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Dianicline - ≥98%(HPLC), high purity , Neuronal acetylcholine receptor; alpha4/beta2 partial agonist, CAS No.292634-27-6, Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

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Dianicline - ≥98%(HPLC), high purity , Neuronal acetylcholine receptor; alpha4/beta2 partial agonist, CAS No.292634-27-6, Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

≥98%(HPLC)

CAS#: 292634-27-6
Formula: C₁₃H₁₆N₂O•₂HCl
Molecular Weight: 289.2
PubChem CID: 10176764

Item Number

D287482

Grouped product items
SKU	Size	Availability	Price	Qty
D287482-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$114.90
D287482-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$478.90

Selective α4β2 nAChR partial agonist

View related series

Membrane Transporter/Ion Channel nAChR Neuronal Signaling

Basic Description

Synonyms	Y0SNM34C6O \| SSR591813L \| SCHEMBL2354672 \| Dianicline dihydrochloride \| Q5271647 \| UNII-Y0SNM34C6O \| (1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.01,10.03,8]hexadeca-3(8),4,6-triene \| (5aS,10aR)-6,7,9,10-Tetrahydro-5aH,11H-8,10a-methanopyrido(2',3':5,6)pyra
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selectiveα4β2 nAChR partial agonist (IC50= 105 nM). Exhibits >20-fold selectivity forα4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbensin vivo. Orally bioavailable.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	PARTIAL AGONIST
Mechanism of action	Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

Product Properties

ALogP	1.4

Associated Targets(non-human)

Chrna3 Neuronal acetylcholine receptor; alpha3/beta2 (421 Activities)

Discover Target: Chrna3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.01,10.03,8]hexadeca-3(8),4,6-triene
INCHI	InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1
InChi Key	SUPRUPHAEXPGPF-QWHCGFSZSA-N
Canonical SMILES	C1CN2CCC3(C2)C1OC4=C(C3)N=CC=C4
Isomeric SMILES	C1CN2CC[C@@]3(C2)[C@H]1OC4=C(C3)N=CC=C4
PubChem CID	10176764
Molecular Weight	289.2

Certificates

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Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 28.92, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 5.78, Max Conc. mM: 20

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