Serine/threonine-protein kinase AKT
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ID: ALA4282
Type: SINGLE PROTEIN
Synonyms: 2.7.11.1 | AKT1 | PKB | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | Proto-oncogene c-Akt | RAC | RAC-alpha serine/threonine-protein kinase | RAC-PK-alpha
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase AKT family
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA4106175 | SUBSET OF | Serine/threonine-protein kinase Rac alpha/beta | PROTEIN FAMILY |
ALA3038463 | SUBSET OF | AKT/p21CIP1 | PROTEIN COMPLEX |
ALA2111353 | SUBSET OF | Serine/threonine-protein kinase AKT | PROTEIN FAMILY |
ALA3885629 | SUBSET OF | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | PROTEIN FAMILY |
ALA4523748 | SUBSET OF | AKT1/PPP1CA | PROTEIN-PROTEIN INTERACTION |
ALA5169081 | SUBSET OF | CRBN/AKT1 | PROTEIN-PROTEIN INTERACTION |
ALA5169068 | SUBSET OF | VHL/AKT1 | PROTEIN-PROTEIN INTERACTION |
Description | Relationship | Accession |
---|---|---|
RAC-alpha serine/threonine-protein kinase | PROTEIN | P31749 |
Name:
6-[4-(4-Benzoimidazol-1-yl-piperidin-1-ylmethyl)-phenyl]-5-phenyl-nicotinonitrile
Mol. Formula:
C31H27N5
M.W.:
469.59
Type:
Small molecule
AlogP:
6.47
Polar Surface Area:
57.74
HBA:
5
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.30
Name:
6-{4-[4-(2-Methyl-benzoimidazol-1-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile
Mol. Formula:
C32H29N5
M.W.:
483.62
Type:
Small molecule
AlogP:
6.78
Polar Surface Area:
57.74
HBA:
5
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.28
Name:
5-Phenyl-6-{4-[(4-[1,2,3]thiadiazol-4-yl-benzylamino)-methyl]-phenyl}-nicotinonitrile
Mol. Formula:
C28H21N5S
M.W.:
459.58
Type:
Small molecule
AlogP:
6.10
Polar Surface Area:
74.49
HBA:
6
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.32
Name:
6-{4-[4-(6-Fluoro-1H-benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile
Mol. Formula:
C31H26FN5
M.W.:
487.58
Type:
Small molecule
AlogP:
6.68
Polar Surface Area:
68.60
HBA:
4
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.30
Name:
6-{4-[4-(6-Methyl-1H-benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile
Mol. Formula:
C32H29N5
M.W.:
483.62
Type:
Small molecule
AlogP:
6.85
Polar Surface Area:
68.60
HBA:
4
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.30
Name:
6-{4-[4-(1H-Benzoimidazol-2-yl)-piperidin-1-ylmethyl]-phenyl}-5-phenyl-nicotinonitrile
Mol. Formula:
C31H27N5
M.W.:
469.59
Type:
Small molecule
AlogP:
6.54
Polar Surface Area:
68.60
HBA:
4
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.32
Name:
2-(1-{4-[3-Phenyl-5-(1H-tetrazol-5-yl)-pyridin-2-yl]-benzyl}-piperidin-4-yl)-1H-benzoimidazole
Mol. Formula:
C31H28N8
M.W.:
512.62
Type:
Small molecule
AlogP:
5.85
Polar Surface Area:
99.27
HBA:
6
HBD:
2
#RO5 Violations:
2
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.29
Name:
1-{1-[4-(5-Isobutyl-6-oxo-3-phenyl-1,6-dihydro-pyrazin-2-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Mol. Formula:
C33H35N5O2
M.W.:
533.68
Type:
Small molecule
AlogP:
6.61
Polar Surface Area:
87.30
HBA:
7
HBD:
2
#RO5 Violations:
2
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.24
Name:
1-(1-{4-[3-Phenyl-5-(1H-tetrazol-5-yl)-pyridin-2-yl]-benzyl}-piperidin-4-yl)-1H-benzoimidazole
Mol. Formula:
C31H28N8
M.W.:
512.62
Type:
Small molecule
AlogP:
5.78
Polar Surface Area:
88.41
HBA:
7
HBD:
1
#RO5 Violations:
2
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.30
Name:
1-{1-[4-(3-Phenyl-quinolin-2-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Mol. Formula:
C34H30N4O
M.W.:
510.64
Type:
Small molecule
AlogP:
7.46
Polar Surface Area:
54.18
HBA:
5
HBD:
1
#RO5 Violations:
2
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.26