ID: ALA4106124
Type: PROTEIN-PROTEIN INTERACTION
Synonyms: BIG3 | BMP2-induced 3-kb gene protein | WD repeat-containing protein 5 | WDR5
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Other nuclear protein
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA5169069 | OVERLAPS WITH | VHL/WDR5 | PROTEIN-PROTEIN INTERACTION |
ALA2093861 | OVERLAPS WITH | Menin/Histone-lysine N-methyltransferase MLL | PROTEIN-PROTEIN INTERACTION |
ALA1293299 | SUPERSET OF | Histone-lysine N-methyltransferase MLL | SINGLE PROTEIN |
ALA3883320 | SUPERSET OF | Histone-lysine N-methyltransferase 2A/WDR5 | PROTEIN-PROTEIN INTERACTION |
ALA3137282 | SUPERSET OF | MLL1/ASH2L/RBBP5/WDR5 complex | PROTEIN COMPLEX |
ALA1075317 | SUPERSET OF | WD repeat-containing protein 5 | SINGLE PROTEIN |
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(3-phenylpropyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C27H38N8O5
M.W.:
554.65
Type:
Unknown
AlogP:
-0.30
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
13
Passes Ro3:
N
QED Weighted:
0.19
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(4-chlorobenzyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C25H33ClN8O5
M.W.:
561.04
Type:
Unknown
AlogP:
-0.08
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.21
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-aminoethyl)amino)butanoic acid
Mol. Formula:
C16H26N8O5
M.W.:
410.44
Type:
Unknown
AlogP:
-2.91
Polar Surface Area:
211.89
HBA:
12
HBD:
6
#RO5 Violations:
2
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.25
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(1-(3-cyclopentylpropyl)azetidin-3-yl)amino)butanoic acid
Mol. Formula:
C25H40N8O5
M.W.:
532.65
Type:
Unknown
AlogP:
-0.21
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
12
Passes Ro3:
N
QED Weighted:
0.24
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(2-chlorobenzyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C25H33ClN8O5
M.W.:
561.04
Type:
Unknown
AlogP:
-0.08
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.21
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(benzofuran-3-ylmethyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C27H34N8O6
M.W.:
566.62
Type:
Unknown
AlogP:
0.01
Polar Surface Area:
202.25
HBA:
13
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.16
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(3-chlorobenzyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C25H33ClN8O5
M.W.:
561.04
Type:
Unknown
AlogP:
-0.08
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.21
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(3,3-diphenylpropyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C33H42N8O5
M.W.:
630.75
Type:
Unknown
AlogP:
1.29
Polar Surface Area:
189.11
HBA:
12
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
14
Passes Ro3:
N
QED Weighted:
0.13
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-((3-cyclopentylpropyl)amino)cyclobutyl)amino)butanoic acid
Mol. Formula:
C26H42N8O5
M.W.:
546.67
Type:
Unknown
AlogP:
0.22
Polar Surface Area:
197.90
HBA:
12
HBD:
6
#RO5 Violations:
3
#Rotatable Bonds:
13
Passes Ro3:
N
QED Weighted:
0.19
Name:
(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(thiophen-2-ylmethyl)azetidin-3-yl)methyl)amino)butanoic acid
Mol. Formula:
C23H32N8O5S
M.W.:
532.63
Type:
Unknown
AlogP:
-0.67
Polar Surface Area:
189.11
HBA:
13
HBD:
5
#RO5 Violations:
2
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.21