DH376 , CAS No.D609862, Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

Item Number
D609862
Grouped product items
SKUSizeAvailabilityPrice Qty
D609862-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609862-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsDH-376;inhibitor 38
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

Associated Targets(Human)

DAGLB Tchem Sn1-specific diacylglycerol lipase beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABHD6 Tchem Monoacylglycerol lipase ABHD6 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (416 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DAGLB Tchem Sn1-specific diacylglycerol lipase beta (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name {2-[(2R,5R)-2-benzyl-5-(but-3-yn-1-yl)piperidine-1-carbonyl]-2H-1,2,3-triazol-4-yl}bis(4-fluorophenyl)methanol
INCHI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1
InChi Key GVLOFRPVRYAFKI-VSGBNLITSA-N
Canonical SMILES C#CCO[C@@H]1CC[C@@H](N(C1)C(=O)n1ncc(n1)C(c1ccc(cc1)F)(c1ccc(cc1)F)O)Cc1ccccc1
Isomeric SMILES C#CCO[C@@H]1CC[C@@H](N(C1)C(=O)N2N=CC(=N2)C(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)O)CC5=CC=CC=C5
PubChem CID 129188688

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, van den Nieuwendijk AM, Soethoudt M, van der Wel T et al..  (2016)  Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition..  Proc Natl Acad Sci USA,  113  (1): (26-33).  [PMID:26668358] [10.1021/op500134e]

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