ID: ALA4296118
Type: PROTEIN-PROTEIN INTERACTION
Synonyms: Androgen receptor | AR | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Transcription factor / Nuclear receptor / Nuclear hormone receptor subfamily 3 / Nuclear hormone receptor subfamily 3 group C / Nuclear hormone receptor subfamily 3 group C member 4
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA2221342 | OVERLAPS WITH | Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | PROTEIN COMPLEX |
ALA4523684 | OVERLAPS WITH | Protein cereblon/Androgen receptor | PROTEIN-PROTEIN INTERACTION |
ALA3885521 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/Estrogen receptor | PROTEIN COMPLEX |
ALA4523653 | OVERLAPS WITH | Androgen receptor/PELP1 | PROTEIN-PROTEIN INTERACTION |
ALA5169084 | OVERLAPS WITH | CRBN/CUL4A/AR | PROTEIN-PROTEIN INTERACTION |
ALA4802030 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/Prostaglandin E synthase | PROTEIN-PROTEIN INTERACTION |
ALA4296119 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/BCR/ABL | PROTEIN-PROTEIN INTERACTION |
ALA4802032 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/Aldo-keto reductase family 1 member B1 | PROTEIN-PROTEIN INTERACTION |
ALA4802031 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/Epidermal growth factor receptor | PROTEIN-PROTEIN INTERACTION |
ALA4680047 | OVERLAPS WITH | Baculoviral IAP repeat-containing protein 2/Hematopoietic prostaglandin D synthase | PROTEIN-PROTEIN INTERACTION |
Name:
N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(2-(3-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)-ethoxy)ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide
Mol. Formula:
C55H65N7O8S
M.W.:
984.23
Type:
Small molecule
AlogP:
8.10
Polar Surface Area:
190.06
HBA:
14
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
25
Passes Ro3:
N
QED Weighted:
0.04
Name:
N-((1S)-2-((2S)-2-(4-(3-(2-(4-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide
Mol. Formula:
C57H61N7O7S
M.W.:
988.22
Type:
Small molecule
AlogP:
9.50
Polar Surface Area:
180.83
HBA:
13
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.05
Name:
(S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(2-(2-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Mol. Formula:
C55H65N7O8S
M.W.:
984.23
Type:
Small molecule
AlogP:
8.10
Polar Surface Area:
190.06
HBA:
14
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
25
Passes Ro3:
N
QED Weighted:
0.04
Name:
4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)-methyl)-N-(2-(2-(2-(3-((2-((2S)-1-((2S)-2-cyclohexyl-2-((N-methyl-Lalanyl)amino)acetyl)pyrrolidin-2-yl)-1,3-thiazol-4-yl)carbonyl)-phenoxy)ethoxy)ethoxy)ethyl)benzamide
Mol. Formula:
C54H62N8O7S
M.W.:
967.21
Type:
Small molecule
AlogP:
7.43
Polar Surface Area:
200.70
HBA:
13
HBD:
3
#RO5 Violations:
3
#Rotatable Bonds:
22
Passes Ro3:
N
QED Weighted:
0.05
Name:
N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)-ethoxy)ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide
Mol. Formula:
C55H65N7O8S
M.W.:
984.23
Type:
Small molecule
AlogP:
8.10
Polar Surface Area:
190.06
HBA:
14
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
25
Passes Ro3:
N
QED Weighted:
0.04
Name:
(S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(3-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenyl)propoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Mol. Formula:
C56H67N7O7S
M.W.:
982.26
Type:
Small molecule
AlogP:
8.65
Polar Surface Area:
180.83
HBA:
13
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
25
Passes Ro3:
N
QED Weighted:
0.04
Name:
(S)-N-((S)-2-((S)-2-(4-(3-(14-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)-3,6,9,12-tetraoxatetradecyloxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Mol. Formula:
C57H69N7O9S
M.W.:
1028.29
Type:
Small molecule
Name:
1-((2S)-2-Cyclohexyl-2-((N-methyl-L-alanyl)amino)acetyl)-L-prolyl-N-(13-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl)-beta-phenyl-L-phenylalaninamide
Mol. Formula:
C62H75N9O8
M.W.:
1074.34
Type:
Small molecule
Name:
N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide
Mol. Formula:
C57H61N7O7S
M.W.:
988.22
Type:
Small molecule
AlogP:
9.50
Polar Surface Area:
180.83
HBA:
13
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.05
Name:
N-((1S)-2-((2S)-2-(4-(3-(2-(3-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide
Mol. Formula:
C57H61N7O7S
M.W.:
988.22
Type:
Small molecule
AlogP:
9.50
Polar Surface Area:
180.83
HBA:
13
HBD:
2
#RO5 Violations:
3
#Rotatable Bonds:
21
Passes Ro3:
N
QED Weighted:
0.05