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Deoxycorticosterone acetate - ≥99%, high purity , Mineralocorticoid receptor agonist, CAS No.56-47-3, Mineralocorticoid receptor agonist
Steroid hormone used via intramuscular injections in the replacement therapy of the adrenocortical steroid
Basic Description Synonyms Cortexone acetate | Percotol | 11-Deoxycorticosterone acetate | Decosterone | Docaquosum | DOCA | DESOXYCORTICOSTERONE ACETATE | Decostrate | Descorterone | Decosteron | Desoxycortone acetate | Dorcostrin | Krinocorts | Sincortex | DOC-21-acetate | MLS000 Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Steroid hormone commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system. Storage Temp Store at 2-8°C Shipped In Wet ice Action Type AGONIST Mechanism of action Mineralocorticoid receptor agonist Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate INCHI InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 InChi Key VPGRYOFKCNULNK-ACXQXYJUSA-N Canonical SMILES CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C Isomeric SMILES CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C WGK Germany 3 RTECS HG0525000 PubChem CID 5952 Molecular Weight 372.5 Beilstein 2570798
Chemical and Physical Properties Solubility Soluble in methanol, ethanol (6 mg/mL at 25 °C), chloroform (100 mg/mL), and DMSO (11 mg/mL at 25 °C). Insoluble in water. Specific Rotation[α] 20/D： +170.0 to +180.0 deg(C=1, Dioxane) Melt Point(°C) 157°C
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS HG0525000
Citations of This Product 1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling. (2023) Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats. Journal of Cardiovascular Translational Research, 16 (1): (127-140). [PMID:35616880 ] [10.1007/s12265-022-10277-2 ] 2. Yanhong Liu, Lingchao Li, Jiyong Liu, Mengnan Yang, Honglan Wang, Xuxin Chu, Jianping Zhou, Meirong Huo, Tingjie Yin. (2021) Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment. BIOMATERIALS, 267 (120481). [PMID:33189053 ] [10.1016/j.biomaterials.2020.120481 ]
References 1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling. (2023) Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats. Journal of Cardiovascular Translational Research, 16 (1): (127-140). [PMID:35616880 ] [10.1007/s12265-022-10277-2 ] 2. Yanhong Liu, Lingchao Li, Jiyong Liu, Mengnan Yang, Honglan Wang, Xuxin Chu, Jianping Zhou, Meirong Huo, Tingjie Yin. (2021) Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment. BIOMATERIALS, 267 (120481). [PMID:33189053 ] [10.1016/j.biomaterials.2020.120481 ]
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