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Serine/threonine-protein kinase AKT

Name And Classification

ID:  ALA4282

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | AKT1 | PKB | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | Proto-oncogene c-Akt | RAC | RAC-alpha serine/threonine-protein kinase | RAC-PK-alpha

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase AKT family

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4106175SUBSET OFSerine/threonine-protein kinase Rac alpha/betaPROTEIN FAMILY
ALA3038463SUBSET OFAKT/p21CIP1PROTEIN COMPLEX
ALA2111353SUBSET OFSerine/threonine-protein kinase AKTPROTEIN FAMILY
ALA3885629SUBSET OFRAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1PROTEIN FAMILY
ALA4523748SUBSET OFAKT1/PPP1CAPROTEIN-PROTEIN INTERACTION
ALA5169081SUBSET OFCRBN/AKT1PROTEIN-PROTEIN INTERACTION
ALA5169068SUBSET OFVHL/AKT1PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
RAC-alpha serine/threonine-protein kinasePROTEINP31749

Associated Active Ligands

  1. Tetrahydrouridine
    ALA361391

    Name:
    6-[4-(4-Benzoimidazol-1-yl-piperidin-1-ylmethyl)-phenyl]-5-phenyl-nicotinonitrile

    Mol. Formula:
    C31H27N5

    M.W.:
    469.59

    Type:
    Small molecule

    AlogP:
    6.47

    Polar Surface Area:
    57.74

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  2. Tetrahydrouridine
    ALA425338

    Name:
    6-{4-[4-(2-Methyl-benzoimidazol-1-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile

    Mol. Formula:
    C32H29N5

    M.W.:
    483.62

    Type:
    Small molecule

    AlogP:
    6.78

    Polar Surface Area:
    57.74

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.28

    DETAILS
  3. Tetrahydrouridine
    ALA360333

    Name:
    5-Phenyl-6-{4-[(4-[1,2,3]thiadiazol-4-yl-benzylamino)-methyl]-phenyl}-nicotinonitrile

    Mol. Formula:
    C28H21N5S

    M.W.:
    459.58

    Type:
    Small molecule

    AlogP:
    6.10

    Polar Surface Area:
    74.49

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS
  4. Tetrahydrouridine
    ALA368010

    Name:
    6-{4-[4-(6-Fluoro-1H-benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile

    Mol. Formula:
    C31H26FN5

    M.W.:
    487.58

    Type:
    Small molecule

    AlogP:
    6.68

    Polar Surface Area:
    68.60

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  5. Tetrahydrouridine
    ALA181927

    Name:
    6-{4-[4-(6-Methyl-1H-benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile

    Mol. Formula:
    C32H29N5

    M.W.:
    483.62

    Type:
    Small molecule

    AlogP:
    6.85

    Polar Surface Area:
    68.60

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  6. Tetrahydrouridine
    ALA369094

    Name:
    6-{4-[4-(1H-Benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile

    Mol. Formula:
    C31H27N5

    M.W.:
    469.59

    Type:
    Small molecule

    AlogP:
    6.54

    Polar Surface Area:
    68.60

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS
  7. Tetrahydrouridine
    ALA178872

    Name:
    2-(1-{4-[3-Phenyl-5-(1H-tetrazol-5-yl)-pyridin-2-yl]-benzyl}-piperidin-4-yl)-1H-benzoimidazole

    Mol. Formula:
    C31H28N8

    M.W.:
    512.62

    Type:
    Small molecule

    AlogP:
    5.85

    Polar Surface Area:
    99.27

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.29

    DETAILS
  8. Tetrahydrouridine
    ALA178468

    Name:
    1-{1-[4-(5-Isobutyl-6-oxo-3-phenyl-1,6-dihydro-pyrazin-2-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

    Mol. Formula:
    C33H35N5O2

    M.W.:
    533.68

    Type:
    Small molecule

    AlogP:
    6.61

    Polar Surface Area:
    87.30

    HBA:
    7

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.24

    DETAILS
  9. Tetrahydrouridine
    ALA178445

    Name:
    1-(1-{4-[3-Phenyl-5-(1H-tetrazol-5-yl)-pyridin-2-yl]-benzyl}-piperidin-4-yl)-1H-benzoimidazole

    Mol. Formula:
    C31H28N8

    M.W.:
    512.62

    Type:
    Small molecule

    AlogP:
    5.78

    Polar Surface Area:
    88.41

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  10. Tetrahydrouridine
    ALA359864

    Name:
    1-{1-[4-(3-Phenyl-quinolin-2-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

    Mol. Formula:
    C34H30N4O

    M.W.:
    510.64

    Type:
    Small molecule

    AlogP:
    7.46

    Polar Surface Area:
    54.18

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.26

    DETAILS