ERK dimerization inhibitor (IC50~ 0.5μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenesin vitro. Induces apoptosis and prevents tumor progressionin vivo.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
application：
DEL 22379 is a useful research chemical.DEL 22379 was used for preparation of hydrosoluble 3-arylidene-2-oxyindole tyrosine kinase inhibitors.
product description：
DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM.
J2130388