Dezamizumab (anti-Serum Amyloid P) - Primary antibody, specific to APCS, >95%, high purity, Human IgG1, Antibody of amyloid P component; serum

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Features and benefits
  • Host species: Human
  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
Item Number
Ab175509
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab175509-100μg
100μg
In stock
$109.90
Ab175509-1mg
1mg
In stock
$519.90
Ab175509-5mg
5mg
In stock
$1,399.90
Ab175509-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameDezamizumab (anti-Serum Amyloid P) - Primary antibody, specific to APCS, >95%, high purity, Human IgG1
Synonyms9.5S alpha 1 glycoprotein antibody | 9.5S alpha-1-glycoprotein antibody | Amyloid P component serum antibody | APCS antibody | MGC88159 antibody | Pentaxin related antibody | Pentraxin 2 antibody | PTX 2 antibody | PTX2 antibody | SAMP_HUMAN antibody | SA
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Host speciesHuman
SpecificityAPCS
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionAntibody of amyloid P component; serum
Product Description

Dezamizumab (anti-Serum Amyloid P) is a fully humanized recombinant monoclonal IgG1 anti-serum amyloid P component (SAP) antibody, with potential anti-amyloid activity. Dezamizumab (anti-Serum Amyloid P) triggers immunotherapeutic clearance of amyloid. Dezamizumab (anti-Serum Amyloid P) can be used in research of Amyloid light-chain (AL) amyloidosis.

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.3 kDa (Light Chain) & 51.3 kDa (Heavy Chain), under reducing conditions; 191.2 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS1662664-56-3

Images

Dezamizumab (anti-Serum Amyloid P) (Ab175509) - SEC
The purity of Dezamizumab (anti-Serum Amyloid P) (Ab175509) is more than 95% verified by HPLC.

Associated Targets(Human)

APCS Tchem Serum amyloid P-component (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0303108Certificate of AnalysisMar 12, 2024 Ab175509
ZJ24F0303107Certificate of AnalysisMar 12, 2024 Ab175509
ZJ24F0303106Certificate of AnalysisMar 12, 2024 Ab175509

Related Documents

References

1. Tennent GA, Lovat LB, Pepys MB.  (1995)  Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis..  Proc Natl Acad Sci USA,  92  (10): (4299-303).  [PMID:7753801] [10.1021/op500134e]
2. Botto M, Hawkins PN, Bickerstaff MC, Herbert J, Bygrave AE, McBride A, Hutchinson WL, Tennent GA, Walport MJ, Pepys MB.  (1997)  Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene..  Nat Med,  (8): (855-9).  [PMID:9256275] [10.1021/op500134e]
3. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ et al..  (2010)  Antibodies to human serum amyloid P component eliminate visceral amyloid deposits..  Nature,  468  (7320): (93-7).  [PMID:20962779] [10.1021/op500134e]
4. Mantzouranis EC, Dowton SB, Whitehead AS, Edge MD, Bruns GA, Colten HR.  (1985)  Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1..  J Biol Chem,  260  (12): (7752-6).  [PMID:2987268] [10.1021/op500134e]
5. Ohnishi S, Maeda S, Shimada K, Arao T.  (1986)  Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component..  J Biochem,  100  (4): (849-58).  [PMID:3029048] [10.1021/op500134e]
6. Thompson, A R AR and Enfield, D L DL..  (1978)  Human plasma P component: isolation and characterization..  Biochemistry,    (3):   [PMID:81686]
7. Prelli, F F, Pras, M M and Frangione, B B..  (1985)  The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis..  The Journal of biological chemistry,    (25):   [PMID:4055725]
8. Emsley, J J and 8 more authors..  (1994)  Structure of pentameric human serum amyloid P component..  Nature,    (27):   [PMID:8114934]
9. Pepys, M B MB and 9 more authors..  (1994)  Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure..  Proceedings of the National Academy of Sciences of the United States of America,    (7):   [PMID:8202534]
10. Hohenester, E E, Hutchinson, W L WL, Pepys, M B MB and Wood, S P SP..  (1997)  Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP..  Journal of molecular biology,    (20):   [PMID:9217261]
11. Kiernan, Urban A UA, Nedelkov, Dobrin D, Tubbs, Kemmons A KA, Niederkofler, Eric E EE and Nelson, Randball W RW..  (2004)  Proteomic characterization of novel serum amyloid P component variants from human plasma and urine..  Proteomics,      [PMID:15174148]
12. Liu, Tao T and 6 more authors..  ()  Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry..  Journal of proteome research,      [PMID:16335952]

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