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Signal transducer and activator of transcription 3
Name And Classification
ID: ALA4026
Type: SINGLE PROTEIN
Synonyms: Acute-phase response factor | Signal transducer and activator of transcription 3 | STAT3 | Synonyms=APRF
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Transcription factor
Target Relations
ALA ID | Relationship | Pref Name | Target Type |
---|
ALA4523691 | SUBSET OF | Protein cereblon/STAT3 | PROTEIN-PROTEIN INTERACTION |
ALA4296101 | SUBSET OF | PTPN9/STAT3 | PROTEIN-PROTEIN INTERACTION |
Target Components
Description | Relationship | Accession |
Signal transducer and activator of transcription 3 | PROTEIN | P40763 |
Associated Recombinant Proteins
Associated Active Ligands
ALA156407Name:
Phosphoric acid mono-(4-{(R)-2-acetylamino-2-[(R)-1-((S)-2-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-propylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-ethyl}-phenyl) ester
Mol. Formula:
C35H55N8O12P
M.W.:
810.84
Type:
Protein
AlogP:
-1.39
Polar Surface Area:
318.75
HBA:
10
HBD:
9
#RO5 Violations:
2
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.06
DETAILS
CLOSE
ALA156465Name:
Phosphoric acid mono-(4-{(R)-2-acetylamino-2-[(R)-1-((S)-2-{(S)-1-[(1S,2R)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propylcarbamoyl]-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-ethyl}-phenyl) ester
Mol. Formula:
C34H54N7O12P
M.W.:
783.82
Type:
Protein
AlogP:
-1.28
Polar Surface Area:
295.89
HBA:
10
HBD:
9
#RO5 Violations:
2
#Rotatable Bonds:
19
Passes Ro3:
N
QED Weighted:
0.07
DETAILS
CLOSE
ALA160730Name:
Phosphoric acid mono-(4-{(S)-2-acetylamino-2-[(S)-1-((R)-2-{(S)-1-[(S)-1-((S)-5-amino-1-carbamoyl-pentylcarbamoyl)-ethylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-3-carbamoyl-propylcarbamoyl]-ethyl}-phenyl) ester
Mol. Formula:
C35H55N10O13P
M.W.:
854.86
Type:
Protein
AlogP:
-3.70
Polar Surface Area:
387.86
HBA:
12
HBD:
11
#RO5 Violations:
3
#Rotatable Bonds:
25
Passes Ro3:
N
QED Weighted:
0.03
DETAILS
CLOSE
ALA347438Name:
(S)-2-[((R)-1-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid 5-amide 1-{[(1S,2R)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propyl]-amide}
Mol. Formula:
C36H56N8O10
M.W.:
760.89
Type:
Protein
AlogP:
-1.80
Polar Surface Area:
292.45
HBA:
10
HBD:
9
#RO5 Violations:
2
#Rotatable Bonds:
20
Passes Ro3:
N
QED Weighted:
0.07
DETAILS
CLOSE
ALA157727Name:
(R)-2-((2R,3R)-2-{(R)-2-[((R)-1-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-4-carbamoyl-butyrylamino}-3-hydroxy-butyrylamino)-propionic acid
Mol. Formula:
C34H52N7O14P
M.W.:
813.80
Type:
Protein
AlogP:
-2.07
Polar Surface Area:
333.19
HBA:
11
HBD:
10
#RO5 Violations:
3
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.06
DETAILS
CLOSE
ALA156046Name:
Phosphoric acid mono-(4-{(S)-2-acetylamino-2-[(S)-1-(1-{(S)-3-carbamoyl-1-[(1S,2R)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propylcarbamoyl]-propylcarbamoyl}-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-ethyl}-phenyl) ester
Mol. Formula:
C34H55N8O13P
M.W.:
814.83
Type:
Small molecule
AlogP:
-2.52
Polar Surface Area:
347.77
HBA:
11
HBD:
11
#RO5 Violations:
3
#Rotatable Bonds:
23
Passes Ro3:
N
QED Weighted:
0.05
DETAILS
CLOSE
ALA405322Name:
4-{(S)-2-Acetylamino-2-[(S)-1-((R)-2-{(S)-3-carbamoyl-1-[(1S,2R)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propylcarbamoyl]-propylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-ethyl}-benzoic acid
Mol. Formula:
C37H56N8O11
M.W.:
788.90
Type:
Protein
AlogP:
-1.80
Polar Surface Area:
309.52
HBA:
10
HBD:
9
#RO5 Violations:
2
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.07
DETAILS
CLOSE
ALA348612Name:
(S)-3-[(S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-methyl-pentanoylamino}-5-guanidino-pentanoylamino)-3-mercapto-propionylamino]-4-((S)-1-carbamoyl-2-hydroxy-ethylamino)-butyric acid
Mol. Formula:
C33H55N10O13PS
M.W.:
862.90
Type:
Small molecule
AlogP:
-3.92
Polar Surface Area:
389.31
HBA:
13
HBD:
14
#RO5 Violations:
3
#Rotatable Bonds:
27
Passes Ro3:
N
QED Weighted:
0.01
DETAILS
CLOSE
ALA156448Name:
(S)-3-{2-[(S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-acetylamino}-succinamic acid
Mol. Formula:
C33H51N8O14P
M.W.:
814.79
Type:
Protein
AlogP:
-2.81
Polar Surface Area:
364.84
HBA:
11
HBD:
11
#RO5 Violations:
3
#Rotatable Bonds:
24
Passes Ro3:
N
QED Weighted:
0.05
DETAILS
CLOSE
ALA436427Name:
(S)-4-[(S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-methyl-pentanoylamino}-6-amino-hexanoylamino)-4-carbamoyl-butyrylamino]-4-((S)-1-carbamoyl-2-hydroxy-ethylcarbamoyl)-butyric acid
Mol. Formula:
C36H58N9O15P
M.W.:
887.88
Type:
Protein
AlogP:
-3.59
Polar Surface Area:
411.09
HBA:
13
HBD:
13
#RO5 Violations:
3
#Rotatable Bonds:
29
Passes Ro3:
N
QED Weighted:
0.03
DETAILS
CLOSE