Grouped product items

SKU

Size

Availability

Price

Qty

D118757-1mg

1mg

Available within 4-8 weeks(?)

$315.90

D118757-5mg

5mg

Available within 4-8 weeks(?)

$979.90

Basic Description

Specifications & Purity	Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms	Islet amyloid polypeptide (IAPP) is a hormone coexpressed with insulin by pancreatic β-cells. IAPP is used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II.Endog
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of AMY 1 receptor;Agonist of AMY 2 receptor;Agonist of AMY 3 receptor;Agonist of CT receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Amino Acid Sequence Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2

Associated Targets(Human)

RAMP2 Tclin Receptor activity-modifying protein 2 (0 Activities)

Discover Target: RAMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAMP1 Tclin Receptor activity-modifying protein 1 (0 Activities)

Discover Target: RAMP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAMP3 Tclin Receptor activity-modifying protein 3 (0 Activities)

Discover Target: RAMP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CALCR Tclin Calcitonin receptor (0 Activities)

Discover Target: CALCR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[4-amino-1-[[1-[[2-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[1-[[2-[[1-[[4-amino-1-[[1-[[1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-2-[[2-[2-[[16-(2-amino-2-oxoethyl)-19-(2,6-diaminohexanoylamino)-7,13-bis(1-hydroxyethyl)-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]propanoylamino]-3-hydroxybutanoyl]amino]pentanediamide
INCHI	InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)
InChi Key	PLOPBXQQPZYQFA-UHFFFAOYSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC3=CN=CN3)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C5CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)C(C)O)C)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N
Isomeric SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC3=CN=CN3)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C5CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)C(C)O)C)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N
WGK Germany	3
PubChem CID	16158170
Molecular Weight	3903.28

Database links

UniProtKB	P10997
CAS Registry No.	122384-88-7
Ensembl Gene	ENSG00000121351
Entrez Gene	3375
Wikipedia	Amylin
GPCRdb Ligand	amylin

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
L1804193	Certificate of Analysis	Sep 21, 2022	D118757
L1804192	Certificate of Analysis	Sep 21, 2022	D118757
I1425085	Certificate of Analysis	Jul 19, 2022	D118757
E1430001	Certificate of Analysis	Mar 29, 2022	D118757

Safety and Hazards(GHS)

WGK Germany	3

References

1. Majumder P et al.. (2021) A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes.. Biochem J, 478 (17): (3297-3317). [PMID:34409981]
2. Majumder P et al.. (2019) Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer's disease and type 2 diabetes.. Mol Cell Biochem, 459 (1-2): (171-182). [PMID:31154588]
3. Suzuki H & Yamamoto T. (2014) Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata.. Tissue Cell, 46 (6): (535-9). [PMID:25458814]
4. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB. (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.. Proc Natl Acad Sci USA, 84 (23): (8628-32). [PMID:3317417] [10.1021/op500134e]
5. Jaikaran ET, Clark A. (2001) Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.. Biochim Biophys Acta, 1537 (3): (179-203). [PMID:11731221] [10.1021/op500134e]
6. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Jiadi Xu,Gianluigi Veglia,Ayyalusamy Ramamoorthy. (2008-11-08) Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.. Biochemistry, 47 ((48)): (12689-12697). [PMID:18989932]
7. Allam S Reddy,Lu Wang,Sadanand Singh,Yun L Ling,Lauren Buchanan,Martin T Zanni,James L Skinner,Juan J de Pablo. (2010-10-07) Stable and metastable states of human amylin in solution.. Biophysical journal, 99 ((7)): (2208-2216). [PMID:20923655]
8. A Clark,M R Nilsson. (2004-01-15) Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?. Diabetologia, 47 ((2)): (157-169). [PMID:14722650]
9. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Subramanian Vivekanandan,Ayyalusamy Ramamoorthy. (2011-07-05) Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.. Biochimica et biophysica acta, 1808 ((10)): (2337-2342). [PMID:21723249]

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Diabetes Associated Peptide Amide human - ≥97% (HPLC), high purity , CAS No.122384-88-7, Agonist of AMY 1 receptor;Agonist of AMY 2 receptor;Agonist of AMY 3 receptor;Agonist of CT receptor