Basic Description

Synonyms	Dexrazoxane hydrochloride \| 149003-01-0 \| Dexrazoxane HCl \| Totect \| Cardioxane \| Cardioxan \| Savene \| Zinecard \| ADR-529 hydrochloride \| ICRF-187 hydrochloride \| 1263283-43-7 \| ICRF-187 \| ICRF 187 hydrochloride \| Dexrazoxane (Hydrochloride) \| (+)-Razoxane hydrochloride \| Razoxane hyd
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Dexrazoxane hydrochloride is a cardioprotective agent. As a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is us
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Dexrazoxane HCl(ICRF-187, ADR-529) is a cardioprotective agent.

Associated Targets(Human)

ENGASE Tchem Endo-beta-N-acetylglucosaminidase (63 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride
INCHI	InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
InChi Key	BIFMNMPSIYHKDN-FJXQXJEOSA-N
Canonical SMILES	CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
Isomeric SMILES	C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
PubChem CID	6918223
Molecular Weight	304.73

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3 results found

Lot Number	Certificate Type	Date	Item
C2223229	Certificate of Analysis	May 03, 2022	D129340
C2223233	Certificate of Analysis	May 03, 2022	D129340
C2223352	Certificate of Analysis	May 03, 2022	D129340

Solubility	DMSO 61 mg/mL Water 61 mg/mL Ethanol <1 mg/mL

1. Miyamoto HD et al.. (2022) Iron Overload via Heme Degradation in\xa0the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.. JACC Basic Transl Sci, 7 (8): (800-819). [PMID:36061338]
2. Tadokoro T et al.. (2020) Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.. JCI Insight, 5 (9): [PMID:32376803]

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SKU	Size	Availability	Price
D129340-10mg	10mg	In stock	$58.90
D129340-50mg	50mg	In stock	$111.90
D129340-250mg	250mg	In stock	$504.90