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Deferoxamine mesylate - ≥98%, high purity , Iron chelating agent, CAS No.138-14-7, Iron chelating agent

6 Citations

≥98%

CAS#: 138-14-7
Formula: C₂₆H₅₂N₆O₁₁S
Molecular Weight: 656.79
MDL number: MFCD00058605
PubChem CID: 62881

Item Number

D302525

Grouped product items
SKU	Size	Availability	Price
D302525-5mg	5mg	In stock	$9.90
D302525-25mg	25mg	In stock	$19.90
D302525-100mg	100mg	In stock	$44.90
D302525-250mg	250mg	In stock	$89.90
D302525-500mg	500mg	In stock	$159.90
D302525-1g	1g	In stock	$279.90
D302525-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,299.90

Iron chelator

View related series

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Basic Description

Synonyms	Deferoxamine mesilate \| Deferoxamine mesylate \| Deferoxamine methanesulfonate \| Desferrioxamine B mesylate
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Action Type	CHELATING AGENT
Mechanism of action	Iron chelating agent
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

Discover Target: MDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTRC Tchem Chymotrypsin C (381 Activities)

Discover Target: CTRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Serine/threonine-protein phosphatase (23 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP-dependent molecular chaperone HSP82 (2186 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid
INCHI	InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChi Key	IDDIJAWJANBQLJ-UHFFFAOYSA-N
Canonical SMILES	CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
Isomeric SMILES	CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
PubChem CID	62881
Molecular Weight	656.79

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

47 results found

Lot Number	Certificate Type	Date	Item
G2408414	Certificate of Analysis	Jun 29, 2024	D302525
G2408420	Certificate of Analysis	Jun 29, 2024	D302525
G2408426	Certificate of Analysis	Jun 29, 2024	D302525
G2408427	Certificate of Analysis	Jun 29, 2024	D302525
G2408429	Certificate of Analysis	Jun 29, 2024	D302525
G2408430	Certificate of Analysis	Jun 29, 2024	D302525
G2408431	Certificate of Analysis	Jun 29, 2024	D302525
C2416210	Certificate of Analysis	Mar 07, 2024	D302525
C2416212	Certificate of Analysis	Mar 07, 2024	D302525
C2416208	Certificate of Analysis	Mar 07, 2024	D302525
C2416207	Certificate of Analysis	Mar 07, 2024	D302525
C2416206	Certificate of Analysis	Mar 07, 2024	D302525
C2416204	Certificate of Analysis	Mar 07, 2024	D302525
C2416202	Certificate of Analysis	Mar 07, 2024	D302525
J2331321	Certificate of Analysis	Oct 21, 2023	D302525
J2331320	Certificate of Analysis	Oct 21, 2023	D302525
J2331322	Certificate of Analysis	Oct 21, 2023	D302525
J2331415	Certificate of Analysis	Oct 21, 2023	D302525
J2331416	Certificate of Analysis	Oct 21, 2023	D302525
J2331417	Certificate of Analysis	Oct 21, 2023	D302525
J2331418	Certificate of Analysis	Oct 21, 2023	D302525
A2415184	Certificate of Analysis	Oct 21, 2023	D302525
L2322155	Certificate of Analysis	Oct 21, 2023	D302525
G2307279	Certificate of Analysis	Jun 12, 2023	D302525
I2306034	Certificate of Analysis	Jun 12, 2023	D302525
G2307276	Certificate of Analysis	Jun 12, 2023	D302525
G2307275	Certificate of Analysis	Jun 12, 2023	D302525
G2307274	Certificate of Analysis	Jun 12, 2023	D302525
G2307273	Certificate of Analysis	Jun 12, 2023	D302525
G2307272	Certificate of Analysis	Jun 12, 2023	D302525
G2307271	Certificate of Analysis	Jun 12, 2023	D302525
G2307301	Certificate of Analysis	Jun 12, 2023	D302525
G2307270	Certificate of Analysis	Jun 12, 2023	D302525
G2307269	Certificate of Analysis	Jun 12, 2023	D302525
B23101012	Certificate of Analysis	Feb 01, 2023	D302525
B2310542	Certificate of Analysis	Feb 01, 2023	D302525
B2310543	Certificate of Analysis	Feb 01, 2023	D302525
B2310544	Certificate of Analysis	Feb 01, 2023	D302525
B2310545	Certificate of Analysis	Feb 01, 2023	D302525
B2310546	Certificate of Analysis	Feb 01, 2023	D302525
D2318960	Certificate of Analysis	Feb 01, 2023	D302525
H2217345	Certificate of Analysis	Aug 01, 2022	D302525
H2217343	Certificate of Analysis	Aug 01, 2022	D302525
H2217342	Certificate of Analysis	Aug 01, 2022	D302525
H2217341	Certificate of Analysis	Aug 01, 2022	D302525
H2217340	Certificate of Analysis	Aug 01, 2022	D302525
H2217334	Certificate of Analysis	Aug 01, 2022	D302525

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Chemical and Physical Properties

Sensitivity	Moisture sensitive、Air sensitive、Heat sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774] [10.1016/j.ejmech.2023.116110]
2. Weimin Yin, Jiao Chang, Jiuyuan Sun, Yuge Zhao, Shiyu Chen, Hui Zhi, Jie Zang, Tingting Zhang, Yongyong Li, Haiqing Dong. (2024) Arginine nanoparticles mediated closed-loop ferroptosis enhancement for T cell activity boosting in cancer immunotherapy. Applied Materials Today, 36 (102047). [PMID:] [10.1016/j.apmt.2023.102047]
3. Wang Shengmei, Guo Qiuyan, Xu Rubing, Lin Peng, Deng Guoyan, Xia Xinhua. (2023) Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-21). [PMID:37858186] [10.1186/s12951-023-02146-0]
4. Shan Gao, Wanlin Zhang, Xingxing Zhai, Xue Zhao, Jianxin Wang, Jie Weng, Jianshu Li, Xingyu Chen. (2023) An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing. Biomaterials Science, 11 (2): (533-541). [PMID:36472206] [10.1039/D2BM01588A]
5. Kai Sun, Jiaying Yu, Jinzhong Hu, Jian Chen, Jia Song, Zhixin Chen, Zhuoer Cai, Zhuoxuan Lu, Liming Zhang, Zhifei Wang. (2022) Salicylic acid-based hypoxia-responsive chemodynamic nanomedicines boost antitumor immunotherapy by modulating immunosuppressive tumor microenvironment. Acta Biomaterialia, 148 (230). [PMID:35724919] [10.1016/j.actbio.2022.06.026]
6. Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou. (2021) Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration. Journal of Advanced Research, 34 (65). [PMID:35024181] [10.1016/j.jare.2021.06.016]

References

1. Furukawa T et al.. (2017) Chronic diazepam administration increases the expression of Lcn2 in the CNS.. Pharmacol Res Perspect, 5 (e00283). [PMID:28596835]
2. Henning Y et al.. (2022) Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.. Cell Death Dis, 13 (7): (662). [PMID:35906211]
3. Rakshit J et al.. (2020) Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction.. J Trace Elem Med Biol, 57 (126406). [PMID:31570251]
4. Sias SR & Ingraham JL. (1979) Isolation and analysis of mutants of Pseudomonas aeruginosa unable to assimilate nitrate.. Arch Microbiol, 122 (3): (263-70). [PMID:120727]
5. Yao Q et al.. (2018) Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering.. J Control Release, 279 (69-78). [PMID:29649529]
6. Tadokoro T et al.. (2020) Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.. JCI Insight, 5 (9): [PMID:32376803]
7. You JH et al.. (2021) PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells.. J Exp Clin Cancer Res, 40 (350). [PMID:34749765]
8. Fu C et al.. (2020) The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1a in liver cancer cells.. J Biol Chem, 295 (20): (7060-7074). [PMID:32277050]
9. Nishimura K et al.. (2018) Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes.. Life Sci, 203 (276-281). [PMID:29684447]
10. Sugiyama A et al.. (2020) xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.. Oncol Lett, 20 (3): (2689-2700). [PMID:32782585]
11. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774] [10.1016/j.ejmech.2023.116110]
12. Weimin Yin, Jiao Chang, Jiuyuan Sun, Yuge Zhao, Shiyu Chen, Hui Zhi, Jie Zang, Tingting Zhang, Yongyong Li, Haiqing Dong. (2024) Arginine nanoparticles mediated closed-loop ferroptosis enhancement for T cell activity boosting in cancer immunotherapy. Applied Materials Today, 36 (102047). [PMID:] [10.1016/j.apmt.2023.102047]
13. Wang Shengmei, Guo Qiuyan, Xu Rubing, Lin Peng, Deng Guoyan, Xia Xinhua. (2023) Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-21). [PMID:37858186] [10.1186/s12951-023-02146-0]
14. Shan Gao, Wanlin Zhang, Xingxing Zhai, Xue Zhao, Jianxin Wang, Jie Weng, Jianshu Li, Xingyu Chen. (2023) An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing. Biomaterials Science, 11 (2): (533-541). [PMID:36472206] [10.1039/D2BM01588A]
15. Kai Sun, Jiaying Yu, Jinzhong Hu, Jian Chen, Jia Song, Zhixin Chen, Zhuoer Cai, Zhuoxuan Lu, Liming Zhang, Zhifei Wang. (2022) Salicylic acid-based hypoxia-responsive chemodynamic nanomedicines boost antitumor immunotherapy by modulating immunosuppressive tumor microenvironment. Acta Biomaterialia, 148 (230). [PMID:35724919] [10.1016/j.actbio.2022.06.026]
16. Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou. (2021) Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration. Journal of Advanced Research, 34 (65). [PMID:35024181] [10.1016/j.jare.2021.06.016]

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Deferoxamine mesylate - ≥98%, high purity , Iron chelating agent, CAS No.138-14-7, Iron chelating agent

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

FAQs and Articles

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator