Diallyl disulfide - ≥98% (HPLC), high purity , CAS No.2179-57-9

  • ≥96%
Item Number
D432326
Grouped product items
SKUSizeAvailabilityPrice Qty
D432326-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$63.90
D432326-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
D432326-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$799.90
D432326-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,399.90

Basic Description

SynonymsAllyl disulfide
Specifications & Purity≥96%
Biochemical and Physiological MechanismsOrganosulfur compound that is naturally found in garlic. Contributes to the pungent odor of crushed garlic. Anticancer agent and may provide protection against cardiovascular disease. Diallyl disulfide has been shown to be an anticancer agent and may prov
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

Diallyl disulfide is an organosulfur compound that is naturally found in garlic ( Allium sativum ) and contributes to the pungent odor of crushed garlic.


Application:
Diallyl disulfide has been used:
· to study its effects in apoptosis induction and cell viability on different glioma cell lines;
· as a treatment and positive control to assess the anti-inflammatory regulation of nuclear factor erythroid-2 related factor-2 (Nrf2) in breast cancer cells;
· as a potential substrate compound to detect hydrogen sulfide (H2S) production via lead acetate/lead sulfide method.

Associated Targets(Human)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2E1 Tchem Cytochrome P450 2E1 (2174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DLD-1 (17511 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-92 (41141 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hs-578T (29457 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Thoracic aorta (838 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-(prop-2-enyldisulfanyl)prop-1-ene
INCHI InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
InChi Key PFRGXCVKLLPLIP-UHFFFAOYSA-N
Canonical SMILES C=CCSSCC=C
Isomeric SMILES C=CCSSCC=C
WGK Germany 3
RTECS BB1000000
PubChem CID 16590
UN Number 2810
Molecular Weight 146.27
Beilstein 1699241
Reaxy-Rn 1699241

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
I2418449Certificate of AnalysisAug 10, 2024 D432326
I2418450Certificate of AnalysisAug 10, 2024 D432326
I2418451Certificate of AnalysisAug 10, 2024 D432326
I2418452Certificate of AnalysisAug 10, 2024 D432326
I2418453Certificate of AnalysisAug 10, 2024 D432326
I2418454Certificate of AnalysisAug 10, 2024 D432326
I2418455Certificate of AnalysisAug 10, 2024 D432326
I2418456Certificate of AnalysisAug 10, 2024 D432326

Chemical and Physical Properties

SensitivityAir and heat sensitive
Refractive Index1.561
Flash Point(°F)143.6 °F
Flash Point(°C)51°C
Boil Point(°C)80-85°C

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H301:Toxic if swallowed

H317:May cause an allergic skin reaction

H226:Flammable liquid and vapor

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378:In case of fire: Use ... to extinguish.

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P233:Keep container tightly closed.

P240:Ground/bond container and receiving equipment.

P264:Wash hands [and …] thoroughly after handling.

P403+P235:Store in a well-ventilated place. Keep cool.

P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower].

P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment.

P270:Do not eat, drink or smoke when using this product.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P242:Use only non-sparking tools.

P243:Take precautionary measures against static discharge.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3
RTECS BB1000000
Reaxy-Rn 1699241

Related Documents

Citations of This Product

1. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu.  (2023)  Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen.  FOOD AND CHEMICAL TOXICOLOGY,  180  (28): (114011).  [PMID:37660943] [10.1016/j.fct.2023.114011]
2. Ting Wang, Jing Deng, Ruijin Ran, Wenqiang Shi, Yunxia Gao, Xiang Ren, Jun Cao, Ming Zhang.  (2022)  In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body.  CHEMICAL ENGINEERING JOURNAL,  449  (137486).  [PMID:] [10.1016/j.cej.2022.137486]
3. Tingting Li, Likun Ren, Dangfeng Wang, Minjie Song, Qiuying Li, Jianrong Li.  (2020)  Effect of allicin and its mechanism of action in purine removal in turbot.  JOURNAL OF FOOD SCIENCE,  85  (10): (3562-3569).  [PMID:32856309] [10.1111/1750-3841.15394]
4. Zhang Bin, Zheng Zhenjia, Liu Nan, Liu Pengli, Qiu Zhichang, Qiao Xuguang.  (2021)  Effect of different combined mechanical and thermal treatments on the quality characteristics of garlic paste.  JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,  58  (3): (1061-1071).  [PMID:33678889] [10.1007/s13197-020-04620-1]
5. Wu Tiaodi, Li Lin, Song Guangjie, Ran Miaomiao, Lu Xiaoquan, Liu Xiuhui.  (2019)  An ultrasensitive electrochemical sensor based on cotton carbon fiber composites for the determination of superoxide anion release from cells.  MICROCHIMICA ACTA,  186  (3): (1-9).  [PMID:30796529] [10.1007/s00604-019-3304-1]
6. Liu Xin Chao, Zhou Ligang, Liu Qiyong, Liu Zhi Long.  (2015)  Laboratory Evaluation of Larvicidal Activity of the Essential oil of Allium tuberosum Roots and its Selected Major Constituent Compounds Against Aedes albopictus (Diptera: Culicidae).  JOURNAL OF MEDICAL ENTOMOLOGY,  52  (3): (437-441).  [PMID:26334818] [10.1093/jme/tjv016]

References

1. Jaehoon Bae,Motofumi Kumazoe,Yoshinori Fujimura,Hirofumi Tachibana.  (2018-12-06)  Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity..  The Journal of nutritional biochemistry,  64  (152-161).  [PMID:30504007]
2. Jie Yang,Paul Minkler,David Grove,Rui Wang,Belinda Willard,Raed Dweik,Christopher Hine.  (2019-05-28)  Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6..  Communications biology,  (194-194).  [PMID:31123718]
3. You Jeong Lee,Song-Hyun Cha,Hyunjo Kim,Sung Eun Choi,Seonho Cho,Youmie Park.  (2020-06-05)  Diallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity..  Artificial cells, nanomedicine, and biotechnology,  48  ((1)): (948-960).  [PMID:32496831]
4. Venugopal R Bovilla,Mahadevaswamy G Kuruburu,Vidya G Bettada,Jayashree Krishnamurthy,Olga A Sukocheva,Rajesh K Thimmulappa,Nanjunda Swamy Shivananju,Janardhan P Balakrishna,SubbaRao V Madhunapantula.  (2021-09-29)  Targeted Inhibition of Anti-Inflammatory Regulator Nrf2 Results in Breast Cancer Retardation In Vitro and In Vivo..  Biomedicines,  ((9)):   [PMID:34572304]
5. V Robert,B Mouillé,C Mayeur,M Michaud,F Blachier.  (2001-07-27)  Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations..  Carcinogenesis,  22  ((8)): (1155-1161).  [PMID:11470743]
6. Lan Yi,Qi Su.  (2013-04-16)  Molecular mechanisms for the anti-cancer effects of diallyl disulfide..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  57  (362-370).  [PMID:23583486]
7. Anna Choromanska,Julita Kulbacka,Jolanta Saczko,Pawel Surowiak.  (2020-08-18)  Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines..  Biomedical reports,  13  ((4)): (32-32).  [PMID:32802329]
8. Xiuxiu Song,Ziqi Yue,Lulingxiao Nie,Pengfei Zhao,Kangjian Zhu,Qi Wang.  (2021-11-09)  Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound..  Evidence-based complementary and alternative medicine : eCAM,  2021  (5103626-5103626).  [PMID:34745287]
9. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu.  (2023)  Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen.  FOOD AND CHEMICAL TOXICOLOGY,  180  (28): (114011).  [PMID:37660943] [10.1016/j.fct.2023.114011]
10. Ting Wang, Jing Deng, Ruijin Ran, Wenqiang Shi, Yunxia Gao, Xiang Ren, Jun Cao, Ming Zhang.  (2022)  In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body.  CHEMICAL ENGINEERING JOURNAL,  449  (137486).  [PMID:] [10.1016/j.cej.2022.137486]
11. Tingting Li, Likun Ren, Dangfeng Wang, Minjie Song, Qiuying Li, Jianrong Li.  (2020)  Effect of allicin and its mechanism of action in purine removal in turbot.  JOURNAL OF FOOD SCIENCE,  85  (10): (3562-3569).  [PMID:32856309] [10.1111/1750-3841.15394]
12. Zhang Bin, Zheng Zhenjia, Liu Nan, Liu Pengli, Qiu Zhichang, Qiao Xuguang.  (2021)  Effect of different combined mechanical and thermal treatments on the quality characteristics of garlic paste.  JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,  58  (3): (1061-1071).  [PMID:33678889] [10.1007/s13197-020-04620-1]
13. Wu Tiaodi, Li Lin, Song Guangjie, Ran Miaomiao, Lu Xiaoquan, Liu Xiuhui.  (2019)  An ultrasensitive electrochemical sensor based on cotton carbon fiber composites for the determination of superoxide anion release from cells.  MICROCHIMICA ACTA,  186  (3): (1-9).  [PMID:30796529] [10.1007/s00604-019-3304-1]
14. Liu Xin Chao, Zhou Ligang, Liu Qiyong, Liu Zhi Long.  (2015)  Laboratory Evaluation of Larvicidal Activity of the Essential oil of Allium tuberosum Roots and its Selected Major Constituent Compounds Against Aedes albopictus (Diptera: Culicidae).  JOURNAL OF MEDICAL ENTOMOLOGY,  52  (3): (437-441).  [PMID:26334818] [10.1093/jme/tjv016]

Solution Calculators