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Daunorubicin hydrochloride - >90%, high purity , DNA inhibitor, CAS No.23541-50-6, DNA inhibitor

≥90%

CAS#: 23541-50-6
Formula: C₂₇H₂₉NO₁₀ · HCl
Molecular Weight: 563.98
Beilstein Registry Number: 4229221
EC Number: 245-723-4
MDL number: MFCD04974507
PubChem CID: 62770
PubChem SID: 488183611

Item Number

D122335

Grouped product items
SKU	Size	Availability	Price
D122335-10mg	10mg	In stock	$9.90
D122335-50mg	50mg	In stock	$19.90
D122335-250mg	250mg	In stock	$49.90
D122335-1g	1g	In stock	$139.90

Anthracycline antibiotic. DNA and RNA synthesis inhibitor.

View related series

Apoptosis Chemical Biology Tetracyclines

Basic Description

Synonyms	23541-50-6\|DAUNORUBICIN HCL\|DAUNORUBICIN HYDROCHLORIDE\|Daunomycin hydrochloride\|Daunoblastina\|Rubidomycin hydrochloride\|Cerubidine\|Ondena\|RP 13057 hydrochloride\|Daunomycin chlorohydrate\|Daunomycin HCL\|Daunomycin, hydrochloride\|RP-13057 Hydrochloride\|NDC 0
Specifications & Purity	>90%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	DNA inhibitor
Product Description	Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. A DNA intercalator which may suppress acute leukemia proliferation

Associated Targets

S100A4 Tchem Protein S100-A4 1 Activities

Discover Target: S100A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488183611
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183611
IUPAC Name	(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
INCHI	InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChi Key	GUGHGUXZJWAIAS-QQYBVWGSSA-N
Canonical SMILES	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
Isomeric SMILES	C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
WGK Germany	3
RTECS	HB7878000
Alternate CAS	20830-81-3
PubChem CID	62770
UN Number	2811
Packing Group	I
Molecular Weight	563.98
Beilstein	4229221

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
F2428225	Certificate of Analysis	Jun 03, 2024	D122335
F2428226	Certificate of Analysis	Jun 03, 2024	D122335
F2428227	Certificate of Analysis	Jun 03, 2024	D122335
F2428228	Certificate of Analysis	Jun 03, 2024	D122335
C2308992	Certificate of Analysis	Dec 17, 2022	D122335
C2308993	Certificate of Analysis	Dec 17, 2022	D122335
C2308994	Certificate of Analysis	Dec 17, 2022	D122335
C2308995	Certificate of Analysis	Dec 17, 2022	D122335
C2308996	Certificate of Analysis	Dec 17, 2022	D122335
C2308997	Certificate of Analysis	Dec 17, 2022	D122335
C2308998	Certificate of Analysis	Dec 17, 2022	D122335
K2210228	Certificate of Analysis	Sep 06, 2021	D122335

Chemical and Physical Properties

Solubility	Soluble in water (≥113), methanol, ethanol (≥10), and DMSO (≥72 mg/mL).
Sensitivity	Moisture & heat sensitive.light sensitive
Specific Rotation[α]	260°
Melt Point(°C)	167 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H341:Suspected of causing genetic defects H351:Suspected of causing cancer H302:Harmful if swallowed H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	HB7878000
Class	6.1
Merck Index	2832

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References

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