Desloratadine - >98.0%(HPLC)(T), high purity , Histamine H1 receptor antagonist, CAS No.100643-71-8, Histamine H1 receptor antagonist

Item Number

D155989

• Synonyms: Desloratadine|100643-71-8|Clarinex|Descarboethoxyloratadine|Desloratidine|Neoclarityn|Aerius|Azomyr|Denosin|Sch-34117|Opulis|Allex|Sch 34117|8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine|Desloratadine Actavis|Dasselta
• Specifications & Purity: Moligand™, ≥98%(HPLC)(T)
• Biochemical and Physiological Mechanisms: It is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ ch
• Storage Temp: Store at 2-8°C,Argon charged
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Histamine H1 receptor antagonist
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro.
It is a potent antagonist for human histamine H1 receptor used to treat allergies.