Deoxycorticosterone acetate - ≥99%, high purity , Mineralocorticoid receptor agonist, CAS No.56-47-3, Mineralocorticoid receptor agonist

1 Citations
  • ≥99%
Item Number
D129628
Grouped product items
SKUSizeAvailabilityPrice Qty
D129628-250mg
250mg
In stock
$79.90
D129628-1g
1g
In stock
$226.90
D129628-5g
5g
In stock
$769.90

Steroid hormone used via intramuscular injections in the replacement therapy of the adrenocortical steroid

Basic Description

SynonymsCortexone acetate | Percotol | 11-Deoxycorticosterone acetate | Decosterone | Docaquosum | DOCA | DESOXYCORTICOSTERONE ACETATE | Decostrate | Descorterone | Decosteron | Desoxycortone acetate | Dorcostrin | Krinocorts | Sincortex | DOC-21-acetate | MLS000
Specifications & Purity≥99%
Biochemical and Physiological MechanismsSteroid hormone commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeAGONIST
Mechanism of actionMineralocorticoid receptor agonist
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Product Properties

ALogP3.1

Associated Targets(Human)

GMNN Tbio Geminin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D3 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KMT2A Tchem Histone-lysine N-methyltransferase 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SMN1 Tchem Survival motor neuron protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PGR Tclin Progesterone receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LMNA Tbio Prelamin-A/C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLP1R Tclin Glucagon-like peptide 1 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name [2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
INCHI InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
InChi Key VPGRYOFKCNULNK-ACXQXYJUSA-N
Canonical SMILES CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Isomeric SMILES CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
WGK Germany 3
RTECS HG0525000
PubChem CID 5952
Molecular Weight 372.5
Beilstein 2570798

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot NumberCertificate TypeDateItem
I2209260Certificate of AnalysisJun 14, 2024 D129628
I2209261Certificate of AnalysisJun 14, 2024 D129628
G2426329Certificate of AnalysisJun 11, 2024 D129628
G2426330Certificate of AnalysisJun 11, 2024 D129628
L2102567Certificate of AnalysisSep 18, 2023 D129628
D2412088Certificate of AnalysisMay 19, 2023 D129628
F2302670Certificate of AnalysisMay 19, 2023 D129628
F2302675Certificate of AnalysisMay 19, 2023 D129628
F2302676Certificate of AnalysisMay 19, 2023 D129628
F2302677Certificate of AnalysisMay 19, 2023 D129628
F2302683Certificate of AnalysisMay 19, 2023 D129628
F2116113Certificate of AnalysisApr 11, 2023 D129628
F1509082Certificate of AnalysisJan 16, 2023 D129628
D2313821Certificate of AnalysisJul 22, 2022 D129628

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Chemical and Physical Properties

SolubilitySoluble in methanol, ethanol (6 mg/mL at 25 °C), chloroform (100 mg/mL), and DMSO (11 mg/mL at 25 °C). Insoluble in water.
Specific Rotation[α]20/D: +170.0 to +180.0 deg(C=1, Dioxane)
Melt Point(°C)157°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS HG0525000

Related Documents

Citations of This Product

1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling.  (2023)  Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats.  Journal of Cardiovascular Translational Research,  16  (1): (127-140).  [PMID:35616880]

References

1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling.  (2023)  Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats.  Journal of Cardiovascular Translational Research,  16  (1): (127-140).  [PMID:35616880]

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