Deguelin - ≥95%, high purity , CAS No.522-17-8

Item Number

D134674

• Synonyms: Deguelin | 522-17-8 | (-)-Deguelin | (-)-cis-deguelin | DEGUELIN(-) | CHEBI:4357 | K5Z93K66IE | (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one | (7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f
• Specifications & Purity: ≥95%
• Biochemical and Physiological Mechanisms: Akt inhibitor. Anticancer agent. Inhibits cell growth (IC 50 = 43.2 nM) in vitro . Anticancer and antiangiogenic activities in vivo . Deguelin is a natural rotenoid compound present abundantly in barks, leaves, seeds, and roots of the plants belonging to
• Storage Temp: Protected from light,Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Application

(−)-Deguelin has been used as:

a nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase (Complex I) inhibitor to study its effects on mitochondrial respiratory inhibition in human hepatocarcinoma cells (HepG2) and human renal proximal tubule epithelial cells (RPTECs)

an antiviral compound to study inhibitory effects on human cytomegalovirus (HCMV)-infected human foreskin fibroblast (HFF) cells

an analytical standard in high-performance liquid chromatography (HPLC)