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DH376 , CAS No.D609862, Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

  • Moligand™
Item Number
D609862
Grouped product items
SKUSizeAvailabilityPrice Qty
D609862-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609862-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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Diacylglycerol lipase α Inhibitor Diacylglycerol lipase β Inhibitor

Basic Description

SynonymsDH-376;inhibitor 38
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

Associated Targets

DAGLB Tchem Sn1-specific diacylglycerol lipase beta 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DAGLA Tchem Sn1-specific diacylglycerol lipase alpha 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABHD6 Tchem Monoacylglycerol lipase ABHD6 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name {2-[(2R,5R)-2-benzyl-5-(but-3-yn-1-yl)piperidine-1-carbonyl]-2H-1,2,3-triazol-4-yl}bis(4-fluorophenyl)methanol
INCHI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1
InChi Key GVLOFRPVRYAFKI-VSGBNLITSA-N
Canonical SMILES C#CCO[C@@H]1CC[C@@H](N(C1)C(=O)n1ncc(n1)C(c1ccc(cc1)F)(c1ccc(cc1)F)O)Cc1ccccc1
Isomeric SMILES C#CCO[C@@H]1CC[C@@H](N(C1)C(=O)N2N=CC(=N2)C(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)O)CC5=CC=CC=C5
PubChem CID 129188688

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, van den Nieuwendijk AM, Soethoudt M, van der Wel T et al..  (2016)  Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition..  Proc Natl Acad Sci USA,  113  (1): (26-33).  [PMID:26668358]

Solution Calculators

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