Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D155733-1g | 1g | In stock | $14.90 | |
D155733-5g | 5g | In stock | $60.90 | |
D155733-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $274.90 | |
D155733-100g | 100g | In stock | $988.90 | |
D155733-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,446.90 |
Synonyms | diclofenac | Diclofenac acid | 15307-86-5 | dichlofenac | Diclofenacum | Diclophenac | Diclofenaco | ProSorb-D | 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid | Diclofenac resinate | Voltarol | Diclofenac free acid | 2-(2,6-Dichloroanilino)phenylacetic Acid | Zorovolex | Zorvol |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST, CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Cyclooxygenase inhibitor |
Product Description | Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. Diclofenac acid is a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor. |
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IUPAC Name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid |
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INCHI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
InChi Key | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
Isomeric SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
RTECS | AG6310000 |
PubChem CID | 3033 |
Molecular Weight | 296.15 |
Reaxy-Rn | 2146636 |
PubChem CID | 3033 |
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DrugBank Ligand | DB00586 |
CAS Registry No. | 15307-86-5 |
ChEBI | CHEBI:47381 |
ChEMBL Ligand | CHEMBL139 |
BindingDB Ligand | 13066 |
Wikipedia | Diclofenac |
BitterDB Ligand | 942 |
RCSB PDB Ligand | DIF |
PEP | diclofenac |
DrugCentral Ligand | 865 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2418443 | Certificate of Analysis | Mar 23, 2024 | D155733 |
D2418446 | Certificate of Analysis | Mar 23, 2024 | D155733 |
D2418449 | Certificate of Analysis | Mar 23, 2024 | D155733 |
C2027110 | Certificate of Analysis | Mar 14, 2024 | D155733 |
C2320434 | Certificate of Analysis | Mar 20, 2022 | D155733 |
C2331014 | Certificate of Analysis | Mar 20, 2022 | D155733 |
D2412059 | Certificate of Analysis | Mar 20, 2022 | D155733 |
F2208050 | Certificate of Analysis | Mar 20, 2022 | D155733 |
F2208051 | Certificate of Analysis | Mar 20, 2022 | D155733 |
F2208052 | Certificate of Analysis | Mar 20, 2022 | D155733 |
F2208054 | Certificate of Analysis | Mar 20, 2022 | D155733 |
F2208351 | Certificate of Analysis | Mar 20, 2022 | D155733 |
K2315094 | Certificate of Analysis | Mar 20, 2022 | D155733 |
Solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
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Melt Point(°C) | 158°C |
Pictogram(s) | GHS06, GHS08, GHS09 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H411:Toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P202:Do not handle until all safety precautions have been read and understood. P301+P310+P330:IF SWALLOWED: Rinse mouth.Immediately call a POISON CENTER/doctor/. |
RTECS | AG6310000 |
Reaxy-Rn | 2146636 |
Merck Index | 3081 |
1. Yiqing Liu, Ting Wang, Zhengjie Chen, Shenglan Liu, Yongsheng Fu. (2024) Enhanced removal of sulfamethoxazole by Mn(II)/bisulfite in presence of nitrilotriacetic acid: Role of Mn(III). Journal of Environmental Chemical Engineering, 12 (111821). [PMID:] |
2. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] |
3. Jiaxin Xu, Jing Zou, Jianying Wu, Huiping Zeng, Yixin Huang, Jingxin Yang, Chunming Gong, Siying Chen, Jun Ma. (2024) Enhanced chlorination of diclofenac using ABTS as electron shuttle: Performance, mechanism and applicability. SCIENCE OF THE TOTAL ENVIRONMENT, 907 (168117). [PMID:37890637] |
4. Huan Zhan, Xiaoyan Liu, Jinbing Huang, Xian Liu, Xulong Zhang, Jiaxiong Yao, Shiwei Xie. (2023) Iron electrocoagulation activated peracetic acid for efficient degradation of sulfamethoxazole. CHEMICAL ENGINEERING RESEARCH & DESIGN, 200 (15): (244). [PMID:1906403] |
5. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] |
6. Siqi Liang, Kangkang Wang, Kefu Wang, Tao Wang, Changyan Guo, Wei Wang, Jide Wang. (2023) Adsorption Behavior of Diclofenac on Polystyrene and Poly(butylene adipate-co-terephthalate) Microplastics: Influencing Factors and Adsorption Mechanism. LANGMUIR, 39 (34): (12216–12225). [PMID:37581507] |
7. Lan-Ying Liu, Guo-Shuai Liu, Shi-Ming Niu, He Liu, Min-Hua Cui, Ai-Jie Wang. (2023) Atomic hydrogen-mediated enhanced electrocatalytic hydrodehalogenation on Pd@MXene electrodes. JOURNAL OF HAZARDOUS MATERIALS, 459 (132113). [PMID:37487329] |
8. Yixin Huang, Jing Zou, Jiawen Li, Hongfang Ma, Siying Chen, Lingying Chen, Xiaobin Liao, Jun Ma. (2023) Rapid spectrophotometric determination of peroxydisulfate in water via oxidative coloration of 2,2′azino-bis(3-ethylbenzothiazoline)-6-sulfonate (ABTS) using ferrous ion as catalyst. Journal of Environmental Chemical Engineering, 11 (110552). [PMID:] |
9. Kaiyuan Luo, Yang Shi, Rongfu Huang, Xipeng Wei, Zelin Wu, Peng Zhou, Heng Zhang, Yin Wang, Zhaokun Xiong, Bo Lai. (2023) Activation of periodate by N-doped iron-based porous carbon for degradation of sulfisoxazole: Significance of catalyst-mediated electron transfer mechanism. JOURNAL OF HAZARDOUS MATERIALS, 457 (131790). [PMID:37295335] |
10. Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang. (2023) Nonsteroidal anti-inflammatory drug diclofenac accelerates the emergence of antibiotic resistance via mutagenesis. ENVIRONMENTAL POLLUTION, 326 (121457). [PMID:36958653] |
11. Pengzhao Han, Kai Hu, Yuanpeng Wang, Lixin Li, Pan Wang, Weixia Zhu, Haiyan Gong, Zhenqiang Zhang, Shusheng Zhang. (2023) Dispersive solid-phase extraction of non-steroidal anti-inflammatory drugs in water and urine samples using a magnetic ionic liquid hypercrosslinked polymer composite. JOURNAL OF CHROMATOGRAPHY A, 1689 (463745). [PMID:36586287] |
12. Chaozhi Kuang, Guoshen Zeng, Yangjian Zhou, Yaoyao Wu, Dexuan Li, Yingfei Wang, Chuanhao Li. (2023) Integrating anodic sulfate activation with cathodic H2O2 production/activation to generate the sulfate and hydroxyl radicals for the degradation of emerging organic contaminants. WATER RESEARCH, 229 (119464). [PMID:36509034] |
13. Chunyan Hu, Jianyi Li, Juncheng Ke, Jianjun Liang, Qiuliang Liu, Qiliang Wang, Wentao Huang. (2023) The preparation and removal performance of carbamazepine/oxcarbazepine double template magnetic molecularly imprinted polymers. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122556). [PMID:] |
14. Hussein Abdelraouf, Jing Ding, Jiayi Ren, Guanshu Zhao, Fanyang Zhou, Shuyan Guan, Xuedong Zhai, Qingliang Zhao. (2022) Gd-BiVO4 photocatalyst for organic contaminants removal: Short-term synthesis at sub-100 °C and enhanced sunlight-driven photocatalytic activity. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 168 (892). [PMID:] |
15. Xin Liu, Peng Xu, Shiqi Xie, Lei Wang, Zhuoyu Yang, Pengfei Zhu, Jingwei Ma, Qiulai He, John C. Crittenden. (2023) Multiple reinforcement of chloride ion on oxidizing acetaminophen with zero-valent copper particles: In-site formation and catalysis of hydrogen peroxide. CHEMICAL ENGINEERING JOURNAL, 451 (138689). [PMID:] |
16. Lizhen Qiao, Yuan Tao, Wang Yao, Jieyu Zhao, Yang Yan. (2022) A magnetic ionic liquid based vortex-assisted dispersive liquid-liquid microextraction coupled with back-extraction for the enrichment of fluoroquinolone antibiotics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 219 (114903). [PMID:35759827] |
17. Sixing Dai, Lei Xiao, Qinliu Li, Gazi Hao, Yubing Hu, Wei Jiang. (2022) 0D/1D Co3O4 quantum dots/surface hydroxylated g-C3N4 nanofibers heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products. SEPARATION AND PURIFICATION TECHNOLOGY, 297 (121481). [PMID:] |
18. Sixing Dai, Yue Wang, Lei Xiao, Gazi Hao, Yubing Hu, Guangpu Zhang, Wei Jiang. (2022) 2D/2D/2D CuO-MXene-OCN heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products: Characterization, efficiency and mechanism. JOURNAL OF ALLOYS AND COMPOUNDS, 919 (165873). [PMID:] |
19. Xin Liu, Peng Xu, Zhuoyu Yang, Pengfei Zhu, Lei Wang, Shiqi Xie. (2022) Catalytic oxidation of 4-acetamidophenol with Fe3+-enhanced Cu0 particles: In-site generation and activation of hydrogen peroxide. JOURNAL OF HAZARDOUS MATERIALS, 436 (129291). [PMID:35739796] |
20. Peng Xu, Shiqi Xie, Xin Liu, Lei Wang, Xiangwen Jia, Chao Yang. (2022) Electrochemical enhanced heterogenous activation of peroxymonosulfate using CuFe2O4 particle electrodes for the degradation of diclofenac. CHEMICAL ENGINEERING JOURNAL, 446 (136941). [PMID:] |
21. Nkoom Matthew, Lu Guanghua, Liu Jianchao. (2022) Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (39): (58963-58979). [PMID:35378650] |
22. Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. (2022) Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. PHARMACEUTICAL BIOLOGY, 60 (1): (359-373). [PMID:35171063] |
23. Shuaibing Liu, Ziteng Wang, Eric Chan, Yibo Zhao, Jian Kang, Xiaojian Zhang, Xin Tian. (2022) Inhibition of cytochrome P450 enzymes and uridine 5′-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions. CHEMICO-BIOLOGICAL INTERACTIONS, 352 (109775). [PMID:34910929] |
24. Yang Zhou, Fan Tong, Weilong Gu, Siqin He, Xiaotong Yang, Jiamei Li, Yue-Dong Gao, Huile Gao. (2022) Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors. Acta Pharmaceutica Sinica B, 12 (1416). [PMID:35530138] |
25. Cong Pan, Libin Fu, Fenna Lide, Yaobin Ding, Chengjun Wang, Jia Huang, Shaobin Wang. (2022) Insights into bromate reduction by Fe(II): Multiple radicals generation and carbamazepine oxidation. CHEMICAL ENGINEERING JOURNAL, 431 (133957). [PMID:] |
26. Jinbin Lin, Jing Zou, Hengyu Cai, Yixin Huang, Jiawen Li, Junyang Xiao, Baoling Yuan, Jun Ma. (2021) Hydroxylamine enhanced Fe(II)-activated peracetic acid process for diclofenac degradation: Efficiency, mechanism and effects of various parameters. WATER RESEARCH, 207 (117796). [PMID:34736001] |
27. Xuefeng Wang,Hua Wang,Qin Jiang,Yong-Ill Lee,Shengyu Feng,Hong-Guo Liu. (2017-07-18) Highly selective and sensitive fluorogenic ferric probes based on aggregation-enhanced emission with -SiMe. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 188 (202-207). [PMID:28715687] |
28. Zhen Chen,Shaoxiong He,Mingshan Zhu,Chaohai Wei. (2019-12-26) The effect of peroxymonosulfate in WS2 nanosheets for the removal of diclofenac: Information exposure and degradation pathway.. Chemosphere, 245 (125678-125678). [PMID:31875574] |
29. Wang, et al.. (2021) Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.. Toxicology Letters, 338 (51-57). [PMID:33290829] |
1. Yiqing Liu, Ting Wang, Zhengjie Chen, Shenglan Liu, Yongsheng Fu. (2024) Enhanced removal of sulfamethoxazole by Mn(II)/bisulfite in presence of nitrilotriacetic acid: Role of Mn(III). Journal of Environmental Chemical Engineering, 12 (111821). [PMID:] |
2. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] |
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