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SKU

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D129794-1g

In stock

$157.90

D129794-5g

In stock

$617.90

Basic Description

Synonyms	Desvenlafaxine\|93413-62-8\|O-Desmethylvenlafaxine\|4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol\|4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol\|O-desmethyl venlafaxine\|Khedezla\|Newven\|D-veniz\|Mdd-xr\|DVS 233\|O-Desvenlafaxine\|d,l-O-Desmet
Specifications & Purity	Moligand™, ≥99%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Norepinephrine transporter inhibitor

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

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ESR1 Tclin Estrogen receptor 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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ABCB1 Tchem Multidrug resistance protein 1 0 Activities

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HRH3 Tclin Histamine H3 receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 1 Activities

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SCN5A Tclin Sodium channel protein type 5 subunit alpha 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 4 Activities

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PGR Tclin Progesterone receptor 0 Activities

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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

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CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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SLC18A2 Tclin Synaptic vesicular amine transporter 0 Activities

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KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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ABCB11 Tchem Bile salt export pump 0 Activities

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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TBXA2R Tclin Thromboxane A2 receptor 0 Activities

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F2 Tclin Prothrombin 0 Activities

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KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 0 Activities

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KCND3 Tclin Potassium voltage-gated channel subfamily D member 3 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
INCHI	InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
InChi Key	KYYIDSXMWOZKMP-UHFFFAOYSA-N
Canonical SMILES	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
Isomeric SMILES	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
PubChem CID	125017
Molecular Weight	263.375

Database links

DrugBank Ligand	DB06700
PubChem CID	125017
CAS Registry No.	93413-62-8
ChEMBL Ligand	CHEMBL1118
Wikipedia	Desvenlafaxine
PEP	desvenlafaxine
DrugCentral Ligand	4380

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2422126	Certificate of Analysis	Aug 26, 2024	D129794
H2229271	Certificate of Analysis	Jun 14, 2024	D129794
H2229272	Certificate of Analysis	Jun 14, 2024	D129794
A2426024	Certificate of Analysis	Jun 17, 2022	D129794

Chemical and Physical Properties

Solubility	Practically insoluble in water, 3,700 mg/l 25 °C
Sensitivity	Air sensitive
Melt Point(°C)	222 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.

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Desvenlafaxine - 99%, high purity , Norepinephrine transporter inhibitor, CAS No.93413-62-8, Norepinephrine transporter inhibitor