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B135944-1mg

1mg

In stock

$411.90

B135944-5mg

5mg

In stock

$1,545.90

Basic Description

Synonyms	DEOXYNIVALENOL \| 51481-10-8 \| Vomitoxin \| Dehydronivalenol \| 4-Deoxynivalenol \| 4-Desoxynivalenol \| Desoxynivalenol \| Rd toxin \| JT37HYP23V \| 12,13-Epoxy-3-alpha,7-alpha,15-trihydroxy-9-trichothecen-8-one \| 3alpha,7alpha,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one \| (3beta,
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Deoxynivalenol is a mycotoxin usually produced by Fusarium species and is often detected in grains. This compound demonstrates immunosuppressive characteristics at high concentrations and immunostimulatory effects at low concentrations. Other effects of this mycotoxin include down-regulation of genes involved in protein synthesis, proliferation, ribosomal proteins, and mitochondria. Further studies show that Deoxynivalenol is an inducer of calcium release from the endoplasmic reticulum. A Fusarium mycotoxin.The main toxic effect of Deoxynivalenol is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, it is widely used to select crops strains with increased resistance against Fusarium.

Associated Targets(Human)

K562 (73714 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COLO 201 (44 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Bipolaris oryzae (287 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Arabidopsis thaliana (307 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Saccharomyces cerevisiae (19171 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(1R,2R,3S,7R,9R,10R,12S)-3,10-dihydroxy-2-(hydroxymethyl)-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-one
INCHI	InChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChi Key	LINOMUASTDIRTM-QGRHZQQGSA-N
Canonical SMILES	CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
Isomeric SMILES	CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO
WGK Germany	3
RTECS	YD0167000
PubChem CID	40024
Molecular Weight	296.32

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2212274	Certificate of Analysis	Aug 21, 2024	B135944
K2212271	Certificate of Analysis	Aug 13, 2024	B135944
H2110115	Certificate of Analysis	May 12, 2023	B135944
H2110393	Certificate of Analysis	May 12, 2023	B135944
G2408015	Certificate of Analysis	Oct 11, 2022	B135944

Chemical and Physical Properties

Solubility	Soluble in methanol, chloroform, water (slightly), ethanol (9.8 - 10.2 mg/ml), and DMSO.
Sensitivity	Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RTECS	YD0167000

Alternative Products

Citations of This Product

1. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486]
2. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084]
3. Mingming Chen, Bihang Su, Huiying Wu, Yawen Dai, Tianwen Chen, Fengfu Fu, Zhenyu Lin, Yongqiang Dong. (2024) Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin. TALANTA, 268 (5): (125329). [PMID:37879204]
4. Ragini Singh, Wen Zhang, Xuecheng Liu, Bingyuan Zhang, Bingyuan Zhang, Santosh Kumar. (2023) Humanoid-shaped WaveFlex biosensor for the detection of food contamination. Biomedical Optics Express, 14 (9): (4660-4676). [PMID:37791266]
5. Ziyang He, Jinxin Zhang, Mei Liu, Yonghong Meng. (2024) Polyvalent aptamer scaffold coordinating light-responsive oxidase-like nanozyme for sensitive detection of zearalenone. FOOD CHEMISTRY, 431 (136908). [PMID:37573743]
6. Xuecheng Liu, Ragini Singh, Guoru Li, Carlos Marques, Bingyuan Zhang, Santosh Kumar. (2023) WaveFlex Biosensor-using Novel Tri-Tapered in Tapered Four-Core Fiber with Multimode Fiber Coupling for Detection of Aflatoxin B1. JOURNAL OF LIGHTWAVE TECHNOLOGY, PP (99): (1-10). [PMID:]
7. Yijian Zhao, Tianyue Liu, Jinghui Gao, Qiaojuan Zhang, Mengyu Liao, He Cheng, Jingsheng Tian, Zhiyi Yao. (2023) Nanoassemblies Based on a Cationic Perylene Diimide Derivative and Sodium Dodecyl Sulfate: A Simple Fluorescent Platform for Efficient Analysis of Aflatoxin B1. ANALYTICAL CHEMISTRY, 95 (21): (8250–8257). [PMID:37186575]
8. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, 421 (136196). [PMID:37116443]
9. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:]
10. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636]
11. Xuecheng Liu, Ragini Singh, Muyang Li, Guoru Li, Rui Min, Carlos Marques, Bingyuan Zhang, Bingyuan Zhang, Santosh Kumar. (2023) Plasmonic sensor based on offset-splicing and waist-expanded taper using multicore fiber for detection of Aflatoxins B1 in critical sectors. OPTICS EXPRESS, 31 (3): (4783-4802). [PMID:36785437]
12. Ming-Hang Yu, Yun-Qi Feng, Yue-Hong Pang, Cheng Yang, Xiao-Fang Shen. (2023) Electrochemical Degradation and Toxicity Evaluation of Deoxynivalenol in Wheat Grains. ACS Food Science & Technology, 3 (1): (224–230). [PMID:]
13. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087]
14. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li. (2022) A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1. RSC Advances, 12 (43): (27940-27947). [PMID:36320289]
15. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:]
16. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524]
17. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang. (2021) Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A. ANALYTICA CHIMICA ACTA, 1188 (339189). [PMID:34794565]

References

1. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486]
2. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084]
3. Mingming Chen, Bihang Su, Huiying Wu, Yawen Dai, Tianwen Chen, Fengfu Fu, Zhenyu Lin, Yongqiang Dong. (2024) Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin. TALANTA, 268 (5): (125329). [PMID:37879204]
4. Ragini Singh, Wen Zhang, Xuecheng Liu, Bingyuan Zhang, Bingyuan Zhang, Santosh Kumar. (2023) Humanoid-shaped WaveFlex biosensor for the detection of food contamination. Biomedical Optics Express, 14 (9): (4660-4676). [PMID:37791266]
5. Ziyang He, Jinxin Zhang, Mei Liu, Yonghong Meng. (2024) Polyvalent aptamer scaffold coordinating light-responsive oxidase-like nanozyme for sensitive detection of zearalenone. FOOD CHEMISTRY, 431 (136908). [PMID:37573743]
6. Xuecheng Liu, Ragini Singh, Guoru Li, Carlos Marques, Bingyuan Zhang, Santosh Kumar. (2023) WaveFlex Biosensor-using Novel Tri-Tapered in Tapered Four-Core Fiber with Multimode Fiber Coupling for Detection of Aflatoxin B1. JOURNAL OF LIGHTWAVE TECHNOLOGY, PP (99): (1-10). [PMID:]
7. Yijian Zhao, Tianyue Liu, Jinghui Gao, Qiaojuan Zhang, Mengyu Liao, He Cheng, Jingsheng Tian, Zhiyi Yao. (2023) Nanoassemblies Based on a Cationic Perylene Diimide Derivative and Sodium Dodecyl Sulfate: A Simple Fluorescent Platform for Efficient Analysis of Aflatoxin B1. ANALYTICAL CHEMISTRY, 95 (21): (8250–8257). [PMID:37186575]
8. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, 421 (136196). [PMID:37116443]
9. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:]
10. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636]
11. Xuecheng Liu, Ragini Singh, Muyang Li, Guoru Li, Rui Min, Carlos Marques, Bingyuan Zhang, Bingyuan Zhang, Santosh Kumar. (2023) Plasmonic sensor based on offset-splicing and waist-expanded taper using multicore fiber for detection of Aflatoxins B1 in critical sectors. OPTICS EXPRESS, 31 (3): (4783-4802). [PMID:36785437]
12. Ming-Hang Yu, Yun-Qi Feng, Yue-Hong Pang, Cheng Yang, Xiao-Fang Shen. (2023) Electrochemical Degradation and Toxicity Evaluation of Deoxynivalenol in Wheat Grains. ACS Food Science & Technology, 3 (1): (224–230). [PMID:]
13. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087]
14. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li. (2022) A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1. RSC Advances, 12 (43): (27940-27947). [PMID:36320289]
15. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:]
16. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524]
17. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang. (2021) Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A. ANALYTICA CHIMICA ACTA, 1188 (339189). [PMID:34794565]

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Deoxynivalenol - ≥98%, high purity , CAS No.51481-10-8