Grouped product items

SKU

Size

Availability

Price

Qty

D432326-250mg

250mg

Available within 8-12 weeks(?)

$63.90

D432326-1g

Available within 8-12 weeks(?)

$229.90

D432326-5g

Available within 8-12 weeks(?)

$799.90

D432326-25g

25g

Available within 8-12 weeks(?)

$2,399.90

Basic Description

Synonyms	DIALLYL DISULFIDE\|2179-57-9\|Allyl disulfide\|Diallyldisulfide\|Diallyl disulphide\|1,2-Diallyldisulfane\|Disulfide, di-2-propenyl\|Allyl disulphide\|2-Propenyl disulphide\|4,5-Dithia-1,7-octadiene\|3-(prop-2-enyldisulfanyl)prop-1-ene\|2-Propenyl disulfide\|3-Allyld
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	Organosulfur compound that is naturally found in garlic. Contributes to the pungent odor of crushed garlic. Anticancer agent and may provide protection against cardiovascular disease. Diallyl disulfide has been shown to be an anticancer agent and may prov
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	Diallyl disulfide is an organosulfur compound that is naturally found in garlic ( Allium sativum ) and contributes to the pungent odor of crushed garlic. Application： Diallyl disulfide has been used: · to study its effects in apoptosis induction and cell viability on different glioma cell lines; · as a treatment and positive control to assess the anti-inflammatory regulation of nuclear factor erythroid-2 related factor-2 (Nrf2) in breast cancer cells; · as a potential substrate compound to detect hydrogen sulfide (H2S) production via lead acetate/lead sulfide method.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2E1 Tchem Cytochrome P450 2E1 0 Activities

Discover Target: CYP2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCNN1A Tclin Amiloride-sensitive sodium channel subunit alpha 0 Activities

Discover Target: SCNN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HBB Tbio Hemoglobin subunit beta 0 Activities

Discover Target: HBB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(prop-2-enyldisulfanyl)prop-1-ene
INCHI	InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
InChi Key	PFRGXCVKLLPLIP-UHFFFAOYSA-N
Canonical SMILES	C=CCSSCC=C
Isomeric SMILES	C=CCSSCC=C
WGK Germany	3
RTECS	BB1000000
PubChem CID	16590
UN Number	2810
Molecular Weight	146.27
Beilstein	1699241
Reaxy-Rn	1699241

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Air and heat sensitive
Refractive Index	1.561
Flash Point(°F)	143.6 °F
Flash Point(°C)	51°C
Boil Point(°C)	80-85°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H317:May cause an allergic skin reaction H226:Flammable liquid and vapor
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P264:Wash hands [and …] thoroughly after handling. P403+P235:Store in a well-ventilated place. Keep cool. P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3
RTECS	BB1000000
Reaxy-Rn	1699241

References

1. Jaehoon Bae,Motofumi Kumazoe,Yoshinori Fujimura,Hirofumi Tachibana. (2018-12-06) Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity.. The Journal of nutritional biochemistry, 64 (152-161). [PMID:30504007]
2. Jie Yang,Paul Minkler,David Grove,Rui Wang,Belinda Willard,Raed Dweik,Christopher Hine. (2019-05-28) Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6.. Communications biology, 2 (194-194). [PMID:31123718]
3. You Jeong Lee,Song-Hyun Cha,Hyunjo Kim,Sung Eun Choi,Seonho Cho,Youmie Park. (2020-06-05) Diallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity.. Artificial cells, nanomedicine, and biotechnology, 48 ((1)): (948-960). [PMID:32496831]
4. Venugopal R Bovilla,Mahadevaswamy G Kuruburu,Vidya G Bettada,Jayashree Krishnamurthy,Olga A Sukocheva,Rajesh K Thimmulappa,Nanjunda Swamy Shivananju,Janardhan P Balakrishna,SubbaRao V Madhunapantula. (2021-09-29) Targeted Inhibition of Anti-Inflammatory Regulator Nrf2 Results in Breast Cancer Retardation In Vitro and In Vivo.. Biomedicines, 9 ((9)): [PMID:34572304]
5. V Robert,B Mouillé,C Mayeur,M Michaud,F Blachier. (2001-07-27) Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations.. Carcinogenesis, 22 ((8)): (1155-1161). [PMID:11470743]
6. Lan Yi,Qi Su. (2013-04-16) Molecular mechanisms for the anti-cancer effects of diallyl disulfide.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 57 (362-370). [PMID:23583486]
7. Anna Choromanska,Julita Kulbacka,Jolanta Saczko,Pawel Surowiak. (2020-08-18) Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines.. Biomedical reports, 13 ((4)): (32-32). [PMID:32802329]
8. Xiuxiu Song,Ziqi Yue,Lulingxiao Nie,Pengfei Zhao,Kangjian Zhu,Qi Wang. (2021-11-09) Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound.. Evidence-based complementary and alternative medicine : eCAM, 2021 (5103626-5103626). [PMID:34745287]

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Diallyl disulfide - ≥98% (HPLC), high purity , CAS No.2179-57-9

Basic Description

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

CYP2E1 Tchem Cytochrome P450 2E1 0 Activities

SCNN1A Tclin Amiloride-sensitive sodium channel subunit alpha 0 Activities

VDR Tclin Vitamin D3 receptor 0 Activities

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

HBB Tbio Hemoglobin subunit beta 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
D432326-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$63.90
D432326-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$229.90
D432326-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$799.90
D432326-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,399.90