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Androgen receptor/Baculoviral IAP repeat-containing protein 2

Name And Classification

ID:  ALA4296118

Type:  PROTEIN-PROTEIN INTERACTION

Synonyms:   Androgen receptor | AR | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Transcription factor / Nuclear receptor / Nuclear hormone receptor subfamily 3 / Nuclear hormone receptor subfamily 3 group C / Nuclear hormone receptor subfamily 3 group C member 4

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2221342OVERLAPS WITHComplex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteinsPROTEIN COMPLEX
ALA4523684OVERLAPS WITHProtein cereblon/Androgen receptorPROTEIN-PROTEIN INTERACTION
ALA3885521OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/Estrogen receptorPROTEIN COMPLEX
ALA4523653OVERLAPS WITHAndrogen receptor/PELP1PROTEIN-PROTEIN INTERACTION
ALA5169084OVERLAPS WITHCRBN/CUL4A/ARPROTEIN-PROTEIN INTERACTION
ALA4802030OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/Prostaglandin E synthasePROTEIN-PROTEIN INTERACTION
ALA4296119OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/BCR/ABLPROTEIN-PROTEIN INTERACTION
ALA4802032OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/Aldo-keto reductase family 1 member B1PROTEIN-PROTEIN INTERACTION
ALA4802031OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/Epidermal growth factor receptorPROTEIN-PROTEIN INTERACTION
ALA4680047OVERLAPS WITHBaculoviral IAP repeat-containing protein 2/Hematopoietic prostaglandin D synthasePROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
Androgen receptorPROTEINP10275
Baculoviral IAP repeat-containing protein 2PROTEINQ13490

Associated Active Ligands

  1. Tetrahydrouridine
    ALA4225000

    Name:
    N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(2-(3-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)-ethoxy)ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide

    Mol. Formula:
    C55H65N7O8S

    M.W.:
    984.23

    Type:
    Small molecule

    AlogP:
    8.10

    Polar Surface Area:
    190.06

    HBA:
    14

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    25

    Passes Ro3:
    N

    QED Weighted:
    0.04

    DETAILS
  2. Tetrahydrouridine
    ALA4225266

    Name:
    N-((1S)-2-((2S)-2-(4-(3-(2-(4-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide

    Mol. Formula:
    C57H61N7O7S

    M.W.:
    988.22

    Type:
    Small molecule

    AlogP:
    9.50

    Polar Surface Area:
    180.83

    HBA:
    13

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    21

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS
  3. Tetrahydrouridine
    ALA4225655

    Name:
    (S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(2-(2-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

    Mol. Formula:
    C55H65N7O8S

    M.W.:
    984.23

    Type:
    Small molecule

    AlogP:
    8.10

    Polar Surface Area:
    190.06

    HBA:
    14

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    25

    Passes Ro3:
    N

    QED Weighted:
    0.04

    DETAILS
  4. Tetrahydrouridine
    ALA4225792

    Name:
    4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)-methyl)-N-(2-(2-(2-(3-((2-((2S)-1-((2S)-2-cyclohexyl-2-((N-methyl-Lalanyl)amino)acetyl)pyrrolidin-2-yl)-1,3-thiazol-4-yl)carbonyl)-phenoxy)ethoxy)ethoxy)ethyl)benzamide

    Mol. Formula:
    C54H62N8O7S

    M.W.:
    967.21

    Type:
    Small molecule

    AlogP:
    7.43

    Polar Surface Area:
    200.70

    HBA:
    13

    HBD:
    3

    #RO5 Violations:
    3

    #Rotatable Bonds:
    22

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS
  5. Tetrahydrouridine
    ALA4225857

    Name:
    N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)-ethoxy)ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide

    Mol. Formula:
    C55H65N7O8S

    M.W.:
    984.23

    Type:
    Small molecule

    AlogP:
    8.10

    Polar Surface Area:
    190.06

    HBA:
    14

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    25

    Passes Ro3:
    N

    QED Weighted:
    0.04

    DETAILS
  6. Tetrahydrouridine
    ALA4226183

    Name:
    (S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(3-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenyl)propoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

    Mol. Formula:
    C56H67N7O7S

    M.W.:
    982.26

    Type:
    Small molecule

    AlogP:
    8.65

    Polar Surface Area:
    180.83

    HBA:
    13

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    25

    Passes Ro3:
    N

    QED Weighted:
    0.04

    DETAILS
  7. Tetrahydrouridine
    ALA4226455

    Name:
    (S)-N-((S)-2-((S)-2-(4-(3-(14-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)-3,6,9,12-tetraoxatetradecyloxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

    Mol. Formula:
    C57H69N7O9S

    M.W.:
    1028.29

    Type:
    Small molecule

    DETAILS
  8. Tetrahydrouridine
    ALA4226640

    Name:
    1-((2S)-2-Cyclohexyl-2-((N-methyl-L-alanyl)amino)acetyl)-L-prolyl-N-(13-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl)-beta-phenyl-L-phenylalaninamide

    Mol. Formula:
    C62H75N9O8

    M.W.:
    1074.34

    Type:
    Small molecule

    DETAILS
  9. Tetrahydrouridine
    ALA4226783

    Name:
    N-((1S)-2-((2S)-2-(4-(3-(2-(2-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide

    Mol. Formula:
    C57H61N7O7S

    M.W.:
    988.22

    Type:
    Small molecule

    AlogP:
    9.50

    Polar Surface Area:
    180.83

    HBA:
    13

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    21

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS
  10. Tetrahydrouridine
    ALA4227240

    Name:
    N-((1S)-2-((2S)-2-(4-(3-(2-(3-(2-(4-((3-Cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)phenoxy)-ethoxy)benzoyl)-1,3-thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-N2-methyl-L-alaninamide

    Mol. Formula:
    C57H61N7O7S

    M.W.:
    988.22

    Type:
    Small molecule

    AlogP:
    9.50

    Polar Surface Area:
    180.83

    HBA:
    13

    HBD:
    2

    #RO5 Violations:
    3

    #Rotatable Bonds:
    21

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS