| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| D424473-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Akt inhibitor. Anticancer agent.
| Synonyms | Deguelin | 522-17-8 | (-)-Deguelin | (-)-cis-deguelin | DEGUELIN(-) | CHEBI:4357 | K5Z93K66IE | (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one | (7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f |
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| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Akt inhibitor. Anticancer agent. Inhibits cell growth (IC 50 = 43.2 nM) in vitro . Anticancer and antiangiogenic activities in vivo . Deguelin is a natural rotenoid compound present abundantly in barks, leaves, seeds, and roots of the plants belonging to |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Application (−)-Deguelin has been used as: a nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase (Complex I) inhibitor to study its effects on mitochondrial respiratory inhibition in human hepatocarcinoma cells (HepG2) and human renal proximal tubule epithelial cells (RPTECs) an antiviral compound to study inhibitory effects on human cytomegalovirus (HCMV)-infected human foreskin fibroblast (HFF) cells an analytical standard in high-performance liquid chromatography (HPLC) |
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| IUPAC Name | (1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one |
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| INCHI | InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1 |
| InChi Key | ORDAZKGHSNRHTD-UXHICEINSA-N |
| Canonical SMILES | CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC)C |
| Isomeric SMILES | CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C |
| WGK Germany | 3 |
| RTECS | DX1500000 |
| PubChem CID | 107935 |
| Molecular Weight | 394.42 |
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| Sensitivity | Heat Sensitive |
|---|---|
| Specific Rotation[α] | -59.0 to -63.0 deg(C=1, methanol) |
| Melt Point(°C) | 87 °C |
| WGK Germany | 3 |
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| RTECS | DX1500000 |
