Dichloromethylenediphosphonic acid disodium salt - 98%, high purity , CAS No.22560-50-5

  • ≥98%
Item Number
D168759
Grouped product items
SKUSizeAvailabilityPrice Qty
D168759-250mg
250mg
In stock
$30.90
D168759-1g
1g
In stock
$101.90
D168759-5g
5g
In stock
$309.90
D168759-25g
25g
In stock
$1,079.90
D168759-100g
100g
In stock
$3,560.90

ATP-ADP transporter inhibitor

Basic Description

SynonymsCl2MDP | DTXCID40159526 | Clodronic acid disodium salt | CHEBI:59586 | Cl2MDP; Clodronic acid disodium magnesium salt; DMDP | Clodron | sodium (dichloro(phosphono)methyl)phosphonate | NCGC00261083-01 | HMS3261O17 | D 4434 | D4160 | Dichloromethane diphosp
Specifications & Purity≥98%
Biochemical and Physiological MechanismsATP-ADP transporter inhibitor. Inhibits bone resorption and soft tissue calcification. Encapsulated in liposomes, depletes macrophages in vivo . Induces apoptosis in osteoclasts.Analog of pyrophosphate ion that inhibits the osteoclastic activity leading t
Storage TempRoom temperature,Argon charged
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KMT2A Tchem Histone-lysine N-methyltransferase 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488183128
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488183128
IUPAC Name disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
INCHI InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChi Key HJKBJIYDJLVSAO-UHFFFAOYSA-L
Canonical SMILES C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]
Isomeric SMILES C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]
WGK Germany 3
RTECS SZ7640700
PubChem CID 31195
Molecular Weight 288.86

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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12 results found

Lot NumberCertificate TypeDateItem
C2331239Certificate of AnalysisMar 13, 2023 D168759
C2331242Certificate of AnalysisMar 13, 2023 D168759
C2331243Certificate of AnalysisMar 13, 2023 D168759
C2331246Certificate of AnalysisMar 13, 2023 D168759
C2331250Certificate of AnalysisMar 13, 2023 D168759
C2331251Certificate of AnalysisMar 13, 2023 D168759
C2331253Certificate of AnalysisMar 13, 2023 D168759
C2331254Certificate of AnalysisMar 13, 2023 D168759
C2331257Certificate of AnalysisMar 13, 2023 D168759
C2331263Certificate of AnalysisMar 13, 2023 D168759
C2302596Certificate of AnalysisFeb 13, 2023 D168759
C2302622Certificate of AnalysisFeb 13, 2023 D168759

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Chemical and Physical Properties

SensitivityMoisture sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS09
Signal Warning
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H411:Toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P391:Collect spillage.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS SZ7640700

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