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Denbufylline , CAS No.57076-71-8
a xanthine derivative PDE IV inhibitor
Basic Description Storage Temp Store at 2-8°C Shipped In Wet ice Product Description Denbufylline is a selective xanthine derivative that inhibits PDE IV and has bronchodilatory properties. Shown to exhibit negative inotropic effects by acting on verapamil-sensitive sites of Ca|2+|channels in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity.
Product Properties Ki Data phosphodiesterase IV : Ki= ~ 1 μM
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione INCHI InChI=1S/C16H24N4O3/c1-4-6-8-19-14-13(18(11-17-14)10-12(3)21)15(22)20(16(19)23)9-7-5-2/h11H,4-10H2,1-3H3 InChi Key HJPRDDKCXVCFOH-UHFFFAOYSA-N Canonical SMILES CCCCN1C2=C(C(=O)N(C1=O)CCCC)N(C=N2)CC(=O)C Isomeric SMILES CCCCN1C2=C(C(=O)N(C1=O)CCCC)N(C=N2)CC(=O)C PubChem CID 2984 Molecular Weight 320.4
Chemical and Physical Properties Solubility Soluble in DMSO, and MeOH. Refractive Index n20D1.59 (Predicted) Boil Point(°C) 514.81° C at 760 mmHg (Predicted) Melt Point(°C) 98-100° C
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