diABZI-4 , CAS No.D609865, Agonist of stimulator of interferon response cGAMP interactor 1

Item Number
D609865
Grouped product items
SKUSizeAvailabilityPrice Qty
D609865-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609865-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsExample 39 [WO2017175147A1]
Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of stimulator of interferon response cGAMP interactor 1

Associated Targets(Human)

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[(E)-4-[5-carbamoyl-7-[3-(dimethylamino)propoxy]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-methoxybenzimidazole-5-carboxamide
INCHI InChI=1S/C40H49N13O6/c1-8-52-29(17-23(3)47-52)37(56)45-39-43-27-19-25(35(41)54)21-31(58-7)33(27)50(39)14-10-11-15-51-34-28(20-26(36(42)55)22-32(34)59-16-12-13-49(5)6)44-40(51)46-38(57)30-18-24(4)48-53(30)9-2/h10-11,17-22H,8-9,12-16H2,1-7H3,(H2,41,54)(H2,42,55)(H,43,45,56)(H,44,46,57)/b11-10+
InChi Key MXHZAYVEIKSPIA-ZHACJKMWSA-N
Canonical SMILES COc1cc(cc2c1n(C/C=C/Cn1/c(=N/C(=O)c3cc(nn3CC)C)/[nH]c3c1c(OCCCN(C)C)cc(c3)C(=O)N)/c(=N/C(=O)c1cc(nn1CC)C)/[nH]2)C(=O)N
PubChem CID 132000148

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References

1. Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng S-L, Parsi K-M, Maehr R, Cruz J, Morales-Ramos A et al..  (2021)  A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection..  Sci Immunol,  (59): (589-97).  [PMID:34010139]

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