Decitabine (NSC 127716) - 10mM in DMSO, high purity , CAS No.2353-33-5(DMSO)

  • 10mM in DMSO
Item Number
D408747
Grouped product items
SKUSizeAvailabilityPrice Qty
D408747-1ml
1ml
Available within 4-8 weeks(?)
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$146.90

Nucleoside Analog/Antimetabolite Inhibitors

Basic Description

Specifications & Purity10mM in DMSO
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

Decitabine (NSC 127716) Decitabine (NSC 127716, Deoxycytidine, Dacogen, 5-aza-2-deoxycytidine, 5-AZA-dC, 5-aza-CdR) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA repl
In vitro

Decitabine inhibits cell growth in a dose and time-dependent manner with IC50 of approximately 438 nM and 43.8 nM for 72 hours and 96 hours exposure in HL-60 and KG1a leukemic cells, respectively. A recent study shows that Decitabine exhibits high anti-proliferative and pro-apoptotic activity against anaplastic large cell lymphoma (ALCL), and inhibits [3H]–thymidine uptake in KARPAS-299 cells with EC50 of 0.49 μM.

In vivo

In a ALK+ KARPAS-299 murine xenograft model, Decitabine at a dose of 2.5 mg/kg causes increased apoptosis and reduced proliferation of tumor cells, and also results in demethylation of tumor suppressor p16INK4A.
Cell Data

cell lines:A498, FaO and NRP 154 cells

Concentrations:0-500 nM

Incubation Time:96 hours

Powder Purity:≥99%

Associated Targets(Human)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2
Molecular Weight 228.21

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