Grouped product items

SKU

Size

Availability

Price

Qty

D129818-50mg

50mg

Available within 8-12 weeks(?)

$462.90

D129818-100mg

100mg

Available within 8-12 weeks(?)

$832.90

D129818-250mg

250mg

Available within 8-12 weeks(?)

$288.90

Basic Description

Synonyms	(S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole \| 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole \| DEXMEDETOMIDINE \| MPV 1440 \| Dexmedetomidina [INN-Spanish] \| Medetomidine, (s)- \| 113775-47-6 (free base) \| 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imid
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	A sedative, analgestic, α2-Adrenergic agonist and (+)-isomer of medetomidine.
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor
Product Description	Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor (0 Activities)

Discover Target: ADRA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor (3 Activities)

Discover Target: ADRA2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor (5 Activities)

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1D Tclin Alpha-1D adrenergic receptor (1 Activities)

Discover Target: ADRA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

Discover Target: ADRA1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)

Discover Target: ADRA2C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra1b Adrenergic receptor alpha-1 (5652 Activities)

Discover Target: Adra1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra2c Adrenergic receptor alpha-2 (3313 Activities)

Discover Target: Adra2c

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
INCHI	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
InChi Key	CUHVIMMYOGQXCV-NSHDSACASA-N
Canonical SMILES	CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
Isomeric SMILES	CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
PubChem CID	5311068
Molecular Weight	200.28

Database links

PubChem CID	5311068
ChEMBL Ligand	CHEMBL778
BindingDB Ligand	50241196
DrugBank Ligand	DB00633
Wikipedia	Dexmedetomidine
CAS Registry No.	113775-47-6
ChEBI	CHEBI:4466
RCSB PDB Ligand	CZX
DrugCentral Ligand	835
GPCRdb Ligand	dexmedetomidine

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Chart	Certificate Type	Date	Item
L2314114	¹H MBR	Certificate of Analysis	Nov 29, 2023	D129818
L2314115	¹H MBR	Certificate of Analysis	Nov 29, 2023	D129818
L2314116	¹H MBR	Certificate of Analysis	Nov 29, 2023	D129818
L2314117	¹H MBR	Certificate of Analysis	Nov 29, 2023	D129818
L2216874		Certificate of Analysis	Jan 06, 2023	D129818
B2317637	¹H MBR	Certificate of Analysis	Dec 13, 2022	D129818
B2317660	¹H MBR	Certificate of Analysis	Dec 13, 2022	D129818
B2317695	¹H MBR	Certificate of Analysis	Dec 13, 2022	D129818
H2325065	¹H MBR	Certificate of Analysis	Dec 13, 2022	D129818
K1628018		Certificate of Analysis	Jun 20, 2022	D129818
B2222164		Certificate of Analysis	Feb 28, 2022	D129818
A2218067		Certificate of Analysis	Jan 25, 2022	D129818

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Chemical and Physical Properties

Solubility	Soluble in chloroform, and methanol.
Sensitivity	Light sensitive
Melt Point(°C)	146-149°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Gao Yang, Kang Kai, Liu Yan-song, Li Na-na, Han Qiu-yuan, Liu Hai-tao, Kong Wei-lan, Zhang Xing, Huang Rui, Yang Zhen-yu, Qi Zhi-dong, Zheng Jun-bo, Li Ming, Wang Hong-liang, Li Jia-yu, Liu Rui-jin, Wang Si-cong, Zhang Wei-hua, Zhao Ming-yan, Yu Kai-jiang. (2021) Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway. INFLAMMATION, 44 (2): (746-757). [PMID:33141376] [10.1007/s10753-020-01374-y]

References

1. Gao Yang, Kang Kai, Liu Yan-song, Li Na-na, Han Qiu-yuan, Liu Hai-tao, Kong Wei-lan, Zhang Xing, Huang Rui, Yang Zhen-yu, Qi Zhi-dong, Zheng Jun-bo, Li Ming, Wang Hong-liang, Li Jia-yu, Liu Rui-jin, Wang Si-cong, Zhang Wei-hua, Zhao Ming-yan, Yu Kai-jiang. (2021) Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway. INFLAMMATION, 44 (2): (746-757). [PMID:33141376] [10.1007/s10753-020-01374-y]

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Dexmedetomidine - ≥98%, high purity , CAS No.113775-47-6, Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
D129818-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$462.90
D129818-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$832.90
D129818-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$288.90