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(+)-Dehydroabietylamine [Optical Resolving Agent] - >90.0%(GC), high purity , CAS No.1446-61-3
Pyruvate dehydrogenase kinase (PDK) inhibitor
Basic Description Synonyms DEHYDROABIETYLAMINE | 1446-61-3 | (+)-Dehydroabietylamine | Leelamine | Dehydroabiethylamine | ((1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanamine | Amine D | CHEMBL70488 | NSC-2955 | 1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10 Specifications & Purity ≥90%(GC) Biochemical and Physiological Mechanisms Pyruvate dehydrogenase kinase (PDK) inhibitor (IC 50 = 9.5 µM). It has weak affinity for human CB 1 and CB 2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Shipped In Normal Note Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers Pubchem Sid 488183548 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183548 IUPAC Name [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine INCHI InChI=1S/C20H31N/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4/h6,8,12,14,18H,5,7,9-11,13,21H2,1-4H3/t18-,19-,20+/m0/s1 InChi Key JVVXZOOGOGPDRZ-SLFFLAALSA-N Canonical SMILES CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C Isomeric SMILES CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)CN)C PubChem CID 62034 Molecular Weight 285.48 Reaxy-Rn 3084620
Chemical and Physical Properties Specific Rotation[α] 45° (C=4,MeOH) Melt Point(°C) 40 °C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
Reaxy-Rn 3084620
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C2320431