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AKT1/PPP1CA

Name And Classification

ID:  ALA4523748

Type:  PROTEIN-PROTEIN INTERACTION

Synonyms:   3.1.3.16 | PP-1A | PPP1A | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Phosphatase / Protein Phosphatase / Serine/threonine protein phosphatase

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4106175OVERLAPS WITHSerine/threonine-protein kinase Rac alpha/betaPROTEIN FAMILY
ALA3038463OVERLAPS WITHAKT/p21CIP1PROTEIN COMPLEX
ALA2111353OVERLAPS WITHSerine/threonine-protein kinase AKTPROTEIN FAMILY
ALA2164SUPERSET OFSerine/threonine protein phosphatase PP1-alpha catalytic subunitSINGLE PROTEIN
ALA3885629OVERLAPS WITHRAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1PROTEIN FAMILY
ALA4523747OVERLAPS WITHEGFR/PPP1CAPROTEIN-PROTEIN INTERACTION
ALA4282SUPERSET OFSerine/threonine-protein kinase AKTSINGLE PROTEIN
ALA5169081OVERLAPS WITHCRBN/AKT1PROTEIN-PROTEIN INTERACTION
ALA5169068OVERLAPS WITHVHL/AKT1PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitPROTEINP62136
RAC-alpha serine/threonine-protein kinasePROTEINP31749

Associated Active Ligands

  1. Tetrahydrouridine
    ALA4440243

    Name:
    N-((2S,24R)-24-Acetamido-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-piperazin-1-yl)-4-isopropyl-7-methyl-1,8,20-trioxo-10,13,16-trioxa-22-thia-4,7,19-triazapentacosan-25-oyl)-L-arginyl-L-valyl-L-seryl-Nmethyl-L-phenylalanine

    Mol. Formula:
    C60H96ClN15O15S

    M.W.:
    1335.04

    Type:
    Unknown

    DETAILS
  2. Tetrahydrouridine
    ALA4470716

    Name:
    (2S,5S,8S,11S,14S,17S)-17-((3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S)-1-((S)-1-((14R,17S)-14-acetamido-17-(3-guanidinopropyl)-1,10,15-trioxo-1-(2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino)-3,6-dioxa-12-thia-9,16-diazaoctadecane)pyrrolidin-2-yl)-18-(2-amino-2-oxoethyl)-3,9,15-tris(4-aminobutyl)-33-benzyl-6,12,24-tris(3-guanidinopropyl)-30-((R)-1-hydroxyethyl)-27-isopropyl-21,36-dimethyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaazaheptatriacontanamido)-2,5-di-sec-butyl-8-(2-carboxyethyl)-11,14-dimethyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid

    Mol. Formula:
    C149H228N44O35S

    M.W.:
    3227.80

    Type:
    Unknown

    DETAILS
  3. Tetrahydrouridine
    ALA4476401

    Name:
    N-(2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)acetamide

    Mol. Formula:
    C35H32N6O3

    M.W.:
    584.68

    Type:
    Unknown

    AlogP:
    5.70

    Polar Surface Area:
    115.88

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.23

    DETAILS
  4. Tetrahydrouridine
    ALA4531937

    Name:
    ((R)-14-Acetamido-1,10-dioxo-1-((2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-3,6-dioxa-12-thia-9-azapentadecan-15-oyl)-L-arginyl-L-valyl-L-seryl-L-alanine

    Mol. Formula:
    C63H81N15O14S

    M.W.:
    1304.50

    Type:
    Unknown

    DETAILS
  5. Tetrahydrouridine
    ALA4547112

    Name:
    N1-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethyl)-N4-(2-(2-(2-oxo-2-((2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)-benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-amino)ethoxy)ethoxy)ethyl)succinamide

    Mol. Formula:
    C53H65ClN8O9

    M.W.:
    993.60

    Type:
    Unknown

    AlogP:
    6.55

    Polar Surface Area:
    211.00

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    29

    Passes Ro3:
    N

    QED Weighted:
    0.03

    DETAILS
  6. Tetrahydrouridine
    ALA4581562

    Name:
    ((2S,24R)-24-Acetamido-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-piperazin-1-yl)-4-isopropyl-7-methyl-1,8,20-trioxo-10,13,16-trioxa-22-thia-4,7,19-triazapentacosan-25-oyl)-L-arginyl-L-valyl-L-seryl-L-alanine

    Mol. Formula:
    C59H94ClN15O15S

    M.W.:
    1321.01

    Type:
    Unknown

    DETAILS
  7. Tetrahydrouridine
    ALA4589266

    Name:
    (2S,5S,8S,11S,14R)-14-acetamido-2-benzyl-11-(3-guanidinopropyl)-5-(hydroxymethyl)-8-isopropyl-3-methyl-4,7,10,13,18,27-hexaoxo-27-(2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino)-22,25-dioxa-16-thia-3,6,9,12,19-pentaazaheptacosan-1-oic acid

    Mol. Formula:
    C70H87N15O14S

    M.W.:
    1394.62

    Type:
    Unknown

    DETAILS