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Deltarasin - 10mM in DMSO, high purity , CAS No.1440898-61-2

10mM in DMSO

CAS#: 1440898-61-2
Formula: C₄₀H₃₇N₅O
Molecular Weight: 603.75
PubChem CID: 73292904

Item Number

D421620

Grouped product items
SKU	Size	Availability	Price	Qty
D421620-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$634.90

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Description: IC50 Value: 41±12 nM (binding to PDEδ in cell) [1] Deltarasin is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction and impairs oncogenic KRAS signalling. Interfering with b
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Product introduction Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.

Associated Targets(Human)

PDE6D Tclin Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (4 Activities)

Discover Target: PDE6D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE6D Tclin Phosphodiesterase 6D (241 Activities)

Discover Target: PDE6D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE6D Tclin PDE6D/KRAS (21 Activities)

Discover Target: PDE6D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (1 Activities)

Discover Target: PDE6D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-benzyl-2-[4-[(2S)-2-(2-phenylbenzimidazol-1-yl)-2-piperidin-4-ylethoxy]phenyl]benzimidazole
INCHI	InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1
InChi Key	LTZKEDSUXKTTTC-KXQOOQHDSA-N
Canonical SMILES	C1CNCCC1C(COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8
Isomeric SMILES	C1CNCCC1[C@@H](COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8
Alternate CAS	1440898-82-7
PubChem CID	73292904
Molecular Weight	603.75

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Deltarasin - 10mM in DMSO, high purity , CAS No.1440898-61-2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

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