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SKU | Size | Availability | Price | Qty |
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D423117-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Carbohydrate Metabolism Inhibitors
Specifications & Purity | 10mM in DMSO |
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Biochemical and Physiological Mechanisms | Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor o |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells. Targets FAS/FASN ; glucose (in rat everted gut sleeves); glucose (in rabbit intestinal membrane vesicles) ; 30.9 μM; 148.3 μM |
ALogP | 1.386 |
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HBD Count | 5 |
Rotatable Bond | 6 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
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INCHI | InChI=1S/C21H24O8/c1-27-15-6-4-12(5-7-15)2-3-13-8-14(23)10-16(9-13)28-21-20(26)19(25)18(24)17(11-22)29-21/h2-10,17-26H,11H2,1H3/b3-2+/t17-,18-,19+,20-,21-/m1/s1 |
InChi Key | MFMQRDLLSRLUJY-DXKBKAGUSA-N |
Canonical SMILES | COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O |
Isomeric SMILES | COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O |
PubChem CID | 5316606 |
Molecular Weight | 404.41 |
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DMSO(mg / mL) Max Solubility | 100 |
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DMSO(mM) Max Solubility | 247.2738062857 |
Water(mg / mL) Max Solubility | -1 |