Basic Description

Synonyms	(Diacetoxyiodo)benzene \| Iodobenzene diacetate \| 3240-34-4 \| Iodosobenzene diacetate \| Phenyliodo diacetate \| Phenyliodoso acetate \| Phenyliodine diacetate \| Phenyliodoso diacetate \| Bis(acetato)phenyliodine \| Benzene, (diacetoxyiodo)- \| Phenyliodine(III) diacetate \| Phenyliod
Specifications & Purity	≥98%
Storage Temp	Argon charged
Shipped In	Normal
Product Description	Stoichiometric oxidant in the TEMPO oxidation of nerol to neral. Oxidant employed in the rhodium-catalyzed aziridination of olefins with sulfamate esters. Unactivated sp3 C-H bonds of both oxime and pyridine substrates undergo highly regio- and chemoselective Pd(II)-catalyzed oxygenation with PhI(OAc)2 as a stoichiometric oxidant. Used in the room temperature Pd-catalyzed 2-arylation of indoles Useful reagent for the synthesis of a wide variety of heterocyclic compounds.

Associated Targets(Human)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488185320
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488185320
IUPAC Name	[acetyloxy(phenyl)-λ3-iodanyl] acetate
INCHI	InChI=1S/C10H11IO4/c1-8(12)14-11(15-9(2)13)10-6-4-3-5-7-10/h3-7H,1-2H3
InChi Key	ZBIKORITPGTTGI-UHFFFAOYSA-N
Canonical SMILES	CC(=O)OI(C1=CC=CC=C1)OC(=O)C
Isomeric SMILES	CC(=O)OI(C1=CC=CC=C1)OC(=O)C
WGK Germany	3
RTECS	DA3525000
PubChem CID	76724
Molecular Weight	322.1
Beilstein	1879369
Reaxy-Rn	1879369

Certificates

Certificate of Analysis(COA)

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26 results found

Lot Number	Certificate Type	Date	Item
L2216804	Certificate of Analysis	Sep 10, 2024	D106797
C2414369	Certificate of Analysis	Feb 29, 2024	D106797
B2427379	Certificate of Analysis	Feb 04, 2024	D106797
B2427376	Certificate of Analysis	Feb 04, 2024	D106797
B2427369	Certificate of Analysis	Feb 04, 2024	D106797
B2221217	Certificate of Analysis	Nov 17, 2023	D106797
B2221262	Certificate of Analysis	Nov 17, 2023	D106797
B2221224	Certificate of Analysis	Nov 17, 2023	D106797
G2310749	Certificate of Analysis	Jun 13, 2023	D106797
G2310774	Certificate of Analysis	Jun 13, 2023	D106797
G2310770	Certificate of Analysis	Jun 13, 2023	D106797
G2310760	Certificate of Analysis	Jun 13, 2023	D106797
G2310759	Certificate of Analysis	Jun 13, 2023	D106797
G2310758	Certificate of Analysis	Jun 13, 2023	D106797
G2310757	Certificate of Analysis	Jun 13, 2023	D106797
G2310755	Certificate of Analysis	Jun 13, 2023	D106797
G2310748	Certificate of Analysis	Jun 13, 2023	D106797
F2116314	Certificate of Analysis	Mar 14, 2023	D106797
L1820040	Certificate of Analysis	Aug 06, 2022	D106797
F2315965	Certificate of Analysis	Dec 24, 2021	D106797
E2310075	Certificate of Analysis	Dec 24, 2021	D106797
B2219153	Certificate of Analysis	Dec 24, 2021	D106797
B2307094	Certificate of Analysis	Apr 19, 2021	D106797
F2118117	Certificate of Analysis	Apr 19, 2021	D106797
F2116290	Certificate of Analysis	Apr 19, 2021	D106797
F2116092	Certificate of Analysis	Apr 19, 2021	D106797

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Chemical and Physical Properties

Solubility	Insoluble in water. Solubility in Methanol almost transparency.
Sensitivity	light sensitive; Moisture sensitive
Melt Point(°C)	161-165°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DA3525000
Reaxy-Rn	1879369

FAQs and Articles

Citations of This Product

1. Xiaolei Ren, Jinwu Bai, Xingxing Gu, Hui Xu, Bochuan Tan, Shenying Xu, Jiangyu Hao, Fang Gao, Xin Li. (2022) Insight into the anti-corrosion performance of three imidazo-pyridazines for Al alloy in different concentrations of hydrochloric acid solutions. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 113 (348). [PMID:]

References

1. S K Vaidya,C Damodaran. (1982-01-01) Determination of vitamin C in tablets and fruits by titration with phenyliodosoacetate.. Il Farmaco; edizione pratica, 37 ((1)): (9-14). [PMID:7056375]
2. G Wells,A Seaton,M F Stevens. (2000-04-26) Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents.. Journal of medicinal chemistry, 43 ((8)): (1550-1562). [PMID:10780912]
3. K C Nicolaou,Vikrant A Adsool,Christopher R H Hale. (2010-03-03) An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4.. Organic letters, 12 ((7)): (1552-1555). [PMID:20192259]
4. Jinbo Huang,Yimiao He,Yong Wang,Qiang Zhu. (2012-09-22) Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((44)): (13964-13967). [PMID:22996950]
5. Chunying Gao,Mackenzie C Bergagnini-Kolev,Michael Z Liao,Zhican Wang,Timothy Wong,Justina C Calamia,Yvonne S Lin,Qingcheng Mao,Kenneth E Thummel. (2017-06-18) Simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum and plasma using liquid chromatography-tandem mass spectrometry coupled with DAPTAD-derivatization.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1060 (158-165). [PMID:28622619]
6. Simon Roehrer,Juergen Behr,Verena Stork,Mara Ramires,Guillaume Médard,Oliver Frank,Karin Kleigrewe,Thomas Hofmann,Mirjana Minceva. (2018-07-28) Xanthohumol C, a minor bioactive hop compound: Production, purification strategies and antimicrobial test.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1095 (39-49). [PMID:30053686]
7. Bikash Dangi,Hyun Park,Tae-Jin Oh. (2018-08-24) Effects of Alternative Redox Partners and Oxidizing Agents on CYP154C8 Catalytic Activity and Product Distribution.. Chembiochem : a European journal of chemical biology, 19 ((21)): (2273-2282). [PMID:30136363]
8. S Garadnay,P Herczegh,S Makleit,T Friedmann,P Riba,S Fürst. (2001-04-03) Reactions of morphine derivatives with phenyliodo(III)diacetate (PIDA): synthesis of new morphine analogues.. Current medicinal chemistry, 8 ((6)): (621-626). [PMID:11281845]
9. Lopa V Desai,Kami L Hull,Melanie S Sanford. (2004-08-05) Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds.. Journal of the American Chemical Society, 126 ((31)): (9542-9543). [PMID:15291549]
10. Renhua Fan,Weixun Li,Bing Wang. (2008-11-29) A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic alpha-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust.. Organic & biomolecular chemistry, 6 ((24)): (4615-4621). [PMID:19039371]
11. Xiaolei Ren, Jinwu Bai, Xingxing Gu, Hui Xu, Bochuan Tan, Shenying Xu, Jiangyu Hao, Fang Gao, Xin Li. (2022) Insight into the anti-corrosion performance of three imidazo-pyridazines for Al alloy in different concentrations of hydrochloric acid solutions. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 113 (348). [PMID:]

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SKU	Size	Availability	Price
D106797-5g	5g	In stock	$15.90
D106797-10g	10g	In stock	$23.90
D106797-25g	25g	In stock	$44.90
D106797-100g	100g	In stock	$160.90
D106797-500g	500g	In stock	$659.90

(Diacetoxyiodo)benzene - 98%, high purity , CAS No.3240-34-4