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G protein-coupled receptors (GPCRs)
Acetylcholine receptors (muscarinic)
dexetimide , CAS No.21888-98-2, Antagonist of M 2 receptor

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dexetimide , CAS No.21888-98-2, Antagonist of M 2 receptor

Moligand™

CAS#: 21888-98-2
PubChem CID: 30843

Item Number

D609848

Grouped product items
SKU	Size	Availability	Price	Qty
D609848-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609848-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

M2 receptor Antagonist

Basic Description

Synonyms	DEXETIMIDE \| 21888-98-2 \| Tremblex \| (+)-Benzetimide \| Dexbenzetimide \| Benzetimide, (s)- \| R 16470 \| R 16,470 [as hydrochloride] \| (3S)-3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione \| 43477QYX3D \| (+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide \| Dexbenzelimid \| Sere
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of M 2 receptor

Associated Targets(Human)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (2 Activities)

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Chrm1 Muscarinic acetylcholine receptor (3770 Activities)

Discover Target: Chrm1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(3S)-3-phenyl-3-[1-(phenylmethyl)piperidin-4-yl]piperidine-2,6-dione
INCHI	InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1
InChi Key	LQQIVYSCPWCSSD-HSZRJFAPSA-N
Canonical SMILES	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1
Isomeric SMILES	C1CN(CCC1[C@@]2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4
PubChem CID	30843

Database links

PubChem CID	30843
Wikipedia	Dexetimide
ChEMBL Ligand	CHEMBL1908364
CAS Registry No.	21888-98-2
DrugCentral Ligand	831
GPCRdb Ligand	dexetimide

Certificates

Certificate of Analysis(COA)

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References

1. Huygens H, Vereecken JL, Tanghe A. (1973) Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.. Psychiatr Neurol Neurochir, 76 (4): (251-9). [PMID:4581374]
2. Dom R, Van Lommel R, Baro F. (1971) A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.. Acta Psychiatr Scand, 47 (4): (399-410). [PMID:4947805]

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