acid ethyl ester

    Mol. Formula:
    C17H20N2O3

    M.W.:
    300.36

    Type:
    Small molecule

    AlogP:
    4.03

    Polar Surface Area:
    50.80

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.91

    DETAILS
  9. Tetrahydrouridine
    ALA7567

    Name:
    Cyclopropanecarboxylic acid {4-[(3-methoxy-phenyl)-methyl-amino]-phenyl}-amide

    Mol. Formula:
    C18H20N2O2

    M.W.:
    296.37

    Type:
    Small molecule

    AlogP:
    3.81

    Polar Surface Area:
    41.57

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.91

    DETAILS
  10. Tetrahydrouridine
    ALA7990

    Name:
    N-{4-[(3-Methoxy-phenyl)-methyl-amino]-phenyl}-isobutyramide

    Mol. Formula:
    C18H22N2O2

    M.W.:
    298.39

    Type:
    Small molecule

    AlogP:
    4.06

    Polar Surface Area:
    41.57

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.90

    DETAILS