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Serine/threonine-protein kinase AKT2

Name And Classification

ID:  ALA2431

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | AKT2 | PKB beta | Protein kinase Akt-2 | Protein kinase B beta | RAC-beta serine/threonine-protein kinase | RAC-PK-beta

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase AKT family

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4106175SUBSET OFSerine/threonine-protein kinase Rac alpha/betaPROTEIN FAMILY
ALA2111353SUBSET OFSerine/threonine-protein kinase AKTPROTEIN FAMILY
ALA5169082SUBSET OFCRBN/AKT2PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
RAC-beta serine/threonine-protein kinasePROTEINP31751

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA383541

    Name:
    (S)-1-(1H-indol-3-yl)-3-(5-(2-(pyridin-4-yl)vinyl)pyridin-3-yloxy)propan-2-amine

    Mol. Formula:
    C23H22N4O

    M.W.:
    370.46

    Type:
    Small molecule

    AlogP:
    4.08

    Polar Surface Area:
    76.82

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  2. Tetrahydrouridine
    ALA227381

    Name:
    N-(2-(2-(4-chlorobenzyloxy)ethylamino)ethyl)isoquinoline-5-sulfonamide

    Mol. Formula:
    C20H22ClN3O3S

    M.W.:
    419.93

    Type:
    Small molecule

    AlogP:
    2.97

    Polar Surface Area:
    80.32

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.49

    DETAILS
  3. Tetrahydrouridine
    ALA227605

    Name:
    1-(4-(9H-purin-6-yl)phenyl)-2-phenylethanamine

    Mol. Formula:
    C19H17N5

    M.W.:
    315.38

    Type:
    Small molecule

    AlogP:
    3.26

    Polar Surface Area:
    80.48

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  4. Tetrahydrouridine
    ALA228114

    Name:
    5-methyl-4-phenyl-1H-pyrazole

    Mol. Formula:
    C10H10N2

    M.W.:
    158.20

    Type:
    Small molecule

    AlogP:
    2.39

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    Y

    QED Weighted:
    0.68

    DETAILS
  5. Tetrahydrouridine
    ALA226712

    Name:
    (4-(9H-purin-6-yl)phenyl)(4-chlorophenyl)methanamine

    Mol. Formula:
    C18H14ClN5

    M.W.:
    335.80

    Type:
    Small molecule

    AlogP:
    3.72

    Polar Surface Area:
    80.48

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  6. Tetrahydrouridine
    ALA226766

    Name:
    (4-(5-methyl-1H-pyrazol-4-yl)phenyl)methanamine

    Mol. Formula:
    C11H13N3

    M.W.:
    187.25

    Type:
    Small molecule

    AlogP:
    1.84

    Polar Surface Area:
    54.70

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    Y

    QED Weighted:
    0.75

    DETAILS
  7. Tetrahydrouridine
    ALA228224

    Name:
    2-(4-(5-methyl-1H-pyrazol-4-yl)phenyl)ethanamine

    Mol. Formula:
    C12H15N3

    M.W.:
    201.27

    Type:
    Small molecule

    AlogP:
    1.89

    Polar Surface Area:
    54.70

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.80

    DETAILS
  8. Tetrahydrouridine
    ALA226870

    Name:
    3-(4-(1H-pyrazol-4-yl)phenyl)propan-1-amine

    Mol. Formula:
    C12H15N3

    M.W.:
    201.27

    Type:
    Small molecule

    AlogP:
    1.97

    Polar Surface Area:
    54.70

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.79

    DETAILS
  9. Tetrahydrouridine
    ALA390066

    Name:
    4-phenyl-1H-pyrazole

    Mol. Formula:
    C9H8N2

    M.W.:
    144.18

    Type:
    Small molecule

    AlogP:
    2.08

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    Y

    QED Weighted:
    0.65

    DETAILS
  10. Tetrahydrouridine
    ALA228042

    Name:
    (4-(9H-purin-6-yl)phenyl)(4-chlorophenyl)-N-methylmethanamine

    Mol. Formula:
    C19H16ClN5

    M.W.:
    349.83

    Type:
    Small molecule

    AlogP:
    3.98

    Polar Surface Area:
    66.49

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.58

    DETAILS