deucrictibant , CAS No.2340111-58-0, Antagonist of B 1 receptor;Antagonist of B 2 receptor

Item Number

D609841

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SKU	Size	Availability	Price	Qty
D609841-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609841-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	DEUCRICTIBANT [USAN] \| PHVS-719 \| N-{(1S)-1-[3-chloro-5-fluoro-2-({[2-methyl-4-(1-methyl-1H-1,2,4-triazol-5-yl)quinolin-8- yl]oxy}methyl)phenyl](1-2H)ethyl}-2-(difluoromethoxy)acetamide \| CS-0376051 \| 69GCA2KX22 \| GLXC-26832 \| (S)-N-(1-Deutero-1-(3-chloro
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of B 1 receptor;Antagonist of B 2 receptor

Associated Targets(Human)

BDKRB2 Tclin B2 bradykinin receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BDKRB1 Tchem B1 bradykinin receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(1S)-1-[3-chloro-5-fluoro-2-[[2-methyl-4-(2-methyl-1,2,4-triazol-3-yl)quinolin-8-yl]oxymethyl]phenyl]-1-deuterioethyl]-2-(difluoromethoxy)acetamide
INCHI	InChI=1S/C25H23ClF3N5O3/c1-13-7-18(24-30-12-31-34(24)3)16-5-4-6-21(23(16)32-13)36-10-19-17(8-15(27)9-20(19)26)14(2)33-22(35)11-37-25(28)29/h4-9,12,14,25H,10-11H2,1-3H3,(H,33,35)/t14-/m0/s1/i14D
InChi Key	ZTCLCSCHTACERP-WTDRUJNCSA-N
Canonical SMILES	[2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC=2C=CC=C3C(=CC(=NC23)C)C4=NC=NN4C)NC(COC(F)F)=O
Isomeric SMILES	[2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC2=CC=CC3=C(C=C(N=C32)C)C4=NC=NN4C)NC(=O)COC(F)F
PubChem CID	154623230

PubChem CID

CAS Registry No.

References

1. Lesage A, Marceau F, Gibson C, Loenders B, Katzer W, Ambrosi HD, Saupe J, Faussner A, Pardali E, Knolle J. (2022) In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B₂ receptor antagonist in clinical development.. Int Immunopharmacol, 105 (13): (108523). [PMID:35086057] [10.1021/op500134e]

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Basic Description