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Serine/threonine-protein kinase AKT

Name And Classification

ID:  ALA2111353

Type:  PROTEIN FAMILY

Synonyms:   2.7.11.1 | AKT2 | PKB beta | Protein kinase Akt-2 | Protein kinase B beta | RAC-beta serine/threonine-protein kinase | RAC-PK-beta

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase AKT family

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4106175SUPERSET OFSerine/threonine-protein kinase Rac alpha/betaPROTEIN FAMILY
ALA3038463OVERLAPS WITHAKT/p21CIP1PROTEIN COMPLEX
ALA3885629OVERLAPS WITHRAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1PROTEIN FAMILY
ALA2431SUPERSET OFSerine/threonine-protein kinase AKT2SINGLE PROTEIN
ALA4816SUPERSET OFSerine/threonine-protein kinase AKT3SINGLE PROTEIN
ALA4523748OVERLAPS WITHAKT1/PPP1CAPROTEIN-PROTEIN INTERACTION
ALA5291687OVERLAPS WITHCereblon/RAC-gamma serine/threonine-protein kinasePROTEIN-PROTEIN INTERACTION
ALA4282SUPERSET OFSerine/threonine-protein kinase AKTSINGLE PROTEIN
ALA5169082OVERLAPS WITHCRBN/AKT2PROTEIN-PROTEIN INTERACTION
ALA5169081OVERLAPS WITHCRBN/AKT1PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
RAC-beta serine/threonine-protein kinasePROTEINP31751
RAC-gamma serine/threonine-protein kinasePROTEINQ9Y243
RAC-alpha serine/threonine-protein kinasePROTEINP31749

Associated Active Ligands

  1. Tetrahydrouridine
    ALA213618

    Name:
    N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide

    Mol. Formula:
    C19H19Cl2N5OS

    M.W.:
    436.37

    Type:
    Small molecule

    AlogP:
    3.85

    Polar Surface Area:
    92.93

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.52

    DETAILS
  2. Tetrahydrouridine
    ALA2367874

    Name:
    Carbonic acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester

    Mol. Formula:
    C30H58O10

    M.W.:
    578.78

    Type:
    Small molecule

    AlogP:
    3.87

    Polar Surface Area:
    155.14

    HBA:
    10

    HBD:
    5

    #RO5 Violations:
    1

    #Rotatable Bonds:
    24

    Passes Ro3:
    N

    QED Weighted:
    0.08

    DETAILS
  3. Tetrahydrouridine
    ALA2367875

    Name:
    Phosphoric acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester

    Mol. Formula:
    C29H59O11P

    M.W.:
    614.75

    Type:
    Small molecule

    AlogP:
    3.85

    Polar Surface Area:
    175.37

    HBA:
    10

    HBD:
    6

    #RO5 Violations:
    2

    #Rotatable Bonds:
    26

    Passes Ro3:
    N

    QED Weighted:
    0.06

    DETAILS
  4. Tetrahydrouridine
    ALA2367876

    Name:
    Carbonic acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4,6-tetrahydroxy-cyclohexyl ester

    Mol. Formula:
    C29H56O9

    M.W.:
    548.76

    Type:
    Small molecule

    AlogP:
    4.65

    Polar Surface Area:
    134.91

    HBA:
    9

    HBD:
    4

    #RO5 Violations:
    1

    #Rotatable Bonds:
    23

    Passes Ro3:
    N

    QED Weighted:
    0.11

    DETAILS
  5. Tetrahydrouridine
    ALA2368944

    Name:
    Phosphoric acid (R)-2-hexadecanoyl-4-oxo-nonadecyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-cyclohexyl ester

    Mol. Formula:
    C41H79O10P

    M.W.:
    763.05

    Type:
    Small molecule

    AlogP:
    9.44

    Polar Surface Area:
    170.82

    HBA:
    9

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    36

    Passes Ro3:
    N

    QED Weighted:
    0.03

    DETAILS
  6. Tetrahydrouridine
    ALA2368945

    Name:
    Phosphoric acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester

    Mol. Formula:
    C31H59N2O10P

    M.W.:
    650.79

    Type:
    Small molecule

    AlogP:
    4.27

    Polar Surface Area:
    183.96

    HBA:
    11

    HBD:
    6

    #RO5 Violations:
    3

    #Rotatable Bonds:
    26

    Passes Ro3:
    N

    QED Weighted:
    0.06

    DETAILS
  7. Tetrahydrouridine
    ALA2368946

    Name:
    Phosphoric acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-cyclohexyl ester

    Mol. Formula:
    C30H57N2O9P

    M.W.:
    620.76

    Type:
    Small molecule

    AlogP:
    5.05

    Polar Surface Area:
    163.73

    HBA:
    10

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    25

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  8. Tetrahydrouridine
    ALA2368947

    Name:
    Phosphoric acid (R)-2-methoxy-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester

    Mol. Formula:
    C29H59O11P

    M.W.:
    614.75

    Type:
    Small molecule

    AlogP:
    3.85

    Polar Surface Area:
    175.37

    HBA:
    10

    HBD:
    6

    #RO5 Violations:
    2

    #Rotatable Bonds:
    26

    Passes Ro3:
    N

    QED Weighted:
    0.06

    DETAILS
  9. Tetrahydrouridine
    ALA2368954

    Name:
    Carbonic acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester

    Mol. Formula:
    C32H58N2O9

    M.W.:
    614.82

    Type:
    Small molecule

    AlogP:
    4.29

    Polar Surface Area:
    163.73

    HBA:
    11

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    24

    Passes Ro3:
    N

    QED Weighted:
    0.08

    DETAILS
  10. Tetrahydrouridine
    ALA3544960

    Name:
    AT-13148

    Mol. Formula:
    C17H16ClN3O

    M.W.:
    313.79

    Type:
    Small molecule

    AlogP:
    2.92

    Polar Surface Area:
    74.93

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS