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Dexmedetomidine - ≥98%, high purity , CAS No.113775-47-6, Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor

Moligand™
≥98%

CAS#: 113775-47-6
Formula: C₁₃H₁₆N₂
Molecular Weight: 200.28
PubChem CID: 5311068

Item Number

D129818

Grouped product items
SKU	Size	Availability	Price
D129818-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$462.90
D129818-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$832.90
D129818-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$288.90

View related series

α2A-adrenoceptor Agonist α2B-adrenoceptor Agonist α2C-adrenoceptor Agonist

Basic Description

Synonyms	DEXMEDETOMIDINE\|113775-47-6\|Dexmedetomidinum\|MPV 1440\|4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole\|5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole\|MPV-1440\|Dexmedetomidina\|(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole\|Medetomidine, (s)-\|(S)-5-(1-(
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	A sedative, analgestic, α2-Adrenergic agonist and (+)-isomer of medetomidine.
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor
Product Description	Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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CYP2C9 Tchem Cytochrome P450 2C9 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1B Tclin Alpha-1B adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 5 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1D Tclin Alpha-1D adrenergic receptor 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Discover Target: ADRA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
INCHI	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
InChi Key	CUHVIMMYOGQXCV-NSHDSACASA-N
Canonical SMILES	CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
Isomeric SMILES	CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
PubChem CID	5311068
Molecular Weight	200.28

PubChem CID

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

Wikipedia

CAS Registry No.

ChEBI

RCSB PDB Ligand

DrugCentral Ligand

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
L2314114	Certificate of Analysis	Nov 29, 2023	D129818
L2314115	Certificate of Analysis	Nov 29, 2023	D129818
L2314116	Certificate of Analysis	Nov 29, 2023	D129818
L2314117	Certificate of Analysis	Nov 29, 2023	D129818
L2216874	Certificate of Analysis	Jan 06, 2023	D129818
B2317637	Certificate of Analysis	Dec 13, 2022	D129818
B2317660	Certificate of Analysis	Dec 13, 2022	D129818
B2317695	Certificate of Analysis	Dec 13, 2022	D129818
H2325065	Certificate of Analysis	Dec 13, 2022	D129818
K1628018	Certificate of Analysis	Jun 20, 2022	D129818
B2222164	Certificate of Analysis	Feb 28, 2022	D129818
A2218067	Certificate of Analysis	Jan 25, 2022	D129818

Solubility

Soluble in chloroform, and methanol.

Sensitivity

Light sensitive

Melt Point(°C)

146-149°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

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